Artikel ; Online: Smart needle to diagnose metastatic lymph node using electrical impedance spectroscopy.
2020 Band 48, Heft 2, Seite(n) 281–287
Abstract: Objectives: The cause of cervical lymphadenopathy varies from inflammation to malignancy. Accurate and prompt diagnosis is crucial as delayed detection of malignant lymph node can lead to a worse prognosis. To improve the diagnostic accuracy of ... ...
Abstract | Objectives: The cause of cervical lymphadenopathy varies from inflammation to malignancy. Accurate and prompt diagnosis is crucial as delayed detection of malignant lymph node can lead to a worse prognosis. To improve the diagnostic accuracy of metastatic lymph node, electrical spectroscopy was employed to study human normal and metastatic lymph nodes using a hypodermic needle with fine interdigitated electrodes on its tip (EoN). Subjects and methods: The electrical impedance of samples collected from 8 patients were analyzed in the sweeping frequency range from 1 Hz to 1 MHz. To align the impedance level data of the patients, normalized impedance was employed. Results: The optimal frequency exhibiting the best discrimination results between the normal and cancerous tissues was introduced based on a discrimination index. A high sensitivity (86.2%) and specificity (88.9%) were obtained, which implied that the EoN holds the potential to improve the in vivo diagnostic accuracy of metastatic lymph node during biopsy and surgery. Conclusion: EoN has a promising potential to be utilized in real-time in actual clinical trials without a need for any pre/post-treatment during FNA or surgery. We believe that the EoN could reduce unnecessary operations with its associated morbidity. |
---|---|
Mesh-Begriff(e) | Biopsy, Needle/instrumentation ; Biopsy, Needle/methods ; Dielectric Spectroscopy ; Electrodes ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis/diagnosis ; Lymphatic Metastasis/pathology ; Reference Values ; Sensitivity and Specificity |
Sprache | Englisch |
Erscheinungsdatum | 2020-12-04 |
Erscheinungsland | Netherlands |
Dokumenttyp | Journal Article |
ZDB-ID | 604552-2 |
ISSN | 1879-1476 ; 0385-8146 |
ISSN (online) | 1879-1476 |
ISSN | 0385-8146 |
DOI | 10.1016/j.anl.2020.08.011 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 1675: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.