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Article ; Online: KDM2A interacts with estrogen receptor α to promote bisphenol A and S-induced breast cancer cell proliferation by repressing TET2 expression

Zhe Li / Yun Ren / Xuan Li / Wenwen Wang

Ecotoxicology and Environmental Safety, Vol 262, Iss , Pp 115132- (2023)

2023

Abstract: As a recognized endocrine disruptor in the environment targeting estrogen receptors (ERs), Bisphenol A (BPA) and its bisphenol S (BPS) analogs are involved in the development of breast cancer. Epigenetic modifications are crucial in many biological ... ...

Abstract	As a recognized endocrine disruptor in the environment targeting estrogen receptors (ERs), Bisphenol A (BPA) and its bisphenol S (BPS) analogs are involved in the development of breast cancer. Epigenetic modifications are crucial in many biological processes, and DNA hydroxymethylation (DNAhm) coupled with histone methylation is implicated in epigenetic machinery covering cancer occurrence. Our previous study indicated that BPA/BPS induces breast cancer cell (BCC) proliferation with enhanced estrogenic transcriptional activity and causes the change of DNAhm depending on ten-eleven translocation 2 (TET2) dioxygenase. Herein, we investigated the interplay of KDM2A-mediated histone demethylation with ER-dependent estrogenic activity (EA) and identified their function in DNAhm catalyzed by TET2 for ER-positive (ER+) BCC proliferation induced by BPA/BPS. We found that BPA/BPS-treated ER+ BCCs presented increased KDM2A mRNA and protein levels but reduced TET2 and genomic DNAhm. Furthermore, KDM2A promoted H3K36me2 loss and suppressed TET2-dependent DNAhm by reducing its chromatin binding during BPA/BPS-induced cell proliferation. Results of Co-IP & ChIP assays suggested the direct interplay of KDM2A with ERα in multiple manners. KDM2A reduced the lysine methylation of ERα protein to increase its phosphorylated activation. On the other hand, ERα did not affect KDM2A expression, while KDM2A protein levels decreased after ERα deletion, indicating that ERα binding might maintain KDM2A protein stability. In conclusion, a potential feedback circuit of KDM2A/ERα-TET2-DNAhm was identified among ER+ BCCs with significant effects on regulating BPA/BPS-induced cell proliferation. These insights advanced the understanding of the relationship between histone methylation, DNAhm, and cancer cell proliferation with EA attributed to BPA/BPS exposure in the environment.
Keywords	Bisphenols exposure ; Breast cancer cell proliferation ; DNA hydroxymethylation ; Estrogenic activity ; Histone demethylation ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	570
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High Expression of TIMM17B Is a Potential Diagnostic and Prognostic Marker of Breast Cancer.

Mingting Duan / Yun Ren / Jiwen Zhang / Tingting Zhang / Yanhong Wang / Hongyan Jia

Cellular and molecular biology (Noisy-le-Grand, France)

2023 Volume 69, Issue 3, Page(s) 169–176

Abstract: Breast cancer (BC) is the most common malignant tumor in women. TIMM17B has been found to be related to the cell cycle. The purpose of this study was to explore the diagnostic and prognostic value of TIMM17B in BC and its correlation with tumor immune ... ...

Abstract	Breast cancer (BC) is the most common malignant tumor in women. TIMM17B has been found to be related to the cell cycle. The purpose of this study was to explore the diagnostic and prognostic value of TIMM17B in BC and its correlation with tumor immune infiltration and ferroptosis. For this purpose, the transcription and expression profile of TIMM17B between BC and normal tissues was downloaded from The Cancer Genome Atlas (TCGA). To verify the expression of TIMM17B in BC, we analyzed it by immunohistochemical staining. The correlation between TIMM17B and clinical features was analyzed using the R package to establish a ROC diagnostic curve. The GSVA package was used to determine the relationship between TIMM17B gene expression levels and immune infiltration. The GDSC was used to predict the IC50 of the drug. Expression of TIMM17B in tamoxifen-resistant breast cancer cells was detected by protein immunoblot analysis. Results showed that the expression of TIMM17B in many kinds of malignant tumors was higher than that in paracancer, with a significantly high expression in BC (P < 0.001). We validated this result by analyzing tissue microarrays. ROC curve analysis showed an AUC value in TIMM17B of 0.920. The Kaplan-Meier method showed a better prognosis for patients with high expression of TIMM17B in basal BC than that of patients with low expression of TIMM17B (HR=2.32 (1.09-4.94), P=0.038). In addition, the expression of TIMM17B in BC was negatively correlated with the level of immune infiltration, Tcm cells, T helper cells, and immune targets such as CD274, HAVCR2, and PDCD1LG2. At the same time, the expression of TIMM17B in BC was significantly correlated with the drug resistance and the expression of GPX4 and other key enzymes of ferroptosis. Protein immunoblot analysis revealed high expression of TIMM17B in tamoxifen-resistant breast cancer cells. In conclusion, the expression of TIMM17B in BC was significantly increased, and it was related to immune infiltration, drug resistance and ferroptosis in BC. Our research shows that TIMM17B can be used as a diagnostic index of BC and one of the targets of immunotherapy.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Prognosis ; Tamoxifen/therapeutic use ; Cell Cycle ; Cell Division
Chemical Substances	Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2023-03-31
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2023.69.3.25
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Editorial

Bo Zhang / Heng Chi / Gen Hua Yue / XianYun Ren

Frontiers in Marine Science, Vol

Mining, development, and utilization of genetic resources related to economic traits of aquatic animals based on omics technology

2023 Volume 10

Keywords	aquatic animals ; RNA-seq ; WGBS ; omics technology ; invertebrates ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Proximity to major roads and the incidence of osteoporotic fractures in elderly women

Yun Ren / Weishi Li / Zhongqiang Chen / Jue Liu / Dongwei Fan

Frontiers in Public Health, Vol

The BONE study in Beijing

2022 Volume 10

Abstract: BackgroundThere is growing evidence to suggest that living near major roads (and suffering from the air pollution of urban streets) can have an adverse effect on bone health. However, little is known about its relationship to fractures caused by ... ...

Abstract	BackgroundThere is growing evidence to suggest that living near major roads (and suffering from the air pollution of urban streets) can have an adverse effect on bone health. However, little is known about its relationship to fractures caused by osteoporosis.ObjectiveThis study was designed to investigate the relationship between residents living near major roads and the incidence of osteoporotic fractures.MethodsA retrospective cohort of 529 subjects was established based on community populations in older women aged 65–91. All participants lived in Beijing between September 27, 2007 and September 26, 2017. The distance between the residential sites of the subjects and the main roads was determined by the authors. Osteoporotic fracture diagnosis was based on medical histories and imaging examinations (DXA and X-rays). The Cox proportional hazard model was used to assess the association between traffic proximity and osteoporotic fractures, with suitable adjustments for individual and background factors.ResultsThe age range of all participants was 65–91 years, with an average age of 75.8 years (and a standard deviation 6.8 years). Of these, 19 (3.59%) suffered from diabetes, and 48 (9%) had hypertension; 85 (14%) families had annual incomes below US $30,000 and 402 (76%) had received a secondary school education or higher. Nearly 25% of people lived within 50 m of a main road, while 50% lived within 300 m. Between 2007 and 2017, a total of 96 osteoporotic fractures were observed. For people living <50 m from a main road, the adjusted hazard ratio (HR) for osteoporotic fractures was 2.509 (95% CI 1.345–4.680), while it was 1.830 (95% CI 1.029–3.255) for those living at a distance of 50–300 m from a main road vs. those living further than 300 m away.ConclusionIn this community-based cohort, living near a major road was associated with a higher incidence of osteoporotic fractures.
Keywords	air pollution ; osteoporotic fracture ; motor vehicle pollution ; road ; street ; Public aspects of medicine ; RA1-1270
Subject code	380
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Inpatient Outcomes of Patients Undergoing Robot-Assisted versus Laparoscopic Radical Cystectomy for Bladder Cancer: A National Inpatient Sample Database Study.

Fan, Le-Wei / Li, Yun-Ren / Wu, Cheng-Mu / Chuang, Kai-Ti / Li, Wei-Chang / Liu, Chung-Yi / Chang, Ying-Hsu

Journal of clinical medicine

2024 Volume 13, Issue 3

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030772
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Article ; Online: Selective separation and recovery of heavy metals from electroplating effluent using shear-induced dissociation coupling with ultrafiltration.

Tang, Shu-Yun / Qiu, Yun-Ren

Chemosphere

2019 Volume 236, Page(s) 124330

Abstract: Shear-induced dissociation coupling with ultrafiltration (SID-UF) is an efficient and environment-friendly technology for the separation of heavy metal ions. In this paper, SID-UF was successfully employed for the selective recovery of nickel, zinc and ... ...

Abstract	Shear-induced dissociation coupling with ultrafiltration (SID-UF) is an efficient and environment-friendly technology for the separation of heavy metal ions. In this paper, SID-UF was successfully employed for the selective recovery of nickel, zinc and copper from electroplating effluent using poly (acrylic acid) sodium (PAAS) and copolymer of maleic acid and acrylic acid (PMA) as complexants, respectively. The effects of the pH, mass ratio of polymer to metal ions (P/M) and the rotating speed on the metals removal efficiency are discussed in detail. The shear stabilities of the polymer-metal complexes were explored and the complexes critical shear rates (γ
MeSH term(s)	Electroplating/methods ; Metals, Heavy/chemistry ; Ultrafiltration/methods
Chemical Substances	Metals, Heavy
Language	English
Publishing date	2019-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2019.07.061
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Article ; Online: Preparation and Modification Technology Analysis of Ionic Polymer-Metal Composites (IPMCs)

Chendong He / Yunqing Gu / Junjun Zhang / Longbiao Ma / Muhan Yan / Jiegang Mou / Yun Ren

International Journal of Molecular Sciences, Vol 23, Iss 3522, p

2022 Volume 3522

Abstract: As a new type of flexible smart material, ionic polymer-metal composite (IPMC) has the advantages of being lightweight and having fast responses, good flexibility, and large deformation ranges. However, IPMC has the disadvantages of a small driving force ...

Abstract	As a new type of flexible smart material, ionic polymer-metal composite (IPMC) has the advantages of being lightweight and having fast responses, good flexibility, and large deformation ranges. However, IPMC has the disadvantages of a small driving force and short lifespan. Based on this, this paper firstly analyzes the driving mechanism of IPMC. Then, it focuses on the current preparation technology of IPMC from the aspects of electroless plating and mechanical plating. The advantages and disadvantages of various preparation methods are analyzed. Due to the special driving mechanism of IPMC, there is a problem of short non-aqueous working time. Therefore, the modification research of IPMC is reviewed from the aspects of the basement membrane, working medium, and electrode materials. Finally, the current challenges and future development prospects of IPMC are discussed.
Keywords	IPMC ; smart materials ; driving mechanism ; preparation technology ; modification research ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	600
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of modified triangular flap for third molar extraction on distal periodontal health of second molar

Jing Zhao / Yuan Zhang / Yongfeng Cheng / Si Xie / Dian-Dian Li / Peng-Fei Zhang / Xiu-Yun Ren / Xing Wang

Heliyon, Vol 9, Iss 5, Pp e16161- (2023)

A randomized controlled study

2023

Abstract: Objective: The aim of this study was to assess the effect of flap design for impacted mandibular third molar extraction on the distal periodontal tissue of their neighbors clinically, immunologically, and microbiologically. Study design: This randomized ... ...

Abstract	Objective: The aim of this study was to assess the effect of flap design for impacted mandibular third molar extraction on the distal periodontal tissue of their neighbors clinically, immunologically, and microbiologically. Study design: This randomized controlled study comprised 100 patients who were allocated randomly to receive either a triangular flap or a modified triangular flap. The distal periodontal pocket depth, plaque index, bleeding on probing, the presence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia, and the level of interleukin-1β, interleukin-8 and matrix metalloproteinase-8 of adjacent second molars were measured at baseline, and 1, 4 and 8 weeks after surgery. Results: After 1 and 4 weeks, distal periodontal conditions of adjacent second molars deteriorated, along with an increase in subgingival microbiota and inflammatory factors in both groups. And compared to the modified triangular flap group, the triangular flap group significantly increased (p < 0.05). Prevotella intermedia, interleukin-1β and probing depth were positively correlated in both groups. After 8 weeks, they returned to the preoperative level. Conclusions: In this study, both flap designs for impacted mandibular third molar extractions was associated with worse clinical periodontal indices, increased inflammatory biomarkers of gingival crevicular fluid, and more subgingival pathogenic microbiota within 4 weeks. But compared with the triangular flap, the modified triangular flap was better for distal periodontal health of adjacent second molars, which provides certain directions for clinical treatment.
Keywords	Impacted mandibular third molar ; Tooth extraction ; Flap design ; Periodontal conditions ; Subgingival microbiota ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The hemocompatibility of the modified polysulfone membrane with 4-(chloromethyl)benzoic acid and sulfonated hydroxypropyl chitosan.

Yan, Sheng / Tu, Ming-Ming / Qiu, Yun-Ren

Colloids and surfaces. B, Biointerfaces

2020 Volume 188, Page(s) 110769

Abstract: Polysulfone (PSf) membrane is widely employed in blood purification fields, but the blood compatibility of PSf membrane is not adequate. To improve the hemocompatibility of PSf membrane, 4-(chloromethyl)benzoic acid (CMBA) and sulfonated hydroxypropyl ... ...

Abstract	Polysulfone (PSf) membrane is widely employed in blood purification fields, but the blood compatibility of PSf membrane is not adequate. To improve the hemocompatibility of PSf membrane, 4-(chloromethyl)benzoic acid (CMBA) and sulfonated hydroxypropyl chitosan (SHPCS) were grafted onto PSf membrane surface. In our strategy, CMBA was firstly grafted on the PSf membrane surface through the Friedel-Crafts alkylation reaction, and the product was named BAPSf membrane. Then, SHPCS was grafted onto the BAPSf membrane surface by esterification, and the product was named SHPCS-BAPSf membrane. The effects of temperature and reaction time on the productivity of BAPSf and the grafting density of carboxyl and the effects of reaction time on the grafting density of SHPCS grafted onto the BAPSf membrane surface were studied. The SHPCS-BAPSf membranes are investigated by ATR-FTIR, XPS, contact angle measurements and evaluated by blood compatibility in vitro. The results reveal that the hydrophilicity of SHPCS-BAPSf membranes were grealy improved and the evaluation of protein adsorption, hemolysis test, platelet adhesion plasma recalcification time(PRT), activated partial thromboplastin time(APTT), prothrombin time(PT) and thrombin time(TT) confirmed that the SHPCS-BAPSf membranes have remarkable blood compatibility.
MeSH term(s)	Adsorption ; Animals ; Benzoic Acid/chemistry ; Biocompatible Materials/chemistry ; Blood Coagulation Tests ; Blood Platelets/chemistry ; Cattle ; Chitosan/chemistry ; Humans ; Hydrophobic and Hydrophilic Interactions ; Materials Testing ; Particle Size ; Platelet Adhesiveness ; Polymers/chemistry ; Serum Albumin, Bovine/chemistry ; Sulfones/chemistry ; Surface Properties
Chemical Substances	Biocompatible Materials ; Polymers ; Sulfones ; polysulfone P 1700 (25135-51-7) ; Serum Albumin, Bovine (27432CM55Q) ; Benzoic Acid (8SKN0B0MIM) ; Chitosan (9012-76-4)
Language	English
Publishing date	2020-01-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2019.110769
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The hemocompatibility of the modified polysulfone membrane with 4-(chloromethyl)benzoic acid and sulfonated hydroxypropyl chitosan

Yan, Sheng / Tu, Ming-Ming / Qiu, Yun-Ren

Colloids and surfaces. 2020 Apr., v. 188

2020

Abstract	Polysulfone (PSf) membrane is widely employed in blood purification fields, but the blood compatibility of PSf membrane is not adequate. To improve the hemocompatibility of PSf membrane, 4-(chloromethyl)benzoic acid (CMBA) and sulfonated hydroxypropyl chitosan (SHPCS) were grafted onto PSf membrane surface. In our strategy, CMBA was firstly grafted on the PSf membrane surface through the Friedel-Crafts alkylation reaction, and the product was named BAPSf membrane. Then, SHPCS was grafted onto the BAPSf membrane surface by esterification, and the product was named SHPCS-BAPSf membrane. The effects of temperature and reaction time on the productivity of BAPSf and the grafting density of carboxyl and the effects of reaction time on the grafting density of SHPCS grafted onto the BAPSf membrane surface were studied. The SHPCS-BAPSf membranes are investigated by ATR-FTIR, XPS, contact angle measurements and evaluated by blood compatibility in vitro. The results reveal that the hydrophilicity of SHPCS-BAPSf membranes were grealy improved and the evaluation of protein adsorption, hemolysis test, platelet adhesion plasma recalcification time(PRT), activated partial thromboplastin time(APTT), prothrombin time(PT) and thrombin time(TT) confirmed that the SHPCS-BAPSf membranes have remarkable blood compatibility.
Keywords	Fourier transform infrared spectroscopy ; X-ray photoelectron spectroscopy ; adhesion ; adsorption ; alkylation ; benzoic acid ; biocompatibility ; blood plasma ; blood platelets ; cell adhesion ; chitosan ; contact angle ; esterification ; hemolysis ; hydrophilicity ; prothrombin ; temperature ; thrombin ; thromboplastin
Language	English
Dates of publication	2020-04
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2019.110769
Database	NAL-Catalogue (AGRICOLA)

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