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Article ; Online: How to appropriately assess the oxygen reduction reaction activity of platinum group metal catalysts with rotating disk electrode

Yun-Fei Xia / Pan Guo / Jia-Zhan Li / Lei Zhao / Xu-Lei Sui / Yan Wang / Zhen-Bo Wang

iScience, Vol 24, Iss 9, Pp 103024- (2021)

2021

Abstract: Summary: The sluggish oxygen reduction reaction (ORR) has becoming the bottleneck of largescale implementation of proton exchange membrane fuel cells. However, when it comes to the ORR activity assessing of platinum group metals (PGMs) with rotating disk ...

Abstract	Summary: The sluggish oxygen reduction reaction (ORR) has becoming the bottleneck of largescale implementation of proton exchange membrane fuel cells. However, when it comes to the ORR activity assessing of platinum group metals (PGMs) with rotating disk electrode, the corresponding potential conversion vs. reversible hydrogen electrode, test protocols, and activity calculation processes are still in chaos in many published literatures. In this work, two standard calculation processes for PGM ORR activities are demonstrated, followed by a specification for the usage of reference electrodes. Then a 4-fold discrepancy in ORR activities obtained via different test protocols is found for the same Pt/C, and an average adsorption model and the “coverage effects” are proposed to illustrate the hysteresis loop between negative and positive-going ORR polarization plots. Finally, four motions over appropriate assessment of PGM ORR activity are emphasized, hoping to bring a fair communication platform for researchers from different groups.
Keywords	Chemical reaction ; Catalysis ; Energy systems ; Energy storage ; Science ; Q
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MRI-based deep learning model predicts distant metastasis and chemotherapy benefit in stage II nasopharyngeal carcinoma

Yu-Jun Hu / Lin Zhang / You-Ping Xiao / Tian-Zhu Lu / Qiao-Juan Guo / Shao-Jun Lin / Lan Liu / Yun-Bin Chen / Zi-Lu Huang / Ya Liu / Yong Su / Li-Zhi Liu / Xiao-Chang Gong / Jian-Ji Pan / Jin-Gao Li / Yun-Fei Xia

iScience, Vol 26, Iss 6, Pp 106932- (2023)

2023

Abstract: Summary: Chemotherapy remains controversial for stage II nasopharyngeal carcinoma because of its considerable prognostic heterogeneity. We aimed to develop an MRI-based deep learning model for predicting distant metastasis and assessing chemotherapy ... ...

Abstract	Summary: Chemotherapy remains controversial for stage II nasopharyngeal carcinoma because of its considerable prognostic heterogeneity. We aimed to develop an MRI-based deep learning model for predicting distant metastasis and assessing chemotherapy efficacy in stage II nasopharyngeal carcinoma. This multicenter retrospective study enrolled 1072 patients from three Chinese centers for training (Center 1, n = 575) and external validation (Centers 2 and 3, n = 497). The deep learning model significantly predicted the risk of distant metastases for stage II nasopharyngeal carcinoma and was validated in the external validation cohort. In addition, the deep learning model outperformed the clinical and radiomics models in terms of predictive performance. Furthermore, the deep learning model facilitates the identification of high-risk patients who could benefit from chemotherapy, providing useful additional information for individualized treatment decisions.
Keywords	Oncology ; Mathematical biosciences ; Biocomputational method ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognostic Value of Cavernous Sinus Invasion in Patients with Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy.

Jun-Fang Liao / Li Ma / Xiao-Jing Du / Mei Lan / Ying Guo / Lie Zheng / Yun-Fei Xia / Wei Luo

PLoS ONE, Vol 11, Iss 1, p e

2016 Volume 0146787

Abstract: To investigate the prognostic value of cavernoussinus invasion (CSI) in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT).Retrospective review of data from 1,087 patients with biopsy-proven, non-metastatic ... ...

Abstract	To investigate the prognostic value of cavernoussinus invasion (CSI) in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT).Retrospective review of data from 1,087 patients with biopsy-proven, non-metastatic NPC. All patients were diagnosed using magnetic resonance imaging (MRI) scans and received IMRT as the primary treatment.The incidence of cavernoussinus invasion in this cohort was 12.1%. In univariate analysis, 5-year overall survival (OS) (70.6% vs. 88.5%, P < 0.001) and distant metastasis-free survival (DMFS) (71.4% vs. 87.7%, P < 0.001), but not locoregional relapse-free survival (LRFS) (93.9% vs. 93.7%, P = 0.341), were significantly different between patients with and without cavernoussinus invasion. In the T4 subgroup, the 5-year OS, DMFS, and LRFS of patients with and without cavernoussinus extension were 70.6% vs. 81.9% (P = 0.011), 71.4% vs. 84.1% (P = 0.011), and 91.2% vs. 89.7% (P = 0.501), respectively. In multivariate analysis, cavernoussinus invasion was an independent prognostic factor for poorer OS (HR = 1.782; P = 0.013) and DMFS (HR = 1.771; P = 0.016), but not LRFS (HR = 0.632; P = 0.294). In patients with lymph node metastasis, the DMFS rates of patients with and without cavernoussinus invasion were significantly different (P < 0.001). Preliminaryanalysis indicated that neoadjuvant chemotherapy led to better DMFS and OS in patients with cavernoussinus invasion than concurrent chemotherapy or radiotherapy alone; however, the differences were not significant.In the IMRT era, cavernoussinus invasion remains a prognostic factor for poor DMFS and OS in NPC, even in patients with T4 disease.
Keywords	Medicine ; R ; Science ; Q
Subject code	616 ; 610
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Lu-Jun Shen / Chen Chen / Bo-Fei Li / Jin Gao / Yun-Fei Xia

PLoS ONE, Vol 8, Iss

High Weight Loss during Radiation Treatment Changes the Prognosis in Under-/Normal Weight Nasopharyngeal Carcinoma Patients for the Worse: A Retrospective Analysis of 2433 Cases

2013 Volume 12

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High weight loss during radiation treatment changes the prognosis in under-/normal weight nasopharyngeal carcinoma patients for the worse

Lu-Jun Shen / Chen Chen / Bo-Fei Li / Jin Gao / Yun-Fei Xia

PLoS ONE, Vol 8, Iss 7, p e

a retrospective analysis of 2433 cases.

2013 Volume 68660

Abstract: BACKGROUND:Although weight loss is common in nasopharyngeal carcinoma (NPC) patients receiving radiotherapy, the prognostic influence of weight loss and its impact modified by body mass index (BMI) are still unclear. METHODS:2433 NPC patients receiving ... ...

Abstract	BACKGROUND:Although weight loss is common in nasopharyngeal carcinoma (NPC) patients receiving radiotherapy, the prognostic influence of weight loss and its impact modified by body mass index (BMI) are still unclear. METHODS:2433 NPC patients receiving radical radiotherapy at Sun Yat-sen University Cancer Center from November, 2000 to December, 2004 were enrolled. Weight change during radiation treatment was categorized into high weight loss (HWL) and low weight loss (LWL). The associations of HWL with overall survival (OS) and disease-specific survival (DSS) were analyzed by Cox regression. RESULTS:Among underweight patients, HWL was independently associated with poor OS (hazard ratio [HR], 2.06; 95% CI 1.36-3.11) and DSS (HR, 2.27; 95% CI 1.38-3.73), as compared with LWL, after adjusting for covariates. In normal weight patients, the impact of HWL on OS (HR, 1.47; 95% CI 1.19-1.80) and DSS (HR, 1.59; 95% CI 1.24-2.03) was moderate. Among overweight/obese patients, no significant association between HWL and OS (HR, 1.22; 95% CI 0.95-1.55), or DSS (HR, 1.23; 95% CI 0.93-1.64) was found. CONCLUSION:Except for overweight/obese patients, high weight loss during radiation treatment was independently associated with poor survival in NPC. This impact was more prominent in the underweight patient group.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction

Lu-Jun Shen / Chen Chen / Bo-Fei Li / Jin Gao / Yun-Fei Xia

PLoS ONE, Vol 8, Iss

High Weight Loss during Radiation Treatment Changes the Prognosis in Under-/Normal Weight Nasopharyngeal Carcinoma Patients for the Worse: A Retrospective Analysis of 2433 Cases.

2013 Volume 12

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An esophagus-sparing technique to limit radiation esophagitis in locally advanced non-small cell lung cancer treated by simultaneous integrated boost intensity-modulated radiotherapy and concurrent chemotherapy

Li Ma / Bo Qiu / QiWen Li / Li Chen / Bin Wang / YongHong Hu / MengZhong Liu / Li Zhang / Yan Huang / XiaoWu Deng / YunFei Xia / MaoSheng Lin / Hui Liu

Radiation Oncology, Vol 13, Iss 1, Pp 1-

2018 Volume 9

Abstract: Abstract Background To investigate the incidence of radiation esophagitis (RE) and tumor local control using esophagus sparing technique in locally advanced non-small cell lung cancer (LANSCLC) treated by simultaneous integrated boost intensity-modulated ...

Abstract	Abstract Background To investigate the incidence of radiation esophagitis (RE) and tumor local control using esophagus sparing technique in locally advanced non-small cell lung cancer (LANSCLC) treated by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) and concurrent chemotherapy. Methods Eighty-seven patients with stage IIIA/B NSCLC who received definitive SIB-IMRT and concurrent chemotherapy had been divided into two groups: 1.with esophagus sparing technique; 2.without esophagus sparing technique. Chi-square test was performed to compare sex, clinical stage, histology, concurrent chemotherapy, RE and nutrition status between two groups. T-test was used to compare the dosimetric parameters. Overall survival (OS) and loco-regional failure free survival (LRFS) were calculated by the Kaplan–Meier method and compared by a log-rank test. Results There were 44 patients in the esophagus sparing group and 43 in the non-sparing group. The incidence of severe RE (Grade 3) was significantly lower in patients with esophagus sparing technique (p = 0.002). Patients in esophagus sparing group had better nutrition status (p = 0.045). With a median follow-up of 18 months (range 1–51 months), the 1-year, 2-year and 3-year OS of all the patients was 86.6, 65.4 and 43.7%. The 1-year, 2-year LRFS was 78.4, 65.9%. OS time (p = 0.301) and LRFS (p = 0.871) was comparable between two groups. Conclusions Esophagus-sparing technique is an effective and essential method to limit RE in LANSCLC treated by SIB-IMRT and concurrent chemotherapy without compromising local control.
Keywords	Non-small cell lung cancer ; Chemoradiotherapy ; Esophagus-sparing technique ; Esophagitis ; Loco-regional failure free survival ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610 ; 616
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas

Sibo Zhao / Jia Li / Huiyuan Zhang / Lin Qi / Yuchen Du / Mari Kogiso / Frank K. Braun / Sophie Xiao / Yulun Huang / Jianfang Li / Wan-Yee Teo / Holly Lindsay / Patricia Baxter / Jack M. F. Su / Adekunle Adesina / Miklós Laczik / Paola Genevini / Anne-Clemence Veillard / Sol Schvartzman /

Geoffrey Berguet / Shi-Rong Ding / Liping Du / Clifford Stephan / Jianhua Yang / Peter J. A. Davies / Xinyan Lu / Murali Chintagumpala / Donald William Parsons / Laszlo Perlaky / Yun-Fei Xia / Tsz-Kwong Man / Yun Huang / Deqiang Sun / Xiao-Nan Li

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 16

Abstract: While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct ... ...

Abstract	While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct patterns of DNA methylation.
Keywords	Science ; Q
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A simple method for industrialization to enhance the tap density of LiNi0.5Co0.2Mn0.3O2 cathode material for high-specific volumetric energy lithium-ion batteries

Zhang, Yin / Wang, Zhen-Bo / Nie, Min / Yu, Fu-Da / Yun-Fei Xia / Liu, Bao-Sheng / Xue, Yuan / Zheng, Li-Li / Wu, Jin

RSC advances. 2016 July 11, v. 6, no. 70

2016

Abstract: Electrode materials with high tap densities and high specific volumetric energies are the key to large-scale industrial applications for the lithium ion battery industry, which faces huge challenges. LiNi0.5Co0.2Mn0.3O2 cathode materials with different ... ...

Abstract	Electrode materials with high tap densities and high specific volumetric energies are the key to large-scale industrial applications for the lithium ion battery industry, which faces huge challenges. LiNi0.5Co0.2Mn0.3O2 cathode materials with different particle sizes are used as the raw materials to study the effect of the mass ratio of mixed materials on the tap density and electrochemical performance of mixed materials in this work. Physical and electrochemical characterizations demonstrate that the tap density of mixed powders with different particle sizes is higher than those of materials with a single particle size. The tap density of as-prepared material has a decreasing trend with the increase of the ratio of 9 μm sized particle in the materials. The highest tap density among all of the kinds of materials reaches up to 2.66 g cm−3. Besides, the mixed material with a mass ratio of 7 : 2 : 1 has a bigger specific surface area and it presents better cycle behaviors and rate capability than other materials. The specific volumetric capacity of this mixed sample reaches up to 394.3 mA h cm−3 with 1C rate charge/discharge, and it has improvements of 8.5%, 22.2% and 40.6% over any single particle size of 9 μm, 6 μm and 3 μm, respectively, which contributes to the industrial production of Li–Ni–Co–Mn–O cathode materials for lithium ion batteries.
Keywords	cathodes ; electrochemistry ; energy ; industrial applications ; industrialization ; lithium batteries ; particle size ; powders ; raw materials ; surface area
Language	English
Dates of publication	2016-0711
Size	p. 65941-65949.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c6ra11052e
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma

Xiao-Yu Zuo / Qi-Sheng Feng / Jian Sun / Pan-Pan Wei / Yoon-Ming Chin / Yun-Miao Guo / Yun-Fei Xia / Bo Li / Xiao-Jun Xia / Wei-Hua Jia / Jian-Jun Liu / Alan Soo-Beng Khoo / Taisei Mushiroda / Ching-Ching Ng / Wen-Hui Su / Yi-Xin Zeng / Jin-Xin Bei

Biology of Sex Differences, Vol 10, Iss 1, Pp 1-

2019 Volume 11

Abstract: Abstract Background The male predominance in the incidence of nasopharyngeal carcinoma (NPC) suggests the contribution of the X chromosome to the susceptibility of NPC. However, no X-linked susceptibility loci have been examined by genome-wide ... ...

Abstract	Abstract Background The male predominance in the incidence of nasopharyngeal carcinoma (NPC) suggests the contribution of the X chromosome to the susceptibility of NPC. However, no X-linked susceptibility loci have been examined by genome-wide association studies (GWASs) for NPC by far. Methods To understand the contribution of the X chromosome in NPC susceptibility, we conducted an X chromosome-wide association analysis on 1615 NPC patients and 1025 healthy controls of Guangdong Chinese, followed by two validation analyses in Taiwan Chinese (n = 562) and Malaysian Chinese (n = 716). Results Firstly, the proportion of variance of X-linked loci over phenotypic variance was estimated in the discovery samples, which revealed that the phenotypic variance explained by X chromosome polymorphisms was estimated to be 12.63% (non-dosage compensation model) in males, as compared with 0.0001% in females. This suggested that the contribution of X chromosome to the genetic variance of NPC should not be neglected. Secondly, association analysis revealed that rs5927056 in DMD gene achieved X chromosome-wide association significance in the discovery sample (OR = 0.81, 95% CI 0.73–0.89, P = 1.49 × 10−5). Combined analysis revealed rs5927056 for DMD gene with suggestive significance (P = 9.44 × 10−5). Moreover, the female-specific association of rs5933886 in ARHGAP6 gene (OR = 0.62, 95%CI: 0.47–0.81, P = 4.37 × 10−4) was successfully replicated in Taiwan Chinese (P = 1.64 × 10−2). rs5933886 also showed nominally significant gender × SNP interaction in both Guangdong (P = 6.25 × 10−4) and Taiwan datasets (P = 2.99 × 10−2). Conclusion Our finding reveals new susceptibility loci at the X chromosome conferring risk of NPC and supports the value of including the X chromosome in large-scale association studies.
Keywords	Nasopharyngeal carcinoma ; Genetic susceptibility ; X chromosome ; Association study ; Male predominance ; Medicine ; R ; Physiology ; QP1-981
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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