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  1. Article ; Online: Immigrant Status and Unmet Home Care Needs: Results from the Canadian Community Health Survey.

    Yung, Seles

    Journal of immigrant and minority health

    2021  Volume 24, Issue 1, Page(s) 154–161

    Abstract: This study assessed the relationship between immigration status, including recency, and unmet home care needs. Data from the 2015-2016 Canadian Community Health Survey (CCHS) was used to analyze the relationship between immigration status and unmet home ... ...

    Abstract This study assessed the relationship between immigration status, including recency, and unmet home care needs. Data from the 2015-2016 Canadian Community Health Survey (CCHS) was used to analyze the relationship between immigration status and unmet home care needs. Descriptive analyses and multivariable logistic regression controlling for age, sex, marital status, and education were calculated. Of the study sample of 5976 respondents, 34.5% had unmet home care needs. Prevalence of unmet needs was highest among recent immigrants (43.8%), compared with long-time immigrants (40.5%) and non-immigrants (32.7%). Adjusted odds of unmet needs was higher for both immigrant categories than non-immigrants, and stronger for long-time immigrants (OR = 1.58, 95% CI: 1.14, 2.20) than recent immigrants (OR = 1.42, 95% CI: 0.67, 3.00). The finding that immigrants are more likely to experience unmet home care needs, with a slight difference between recent and long-time immigrants, suggests home care access inequities exist between immigrants and non-immigrants, and among immigrants.
    MeSH term(s) Canada ; Emigrants and Immigrants ; Health Services Accessibility ; Health Services Needs and Demand ; Health Status ; Health Surveys ; Home Care Services ; Humans ; Public Health
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2220162-2
    ISSN 1557-1920 ; 1557-1912
    ISSN (online) 1557-1920
    ISSN 1557-1912
    DOI 10.1007/s10903-020-01135-x
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  2. Article ; Online: Endothelial cell activation and glycocalyx shedding - potential as biomarkers in patients with lupus nephritis.

    Yung, Susan / Chan, Tak Mao

    Frontiers in immunology

    2023  Volume 14, Page(s) 1251876

    Abstract: Lupus nephritis (LN) is a common and severe manifestation of systemic lupus erythematosus and an important cause of acute and chronic kidney injury. Early diagnosis of LN and preventing relapses are key to preserving renal reserve. However, due to the ... ...

    Abstract Lupus nephritis (LN) is a common and severe manifestation of systemic lupus erythematosus and an important cause of acute and chronic kidney injury. Early diagnosis of LN and preventing relapses are key to preserving renal reserve. However, due to the complexity and heterogeneity of the disease, clinical management remains challenging. Kidney biopsy remains the gold standard for confirming the diagnosis of LN and subsequent assessment of kidney histopathology, but it is invasive and cannot be repeated frequently. Current clinical indicators of kidney function such as proteinuria and serum creatinine level are non-specific and do not accurately reflect histopathological changes, while anti-dsDNA antibody and C3 levels reflect immunological status but not kidney injury. Identification of novel and specific biomarkers for LN is prerequisite to improve management. Renal function deterioration is associated with changes in the endothelial glycocalyx, a delicate gel-like layer located at the interface between the endothelium and bloodstream. Inflammation induces endothelial cell activation and shedding of glycocalyx constituents into the circulation. This review discusses the potential role of soluble glycocalyx components as biomarkers of active LN, especially in patients in whom conventional serological and biochemical markers do not appear helpful.
    MeSH term(s) Humans ; Lupus Nephritis/pathology ; Glycocalyx/pathology ; Kidney/pathology ; Biomarkers ; Endothelial Cells/pathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1251876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: B-cell signatures for disease flare and response to pre-emptive immunosuppressive therapy in patients with lupus nephritis: abridged secondary publication.

    Yap, Y H D / Chan, T M / Yung, S / Wong, S

    Hong Kong medical journal = Xianggang yi xue za zhi

    2023  Volume 29 Suppl 3, Issue 3, Page(s) 23–26

    MeSH term(s) Humans ; Lupus Nephritis/drug therapy ; Lupus Nephritis/complications ; Symptom Flare Up ; Immunosuppressive Agents/therapeutic use ; Treatment Outcome ; Immunosuppression Therapy
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-06-26
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Lymphocyte subset profile and clinical phenotype in lupus nephritis: abridged secondary publication.

    Yap, D Y H / Chan, T M / Yung, S / Wong, S

    Hong Kong medical journal = Xianggang yi xue za zhi

    2022  Volume 28 Suppl 1, Issue 1, Page(s) 35–37

    MeSH term(s) Humans ; Lupus Erythematosus, Systemic ; Lupus Nephritis ; Lymphocyte Subsets ; Phenotype
    Language English
    Publishing date 2022-03-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
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  5. Article: High-dose N-acetylcysteine in an immunocompromised patient with COVID-19: a case report.

    Lai, K Y / Au, S Y / Sin, K C / Yung, S K / Leung, A K H

    Hong Kong medical journal = Xianggang yi xue za zhi

    2024  Volume 30, Issue 1, Page(s) 69–71

    MeSH term(s) Humans ; Acetylcysteine/therapeutic use ; COVID-19 ; Immunocompromised Host ; Antioxidants
    Chemical Substances Acetylcysteine (WYQ7N0BPYC) ; Antioxidants
    Language English
    Publishing date 2024-02-08
    Publishing country China
    Document type Case Reports
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj2210461
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  6. Article ; Online: Myeloarchitectonic cortical parcellation data for contemporary neuroimaging - the Vogt-Vogt legacy in the 21st century.

    Foit, Niels Alexander / Yung, Seles / Lee, Hyo Min / Bernasconi, Andrea / Bernasconi, Neda / Hong, Seok-Jun

    Data in brief

    2023  Volume 47, Page(s) 108999

    Abstract: Obtaining precise and detailed parcellations of the human brain has been a major focus of neuroscience research. Here, we present a multimodal dataset, MYATLAS, based on histology-derived myeloarchitectonic parcellations for use with contemporary ... ...

    Abstract Obtaining precise and detailed parcellations of the human brain has been a major focus of neuroscience research. Here, we present a multimodal dataset, MYATLAS, based on histology-derived myeloarchitectonic parcellations for use with contemporary neuroimaging analyses software. The core of MYATLAS is a novel 3D neocortical, surface-based atlas derived from legacy myeloarchitectonic histology studies. Additionally, we provide digitized quantitative laminar profiles of intracortical myelin content derived from postmortem photometric data, cross-correlated with
    Language English
    Publishing date 2023-02-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2023.108999
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  7. Article ; Online: Tamoxifen Therapy for Recurrent Mucosal Bleeding in Hereditary Hemorrhagic Telangiectasia.

    Yung, Stephanie / Bell, Julie-Anne / Brooker, Jim

    Journal of hematology

    2021  Volume 10, Issue 1, Page(s) 22–24

    Abstract: A 60-year-old Caucasian man had a 55-year history of recurrent severe epistaxis and later presented with multiple gastrointestinal (GI) bleeding from hereditary hemorrhagic telangiectasia (HHT). Bleeding was exacerbated due to coexistent mild hemophilia ... ...

    Abstract A 60-year-old Caucasian man had a 55-year history of recurrent severe epistaxis and later presented with multiple gastrointestinal (GI) bleeding from hereditary hemorrhagic telangiectasia (HHT). Bleeding was exacerbated due to coexistent mild hemophilia A. Despite repeated conventional surgical interventions, tranexamic acid and recombinant factor VIII (FVIII) prophylaxis, bleeding episodes worsened in frequency and severity, resulting in the patient becoming transfusion dependent. The introduction of tamoxifen therapy resulted in reduced transfusion requirement.
    Language English
    Publishing date 2021-02-06
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2662519-2
    ISSN 1927-1220 ; 1927-1220
    ISSN (online) 1927-1220
    ISSN 1927-1220
    DOI 10.14740/jh794
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  8. Article ; Online: A spotlight on the treatment of intraabdominal infections.

    Montravers, Philippe / Yung, Sonia / Tran-Dinh, Alexy

    Expert review of clinical pharmacology

    2020  Volume 13, Issue 5, Page(s) 469–472

    MeSH term(s) Bacteria/drug effects ; Bacteria/isolation & purification ; Bacterial Infections/epidemiology ; Bacterial Infections/microbiology ; Bacterial Infections/therapy ; Drug Resistance, Multiple, Bacterial ; Humans ; Intensive Care Units ; Intraabdominal Infections/epidemiology ; Intraabdominal Infections/microbiology ; Intraabdominal Infections/therapy
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Editorial
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2020.1766963
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  9. Article ; Online: A review of advances in the understanding of lupus nephritis pathogenesis as a basis for emerging therapies.

    Yung, Susan / Yap, Desmond Yh / Chan, Tak Mao

    F1000Research

    2020  Volume 9

    Abstract: Lupus nephritis is an important cause of both acute kidney injury and chronic kidney disease that can result in end-stage renal disease. Its pathogenic mechanisms are characterized by aberrant activation of both innate and adaptive immune responses, ... ...

    Abstract Lupus nephritis is an important cause of both acute kidney injury and chronic kidney disease that can result in end-stage renal disease. Its pathogenic mechanisms are characterized by aberrant activation of both innate and adaptive immune responses, dysregulation of inflammatory signaling pathways, and increased cytokine production. Treatment of lupus nephritis remains a challenging issue in the management of systemic lupus erythematosus since the clinical presentation, response to treatment, and prognosis all vary considerably between patients and are influenced by ethnicity, gender, the degree of chronic kidney damage, pharmacogenomics, and non-immunological modulating factors. Elucidation of the various immunopathogenic pathways in lupus nephritis has resulted in the development of novel therapies, including biologics that target specific antigens on B lymphocytes to achieve B cell depletion, agents that modulate B cell proliferation and development, drugs that block co-stimulatory pathways, drugs that target T lymphocytes primarily, and therapies that target complement activation, signaling pathways, pro-inflammatory cytokines, and neutrophil extracellular traps. This review will discuss recent advances in the understanding of disease pathogenesis in lupus nephritis in the context of potential emerging therapies.
    MeSH term(s) B-Lymphocytes ; Cytokines ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Nephritis/drug therapy ; Lupus Nephritis/pathology ; T-Lymphocytes
    Chemical Substances Cytokines
    Language English
    Publishing date 2020-08-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.22438.1
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  10. Article ; Online: A whole-brain 3D myeloarchitectonic atlas: Mapping the Vogt-Vogt legacy to the cortical surface.

    Foit, Niels A / Yung, Seles / Lee, Hyo Min / Bernasconi, Andrea / Bernasconi, Neda / Hong, Seok-Jun

    NeuroImage

    2022  Volume 263, Page(s) 119617

    Abstract: Building precise and detailed parcellations of anatomically and functionally distinct brain areas has been a major focus in Neuroscience. Pioneer anatomists parcellated the cortical manifold based on extensive histological studies of post-mortem brain, ... ...

    Abstract Building precise and detailed parcellations of anatomically and functionally distinct brain areas has been a major focus in Neuroscience. Pioneer anatomists parcellated the cortical manifold based on extensive histological studies of post-mortem brain, harnessing local variations in cortical cyto- and myeloarchitecture to define areal boundaries. Compared to the cytoarchitectonic field, where multiple neuroimaging studies have recently translated this old legacy data into useful analytical resources, myeloarchitectonics, which parcellate the cortex based on the organization of myelinated fibers, has received less attention. Here, we present the neocortical surface-based myeloarchitectonic atlas based on the histology-derived maps of the Vogt-Vogt school and its 2D translation by Nieuwenhuys. In addition to a myeloarchitectonic parcellation, our package includes intracortical laminar profiles of myelin content based on Vogt-Vogt-Hopf original publications. Histology-derived myelin density mapped on our atlas demonstrated a close overlap with in vivo quantitative MRI markers for myelin and relates to cytoarchitectural features. Complementing the existing battery of approaches for digital cartography, the whole-brain myeloarchitectonic atlas offers an opportunity to validate imaging surrogate markers of myelin in both health and disease.
    MeSH term(s) Humans ; Cerebral Cortex/diagnostic imaging ; Brain Mapping/methods ; Myelin Sheath ; Brain ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2022.119617
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