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  1. Article ; Online: Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs

    Shih-Hui Chiu / Wen-Lin Ho / Yung-Chen Sun / Jean-Cheng Kuo / Jie-rong Huang

    Communications Biology, Vol 5, Iss 1, Pp 1-

    2022  Volume 12

    Abstract: A comparison of structure-function relationship for intrinsically disordered regions (IDRs) among paralogs shows that differences in physicochemical properties of the IDR between paralogs are compensated for to converge on the same biophysical function. ...

    Abstract A comparison of structure-function relationship for intrinsically disordered regions (IDRs) among paralogs shows that differences in physicochemical properties of the IDR between paralogs are compensated for to converge on the same biophysical function.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3

    Yi-Ping Chiu / Yung-Chen Sun / De-Chen Qiu / Yu-Hao Lin / Yin-Quan Chen / Jean-Cheng Kuo / Jie-rong Huang

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 12

    Abstract: Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical ... ...

    Abstract Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical experiments with NMR measurements and show that the galectin-3 NTD undergoes liquid-liquid phase separation (LLPS) and agglutinates other molecules through this process.
    Keywords Science ; Q
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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