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Artikel ; Online: Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils

Christina Pfirschke / Camilla Engblom / Jeremy Gungabeesoon / Yunkang Lin / Steffen Rickelt / Rapolas Zilionis / Marius Messemaker / Marie Siwicki / Genevieve M. Gerhard / Anna Kohl / Etienne Meylan / Ralph Weissleder / Allon M. Klein / Mikael J. Pittet

Cell Reports, Vol 32, Iss 12, Pp 108164- (2020)

2020  

Abstract: Summary: Myeloid cells co-expressing the markers CD11b, Ly-6G, and SiglecF can be found in large numbers in murine lung adenocarcinomas and accelerate cancer growth by fostering tumor cell invasion, angiogenesis, and immunosuppression; however, some of ... ...

Abstract Summary: Myeloid cells co-expressing the markers CD11b, Ly-6G, and SiglecF can be found in large numbers in murine lung adenocarcinomas and accelerate cancer growth by fostering tumor cell invasion, angiogenesis, and immunosuppression; however, some of these cells’ fundamental features remain unexplored. Here, we show that tumor-infiltrating CD11b+ Ly-6G+ SiglecFhigh cells are bona fide mature neutrophils and therefore differ from other myeloid cells, including SiglecFhigh eosinophils, SiglecFhigh macrophages, and CD11b+ Ly-6G+ myeloid-derived suppressor cells. We further show that SiglecFhigh neutrophils gradually accumulate in growing tumors, where they can live for several days; this lifespan is in marked contrast to that of their SiglecFlow counterparts and neutrophils in general, which live for several hours only. Together, these findings reveal distinct attributes for tumor-promoting SiglecFhigh neutrophils and help explain their deleterious accumulation in the tumor bed.
Schlagwörter neutrophils ; cancer ; myeloid cells ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code) 610
Sprache Englisch
Erscheinungsdatum 2020-09-01T00:00:00Z
Verlag Elsevier
Dokumenttyp Artikel ; Online
Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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