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  1. Article: Rare Case of Large Catecholamine Secreting Ganglioneuroma in an Asymptomatic Elderly Male.

    Soundarajan, Tivya / Bidin, Mohamed Badrulnizam Long / Rajoo, Subashini / Yunus, Rosna

    Journal of the ASEAN Federation of Endocrine Societies

    2022  Volume 37, Issue 1, Page(s) 87–90

    Abstract: Ganglioneuromas (GNs) are benign tumors that originate from neural crest cells, composed mainly of mature ganglion cells. These tumors, which are usually hormonally silent, tend to be discovered incidentally on imaging tests and occur along the ... ...

    Abstract Ganglioneuromas (GNs) are benign tumors that originate from neural crest cells, composed mainly of mature ganglion cells. These tumors, which are usually hormonally silent, tend to be discovered incidentally on imaging tests and occur along the paravertebral sympathetic chain, from the neck to the pelvis and occasionally in the adrenal medulla. Rarely, GNs secrete catecholamines.
    Language English
    Publishing date 2022-02-04
    Publishing country Thailand
    Document type Case Reports
    ZDB-ID 2893162-2
    ISSN 2308-118X ; 0857-1074
    ISSN (online) 2308-118X
    ISSN 0857-1074
    DOI 10.15605/jafes.037.01.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Differential Protein Expression Patterns of HOXA13 and HOXB13 Are Associated with Bladder Cancer Progression.

    Chin, Fee-Wai / Hussin, Huzlinda / Chau, De-Ming / Ong, Teng-Aik / Yunus, Rosna / Abdul Razack, Azad Hassan / Yusoff, Khatijah / Chan, Soon-Choy / Veerakumarasivam, Abhi

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 16

    Abstract: Bladder cancer is a common urological cancer and has the highest recurrence rate of any cancer. The aim of our study was to profile and characterize the protein expression of homeobox A13 ( ...

    Abstract Bladder cancer is a common urological cancer and has the highest recurrence rate of any cancer. The aim of our study was to profile and characterize the protein expression of homeobox A13 (
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13162636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of

    Aldoghachi, Ahmed Faris / Baharudin, Aminuddin / Ahmad, Umar / Chan, Soon Choy / Ong, Teng Aik / Yunus, Rosna / Razack, Azad Hassan / Yusoff, Khatijah / Veerakumarasivam, Abhi

    Disease markers

    2019  Volume 2019, Page(s) 3875147

    Abstract: The ceramide synthase 2 ( ...

    Abstract The ceramide synthase 2 (
    MeSH term(s) Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Movement ; Gene Expression Regulation, Neoplastic ; Humans ; Inhibitory Concentration 50 ; Membrane Proteins/metabolism ; Neoplasm Recurrence, Local ; Newcastle disease virus ; Oncolytic Virotherapy ; Phenotype ; RNA, Small Interfering/metabolism ; Sphingosine N-Acyltransferase/metabolism ; Tumor Suppressor Proteins/metabolism ; Urinary Bladder Neoplasms/metabolism
    Chemical Substances Biomarkers, Tumor ; Membrane Proteins ; RNA, Small Interfering ; Tumor Suppressor Proteins ; CERS2 protein, human (EC 2.3.1.24) ; Sphingosine N-Acyltransferase (EC 2.3.1.24)
    Language English
    Publishing date 2019-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2019/3875147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1856: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Giant Intradiverticular Bladder Tumor.

    Md Noh, Mohamad Syafeeq Faeez / Abdul Aziz, Ahmad Fuad / Mohd Ghani, Khairul Asri / Lee Kheng Siang, Christopher / Yunus, Rosna / Mohd Yusof, Mubarak

    The American journal of case reports

    2017  Volume 18, Page(s) 212–216

    Abstract: BACKGROUND Intradiverticular bladder tumors are rare. This renders diagnosis of an intradiverticular bladder tumor difficult. Imaging plays a vital role in achieving the diagnosis, and subsequently staging of the disease. CASE REPORT A 74-year-old male ... ...

    Abstract BACKGROUND Intradiverticular bladder tumors are rare. This renders diagnosis of an intradiverticular bladder tumor difficult. Imaging plays a vital role in achieving the diagnosis, and subsequently staging of the disease. CASE REPORT A 74-year-old male presented to our center with a few months history of constitutional symptoms. Upon further history, he reported hematuria two months prior to presentation, which stopped temporarily, only to recur a few days prior to coming to the hospital. The patient admitted to having lower urinary tract symptoms. However, there was no dysuria, no sandy urine, and no fever. Palpation of his abdomen revealed a vague mass at the suprapubic region, which was non tender. In view of his history and the clinical examination findings, an ultrasound of the abdomen and computed tomography (CT) was arranged. These investigations revealed a giant tumor that seemed to be arising from a bladder diverticulum, with a mass effect and hydronephrosis. He later underwent operative intervention. CONCLUSIONS Intradiverticular bladder tumors may present a challenge to the treating physician in an atypical presentation; thus requiring a high index of suspicion and knowledge of tumor pathophysiology. As illustrated in our case, CT with its wide availability and multiplanar imaging capabilities offers a useful means for diagnosis, disease staging, operative planning, and follow-up.
    MeSH term(s) Aged ; Carcinoma/diagnostic imaging ; Carcinoma/pathology ; Carcinoma/surgery ; Diverticulum ; Humans ; Male ; Tomography, X-Ray Computed ; Tumor Burden ; Ultrasonography ; Urinary Bladder/abnormalities ; Urinary Bladder Neoplasms/diagnostic imaging ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery
    Language English
    Publishing date 2017-03-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/ajcr.902101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Roles of MicroRNA21 and MicroRNA29a in Regulating Cell Adhesion Related Genes in Bone Metastasis Secondary to Prostate Cancer.

    Mohamad, Maisarah / Wahab, Norhazlina Abdul / Yunus, Rosna / Murad, Nor Azian Abdul / Zainuddin, Zulkifli Md / Sundaram, Murali / Mokhtar, Norfilza Mohd

    Asian Pacific journal of cancer prevention : APJCP

    2016  Volume 17, Issue 7, Page(s) 3437–3445

    Abstract: Background: There is an increasing concern in the role of microRNA (miRNA) in the pathogenesis of bone metastasis (BM) secondary to prostate cancer (CaP). In this exploratory study, we hypothesized that the expression of vinculin (VCL) and chemokine X3C ...

    Abstract Background: There is an increasing concern in the role of microRNA (miRNA) in the pathogenesis of bone metastasis (BM) secondary to prostate cancer (CaP). In this exploratory study, we hypothesized that the expression of vinculin (VCL) and chemokine X3C ligand 1 (CX3CL1) might be downregulated in clinical samples, most likely due to the posttranscriptional modification by microRNAs. Targeted genes would be upregulated upon transfection of the bone metastatic prostate cancer cell line, PC3, with specific microRNA inhibitors.
    Materials and methods: MicroRNA software predicted that miR21 targets VCL while miR29a targets CX3CL1. Twenty benign prostatic hyperplasia (BPH) and 16 high grade CaP formalinfixed paraffin embedded (FFPE) specimens were analysed. From the bone scan results, high grade CaP samples were further classified into CaP with no BM and CaP with BM. Transient transfection with respective microRNA inhibitors was done in both RWPE1 (normal) and PC3 cell lines. QPCR was performed in all FFPE samples and transfected cell lines to measure VCL and CX3CL1 levels.
    Results: QPCR confirmed that VCL messenger RNA (mRNA) was significantly down regulated while CX3CL1 was upregulated in all FFPE specimens. Transient transfection with microRNA inhibitors in PC3 cells followed by qPCR of the targeted genes showed that VCL mRNA was significantly up regulated while CX3CL1 mRNA was significantly downregulated compared to the RWPE1 case.
    Conclusions: The downregulation of VCL in FFPE specimens is most likely regulated by miR21 based on the in vitro evidence but the exact mechanism of how miR21 can regulate VCL is unclear. Upregulated in CaP, CX3CL1 was found not regulated by miR29a. More microRNA screening is required to understand the regulation of this chemokine in CaP with bone metastasis. Understanding miRNAmRNA interactions may provide additional knowledge for individualized study of cancers.
    MeSH term(s) Aged ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Cell Adhesion/genetics ; Cell Line, Tumor ; Down-Regulation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; MicroRNAs/genetics ; Prostatic Hyperplasia/genetics ; Prostatic Hyperplasia/pathology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; RNA, Messenger/genetics ; Transfection/methods ; Up-Regulation/genetics
    Chemical Substances MIRN21 microRNA, human ; MIRN29a microRNA, human ; MicroRNAs ; RNA, Messenger
    Language English
    Publishing date 2016-08-04
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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