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  1. AU="Yunyuan Li"
  2. AU="Li, Qingtian"
  3. AU="Song, An"
  4. AU="Ersin Akinci"
  5. AU="Lale Say"
  6. AU="Nada, Khaled M"
  7. AU="Letesson, Gaetan"
  8. AU="Łukasik, Sylwia"
  9. AU="Van Der Meer, Peter J."
  10. AU="Jojoa Jojoa, Ruby Isabel"
  11. AU="Tan, Qingshan" AU="Tan, Qingshan"
  12. AU="Pennington, R Toby"
  13. AU="Bou Sanayeh, Elie"
  14. AU="Yun, Hwa Young"
  15. AU="C. Maridith Arthur"
  16. AU="Kunze, Ursula"
  17. AU="Adam Bienenstock"
  18. AU="Laviolette, M"
  19. AU="Mama, Khursheed R"
  20. AU="Sachse, Katharina" AU="Sachse, Katharina"
  21. AU="Skrlin, Branimir"
  22. AU="Mathais, Quentin"
  23. AU=Armstrong Ehrin J
  24. AU="Bahadi, Abdelaali"
  25. AU="Qin, Shuhui"
  26. AU="Huaraca-Quispe, Lidia P"
  27. AU=Petrovan Vlad AU=Petrovan Vlad AU=Petrovan Vlad
  28. AU="Elaina M Blair"
  29. AU="Hui Ram Kim"
  30. AU="Litvak, Yael"
  31. AU="Chen, Xiang-Yan"
  32. AU="Honorio Coronado, Eurídice N."
  33. AU="Garny, Hella"
  34. AU="Idris, Zamzuri"
  35. AU="Gao, Xinyu"
  36. AU="Tewari, Srishti"
  37. AU="Behrendt, Ulrike" AU="Behrendt, Ulrike"
  38. AU="Margenthaler, Julie A"
  39. AU="Si, Lian-Jing"
  40. AU="Strand, Torbjørn"
  41. AU=Abdoli Amir

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  1. Artikel ; Online: Assessing urban park equity in Chaoyang District, Beijing using online review data

    Ning Zou / Xiayuan Mi / Yang Xiao / Yunyuan Li / Nan Hu

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Band 15

    Abstract: Abstract Urban parks are essential components of urban ecosystems, providing vital ecological resources for city residents. However, the rapid expansion of high-density urban areas has led to an unequal distribution of park resources, raising growing ... ...

    Abstract Abstract Urban parks are essential components of urban ecosystems, providing vital ecological resources for city residents. However, the rapid expansion of high-density urban areas has led to an unequal distribution of park resources, raising growing concerns about spatial equity. To address these challenges, we employed an improved Gaussian two-step floating catchment area (2SFCA) method, considering park quality variations and integrating sentiment scores from park reviews to calculate a comprehensive park accessibility index, accounting for both supply and demand dynamics among park users. The results demonstrate the significance of park management, as users prioritise convenience and cleanliness of public facilities. Recreational quality significantly influences park distribution equity, with areas near Beijing’s initial greenbelt zone showing improved accessibility (IA). Nonetheless, our analysis exposes disparities in urban park resource allocation within the Chaoyang District, indicating relative inequity. Spatial supply and demand mismatches, especially in the northwest and southeast, are evident. To enhance park layout equity, we recommend strategies like identifying and repurposing underused spaces, establishing pocket parks and micro-green areas, and improving recreational facilities. It is crucial to address the needs of vulnerable groups such as older residents and children. These insights stress the importance of ensuring fair urban park access to enhance the well-being of all city residents.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 710
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The Social Equity of Urban Parks in High-Density Urban Areas

    Chang Wang / Siyuan Wang / Yilun Cao / Haojun Yan / Yunyuan Li

    Sustainability, Vol 15, Iss 13849, p

    A Case Study in the Core Area of Beijing

    2023  Band 13849

    Abstract: Urban parks beautify the environment and promote urban public health, and their spatial allocation is significant in maintaining environmental justice. However, the current allocation of urban parks focuses on quantity fairness and pays insufficient ... ...

    Abstract Urban parks beautify the environment and promote urban public health, and their spatial allocation is significant in maintaining environmental justice. However, the current allocation of urban parks focuses on quantity fairness and pays insufficient attention to accessibility and quality fairness. This study investigated the core area of Beijing and analyzed the fairness of urban park allocation based on park accessibility, area, and quality. We used big data crawling, the two-step floating catchment area method, comprehensive equity evaluation of parks, spatial autocorrelation, and non-parametric tests. The results showed inequality in terms of accessibility, area, and quality, with high spatial distribution in the north and low spatial distribution in the south. The accessibility, shortest distance, and total area of urban parks in high-income residential areas were 3.0, 2.1, and 1.8 times higher, respectively, than those of the low-income residential areas. This indicates that high-income groups have better accessibility, live closer to, and have access to larger urban parks. Middle-income and above groups had access to green space, whereas medium-to-low-income residential areas had poor access to parks, particularly high-quality parks. These findings provide decision-making and planning references for the optimal allocation and rational planning of urban parks.
    Schlagwörter green space equity ; urban parks ; accessibility ; green space quality assessment ; high-density city ; Beijing core area ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 710
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Evaluation and Optimization of Refuge Green Space in the Central Area of Tianjin for Geological Disasters

    Yilun Cao / Yuhan Guo / Chang Wang / Yunyuan Li

    Sustainability, Vol 14, Iss 15507, p

    2022  Band 15507

    Abstract: Refuge Green Space (RGS) plays roles in both rapid evacuation and short-term resettlement in response to sudden natural hazards, especially geological disasters. As a result, its evaluation and location optimization are crucial for the development of ... ...

    Abstract Refuge Green Space (RGS) plays roles in both rapid evacuation and short-term resettlement in response to sudden natural hazards, especially geological disasters. As a result, its evaluation and location optimization are crucial for the development of sustainable cities. In this study, the Three-Step Floating Catchment Area Method (3SFCA) and Moran’s I index were used as measurement models. The rapid evacuation and short-term resettlement capacity of RGS were evaluated by calculating accessibility with 5, 10, 15 and 30 min of walking. The purpose of this study was to quantitatively evaluate the supply capacity of RGS in the central area of Tianjin and to provide recommendations for future additions to RGS. The results show that over 80% of the research area exhibited relatively poor service capacity within a 5–10 min walking distance, while less than 20% exhibited relatively good service capacity. Within a 15–30 min walking distance, approximately 60% of the study area was not well served by the RGS, while approximately 40% was well served. In conclusion, the layout of RGS in the central area of Tianjin exhibits unevenness and polarization of phenomena, and the supply of different categories of RGS varies widely. There is an insufficient supply of Emergency Sheltered Green Space and Temporary Sheltered Green Space, and that which is available is difficult to reach within 5–10 min. The coverage capacity of Disaster Prevention Park Space is relatively good, essentially covering the entire study area within a 15–30 min walking distance; however, the service capacity is average. Based on these conclusions, areas in which the RGS supply was weak were identified, and future potential RGS additions were identified in conjunction with the Green Space System Plan.
    Schlagwörter Refuge Green Space (RGS) ; accessibility ; rapid evacuation ; Three-Step Floating Catchment Area Method (3SFCA) ; Moran’s I ; central area of Tianjin ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 710
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing.

    Yunyuan Li / Hatem Alnojeidi / Ruhangiz T Kilani / Aziz Ghahary

    PLoS ONE, Vol 17, Iss 6, p e

    2022  Band 0262060

    Abstract: Dermal wound healing is a complex process which requires the interaction of many cell types and mediators in a highly sophisticated temporal sequence. Myeloid cells which compose of a significant proportion of the inflammatory cells infiltrate to the to ... ...

    Abstract Dermal wound healing is a complex process which requires the interaction of many cell types and mediators in a highly sophisticated temporal sequence. Myeloid cells which compose of a significant proportion of the inflammatory cells infiltrate to the to a wound site where they play important roles in clearance of damaged tissue and microorganisms. Myeloid cells have the capacity to be converted into fibroblast-like cells and endothelial cells during wound healing process. However, whether myeloid cells in wounds can convert into epithelial cells where they contribute to healing process is not clear. In this study, we performed double immunofluorescent staining with antibodies for hematopoietic cells and keratinocytes as well as cell tracing technique to investigate hematopoietic cell conversion. The result showed that during the healing process, some of the CD45-positive hematopoietic cells also expressed keratin 14, a marker for keratinocytes. Further, double immunofluorescent staining in dermal wounds, using CD11b and K14 antibodies indicated that CD11b-positive myeloid cells were the origin of newly generated epithelial cells. Through tracing injected labeled splenocyte-derived myeloid cells in skin, we confirmed that myeloid cells were able to convert into keratinocytes in repaired skin. Furthermore, our results from in vivo experiments provided new information on contribution of myeloid cells in hair follicle regeneration. In conclusion, this work highlights the myeloid cell contributions in wound repair and hair follicle regeneration through conversion of M-CSF-stimulated CD11b-positive myeloid cells into epithelial cells in a murine model.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Fibroblast cell-based therapy prevents induction of alopecia areata in an experimental model

    Reza B Jalili / Ruhangiz T Kilani / Yunyuan Li / Mohsen Khosravi-maharlooie / Layla Nabai / Eddy Hsi Chun Wang / Kevin J McElwee / Aziz Ghahary

    Cell Transplantation, Vol

    2018  Band 27

    Abstract: Alopecia areata (AA) is an autoimmune hair loss disease with infiltration of proinflammatory cells into hair follicles. Current therapeutic regimens are unsatisfactory mainly because of the potential for side effects and/or limited efficacy. Here we ... ...

    Abstract Alopecia areata (AA) is an autoimmune hair loss disease with infiltration of proinflammatory cells into hair follicles. Current therapeutic regimens are unsatisfactory mainly because of the potential for side effects and/or limited efficacy. Here we report that cultured, transduced fibroblasts, which express the immunomodulatory molecule indoleamine 2,3-dioxygenase (IDO), can be applied to prevent hair loss in an experimental AA model. A single intraperitoneal (IP) injection of IDO-expressing primary dermal fibroblasts was given to C3H/HeJ mice at the time of AA induction. While 60–70% of mice that received either control fibroblasts or vehicle injections developed extensive AA, none of the IDO-expressing fibroblast-treated mice showed new hair loss up to 20 weeks post injection. IDO cell therapy significantly reduced infiltration of CD4 + and CD8 + T cells into hair follicles and resulted in decreased expression of TNF-α, IFN-γ and IL-17 in the skin. Skin draining lymph nodes of IDO fibroblast-treated mice were significantly smaller, with more CD4 + CD25 + FoxP3 + regulatory T cells and fewer Th17 cells than those of control fibroblast and vehicle-injected mice. These findings indicate that IP injected IDO-expressing dermal fibroblasts can control inflammation and thereby prevent AA hair loss.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2018-06-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Fibroblast Cell-Based Therapy for Experimental Autoimmune Diabetes.

    Reza B Jalili / Yun Zhang / Azadeh Hosseini-Tabatabaei / Ruhangiz T Kilani / Mohsen Khosravi Maharlooei / Yunyuan Li / Sanam Salimi Elizei / Garth L Warnock / Aziz Ghahary

    PLoS ONE, Vol 11, Iss 1, p e

    2016  Band 0146970

    Abstract: Type 1 diabetes (T1D) results from autoimmune destruction of insulin producing β cells of the pancreatic islets. Curbing autoimmunity at the initiation of T1D can result in recovery of residual β cells and consequently remission of diabetes. Here we ... ...

    Abstract Type 1 diabetes (T1D) results from autoimmune destruction of insulin producing β cells of the pancreatic islets. Curbing autoimmunity at the initiation of T1D can result in recovery of residual β cells and consequently remission of diabetes. Here we report a cell-based therapy for autoimmune diabetes in non-obese diabetic (NOD) mice using dermal fibroblasts. This was achieved by a single injection of fibroblasts, expressing the immunoregulatory molecule indoleamine 2,3 dioxygenase (IDO), into peritoneal cavity of NOD mice shortly after the onset of overt hyperglycemia. Mice were then monitored for reversal of hyperglycemia and changes in inflammatory/regulatory T cell profiles. Blood glucose levels dropped into the normal range in 82% of NOD mice after receiving IDO-expressing fibroblasts while all control mice remained diabetic. We found significantly reduced islet inflammation, increased regulatory T cells, and decreased T helper 17 cells and β cell specific autoreactive CD8+ T cells following IDO cell therapy. We further showed that some of intraperitoneal injected fibroblasts migrated to local lymph nodes and expressed co-inhibitory molecules. These findings suggest that IDO fibroblasts therapy can reinstate self-tolerance and alleviate β cell autoreactivity in NOD mice, resulting in remission of autoimmune diabetes.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Mechanism underlying defective interferon gamma-induced IDO expression in non-obese diabetic mouse fibroblasts.

    Azadeh Hosseini-Tabatabaei / Reza Baradar Jalili / Yunyuan Li / Ruhangiz T Kilani / Alireza Moeen Rezakhanlou / Aziz Ghahary

    PLoS ONE, Vol 7, Iss 5, p e

    2012  Band 37747

    Abstract: Indoleamine 2,3-dioxygenase (IDO) can locally suppress T cell-mediated immune responses. It has been shown that defective self-tolerance in early prediabetic female non-obese diabetic (NOD) mice can be attributed to the impaired interferon-gamma (IFN-γ)- ...

    Abstract Indoleamine 2,3-dioxygenase (IDO) can locally suppress T cell-mediated immune responses. It has been shown that defective self-tolerance in early prediabetic female non-obese diabetic (NOD) mice can be attributed to the impaired interferon-gamma (IFN-γ)- induced IDO expression in dendritic cells of these animals. As IFN-γ can induce IDO in both dendritic cells and fibroblasts, we asked the question of whether there exists a similar defect in IFN-γ-induced IDO expression in NOD mice dermal fibroblasts. To this end, we examined the effect of IFN-γ on expression of IDO and its enzymatic activity in NOD dermal fibroblasts. The results showed that fibroblasts from either prediabetic (8 wks of age) female or male, and diabetic female or male (12 and 24 wks of age respectively) NOD mice failed to express IDO in response to IFN-γ treatment. To find underlying mechanisms, we scrutinized the IFN- γ signaling pathway and investigated expression of other IFN-γ-modulated factors including major histocompatibility complex class I (MHC-I) and type I collagen (COL-I). The findings revealed a defect of signal transducer and activator of transcription 1 (STAT1) phosphorylation in NOD cells relative to that of controls. Furthermore, we found an increase in MHC-I and suppression of COL-I expression in fibroblasts from both NOD and control mice following IFN-γ treatment; indicating that the impaired response to IFN-γ in NOD fibroblasts is specific to IDO gene. Finally, we showed that an IFN-γ-independent IDO expression pathway i.e. lipopolysaccharide (LPS)-mediated-c-Jun kinase is operative in NOD mice fibroblast. In conclusion, the findings of this study for the first time indicate that IFN-γ fails to induce IDO expression in NOD dermal fibroblasts; this may partially be due to defective STAT1 phosphorylation in IFN-γ-induced-IDO signaling pathway.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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