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  1. Article ; Online: In vivo

    Durkan, Kubra / Ichedef, Cigdem / Yurt Kilcar, Ayfer / Koksal Karayildirim, Cinel

    Drug development and industrial pharmacy

    2023  Volume 49, Issue 8, Page(s) 479–484

    Abstract: Objective: The objective of this study was to develop radiolabeled ibuprofen (: Significance: The development of radiolabeled ibuprofen as an imaging agent for inflammation and infection may have significant clinical implications for the diagnosis ... ...

    Abstract Objective: The objective of this study was to develop radiolabeled ibuprofen (
    Significance: The development of radiolabeled ibuprofen as an imaging agent for inflammation and infection may have significant clinical implications for the diagnosis and management of various inflammatory and infectious diseases. This study provides a promising approach to the detection of sterile infections.
    Methods: Ibuprofen was radiolabeled with
    Results: The uptake of
    Conclusions: The results of this study suggest that the detection of sterile infections with
    MeSH term(s) Rats ; Animals ; Technetium ; Ibuprofen ; Tissue Distribution ; Radionuclide Imaging ; Staphylococcal Infections/diagnostic imaging ; Rats, Wistar ; Models, Animal ; Inflammation/diagnostic imaging ; Radiopharmaceuticals
    Chemical Substances Technetium (7440-26-8) ; Ibuprofen (WK2XYI10QM) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 751874-2
    ISSN 1520-5762 ; 0363-9045
    ISSN (online) 1520-5762
    ISSN 0363-9045
    DOI 10.1080/03639045.2023.2235009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1335: Show issues Location:
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  2. Article ; Online: Preparation and in vitro investigation of prostate-specific membrane antigen targeted lycopene loaded niosomes on prostate cancer cells.

    Kusdemir, Bekir Cem / Kozgus Guldu, Ozge / Yurt Kilcar, Ayfer / Medine, Emin Ilker

    International journal of pharmaceutics

    2023  Volume 640, Page(s) 123013

    Abstract: In this study, it's aimed to develop prostate-specific membrane antigen (PSMA) targeted niosomes with a multifunctional theranostic approach. With this aim, PSMA-targeted niosomes were synthesized by a thin-film hydration method followed by bath ... ...

    Abstract In this study, it's aimed to develop prostate-specific membrane antigen (PSMA) targeted niosomes with a multifunctional theranostic approach. With this aim, PSMA-targeted niosomes were synthesized by a thin-film hydration method followed by bath sonication. Drug-loaded niosomes (Lyc-ICG-Nio) were coated with DSPE-PEG-COOH (Lyc-ICG-Nio-PEG) and subsequently anti-PSMA antibody conjugated to niosomes (Lyc-ICG-Nio-PSMA) with amide bond formation. Dynamic light scattering (DLS) analysis showed that the hydrodynamic diameter of Lyc-ICG-Nio-PSMA was approximately 285 nm and it was found with transmission electron microscopy (TEM) that the niosome formulation was spherical. Encapsulation efficiency was 45% and %65 upon dual encapsulation of ICG and lycopene. The results of fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) demonstrated that PEG coating and antibody coupling were successfully done. In vitro studies showed that cell viability decreased when lycopene was entrapped into niosomes applied while the total apoptotic cell population rose slightly. When Lyc-ICG-Nio-PSMA was applied to cells, decreased cell viability and enhanced apoptotic effect were seen compared to those for Lyc-ICG-Nio. In conclusion, it was demonstrated that targeted niosomes displayed improved cellular association and decreased cell viability on PSMA + cells.
    MeSH term(s) Male ; Humans ; Liposomes/chemistry ; Lycopene ; Prostate ; Prostatic Neoplasms/drug therapy
    Chemical Substances Liposomes ; Lycopene (SB0N2N0WV6)
    Language English
    Publishing date 2023-05-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2023.123013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1409: Show issues Location:
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  3. Article ; Online: Preparation of technetium-99m labeled ibuprofen by direct route and technetium-99m tricarbonyl route: a comparison of

    Durkan, Kubra / Ichedef, Cigdem / Yurt Kılcar, Ayfer / Arıcı, Mesut / Ucar, Eser

    Drug development and industrial pharmacy

    2020  Volume 46, Issue 7, Page(s) 1108–1113

    Abstract: In the current study, ibuprofen (ibu) which is a non-steroidal anti-inflammatory drug (NSAID) was radiolabeled ... ...

    Abstract In the current study, ibuprofen (ibu) which is a non-steroidal anti-inflammatory drug (NSAID) was radiolabeled with
    MeSH term(s) Animals ; Chromatography, Thin Layer ; Ibuprofen ; Male ; Radiopharmaceuticals/chemistry ; Rats ; Rats, Wistar ; Technetium ; Tissue Distribution
    Chemical Substances Radiopharmaceuticals ; Technetium (7440-26-8) ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2020-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 751874-2
    ISSN 1520-5762 ; 0363-9045
    ISSN (online) 1520-5762
    ISSN 0363-9045
    DOI 10.1080/03639045.2020.1776316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In Vitro Incorporation of Radioiodinated Eugenol on Adenocarcinoma Cell Lines (Caco2, MCF7, and PC3).

    Dervis, Emine / Yurt Kilcar, Ayfer / Medine, Emin Ilker / Tekin, Volkan / Cetkin, Buse / Uygur, Emre / Muftuler, Fazilet Zumrut Biber

    Cancer biotherapy & radiopharmaceuticals

    2017  Volume 32, Issue 3, Page(s) 75–81

    Abstract: Recently, the synthesis of radiolabeled plant origin compounds has been increased due to their high uptake on some cancer cell lines. Eugenol (EUG), a phenolic natural compound in the essential oils of different spices such as Syzygium aromaticum (clove), ...

    Abstract Recently, the synthesis of radiolabeled plant origin compounds has been increased due to their high uptake on some cancer cell lines. Eugenol (EUG), a phenolic natural compound in the essential oils of different spices such as Syzygium aromaticum (clove), Pimenta racemosa (bay leaves), and Cinnamomum verum (cinnamon leaf), has been exploited for various medicinal applications. EUG has antiviral, antioxidant, and anti-inflammatory functions and several anticancer properties. The objective of this article is to synthesize radioiodinated (
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/radiotherapy ; Caco-2 Cells ; Cell Line, Tumor ; Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Eugenol/administration & dosage ; Eugenol/chemical synthesis ; Eugenol/chemistry ; Eugenol/isolation & purification ; Humans ; Iodine Radioisotopes/administration & dosage ; Iodine Radioisotopes/chemistry ; Isotope Labeling ; MCF-7 Cells ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/chemistry
    Chemical Substances Iodine Radioisotopes ; Radiopharmaceuticals ; Eugenol (3T8H1794QW)
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1315649-4
    ISSN 1557-8852 ; 1084-9785
    ISSN (online) 1557-8852
    ISSN 1084-9785
    DOI 10.1089/cbr.2017.2181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1896: Show issues Location:
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  5. Article ; Online: Anti toxic effect of broccoli extract on stannous dichloride toxicity.

    Cekic, Betul / Biber Muftuler, Fazilet Zumrut / Yurt Kilcar, Ayfer / Gunay, Necati / Sakarya, Serhan / Unak, Perihan

    Acta cirurgica brasileira

    2012  Volume 27, Issue 9, Page(s) 606–610

    Abstract: Purpose: Since Technetium-99m ((99m)Tc) has favorable physical and chemical characteristics, it is widely used radioisotope in Nuclear Medicine. However, stannous dichloride (SnCl(2)) has been widely used as a reducing agent in labeling procedure of ... ...

    Abstract Purpose: Since Technetium-99m ((99m)Tc) has favorable physical and chemical characteristics, it is widely used radioisotope in Nuclear Medicine. However, stannous dichloride (SnCl(2)) has been widely used as a reducing agent in labeling procedure of pharmaceutical with radionuclide, it has been realized that SnCl(2) have genotoxic and cytotoxic effects on biological systems. In previous studies, it has been shown that some herbal extract can reduce genotoxic and cytotoxic effects of SnCl(2). In the present study, it is aimed to evaluate the effect of the broccoli extract on the survival of E. coli ATCC 25922 strain against to toxic effects of SnCl(2).
    Methods: Broccoli was extracted with methanol extraction. HPLC and TLC analysis of broccoli extract were performed. Then antitoxicity and dose response assays were performed on bacterial strain.
    Results: The broccoli extract had dose dependent protective effect against SnCl(2) toxic effect on E. coli.
    Conclusions: The consumption of broccoli may alter the stannous dichloride toxicity. Broccoli extract may use as a new protective strategies against the toxic effect of SnCl(2) on patients who were taken (99m)Tc radiopharmaceuticals.
    MeSH term(s) Brassica/chemistry ; Chromatography, Thin Layer ; Escherichia coli/drug effects ; Plant Extracts/pharmacology ; Radiopharmaceuticals/antagonists & inhibitors ; Radiopharmaceuticals/toxicity ; Technetium/toxicity ; Tin Compounds/antagonists & inhibitors ; Tin Compounds/toxicity
    Chemical Substances Plant Extracts ; Radiopharmaceuticals ; Tin Compounds ; stannous chloride (1BQV3749L5) ; Technetium (7440-26-8)
    Language English
    Publishing date 2012-05-01
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2012156-8
    ISSN 1678-2674 ; 0102-8650
    ISSN (online) 1678-2674
    ISSN 0102-8650
    DOI 10.1590/s0102-86502012000900003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Investigation of therapeutic efficiency of bleomycin and bleomycin-glucuronide labeled with (131)I on the cancer cell lines.

    Ediz, Melis / Avcıbaşı, Uğur / Unak, Perihan / Müftüler, Fazilet Zümrüt Biber / Medine, Emin İlker / Yurt Kılçar, Ayfer / Demiroğlu, Hasan / Gümüşer, Fikriye Gül / Sakarya, Serhan

    Cancer biotherapy & radiopharmaceuticals

    2013  Volume 28, Issue 4, Page(s) 310–319

    Abstract: The aim of this study is to determine the incorporations of radiolabeled bleomycin ((131)I-BLM) and bleomycin-glucuronide ((131)I-BLMGLU) on PC-3 (human prostate carcinoma cell line), Caco-2 (human colon adenocarcinoma cell line), Hutu-80 (Human Duodenum ...

    Abstract The aim of this study is to determine the incorporations of radiolabeled bleomycin ((131)I-BLM) and bleomycin-glucuronide ((131)I-BLMGLU) on PC-3 (human prostate carcinoma cell line), Caco-2 (human colon adenocarcinoma cell line), Hutu-80 (Human Duodenum adenocarcinoma cell line), and A549 (Human lung adenocarcinoma epithelial cell line) cancerous cell lines. For this purpose, BLM and BLMGLU enyzmatically synthesized were labeled with (131)I, quality control studies were done and the incorporation yields of (131)I-BLM and (131)I-BLMGLU on these cell lines were measured. Quality-control studies showed that the radiolabeling yields were obtained as 95% and 90% for (131)I-BLM and (131)I-BLMGLU, respectively. Also, as a result of the cell culture studies, it was found that (131)I-BLM and (131)I-BLMGLU had higher incorporation on PC-3 cells than that of other cell lines. In addition to this, it was reported that the incorporation yield of (131)I-BLMGLU was higher than that (131)I-BLM. At the end of the study, cytotoxicities of BLM and BLMGLU on PC-3 cancerous cell line were inspected and fluorescent images of BLM and BLMGLU were taken on PC-3 cells by using fluorescein isothiocyanate. In conclusion, cell culture studies demonstrated that the incorporation values of (131)I-BLMGLU on the four cell lines were about five to six times higher than (131)I-BLM. Radiolabeled glucuronide derivatives can be used in cancer therapy and tumor imaging, depending on the properties of radioiodine for the β-glucuronidase-rich tissues because glucuronidation leads to rapid and higher incorporation on adenocarcinoma cells.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/metabolism ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Bleomycin/chemistry ; Bleomycin/pharmacokinetics ; Bleomycin/pharmacology ; Caco-2 Cells ; Cell Proliferation/drug effects ; Duodenal Neoplasms/metabolism ; Glucuronides/chemistry ; Glucuronides/pharmacokinetics ; Glucuronides/pharmacology ; Humans ; Iodine Radioisotopes ; Lung Neoplasms/metabolism ; Male ; Optical Imaging ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism
    Chemical Substances Antineoplastic Agents ; Glucuronides ; Iodine Radioisotopes ; Bleomycin (11056-06-7)
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1315649-4
    ISSN 1557-8852 ; 1084-9785
    ISSN (online) 1557-8852
    ISSN 1084-9785
    DOI 10.1089/cbr.2012.1316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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