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Article ; Online: An Investigation into the Relationship of SUR-1TRPM4 Receptor with Peritumoral Edema in High-Grade Glial Tumors.

Dundar, Tolga Turan / Seyithanoglu, Mehmet Hakan / Coban, Ganime / Yurtsever, Ismail / Toprak, Ali / Oztanir, Mustafa Namık

Turkish neurosurgery

2024 Volume 34, Issue 1, Page(s) 93–101

Abstract: Aim: To investigate the presence of Sur1-Trpm4 receptors in high-grade glial tumors, and their relationship with edema volumes in preoperative magnetic resonance imaging (MRI) sequences.: Material and methods: MRI sections were extracted from T1- ... ...

Abstract	Aim: To investigate the presence of Sur1-Trpm4 receptors in high-grade glial tumors, and their relationship with edema volumes in preoperative magnetic resonance imaging (MRI) sequences. Material and methods: MRI sections were extracted from T1-weighted (T1W) and T2-weighted (T2W) sequences and fluidattenuated inversion recovery (FLAIR) images. After that, T1W 3D magnetization-prepared rapid gradient echo (MP-RAGE) sequences were taken with and without contrast medium. Tumor and peritumoral edema volumes were calculated in cubic centimeters. Sur1- Trpm4 receptors were studied by immunohistochemical examination of tissue samples. Relationships between data were analyzed using Spearman's correlation coefficient. Results: In the immunohistochemical examinations, 58% of the samples from patients with high-grade glial tumors were positive for Sur1 and 74% were positive for Trpm4. The volume of tumors was correlated with the volume of peritumoral edema. Conclusion: The presence of the Sur1-Trpm4 receptor complex in high-grade glial tumors was confirmed. Further preclinical or clinical studies are required to identify and validate the role of Sur1-Trpm4 in glial tumor subgroups.
MeSH term(s)	Humans ; Glioma/complications ; Glioma/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Edema/diagnostic imaging
Language	English
Publishing date	2024-01-29
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1203779-5
ISSN	2651-5032 ; 1019-5149
ISSN (online)	2651-5032
ISSN	1019-5149
DOI	10.5137/1019-5149.JTN.36251-21.4
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Article ; Online: Co-occurrence of central tegmental tract hyperintensity and Tay-Sachs disease: A case report.

Balsak, Serdar / Uyanık, Bulent / Atasoy, Bahar / Yozgat, Can Yilmaz / Yurtsever, Ismail / Alkan, Alpay

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15515

MeSH term(s)	Humans ; Tay-Sachs Disease/complications ; Tay-Sachs Disease/diagnosis
Language	English
Publishing date	2023-02-25
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15515
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Article ; Online: Follow-Up of High-Grade Glial Tumor; Differentiation of Posttreatment Enhancement and Tumoral Enhancement by DCE-MR Perfusion.

Dündar, Tolga Turan / Cetinkaya, Ezra / Yurtsever, İsmail / Uysal, Ömer / Aralaşmak, Ayşe

Contrast media & molecular imaging

2022 Volume 2022, Page(s) 6948422

Abstract: Purpose: To search for the utility of DCE-MRP to differentiate between posttreatment enhancement (PT) and tumoral enhancement (TM) in high-grade glial tumors.: Materials and methods: Thirty-four patients with glioma (11 grade 3; 23 grade 4) were ... ...

Abstract	Purpose: To search for the utility of DCE-MRP to differentiate between posttreatment enhancement (PT) and tumoral enhancement (TM) in high-grade glial tumors. Materials and methods: Thirty-four patients with glioma (11 grade 3; 23 grade 4) were enrolled. Enhancement in the vicinity of the resection cavity demonstrated by DCE-MRP was taken into consideration. Based on the follow-up scans, reoperation or biopsy results, the enhancement type was categorized as PT or TM. Measurements were performed at the enhancing area near the resection cavity (ERC), nearby (NNA) and contralateral nonenhancing areas (CLNA). Perfusion parameters of the ERC were also subtracted from NNA and CLNA. Intragroup comparison (paired sample Results: There were 7 PTs and 27 TMs. In the PT, the subtracted values of Ve and IAUC from the CLNA and NNA and the subtracted value of Kep from NNA were statistically different. In TM, all metrics were significantly different comparing the CLNA and NNA. Comparing PT with TM, Ktrans, IAUC, Kep, and subtracted values of Ktrans and IAUC from both NNA and CLNA were significantly different. Conclusions: In PT, only Ktrans values did not reveal any difference comparing NNA and CLNA. To differentiate PT from TM, Ktrans, Kep, IAUC, and subtracted values of Ktrans and IAUC from NNA and CLNA can be used. These findings are in concordance with literature.
MeSH term(s)	Contrast Media ; Follow-Up Studies ; Glioma/diagnostic imaging ; Glioma/therapy ; Humans ; Magnetic Resonance Imaging/methods ; Perfusion
Chemical Substances	Contrast Media
Language	English
Publishing date	2022-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2232678-9
ISSN	1555-4317 ; 1555-4309
ISSN (online)	1555-4317
ISSN	1555-4309
DOI	10.1155/2022/6948422
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Zs.A 6273: Show issues

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Article ; Online: New variation of scimitar syndrome with tracheal bronchus, upper lobe agenesis, and ventricular septal defect in a child.

Yurtsever, Ismail / Yesilbas, Osman / Yozgat, Can Yilmaz / Tekin, Eser / Yozgat, Yilmaz

Pediatrics international : official journal of the Japan Pediatric Society

2022 Volume 64, Issue 1, Page(s) e15029

MeSH term(s)	Bronchi/abnormalities ; Bronchi/diagnostic imaging ; Child ; Heart Septal Defects, Ventricular/diagnostic imaging ; Humans ; Lung ; Respiratory System Abnormalities ; Scimitar Syndrome/diagnostic imaging ; Trachea/abnormalities ; Trachea/diagnostic imaging
Language	English
Publishing date	2022-04-18
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15029
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Article: Diagnostic role of gray-scale and shear-wave elastography in pediatric patients with undescended testes: a prospective controlled study.

Yurtsever, Ismail / Yildiz, Seyma / Amirjanov, Samil / Yozgat, Can Yilmaz / Balsak, Serdar / Peker, Abdüsselim Adil / Atasoy, Bahar / Erol, Ahmet Berk / Toluk, Ozlem / Aydoğdu, İbrahim

Journal of ultrasonography

2024 Volume 24, Issue 94, Page(s) 1–7

Abstract: Aim: Ultrasound elastography is a simple non-invasive method for measuring tissue elasticity in relation to tissue fibrosis. The aim of this study was to compare echogenicity, volume and shear wave velocities of undescended vs normally descended testes.! ...

Abstract	Aim: Ultrasound elastography is a simple non-invasive method for measuring tissue elasticity in relation to tissue fibrosis. The aim of this study was to compare echogenicity, volume and shear wave velocities of undescended vs normally descended testes. Material and methods: Sixty-six boys with undescended testes were included in this study. The median age range was 35.5 (10-118) months old. The cases included in this prospective study consisted of 66 patients with non-operated undescended testes, with 51 of them being affected unilaterally and 15 affected bilaterally, as diagnosed by physical examination. The control group consisted of 31 healthy boys without any particular health problems. This prospective study was performed by gray-scale ultrasonography and shear wave elastography in boys with undescended testes and healthy testes. The testicular volumes were established by ultrasound measurement, the echogenicity and shear wave elastography values were measured in boys with unilateral and bilateral undescended testes, and the results were compared with healthy boys' testes and their contralateral testes. The stiffness values were recorded for speed (m/s) and elasticity (kPa), and the stiffness values of undescended testes were compared with the healthy control group. Results: Echogenicity values were lower in the bilateral undescended testes group than in the healthy group, and the healthy group's echogenicity was normal ( Conclusion: The study provides interesting findings in that it proposes an alternative non-invasive method for the assessment of testicular tissue in undescended testes. We used shear wave elastography to compare the stiffness of normal testes in both heathy patients and in the contralateral healthy testes of boys with undescended testes, with the values obtained for the undescended testes reflecting the level of fibrosis of the parenchyma. Another outcome of this study was observed in patients with unilateral undescended testes, where the normally descended testes showed increased shear wave elastography values, which could be an early indication of parenchymal change.
Language	English
Publishing date	2024-02-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2843824-3
ISSN	2084-8404
ISSN	2084-8404
DOI	10.15557/jou.2024.0004
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Article ; Online: Usefulness of oxidative stress marker evaluation at admission to the intensive care unit in patients with COVID-19.

Daskaya, Hayrettin / Yilmaz, Sinan / Uysal, Harun / Calim, Muhittin / Sümbül, Bilge / Yurtsever, Ismail / Karaaslan, Kazım

The Journal of international medical research

2021 Volume 49, Issue 7, Page(s) 3000605211027733

Abstract: Objective: Two critical processes in the coronavirus disease 2019 (COVID-19) pandemic involve assessing patients' intensive care needs and predicting disease progression during patients' intensive care unit (ICU) stay. We aimed to evaluate oxidative ... ...

Abstract	Objective: Two critical processes in the coronavirus disease 2019 (COVID-19) pandemic involve assessing patients' intensive care needs and predicting disease progression during patients' intensive care unit (ICU) stay. We aimed to evaluate oxidative stress marker status at ICU admission and ICU discharge status in patients with COVID-19. Methods: We included patients in a tertiary referral center ICU during June-December 2020. Scores of Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), and clinical severity, radiologic scores, and healthy discharge status were noted. We collected peripheral blood samples at ICU admission to evaluate total antioxidants, total oxidants, catalase, and myeloperoxidase levels. Results: Thirty-one (24 male, 7 female) patients were included. At ICU admission, patients' mean APACHE II score at ICU admission was 17.61 ± 8.9; the mean SOFA score was 6.29 ± 3.16. There was no significant relationship between clinical severity and oxidative stress (OS) markers nor between radiological imaging and COVID-19 data classification and OS levels. Differences in OS levels between patients with healthy and exitus discharge status were not significant. Conclusions: We found no significant relationship between oxidative stress marker status in patients with COVID-19 at ICU admission and patients' ICU discharge status.
MeSH term(s)	COVID-19 ; Female ; Hospital Mortality ; Humans ; Intensive Care Units ; Male ; Oxidative Stress ; SARS-CoV-2 ; Severity of Illness Index
Language	English
Publishing date	2021-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605211027733
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Zs.A 925: Show issues

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Article ; Online: Thorax computed tomography findings and anti-SARS-CoV-2 immunoglobulin G levels in polymerase chain reaction-negative probable COVID-19 cases.

Yurtsever, Ismail / Karatoprak, Cumali / Sumbul, Bilge / Kiskac, Muharrem / Tunc, Muhammed / Zorlu, Mehmet / Ogun, Hamza / Durdu, Bulent / Toluk, Ozlem / Cakirca, Mustafa

Revista da Associacao Medica Brasileira (1992)

2022

Abstract: Objective: This study aimed to evaluate the SARS-CoV-2 immunoglobulin G (IgG) levels after 6 months of polymerase chain reaction (PCR) negative but assumed to be COVID-19 positive cases to investigate the relationship between IgG levels and thoracic ... ...

Abstract	Objective: This study aimed to evaluate the SARS-CoV-2 immunoglobulin G (IgG) levels after 6 months of polymerase chain reaction (PCR) negative but assumed to be COVID-19 positive cases to investigate the relationship between IgG levels and thoracic computed tomography (CT) findings. Methods: This was a single-center study that included patients whose PCR test results were negative at least three times using nasopharyngeal swabs but had clinical findings of COVID-19 and thoracic CT findings compatible with viral pneumonia. Six months after discharge, the IgG antibodies were analyzed. The cutoff value for negative and positive serology was defined as <1.4 (index S/C) and ≥1.4 (index S/C), respectively. In addition, the patients were categorized according to their thoracic CT findings as high (typical) and low (atypical). Also, the patients were grouped into classes as <5% lung involvement versus ≥5% lung involvement. Results: The patients' mean age was 49.78±12.96 years. PCR was negative, but patients with COVID-19 symptoms who had SARS-CoV-2 IgG positive were 81.9% (n=95). The antibody titer and lung involvement ≥5% were statistically significantly higher in SARS-CoV-2 IgG positive cases (p<0.001 and p=0.021). Age and chest CT findings were the risk factors for lung involvement (OR=1.08, p<0.001 and OR=2.19, p=0.010, respectively). Conclusion: This study is valuable because increasing severity (≥5%) of lung involvement appears to be associated with high and persistent IgG antibody titers. In probable cases of COVID-19, even if the PCR test is negative, high IgG titers 6 months after discharge can predict the rate of lung parenchymal involvement.
Language	English
Publishing date	2022-11-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20220921
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Article ; Online: The effect of sarcopenia on erlotinib therapy in patients with metastatic lung adenocarcinoma.

Topcu, Atakan / Ozturk, Akin / Yurtsever, Ismail / Besiroglu, Mehmet / Yasin, Ayse Irem / Turk, Haci Mehmet / Seker, Mesut

Bosnian journal of basic medical sciences

2022 Volume 22, Issue 6, Page(s) 982–991

Abstract: Erlotinib, a tyrosine kinase inhibitor, has been shown to improve the survival of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer. Sarcopenia is a status with increasing importance in lung cancer, and it may ... ...

Abstract	Erlotinib, a tyrosine kinase inhibitor, has been shown to improve the survival of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer. Sarcopenia is a status with increasing importance in lung cancer, and it may predict a poor prognosis. We aimed to evaluate the impact of sarcopenia on erlotinib therapy and prognosis in patients with EGFR-mutated (exon 19 or 21 L858R) metastatic lung adenocarcinoma. Sarcopenia was defined as skeletal muscle index ≤39 cm2/m2 for women and ≤55 cm2/m2 for men. The patient characteristics, inflammation parameters, clinical and survival outcomes of the erlotinib therapy were examined according to sarcopenia status. We also analyzed the erlotinib treatment-related toxicity. Seventy-two patients were included in our retrospective study, and the mean age of the patients was 63.7 years. A total of 39 (54.2%) patients were diagnosed with sarcopenia. Patients with sarcopenia had a poor prognosis and had a shorter median progression-free survival (PFS) than patients without sarcopenia (10.5 months vs. 21.8 months, p=0.002). Sarcopenia (HR 2.08) and C-reactive protein > 6.5 mg/L (HR 2.57) were determined as independent poor prognostic factors for PFS of erlotinib therapy. Treatment-related toxicity occurred in 34.7% of patients treated with erlotinib, and sarcopenia did not significantly affect treatment-related toxicity. We also found that sarcopenia significantly affected the response to erlotinib. The expected survival outcomes may be low when erlotinib therapy is used in patients with sarcopenia and metastatic lung adenocarcinoma. This study showed that survival and clinical outcomes could be better predicted by detecting sarcopenia in patients with lung cancer using erlotinib.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Erlotinib Hydrochloride/therapeutic use ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Retrospective Studies ; Sarcopenia/drug therapy ; C-Reactive Protein ; Mutation ; Adenocarcinoma of Lung/complications ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/pathology ; ErbB Receptors/genetics ; Protein Kinase Inhibitors/adverse effects ; Disease-Free Survival
Chemical Substances	Erlotinib Hydrochloride (DA87705X9K) ; C-Reactive Protein (9007-41-4) ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors
Language	English
Publishing date	2022-10-23
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ZDB-ID	2240029-1
ISSN	1840-4812 ; 1512-8601
ISSN (online)	1840-4812
ISSN	1512-8601
DOI	10.17305/bjbms.2022.7147
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Article ; Online: One-year follow-up evaluation of radiological and respiratory findings and functional capacity in COVID-19 survivors without comorbidities.

Ogun, Hamza / Gül, Merve / Akkoyunlu, Yasemin / Hayat, Esat / Gökbulut, Nuran / Sümbül, Bilge / Karaçöp, Handan Başel / Yurtsever, İsmail / Yabaci, Ayşegül / Kansu, Abdullah / Okyaltirik, Fatmanur

Medicine

2023 Volume 102, Issue 22, Page(s) e33960

Abstract: The aim of this study was to assess clinical findings, radiological data, pulmonary functions and physical capacity change over time and to investigate factors associated with radiological abnormalities after coronavirus disease 2019 (COVID-19) in non- ... ...

Abstract	The aim of this study was to assess clinical findings, radiological data, pulmonary functions and physical capacity change over time and to investigate factors associated with radiological abnormalities after coronavirus disease 2019 (COVID-19) in non-comorbid patients. This prospective cohort study was conducted between April 2020 and June 2020. A total of 62 symptomatic in non-comorbid patients with COVID-19 pneumonia were included in the study. At baseline and the 2nd, 5th and 12th months, patients were scheduled for follow-up. Males represented 51.6% of the participants and overall mean age was 51.60 ± 12.45 years. The percentage of patients with radiological abnormalities at 2 months was significantly higher than at 5 months (P < .001). At 12 months, dyspnea frequency (P = .008), 6-minute walk test (6MWT) distance (P = .045), BORG-dyspnea (P < .001) and BORG-fatigue (P < .001) scores was significantly lower, while median SpO2 after 6MWT (P < .001) was significantly higher compared to results at 2 months. The presence of radiological abnormalities at 2 months was associated with the following values measured at 5 months: advanced age (P = .006), lung involvement at baseline (P = .046), low forced expiratory volume in 1 second (P = .018) and low forced vital capacity (P = .006). Even in COVID-19 patients without comorbidities, control computed tomography at 2 months and pulmonary rehabilitation may be beneficial, especially in COVID-19 patients with advanced age and greater baseline lung involvement.
MeSH term(s)	Male ; Humans ; Adult ; Middle Aged ; Follow-Up Studies ; Prospective Studies ; COVID-19 ; Lung/diagnostic imaging ; Dyspnea ; Survivors
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033960
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Article ; Online: The correlation between skeletal muscle index and anxiety in patients with lung cancer on the first day of chemotherapy.

Topcu, Atakan / Yurtsever, Ismail / Isleyen, Zehra Sucuoglu / Besiroglu, Mehmet / Yasin, Ayse Irem / Topcu, Zeynep Alaca / Shbair, Abdallah Tm / Toluk, Ozlem / Simsek, Melih / Seker, Mesut / Turk, Haci Mehmet

Future oncology (London, England)

2023 Volume 19, Issue 16, Page(s) 1139–1149

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Humans ; Sarcopenia ; Cross-Sectional Studies ; Muscle, Skeletal/pathology ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Lung Neoplasms/epidemiology ; Anxiety/epidemiology ; Anxiety/etiology ; Pain/epidemiology ; Pain/etiology ; Retrospective Studies
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2022-1200
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