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Article ; Online: Editorial

Yuzhen Li / Xianglan Yao / Stewart J. Levine / Sang-Bing Ong

Frontiers in Molecular Biosciences, Vol

Organellar dynamics in cell fate

2022 Volume 9

Keywords	organellar dynamics ; cardiac differentiation ; non-coding RNA ; endoplasmic reticulum ; mitochondria ; cardiomyocyte fate ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predicting psoriasis using routine laboratory tests with random forest.

Jing Zhou / Yuzhen Li / Xuan Guo

PLoS ONE, Vol 16, Iss 10, p e

2021 Volume 0258768

Abstract: Psoriasis is a chronic inflammatory skin disease that affects approximately 125 million people worldwide. It has significant impacts on both physical and emotional health-related quality of life comparable to other major illnesses. Accurately prediction ... ...

Abstract	Psoriasis is a chronic inflammatory skin disease that affects approximately 125 million people worldwide. It has significant impacts on both physical and emotional health-related quality of life comparable to other major illnesses. Accurately prediction of psoriasis using biomarkers from routine laboratory tests has important practical values. Our goal is to derive a powerful predictive model for psoriasis disease based on only routine hospital tests. We collected a data set including 466 psoriasis patients and 520 healthy controls with 81 variables from only laboratory routine tests, such as age, total cholesterol, HDL cholesterol, blood pressure, albumin, and platelet distribution width. In this study, Boruta feature selection method was applied to select the most relevant features, with which a Random Forest model was constructed. The model was tested with 30 repetitions of 10-fold cross-validation. Our classification model yielded an average accuracy of 86.9%. 26 notable features were selected by Boruta, among which 15 features are confirmed from previous studies, and the rest are worth further investigations. The experimental results demonstrate that the machine learning approach has good potential in predictive modeling for the psoriasis disease given the information only from routine hospital tests.
Keywords	Medicine ; R ; Science ; Q
Subject code	519
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Elevated SIRT3 Parkin-dependently activates cell mitophagy to ameliorate TNF-α-induced psoriasis-related phenotypes in HaCaT cells through deacetylating FOXO3a for its activation.

Yanli, Ma / Yu, Wang / Yuzhen, Li

Archives of dermatological research

2022 Volume 315, Issue 4, Page(s) 847–857

Abstract: Sirtuin 3 (SIRT3) is reported to be closely relevant to the pathogenesis of psoriasis, but its detailed functions and molecular mechanisms have not been fully studied. Thus, this study aimed to investigate the effects and underlying mechanisms by which ... ...

Abstract	Sirtuin 3 (SIRT3) is reported to be closely relevant to the pathogenesis of psoriasis, but its detailed functions and molecular mechanisms have not been fully studied. Thus, this study aimed to investigate the effects and underlying mechanisms by which SIRT3 regulated the development of psoriasis. Specifically, we verified that SIRT3 was aberrantly downregulated in psoriasis-like skin tissues in mice models in vivo and TNF-α-stimulated HaCaT cells in vitro, compared to their corresponding normal counterparts. Functional experiments confirmed that upregulation of SIRT3 triggered cell mitophagy, restrained oxidative stress and inflammation, and inhibited excessive cell proliferation in the TNF-α-stimulated HaCaT cells in vitro, which were all ablated by co-treating cells with the mitophagy inhibitor 3-MA. Subsequently, the mechanism experiments uncovered that elevated SIRT3 deacetylated forkhead box class o 3A (FOXO3a) for its activation, which further activated the Parkin-dependent cell mitophagy in the HaCaT cells. Next, through performing the rescuing experiments, we validated that SIRT3 ameliorated TNF-α-induced psoriasis-associated phenotypes in the HaCaT cells via modulating the FOXO3a/Parkin signal pathway. Collectively, we concluded that SIRT3 triggered cell mitophagy through activating the FOXO3a/Parkin pathway to ameliorate TNF-α-induced psoriasis in the HaCaT cells, and this study provided evidences to support that SIRT3 could be used as important therapeutic target for the treatment of psoriasis.
MeSH term(s)	Animals ; Humans ; Mice ; HaCaT Cells/metabolism ; Mitophagy ; Psoriasis/chemically induced ; Sirtuin 3/genetics ; Sirtuin 3/metabolism ; Sirtuin 3/pharmacology ; Tumor Necrosis Factor-alpha ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/pharmacology
Chemical Substances	Sirt3 protein, mouse ; Sirtuin 3 (EC 3.5.1.-) ; Tumor Necrosis Factor-alpha ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; FOXO3 protein, human
Language	English
Publishing date	2022-11-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02453-w
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Article ; Online: Scenario simulation of ecological risk based on land use/cover change – A case study of the Jinghe county, China

Yue Zhang / Yuzhen Li / Jing Lv / Juan Wang / Yan Wu

Ecological Indicators, Vol 131, Iss , Pp 108176- (2021)

2021

Abstract: The Jinghe County of the Ebinur Lake Basin was chosen as the study area. Based on Landsat TM / OLI images obtained in 2007 and 2017, this paper attempts to use CLUE-S model to predict LUCC under three different scenarios (Natural Development scenario, ... ...

Abstract	The Jinghe County of the Ebinur Lake Basin was chosen as the study area. Based on Landsat TM / OLI images obtained in 2007 and 2017, this paper attempts to use CLUE-S model to predict LUCC under three different scenarios (Natural Development scenario, Farmland Protection scenario, Water Resources Protection scenarios) in 2027. Landscape indices and ecological risk index were calculated and spatially interpolated for the whole region, and the results of ecological risk could be divided into five different zones: extremely low, low, moderate, high and extremely high. They were carried out for assessing the spatial–temporal changes in ecological risk for each landscape pattern. The results show that: (1) Among the three scenarios designed in this paper, the spatial distribution of LUCC in the Water Resource Protection scenario has the most obvious changes, followed by the Farmland Protection scenario and the Natural Development scenario becomes the third. In the water resources protection scenario, the scale of the desert decreases, but the forest and grass part increases, which is conducive to ecological improvement. (2) the distribution area of high ecological risk areas was the largest of three different scenarios, especially the farmland protection scenario. The area of low-risk level is the largest under the water conservation scenario. The ecological risk of LUCC under the water resources protection scenario is lower, which is better for ecological environment. (3) Water bodies mainly concentrate upon low ecological risk degree, accounting for approximately 62.8%, 82.2%, and 73.1% of low ecological risk; Farmland mainly lies in the low-risk areas, accounting for 59.1%, 63.5% and 68.8% of the lower ecological risk levels; In 2027, the unused land and other land types are the main land types of the higher ecological risk areas under three different scenarios, whose proportions are 67.40%, 68.24% and 65.90%, respectively.
Keywords	Land use/cover change (LUCC) ; CLUE-S Model ; Scenario Simulation ; Landscape Ecological Risk ; Ecology ; QH540-549.5
Subject code	910 ; 710
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy of bivalent CEACAM6/4-1BBL genetic vaccine combined with anti-PD1 antibody in MC38 tumor model of mice

Yuzhen Li / Xiaodan Zhu / Jianliang You / Baonan Zhang / Xiaona Huang / Chunhui Jin

Heliyon, Vol 8, Iss 10, Pp e10775- (2022)

2022

Abstract: We used mouse CRC cell line (MC38) to establish a heterotopic mouse model, and applied [89Zr]-labeled PD-L1 antibody KN035 for PET imaging. Attenuated Salmonella typhimurium 3261 was used as an anti-tumor vaccine, and the combined anti-tumor ... ...

Abstract	We used mouse CRC cell line (MC38) to establish a heterotopic mouse model, and applied [89Zr]-labeled PD-L1 antibody KN035 for PET imaging. Attenuated Salmonella typhimurium 3261 was used as an anti-tumor vaccine, and the combined anti-tumor immunotherapy with bivalent genetic vaccine and anti-PD1 antibody Nivolumab was conducted. MicroPET was performed to observe the changes of tumor tissues and expression of PD-L1. We found that the recombinant double-gene plasmids were stably expressed in COS7 cells. Study results showed the combined immunotherapy improved the effectiveness over genetic vaccine alone. This study supports that combination of genetic vaccines and anti-immunocheckpoint immunotherapy can inhibit MC38 tumor growth.
Keywords	Colorectal cancer ; Anti-tumor immunotherapy ; Genetic vaccine ; CEACAM6 ; 4-1BBL ; Anti-PD1 drug ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction of Highly Active Zn 3 In 2 S 6 (110)/g-C 3 N 4 System by Low Temperature Solvothermal for Efficient Degradation of Tetracycline under Visible Light

Haohao Huo / Yuzhen Li / Shaojie Wang / Siyang Tan / Xin Li / Siyuan Yi / Lizhen Gao

International Journal of Molecular Sciences, Vol 23, Iss 13221, p

2022 Volume 13221

Abstract: Herein, Zn 3 In 2 S 6 photocatalyst with (110) exposed facet was prepared by low temperature solvothermal method. On this basis, a highly efficient binary Zn 3 In 2 S 6 /g-C 3 N 4 was obtained by low temperature solvothermal method and applied to the ... ...

Abstract	Herein, Zn 3 In 2 S 6 photocatalyst with (110) exposed facet was prepared by low temperature solvothermal method. On this basis, a highly efficient binary Zn 3 In 2 S 6 /g-C 3 N 4 was obtained by low temperature solvothermal method and applied to the degradation of tetracycline (TC). The samples of the preparation were characterized by X-ray diffraction, scanning electron microscope, transmission electron microscope, UV–vis diffuse reflection spectroscopy, and photoluminescence spectroscopy. Furthermore, the degradation performance of photocatalysts on TC was investigated under different experimental conditions. Finally, the mechanism of Zn 3 In 2 S 6 /g-C 3 N 4 composite material degrading TC is discussed. The results show that Zn 3 In 2 S 6 and Zn 3 In 2 S 6 /g-C 3 N 4 photocatalysts with excellent performance could be successfully prepared at lower temperature. The Zn 3 In 2 S 6 /g-C 3 N 4 heterojunction photocatalyst could significantly improve the photocatalytic activity compared with g-C 3 N 4 . After 150 min of illumination, the efficiency of 80%Zn 3 In 2 S 6 /g-C 3 N 4 to degrade TC was 1.35 times that of g-C 3 N 4 . The improvement of photocatalytic activity was due to the formation of Zn 3 In 2 S 6 /g-C 3 N 4 heterojunction, which promoted the transfer of photogenerated electron–holes. The cycle experiment test confirmed that Zn 3 In 2 S 6 /g-C 3 N 4 composite material had excellent stability. The free radical capture experiment showed that ·O 2 − was the primary active material. This study provides a new strategy for the preparation of photocatalysts with excellent performance at low temperature.
Keywords	Zn 3 In 2 S 6 /g-C 3 N 4 ; tetracycline ; low temperature ; photocatalytic ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Living Bacteria‐Based Immuno‐Photodynamic Therapy

Leilei Shi / Xiaoxiao Liu / Yuzhen Li / Sha Li / Wenbo Wu / Xihui Gao / Bin Liu

Advanced Science, Vol 9, Iss 14, Pp n/a-n/a (2022)

Metabolic Labeling of Clostridium butyricum for Eradicating Malignant Melanoma

2022

Abstract: Abstract Due to the complexity, aggressiveness, and heterogeneity of malignant melanoma, it is difficult to eradicate the whole tumor through conventional treatment. Herein, a strategy of metabolic engineering labeled anaerobic oncolytic bacteria ( ... ...

Abstract	Abstract Due to the complexity, aggressiveness, and heterogeneity of malignant melanoma, it is difficult to eradicate the whole tumor through conventional treatment. Herein, a strategy of metabolic engineering labeled anaerobic oncolytic bacteria (Clostridium butyricum) is demonstrated to achieve the ablation of melanoma. In this system, the metabolic substrate of C. butyricum d‐alanine (d‐Ala) is first conjugated with a photosensitizer (TPApy) showing aggregation‐induced emission (AIE). The yielded metabolic substrate of d‐Ala‐TPAPy can be metabolically incorporated into bacterial peptidoglycan to form engineered C. Butyricum. Once the engineered C. butyricum is injected into melanoma, the bacteria can only proliferate in an anaerobic zone, stimulate the tumor immune microenvironment, and ablate the tumor hypoxia region. Following that, the relatively rich oxygen content in the peripheral area can induce the death of C. butyricum. The photosensitizer (PS) on the bacteria can subsequently exert a photodynamic effect in the oxygen‐rich region and further remove the melanoma residue under light irradiation. Prominent in vivo melanoma ablation results revealed that the engineering oncolytic bacteria can provide a promising regime for solid tumor eradication.
Keywords	Clostridium butyricum ; immunotherapy ; melanoma ; metabolic labeling ; photodynamic therapy ; Science ; Q
Subject code	570
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Network Structure Features and Influencing Factors of Tourism Flow in Rural Areas

Yuzhen Li / Guofang Gong / Fengtai Zhang / Lei Gao / Yuedong Xiao / Xingyu Yang / Pengzhen Yu

Sustainability, Vol 14, Iss 9623, p

Evidence from China

2022 Volume 9623

Abstract: Exploring the spatial network structure of tourism flow and its influencing factors is of great significance to the transmission of characteristic culture and the sustainable development of tourism in tourist destinations, especially in backward rural ... ...

Abstract	Exploring the spatial network structure of tourism flow and its influencing factors is of great significance to the transmission of characteristic culture and the sustainable development of tourism in tourist destinations, especially in backward rural areas. Taking Qiandongnan Miao and Dong Autonomous Prefecture (hereinafter referred to as Qiandongnan Prefecture) as an example, this paper adopts social network analysis and Quadratic Assignment Procedure regression analysis to study the network structural characteristics and influencing factors of tourism flow using online travel blog data. The results show that: (1) There are seasonal changes in tourism flow, but the attractions that tourists pay attention to do not change with the seasons. (2) The tightness of the tourism flow network structure is poor. The core nodes are unevenly distributed, and there are obvious structural holes. (3) The density of the tourism flow network is low. There is a clear core–periphery structure in the network, and the core area has a weak driving effect on the periphery area. There are more cohesive subgroups in the network, but the degree of connectedness between the subgroups varies greatly. (4) Geographical adjacency, transportation accessibility, and tourism resource endowment influence tourism flow network structure. The study found that the influencing factors of tourism flow in rural areas are different from those in urban areas. These results provide useful information for the marketing and development of tourism management departments in rural areas.
Keywords	tourism flow ; network structure ; social network analysis ; QAP regression analysis ; rural areas ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China

Pei Yu / Bingmei Liu / Siyu Hao / Ronggui Xing / Yuzhen Li

BioMed Research International, Vol

2020 Volume 2020

Abstract: Caspase recruitment domain family member 8 (CARD8) is an adaptor molecule that negatively regulates nuclear factor-κB (NF-κB) activation, interleukin (IL)-1β secretion, and apoptosis. These play important roles in the pathogenesis of psoriasis. Genetic ... ...

Abstract	Caspase recruitment domain family member 8 (CARD8) is an adaptor molecule that negatively regulates nuclear factor-κB (NF-κB) activation, interleukin (IL)-1β secretion, and apoptosis. These play important roles in the pathogenesis of psoriasis. Genetic variants of CARD8 have been associated with an increased risk of several inflammatory diseases and psoriasis in Europe. However, nothing is known about the association of the polymorphisms of CARD8 and psoriasis vulgaris (PsV) in the Han population of northeastern China. To investigate the potential association between them, we designed a case-control study to genotype four selected single nucleotide polymorphisms (SNPs) using the improved multiplex ligation reaction (iMLDR) method. Model-based single SNP frequentist-test and haplotype association studies were performed to assess the association between SNPs and PsV. The results showed that the intron SNP rs10403848 was significantly associated with PsV (additive model p=0.0418, p′=0.0411, and statistical power 0.1902; heterozygous model p=0.0418, p′=0.0164, and statistical power 0.9406). A potential risk locus of nonsynonymous SNP rs2043211 found in the European population did not show a significant association in our study. We found that the polymorphism rs10403848 in CARD8 is significantly associated with PsV risk in the Han population of northeastern China. CARD8 may be involved in PsV in this population, as in the European population, but a different genetic process should be considered for the heterogeneity of risk loci.
Keywords	Medicine ; R
Subject code	616
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design, Synthesis, and Biological Evaluation of [1,2,4]triazolo[4,3-a] Pyrazine Derivatives as Novel Dual c-Met/VEGFR-2 Inhibitors

Xiaobo Liu / Yuzhen Li / Qian Zhang / Qingshan Pan / Pengwu Zheng / Xinyang Dai / Zhaoshi Bai / Wufu Zhu

Frontiers in Chemistry, Vol

2022 Volume 10

Abstract: In this study, we designed and synthesized a series of novel [1,2,4]triazolo [4,3-a]pyrazine derivatives, and evaluated them for their inhibitory activities toward c-Met/VEGFR-2 kinases and antiproliferative activities against tested three cell lines in ... ...

Abstract	In this study, we designed and synthesized a series of novel [1,2,4]triazolo [4,3-a]pyrazine derivatives, and evaluated them for their inhibitory activities toward c-Met/VEGFR-2 kinases and antiproliferative activities against tested three cell lines in vitro. Most of the compounds showed satisfactory activity compared with lead compound foretinib. Among them, the most promising compound 17l exhibited excellent antiproliferative activities against A549, MCF-7, and Hela cancer cell lines with IC50 values of 0.98 ± 0.08, 1.05 ± 0.17, and 1.28 ± 0.25 µM, respectively, as well as excellent kinase inhibitory activities (c-Met IC50 = 26.00 nM and VEGFR-2 IC50 = 2.6 µM). Moreover, compound 17l inhibited the growth of A549 cells in G0/G1 phase in a dose-dependent manner, and induced the late apoptosis of A549 cells. Its intervention on intracellular c-Met signaling of A549 was verified by the result of Western blot. Fluorescence quantitative PCR showed that compound 17l inhibited the growth of A549 cells by inhibiting the expression of c-Met and VEGFR-2, and its hemolytic toxicity was low. Molecular docking and molecular dynamics simulation indicated that compound 17l could bind to c-Met and VEGFR-2 protein, which was similar to that of foretinib.
Keywords	c-Met inhibitor ; antiproliferative activity ; antitumor ; targeted drug ; pyrazine derivatives ; Chemistry ; QD1-999
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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