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  1. Article ; Online: A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

    Jean Claude Semuto Ngabonziza / Chloé Loiseau / Michael Marceau / Agathe Jouet / Fabrizio Menardo / Oren Tzfadia / Rudy Antoine / Esdras Belamo Niyigena / Wim Mulders / Kristina Fissette / Maren Diels / Cyril Gaudin / Stéphanie Duthoy / Willy Ssengooba / Emmanuel André / Michel K. Kaswa / Yves Mucyo Habimana / Daniela Brites / Dissou Affolabi /
    Jean Baptiste Mazarati / Bouke Catherine de Jong / Leen Rigouts / Sebastien Gagneux / Conor Joseph Meehan / Philip Supply

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, ...

    Abstract The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, representing an as-yet-unknown lineage further supporting an East African origin for the MTBC.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

    Jean Claude Semuto Ngabonziza / Chloé Loiseau / Michael Marceau / Agathe Jouet / Fabrizio Menardo / Oren Tzfadia / Rudy Antoine / Esdras Belamo Niyigena / Wim Mulders / Kristina Fissette / Maren Diels / Cyril Gaudin / Stéphanie Duthoy / Willy Ssengooba / Emmanuel André / Michel K. Kaswa / Yves Mucyo Habimana / Daniela Brites / Dissou Affolabi /
    Jean Baptiste Mazarati / Bouke Catherine de Jong / Leen Rigouts / Sebastien Gagneux / Conor Joseph Meehan / Philip Supply

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, ...

    Abstract The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to be evolved from a common progenitor in Africa. Here, the authors identify two MTBC strains isolated from patients with multidrug-resistant tuberculosis, representing an as-yet-unknown lineage further supporting an East African origin for the MTBC.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Prevalence and drivers of false-positive rifampicin-resistant Xpert MTB/RIF results

    Jean Claude Semuto Ngabonziza, MSc / Tom Decroo, PhD / Patrick Migambi, MSc / Yves Mucyo Habimana, MD / Armand Van Deun, PhD / Conor J Meehan, PhD / Gabriela Torrea, PhD / Faridath Massou, PharmD / Willem Bram de Rijk, BS / Bertin Ushizimpumu, BS / Esdras Belamo Niyigena, BS / Emil Ivan, PhD / Jules Mugabo Semahore, MD / Jean Baptiste Mazarati, PhD / Corinne Simone Merle, PhD / Philip Supply, PhD / Dissou Affolabi, ProfPhD / Leen Rigouts, PhD / Bouke Catherine de Jong, ProfPhD

    The Lancet Microbe, Vol 1, Iss 2, Pp e74-e

    a prospective observational study in Rwanda

    2020  Volume 83

    Abstract: Summary: Background: The Xpert MTB/RIF (Xpert) assay is used globally to rapidly diagnose tuberculosis and resistance to rifampicin. We investigated the frequency and predictors of false-positive findings of rifampicin resistance with Xpert. Methods: We ... ...

    Abstract Summary: Background: The Xpert MTB/RIF (Xpert) assay is used globally to rapidly diagnose tuberculosis and resistance to rifampicin. We investigated the frequency and predictors of false-positive findings of rifampicin resistance with Xpert. Methods: We did a prospective, observational study of individuals who were enrolled in a Rwandan nationwide diagnostic cohort study (DIAMA trial; NCT03303963). We included patients identified to have rifampicin resistance on initial Xpert testing. We did a repeat Xpert assay and used rpoB Sanger and deep sequencing alongside phenotypic drug susceptibility testing (pDST) to ascertain final rifampicin susceptibility status, with any (hetero)resistant result overriding. We used multivariable logistic regression to assess predictors of false rifampicin resistance on initial Xpert testing, adjusted for HIV status, tuberculosis treatment history, initial Xpert semi-quantitative bacillary load, and initial Xpert probe. Findings: Between May 4, 2017, and April 30, 2019, 175 people were identified with rifampicin resistance at initial Xpert testing, of whom 154 (88%) underwent repeat Xpert assay. 54 (35%) patients were confirmed as rifampicin resistant on repeat testing and 100 (65%) were not confirmed with resistance. After further testing and sequencing, 121 (79%) of 154 patients had a final confirmed status for rifampicin susceptibility. 57 (47%) of 121 patients were confirmed to have a false rifampicin resistance result and 64 (53%) had true rifampicin resistance. A high pretest probability of rifampicin resistance did not decrease the odds of false rifampicin resistance (adjusted odds ratio [aOR] 6·0, 95% CI 1·0–35·0, for new tuberculosis patients vs patients who needed retreatment). Ten (16%) of the 64 patients with true rifampicin resistance did not have confirmed rifampicin resistance on repeat Xpert testing, of whom four had heteroresistance. Of 63 patients with a very low bacillary load on Xpert testing, 54 (86%) were falsely diagnosed with rifampicin-resistant ...
    Keywords Medicine (General) ; R5-920 ; Microbiology ; QR1-502
    Subject code 610 ; 616
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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