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  1. Article ; Online: Swedish Chronic Pain Biobank

    Hans Westergren / Björn Gerdle / Eva Kosek / Britt-Marie Stålnacke / Paulin Andréll / Rolf Karlsten / Monika Lofgren / Bijar Ghafouri / Malin Ernberg / Emmanuel Bäckryd / Marcelo Rivano Fisher / Yvonne Freund-Levi / Henrik Grelz / Olaf Gräbel / Åsa Ringqvist / Karin Rudling / Niklas Sörlén / Karin Uhlin

    BMJ Open, Vol 12, Iss

    protocol for a multicentre registry and biomarker project

    2022  Volume 11

    Abstract: Introduction About 20% of the adult population have chronic pain, often associated with psychological distress, sick leave and poor health. There are large variations in the clinical picture. A biopsychosocial approach is used in investigation and ... ...

    Abstract Introduction About 20% of the adult population have chronic pain, often associated with psychological distress, sick leave and poor health. There are large variations in the clinical picture. A biopsychosocial approach is used in investigation and treatment. The concept of personalised medicine, that is, optimising medication types and dosages for individual patients based on biomarkers and other patient-related factors, has received increasing attention in different diseases but used less in chronic pain. This cooperative project from all Swedish University Hospitals will investigate whether there are changes in inflammation and metabolism patterns in saliva and blood in chronic pain patients and whether the changes correlate with clinical characteristics and rehabilitation outcomes.Methods and analysis Patients at multidisciplinary pain centres at University Hospitals in Sweden who have chosen to participate in the Swedish Quality Registry for Pain Rehabilitation and healthy sex-matched and age-matched individuals will be included in the study. Saliva and blood samples will be collected in addition to questionnaire data obtained from the register. From the samples, proteins, lipids, metabolites and micro-RNA will be analysed in relation to, for example, diagnosis, pain characteristics, psychological distress, body weight, pharmacological treatment and clinical rehabilitation results using advanced multivariate data analysis and bioinformatics.Ethics and dissemination The study is approved by the Swedish Ethical Review Authority (Dnr 2021–04929) and will be conducted in accordance with the declaration of Helsinki.The results will be published in open access scientific journals and in popular scientific relevant journals such as those from patient organisations. Data will be also presented in scientific meetings, meeting with healthcare organisations and disseminated in different lecturers at the clinics and universities.
    Keywords Medicine ; R
    Subject code 170
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study

    Karimi, Mohsen / Inger Vedin / Yvonne Freund Levi / Hans Basun / Gerd Faxén Irving / Maria Eriksdotter / Lars-Olof Wahlund / Marianne Schultzberg / Erik Hjorth / Tommy Cederholm / Jan Palmblad

    American journal of clinical nutrition. 2017 Oct. 01, v. 106, no. 4

    2017  

    Abstract: Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions through various mechanisms, including gene expression, ... ...

    Abstract Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions through various mechanisms, including gene expression, which is measured as messenger RNA concentration. However, the effects of long-term treatment of humans with DHA and EPA on various epigenetic factors—such as DNA methylation, which controls messenger RNA generation—are poorly described. Objective: We wanted to determine the effects of 6 mo of dietary supplementation with an n–3 FA preparation rich in DHA on global DNA methylation of peripheral blood leukocytes (PBLs) and the relation to plasma EPA and DHA concentrations in Alzheimer disease (AD) patients. Design: In the present study, DNA methylation in four 5′-cytosine-phosphate-guanine-3′ (CpG) sites of long interspersed nuclear element-1 repetitive sequences was assessed in a group of 63 patients (30 given the n–3 FA preparation and 33 given placebo) as an estimation of the global DNA methylation in blood cells. Patients originated from the randomized, double-blind, placebo-controlled OmegAD study, in which 174 AD patients received either 1.7 g DHA and 0.6 g EPA (the n–3 FA group) or placebo daily for 6 mo. Results: At 6 mo, the n–3 FA group displayed marked increases in DHA and EPA plasma concentrations (2.6- and 3.5-fold), as well as decreased methylation in 2 out of 4 CpG sites (P < 0.05 for all), respectively. This hypomethylation in CpG2 and CpG4 sites showed a reverse correlation to changes in plasma EPA concentration (r = −0.25, P = 0.045; and r = −0.26, P = 0.041, respectively), but not to changes in plasma DHA concentration, and were not related to apolipoprotein E-4 allele frequency. Conclusion: Supplementation with n–3 FA for 6 mo was associated with global DNA hypomethylation in PBLs. Our data may be of importance in measuring various effects of marine oils, including gene expression, in patients with AD and in other patients taking n–3 FA supplements. This trial was registered at clinicaltrials.gov as NCT00211159.
    Keywords Alzheimer disease ; DNA hypomethylation ; docosahexaenoic acid ; eicosapentaenoic acid ; epigenetics ; fish oils ; gene expression ; gene frequency ; leukocytes ; messenger RNA ; omega-3 fatty acids ; patients ; placebos ; repetitive sequences
    Language English
    Dates of publication 2017-1001
    Size p. 1157-1165.
    Publishing place Oxford University Press
    Document type Article
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.3945/ajcn.117.155648
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Sex-Specific Metabolic Pathways Were Associated with Alzheimer’s Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort

    Jin Xu / Rebecca Green / Min Kim / Jodie Lord / Amera Ebshiana / Sarah Westwood / Alison L. Baird / Alejo J. Nevado-Holgado / Liu Shi / Abdul Hye / Stuart G. Snowden / Isabelle Bos / Stephanie J. B. Vos / Rik Vandenberghe / Charlotte E. Teunissen / Mara Ten Kate / Philip Scheltens / Silvy Gabel / Karen Meersmans /
    Olivier Blin / Jill Richardson / Ellen Elisa De Roeck / Sebastiaan Engelborghs / Kristel Sleegers / Régis Bordet / Lorena Rami / Petronella Kettunen / Magda Tsolaki / Frans R. J. Verhey / Daniel Alcolea / Alberto Lleó / Gwendoline Peyratout / Mikel Tainta / Peter Johannsen / Yvonne Freund-Levi / Lutz Frölich / Valerija Dobricic / Giovanni B. Frisoni / José Luis Molinuevo / Anders Wallin / Julius Popp / Pablo Martinez-Lage / Lars Bertram / Kaj Blennow / Henrik Zetterberg / Johannes Streffer / Pieter Jelle Visser / Simon Lovestone / Petroula Proitsi / Cristina Legido-Quigley

    Biomedicines, Vol 9, Iss 1610, p

    2021  Volume 1610

    Abstract: Background: physiological differences between males and females could contribute to the development of Alzheimer’s Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. Methods: We explored whether sex ... ...

    Abstract Background: physiological differences between males and females could contribute to the development of Alzheimer’s Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. Methods: We explored whether sex modifies the association of 540 plasma metabolites with AD endophenotypes including diagnosis, cerebrospinal fluid (CSF) biomarkers, brain imaging, and cognition using regression analyses for 695 participants (377 females), followed by sex-specific pathway overrepresentation analyses, APOE ε4 stratification and assessment of metabolites’ discriminatory performance in AD. Results: In females with AD, vanillylmandelate (tyrosine pathway) was increased and tryptophan betaine (tryptophan pathway) was decreased. The inclusion of these two metabolites (area under curve (AUC) = 0.83, standard error (SE) = 0.029) to a baseline model (covariates + CSF biomarkers, AUC = 0.92, SE = 0.019) resulted in a significantly higher AUC of 0.96 (SE = 0.012). Kynurenate was decreased in males with AD (AUC = 0.679, SE = 0.046). Conclusions: metabolic sex-specific differences were reported, covering neurotransmission and inflammation pathways with AD endophenotypes. Two metabolites, in pathways related to dopamine and serotonin, were associated to females, paving the way to personalised treatment.
    Keywords sex ; Alzheimer’s disease ; metabolomics ; metabolic pathway ; blood ; vanillylmandelate ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes

    Inger Vedin / Tommy Cederholm / Yvonne Freund-Levi / Hans Basun / Anita Garlind / Gerd Faxén Irving / Maria Eriksdotter-Jönhagen / Lars-Olof Wahlund / Ingrid Dahlman / Jan Palmblad

    PLoS ONE, Vol 7, Iss 4, p e

    the OmegAD study.

    2012  Volume 35425

    Abstract: Dietary fish oil, rich in n-3 fatty acids (n-3 FAs), e.g. docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), regulate inflammatory reactions by various mechanisms, e.g. gene activation. However, the effects of long-term treatment with DHA and ... ...

    Abstract Dietary fish oil, rich in n-3 fatty acids (n-3 FAs), e.g. docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), regulate inflammatory reactions by various mechanisms, e.g. gene activation. However, the effects of long-term treatment with DHA and EPA in humans, using genome wide techniques, are poorly described. Hence, our aim was to determine the effects of 6 mo of dietary supplementation with an n-3 FA preparation rich in DHA on global gene expression in peripheral blood mononuclear cells.In the present study, blood samples were obtained from a subgroup of 16 patients originating from the randomized double-blind, placebo-controlled OmegAD study, where 174 Alzheimer disease (AD) patients received daily either 1.7 g of DHA and 0.6 g EPA or placebo for 6 months. In blood samples obtained from 11 patients receiving n-3 FA and five placebo, expressions of approximately 8000 genes were assessed by gene array. Significant changes were confirmed by real-time PCR. At 6 months, the n-3 FAs group displayed significant rises of DHA and EPA plasma concentrations, as well as up- and down-regulation of nine and ten genes, respectively, was noticed. Many of these genes are involved in inflammation regulation and neurodegeneration, e.g. CD63, MAN2A1, CASP4, LOC399491, NAIP, and SORL1 and in ubiqutination processes, e.g. ANAPC5 and UBE2V1. Down-regulations of ANAPC5 and RHOB correlated to increases of plasma DHA and EPA levels.We suggest that 6 months of dietary n-3 FA supplementation affected expression of genes that might influence inflammatory processes and could be of significance for AD.ClinicalTrials.gov NCT00211159.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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