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Article: Caspase-8: Friend or Foe in Bortezomib/Lenalidomide-Based Therapy for Myeloma.

Zhou, Liang

2022 Volume 12, Page(s) 861709

Abstract: Antiproliferation and proapoptosis are two major molecular mechanisms of action of drugs used for the treatment of multiple myeloma. Proteasome inhibitors, such as bortezomib (PS-341), and immunomodulatory drugs (IMiDs), such as lenalidomide, are the two ...

Abstract	Antiproliferation and proapoptosis are two major molecular mechanisms of action of drugs used for the treatment of multiple myeloma. Proteasome inhibitors, such as bortezomib (PS-341), and immunomodulatory drugs (IMiDs), such as lenalidomide, are the two drug types approved for the treatment of myeloma. Bortezomib and lenalidomide activate caspase-8 and promote the apoptosis of myeloma cells. However, caspase-8 inhibition potentiated the antiproliferative effect of lenalidomide and bortezomib in myeloma cells, suggesting that caspase-8 could regulate proliferation and apoptosis in the opposite pathway. In this mini-review, I summarized recent advances in determining the molecular mechanisms of caspase-8 in bortezomib-lenalidomide-based therapy for myeloma and explored the possible functions of caspase-8 in the proliferation and apoptosis of myeloma cells. Furthermore, future directions of caspase-8-based therapy for myeloma have been discussed.
Language	English
Publishing date	2022-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.861709
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Article ; Online: Assessment of Ecological Environment Quality for Urban Sustainable Development Based on AHP.

Zhou, Liang

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 4056713

Abstract: Cities are gradually developed on the basis of adapting and transforming the natural environment. In a certain urban area, human activities, natural environment, and other factors and their mutual influence constitute the urban ecological environment. ... ...

Abstract	Cities are gradually developed on the basis of adapting and transforming the natural environment. In a certain urban area, human activities, natural environment, and other factors and their mutual influence constitute the urban ecological environment. Therefore, the evaluation of urban ecological environment quality is of great significance to the analysis of urban development. This paper takes a city in Western China as the evaluation object, uses AHP to determine the index weight, reasonably analyzes the current situation of the urban ecological environment, and further comprehensively evaluates the quality of the urban ecological environment. The study shows that from 2013 to 2018, the comprehensive capacity of the city's ecological environment quality showed a steady upward trend, except that the natural disasters of floods and mudslides in 2014 had a certain degree of fluctuation. The comprehensive index of ecological environment quality has increased from 0.337 in 2013 to 0.412 in 2018. The overall level is still low, but the development speed is relatively stable. The urban ecological environment has been gradually improved, and society, economy, and nature have maintained a certain degree of sustainable development.
MeSH term(s)	China ; Cities ; Conservation of Natural Resources ; Humans ; Sustainable Development ; Urban Renewal
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/4056713
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Article ; Online: Author's reply regarding the letter to the editor about our article: A nomogram for predicting occult lymph node metastasis in early hypopharyngeal cancer with cN0.

Zhou, Liang

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2021 Volume 278, Issue 9, Page(s) 3603

MeSH term(s)	Humans ; Hypopharyngeal Neoplasms ; Lymph Nodes ; Lymphatic Metastasis ; Neck Dissection ; Nomograms
Language	English
Publishing date	2021-07-15
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-021-06991-3
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Article ; Online: Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor.

Helm, Eric Y / Zhou, Liang

Frontiers in immunology

2023 Volume 14, Page(s) 1056267

Abstract: The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates immune cell environmental sensing through its activation by cellular, dietary, and microbial metabolites, as well as environmental toxins. Although expressed ... ...

Abstract	The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates immune cell environmental sensing through its activation by cellular, dietary, and microbial metabolites, as well as environmental toxins. Although expressed in various cell types, Ahr in innate lymphoid cells (ILCs) and their adaptive T cell counterparts regulates essential aspects of their development and function. As opposed to T cells, ILCs exclusively rely on germ-line encoded receptors for activation, but often share expression of core transcription factors and produce shared effector molecules with their T cell counterparts. As such, core modules of transcriptional regulation are both shared and diverge between ILCs and T cells. In this review, we highlight the most recent findings regarding Ahr's transcriptional regulation of both ILCs and T cells. Furthermore, we focus on insights elucidating the shared and distinct mechanisms by which Ahr regulates both innate and adaptive lymphocytes.
MeSH term(s)	Lymphocytes ; Receptors, Aryl Hydrocarbon/metabolism ; T-Lymphocytes/metabolism ; Immunity, Innate ; Gene Expression Regulation
Chemical Substances	Receptors, Aryl Hydrocarbon
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1056267
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Article ; Online: The role of NMDARs in the anesthetic and antidepressant effects of ketamine.

Zhou, Liang / Duan, Jingjing

CNS neuroscience & therapeutics

2023 Volume 30, Issue 4, Page(s) e14464

Abstract: Background: As a phencyclidine (PCP) analog, ketamine can generate rapid-onset and substantial anesthetic effects. Contrary to traditional anesthetics, ketamine is a dissociative anesthetic and can induce loss of consciousness in patients. Recently, the ...

Abstract	Background: As a phencyclidine (PCP) analog, ketamine can generate rapid-onset and substantial anesthetic effects. Contrary to traditional anesthetics, ketamine is a dissociative anesthetic and can induce loss of consciousness in patients. Recently, the subanaesthetic dose of ketamine was found to produce rapid-onset and lasting antidepressant effects. Aim: However, how different concentrations of ketamine can induce diverse actions remains unclear. Furthermore, the molecular mechanisms underlying the NMDAR-mediated anesthetic and antidepressant effects of ketamine are not fully understood. Method: In this review, we have introduced ketamine and its metabolism, summarized recent advances in the molecular mechanisms underlying NMDAR inhibition in the anesthetic and antidepressant effects of ketamine, explored the possible functions of NMDAR subunits in the effects of ketamine, and discussed the future directions of ketamine-based anesthetic and antidepressant drugs. Result: Both the anesthetic and antidepressant effects of ketamine were thought to be mediated by N-methyl-D-aspartate receptor (NMDAR) inhibition. Conclusion: The roles of NMDARs have been extensively studied in the anaesthetic effects of ketamine. However, the roles of NMDARs in antidepressant effects of ketamine are complicated and controversial.
MeSH term(s)	Humans ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Receptors, N-Methyl-D-Aspartate/metabolism ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Anesthetics/pharmacology ; Anesthetics/therapeutic use
Chemical Substances	Ketamine (690G0D6V8H) ; Receptors, N-Methyl-D-Aspartate ; Antidepressive Agents ; Anesthetics
Language	English
Publishing date	2023-09-07
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2423461-8
ISSN	1755-5949 ; 1755-5930
ISSN (online)	1755-5949
ISSN	1755-5930
DOI	10.1111/cns.14464
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Zs.A 4537: Show issues

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Article ; Online: Intrathecal Analgesia via a Percutaneous Port With Patient-Controlled Intrathecal Analgesia for the Management of Movement-Evoked Breakthrough Cancer Pain of Refractory Lower Extremity Cancer Pain: A Retrospective Review.

Zhou, Liang / Guo, Zhenggang

Pain physician

2023 Volume 26, Issue 4, Page(s) 375–382

Abstract: Background: Intrathecal analgesia (ITA) is a valuable treatment option for refractory cancer-related pain. However, there is still no general consensus on the analgesic effect of movement-evoked breakthrough pain (MEBTP) in the ITA setting.: ... ...

Abstract	Background: Intrathecal analgesia (ITA) is a valuable treatment option for refractory cancer-related pain. However, there is still no general consensus on the analgesic effect of movement-evoked breakthrough pain (MEBTP) in the ITA setting. Objectives: This study aimed to conduct a retrospective observational study to examine the effect of ITA via percutaneous port (ITAPP) with patient-controlled ITA (PCIA) on analgesic efficacy, emphasizing MEBTP in patients with refractory lower extremity cancer pain. Study design: A retrospective chart review included all patients with refractory lower extremity cancer pain who received ITAPP at our hospital between January 2017 and December 2020. Methods: Data on the Numeric Rating Scale scores of spontaneous resting pain intensity (SRPI) and MEBTP intensity (MEPI), opioid doses, and perceived time to onset were collected from medical records prior to ITAPP and at a one-month postimplant visit. Results: A total of 16 patients were included in the study group. Mean SRPI decreased from 8.75 pre-ITAPP to 3.75 post-ITAPP (P < 0.05); mean MEPI fell from 8.83 pre-ITAPP to 4.25 post-ITAPP (P < 0.05); mean daily morphine equivalent dosing decreased from 360 mg/d to 48 mg/d (P < 0.05); and mean daily morphine equivalent dosing for MEBTP decreased from 87 mg/d to 6 mg/d (P < 0.05). Both total and breakthrough dosing of conventional opioid medications significantly decreased following the initiation of ITAPP with PCIA. The mean perceived time to onset with conventional MEBT medications was 38 minutes, and the mean perceived time to onset with PCIA was 8 minutes (P < 0.05). Limitations: An effective analysis of IT opioid efficacy was not possible because the power of such a small sample size was low. Second, it is a retrospective study without long-term follow-ups. Conclusions: In patients with refractory lower extremity cancer pain, ITAPP with PCIA was associated with improved pain control. Compared with conventional MEBTP regimens, appropriate ITAPP with PCIA provided superior analgesia and a much faster onset of action.
MeSH term(s)	Humans ; Analgesics, Opioid/therapeutic use ; Retrospective Studies ; Breakthrough Pain/drug therapy ; Breakthrough Pain/complications ; Cancer Pain/drug therapy ; Cancer Pain/complications ; Morphine/therapeutic use ; Analgesia, Patient-Controlled ; Analgesics/therapeutic use ; Lower Extremity ; Pain, Postoperative/drug therapy ; Injections, Spinal/adverse effects ; Neoplasms
Chemical Substances	Analgesics, Opioid ; Morphine (76I7G6D29C) ; Analgesics
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2146393-1
ISSN	2150-1149 ; 1533-3159
ISSN (online)	2150-1149
ISSN	1533-3159
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Article ; Online: 'Silent' flagellin drives immunotolerance to commensal bacteria.

Xiong, Lifeng / Zhou, Liang

Trends in immunology

2023 Volume 44, Issue 3, Page(s) 150–152

Abstract: Distinguishing between commensal and pathogenic bacteria to generate appropriate responses (tolerance vs. immunogenicity) is a key decision that the human immune system must make to maintain homeostasis. Recently, Clasen and colleagues reported a ... ...

Abstract	Distinguishing between commensal and pathogenic bacteria to generate appropriate responses (tolerance vs. immunogenicity) is a key decision that the human immune system must make to maintain homeostasis. Recently, Clasen and colleagues reported a distinct allosteric interaction between bacterial flagellin and host Toll-like receptor 5 (TLR5), which may shed light on these differences.
MeSH term(s)	Humans ; Flagellin ; Toll-Like Receptor 5 ; Bacteria
Chemical Substances	Flagellin (12777-81-0) ; Toll-Like Receptor 5
Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2023.01.010
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Article ; Online: CapMax: A Framework for Dynamic Network Representation Learning From the View of Multiuser Communication.

Yang, Chenming / Wen, Hui / Hooi, Bryan / Zhou, Liang

IEEE transactions on neural networks and learning systems

2024 Volume 35, Issue 4, Page(s) 4554–4566

Abstract: In this article, a modified mutual information maximization (InfoMax) framework, named channel capacity maximization (CapMax), is proposed and applied to learn informative representations for dynamic networks with time-varying topology and/or time- ... ...

Abstract	In this article, a modified mutual information maximization (InfoMax) framework, named channel capacity maximization (CapMax), is proposed and applied to learn informative representations for dynamic networks with time-varying topology and/or time-evolving node attributes. The CapMax is based on the network information theory for multiuser communication, where the representation model is treated as a multiaccess communication channel with memory and feedback. Without requirements of the backbone structure, the learning objective of our CapMax is maximizing the channel capacity, which is measured by directed information (DI) rather than mutual information. For efficient implementation, we design an estimator of the channel capacity through the combination of graph neural networks (GNNs) and recurrent neural networks (RNNs). Under some mild conditions, we theoretically prove that DI is a better measure than mutual information in capturing useful information. The experiments are conducted on multiple real-world dynamic network datasets, and the outperformance of our CapMax on different backbone models on link detection and prediction validates the effectiveness of modeling the representation model as a communication channel.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2022.3222165
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Article ; Online: Multistage Supply Chain Channel Principal-Agent Model in the Context of e-Commerce With Fairness Preference.

Liu, Xin / Xu, Zhen / Zhang, Qingxia / Zhou, Liang

Evaluation review

2024 , Page(s) 193841X241227878

Abstract: This research aims to investigate information asymmetry in e-commerce supply chain channels and the impact of the fair preference model on the behavior and returns of channel members. Therefore, by contrasting it with the model in the completely rational ...

Abstract	This research aims to investigate information asymmetry in e-commerce supply chain channels and the impact of the fair preference model on the behavior and returns of channel members. Therefore, by contrasting it with the model in the completely rational case, this research establishes a more realistic principal-agent model and incorporates the fair preference model into the e-commerce supply chain channel. According to the model's analysis, the effort level of the retailer at each stage is positively correlated with the e-commerce efficiency coefficient, and the incentive coefficient of manufacturers is positively correlated with the e-commerce efficiency coefficient in the case where all rationality is assumed. Manufacturing companies' anticipated profits are positively correlated with the e-commerce efficiency coefficient. According to the fair preference model, retailers will put forth more effort to sell products when their fixed income from manufacturers is higher and their optimal effort level is positively correlated with that income. When e-commerce's efficiency coefficient is higher than 1, the retailer's revenue and effort exceeded those of traditional channels. Manufacturers and retailers both experience Pareto improvements in their earnings after the fair preference model is introduced.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1500138-6
ISSN	1552-3926 ; 0193-841X ; 0145-4692
ISSN (online)	1552-3926
ISSN	0193-841X ; 0145-4692
DOI	10.1177/0193841X241227878
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Article ; Online: Moving stimuli enhance beat timing and sensorimotor coupling in vision.

Zhou, Liang / Xing, Lianzi / Zheng, Chenhao / Li, Shouxin

Journal of experimental psychology. Human perception and performance

2024 Volume 50, Issue 4, Page(s) 416–429

Abstract: Vision has long been known for its inefficiency in beat perception and synchronization. However, this has been challenged by the finding that moving stimuli (bouncing ball or moving bar) can significantly improve visual beat synchronization. The present ... ...

Abstract	Vision has long been known for its inefficiency in beat perception and synchronization. However, this has been challenged by the finding that moving stimuli (bouncing ball or moving bar) can significantly improve visual beat synchronization. The present study examined two possible mechanisms for this phenomenon: visual motion facilitates temporal processing or promotes sensorimotor coupling. Instead of a single visual object (such as a ball or bar), random-dot kinematograms (RDKs) were used to construct visual motion sequences to avoid confounding factors, such as changes in trajectory and velocity. Experiment 1 showed that RDKs improved beat-timing discrimination compared with visual flashes, but auditory tones were still superior to RDKs. In Experiment 2, synchronized movements improved auditory-tone beat timing but impaired visual-flash beat timing, with no effect on RDK beat timing. Experiment 3 indicated that the regression slope of the phase correction response in RDKs was higher than that in visual flashes but still lower than that in auditory tones. The results showed that moving stimuli enhances both temporal processing (Experiment 1) and sensorimotor coupling (Experiments 2 and 3) in vision, but to a lesser degree, with audition retaining an advantage. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Humans ; Visual Perception/physiology ; Motion Perception ; Auditory Perception/physiology ; Movement/physiology ; Time Perception/physiology
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	189734-2
ISSN	1939-1277 ; 0096-1523
ISSN (online)	1939-1277
ISSN	0096-1523
DOI	10.1037/xhp0001193
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