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  1. Article ; Online: The role of transoral incisionless fundoplication (TIF) in the management of gastroesophageal reflux disease (GERD) following peroral endoscopic myotomy (POEM): A pilot, prospective, patient-driven study.

    Ayoub, Fares / Keihanian, Tara / Zabad, Noor / Jawaid, Salmaan / Patel, Kalpesh / Othman, Mohamed O

    Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

    2024  

    Abstract: Background: Gastroesophageal reflux (GERD) is a concern after peroral endoscopic myotomy (POEM). Transoral incisionless fundoplication (TIF) has been recently described as a possible therapy for post-POEM GERD in case series.: Methods: We ... ...

    Abstract Background: Gastroesophageal reflux (GERD) is a concern after peroral endoscopic myotomy (POEM). Transoral incisionless fundoplication (TIF) has been recently described as a possible therapy for post-POEM GERD in case series.
    Methods: We prospectively enrolled patients undergoing POEM who agreed to participate in objective post-procedure GERD evaluation. Patients with objective evidence of GERD and suitable anatomy were offered TIF vs. proton pump inhibitor (PPI) only. Patients who underwent TIF were compared to those on PPI-only therapy after follow-up.
    Results: Of 21 enrolled POEM patients with objective testing, GERD was found in 11 (52%). Of those eligible for TIF, 4 (40%) opted to pursue TIF and were compared to those on PPI-only therapy (n = 6). Three months post-TIF, 75% of patients had discontinued or significantly decreased PPI. There were no adverse events. GERD health-related quality of life scores were low and comparable between TIF (3.75 ± 6.2) and those who remained on PPI-only therapy (4.1 ± 5).
    Conclusion: In this pilot, patient-driven prospective study, 75% of patients with post-POEM GERD undergoing TIF had stopped or significantly reduced PPI use. Post-POEM TIF is safe and effective and may be a viable alternative to PPI for POEM-related GERD; however, future studies should include a control arm and post-intervention pH monitoring.
    Language English
    Publishing date 2024-03-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2299174-8
    ISSN 1998-4049 ; 1319-3767
    ISSN (online) 1998-4049
    ISSN 1319-3767
    DOI 10.4103/sjg.sjg_22_24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Settings of a novel electrosurgical generator to enable efficient and safe submucosal endoscopic procedures.

    Jawaid, Salmaan / Keihanian, Tara / Khalaf, Mai / Riojas-Barrett, Margarita / Abdeljaber, Wesam / Mercado, Michael / Zabad, Noor / Othman, Mohamed O

    Endoscopy international open

    2023  Volume 11, Issue 8, Page(s) E743–E751

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2023-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-2085-3757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Safety and efficacy of a novel suturing device for closure of large defects after endoscopic submucosal dissection (with video).

    Keihanian, Tara / Zabad, Noor / Khalaf, Mai / Abdel-Jaber, Wesam / Kim, Young-Il / Jawaid, Salmaan A / Abidi, Wasif M / Marginean, Esmeralda Celia / Othman, Mohamed O

    Gastrointestinal endoscopy

    2023  Volume 98, Issue 3, Page(s) 381–391

    Abstract: Background and aims: Endoscopic suturing enables full closure of large defects after endoscopic submucosal dissection (ESD). However, its use is limited by the need for a double-channel endoscope. A novel closure system, the OverStitch Sx (Apollo ... ...

    Abstract Background and aims: Endoscopic suturing enables full closure of large defects after endoscopic submucosal dissection (ESD). However, its use is limited by the need for a double-channel endoscope. A novel closure system, the OverStitch Sx (Apollo Endosurgery, Austin, Tex, USA), compatible with any single-channel endoscope, was introduced to address these shortcomings. The aim of this study was to assess the safety and feasibility of OverStitch Sx for the closure of large defects after ESD.
    Methods: This is a prospective single-center feasibility study of patients who underwent closure of large defects after ESD using the OverStitch Sx system. Main outcomes of the study are technical and clinical success, same-day discharge rate, and adverse event rate.
    Results: Thirty-three patients were enrolled. The mean diameter of included lesions was 5.38 ± 2.52 cm. The defect occupied ≥50% of the lumen circumference in 70% of the cases. En-bloc resection, R0 resection, and curative resection were achieved in 97%, 87.5%, and 78.8% of patients, respectively. Technical success and clinical success were seen in 93.9% and 90.9% of the cases, respectively. Same-day hospital discharge was achieved in 77.4% of patients. Total adverse event rate was 35.7%, including delayed bleeding in 1 patient after rectal ESD that was managed conservatively, self-resolving rectal pain in 7 patients, rectal stricture requiring dilation in 1 patient, and temporary dysphagia in 1 patient. No immediate or delayed perforation was reported.
    Conclusions: OverStitch Sx enabled safe and effective closure of large defects after ESD. Future trials are needed to determine its superiority over OverStitch for the closure of defects in challenging locations. (Clinical trial registration number: NCT04361227.).
    MeSH term(s) Humans ; Endoscopic Mucosal Resection/adverse effects ; Prospective Studies ; Rectum ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Video-Audio Media ; Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2023.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 283: Show issues Location:
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    Zs.MO 519: Show issues

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  4. Article: Settings of a novel electrosurgical generator to enable efficient and safe submucosal endoscopic procedures

    Jawaid, Salmaan / Keihanian, Tara / Khalaf, Mai / Riojas-Barrett, Margarita / Abdeljaber, Wesam / Mercado, Michael / Zabad, Noor / Othman, Mohamed O.

    Endoscopy International Open

    2023  Volume 11, Issue 08, Page(s) E743–E751

    Abstract: Background and study aims: A novel electrosurgical generator unit (ESU), ConMed Beamer, was recently introduced to facilitate endoscopic submucosal dissection (ESD) by employing Automatic Cutting Effect (ACE) technology. Its use in submucosal endoscopy ... ...

    Abstract Background and study aims: A novel electrosurgical generator unit (ESU), ConMed Beamer, was recently introduced to facilitate endoscopic submucosal dissection (ESD) by employing Automatic Cutting Effect (ACE) technology. Its use in submucosal endoscopy has yet to be investigated. The aim of this study was to evaluate the feasibility and safety of performing ESD and peroral endoscopic myotomy (POEM) using novel settings generated with ConMed Beamer ESU.
    Patients and methods: This was a single-center prospective study of 59 consecutive patients undergoing ESD/POEM at a tertiary referral center. ESU settings were initially generated by testing in live animal models prior to first in-human study. The primary outcome was technical success. Secondary outcomes were procedure times, rate of en bloc/R0 resection, and rate of adverse events (AEs).
    Results: A total of 44 patients (50 polyps) and 15 patients underwent ESD and POEM, respectively. En bloc resection, R0 resection, and curative resection rates were 90%, 77.1%, and 70.8%, respectively. Mean maximal length of the lesion was 3.07 cm ± 1.43 with an average dissection speed of 14.2 cm 2 /hr ± 11.1. Technical success was achieved in 100% of POEM patients. Mean time (minutes) to complete the POEM procedure was 50.1 min ± 12.4. Two major AEs occurred among all patients (3.4%). All intraprocedural bleeding events were controlled using the ConMed Beamer ESU.
    Conclusions: ConMed Beamer ESU settings generated from this study were proven safe and effective in a prospective cohort of patients who underwent submucosal endoscopic procedures. This novel ESU can be added to the armamentarium of ESD capable generators.
    Language English
    Publishing date 2023-05-03
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722 ; 2196-9736
    ISSN (online) 2196-9736
    ISSN 2364-3722 ; 2196-9736
    DOI 10.1055/a-2085-3757
    Database Thieme publisher's database

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