Article ; Online: Screening for asymptomatic nephrolithiasis in primary hyperparathyroidism patients is warranted.
2024 Volume 231, Page(s) 91–95
Abstract: Background: We aimed to investigate the prevalence, characteristics, and management of nephrolithiasis in primary hyperparathyroidism (PHPT) patients.: Methods: Medical records of patients who underwent parathyroidectomy at a tertiary care hospital ... ...
| Abstract | Background: We aimed to investigate the prevalence, characteristics, and management of nephrolithiasis in primary hyperparathyroidism (PHPT) patients. Methods: Medical records of patients who underwent parathyroidectomy at a tertiary care hospital in British Columbia from January 2016 to April 2023 were retrospectively reviewed. Demographic data, laboratory results, imaging reports, and urologic consultations were examined. Descriptive statistics and relevant statistical tests, including logistic regressions, were utilized for data analysis. Result: Of the 413 PHPT patients included in the study population, 41.9% harbored renal stones, and nearly half (48.6%) required urological interventions. Male sex, elevated preoperative serum ionized calcium (iCa) and 24-h urinary calcium (24 h urine Ca) levels were independent risk factors for stone formation. Additionally, male sex, younger age, and lower preoperative serum 25-hydroxyvitamin D (25(OH)D) level were associated with higher odds of requiring urological intervention for stones. Conclusions: This study identified significant prevalence of asymptomatic renal calcifications in PHPT patients, with a substantial proportion necessitating urological intervention. These findings emphasize the importance of incorporating screening and treatment of renal stones into the management of PHPT patients. |
|---|---|
| MeSH term(s) | Humans ; Male ; Calcium ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/surgery ; Retrospective Studies ; Nephrolithiasis/complications ; Nephrolithiasis/diagnosis ; Nephrolithiasis/epidemiology ; British Columbia ; Parathyroidectomy/adverse effects ; Parathyroid Hormone |
| Chemical Substances | Calcium (SY7Q814VUP) ; Parathyroid Hormone |
| Language | English |
| Publishing date | 2024-03-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2953-1 |
| ISSN | 1879-1883 ; 0002-9610 |
| ISSN (online) | 1879-1883 |
| ISSN | 0002-9610 |
| DOI | 10.1016/j.amjsurg.2024.03.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uk I Zs.42: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.