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Article ; Online: Dose-Dependent Transcriptional Response to Ionizing Radiation Is Orchestrated with DNA Repair within the Nuclear Space.

Chaturvedi, Garima / Sarusi-Portuguez, Avital / Loza, Olga / Shimoni-Sebag, Ariel / Yoron, Orly / Lawrence, Yaacov Richard / Zach, Leor / Hakim, Ofir

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Radiation therapy is commonly used to treat glioblastoma multiforme (GBM) brain tumors. Ionizing radiation (IR) induces dose-specific variations in transcriptional programs, implicating that they are tightly regulated and critical components in the tumor ...

Abstract	Radiation therapy is commonly used to treat glioblastoma multiforme (GBM) brain tumors. Ionizing radiation (IR) induces dose-specific variations in transcriptional programs, implicating that they are tightly regulated and critical components in the tumor response and survival. Yet, our understanding of the downstream molecular events triggered by effective vs. non-effective IR doses is limited. Herein, we report that variations in the genetic programs are positively and functionally correlated with the exposure to effective or non-effective IR doses. Genome architecture analysis revealed that gene regulation is spatially and temporally coordinated with DNA repair kinetics. The radiation-activated genes were pre-positioned in active sub-nuclear compartments and were upregulated following the DNA damage response, while the DNA repair activity shifted to the inactive heterochromatic spatial compartments. The IR dose affected the levels of DNA damage repair and transcription modulation, but not the order of the events, which was linked to their spatial nuclear positioning. Thus, the distinct coordinated temporal dynamics of DNA damage repair and transcription reprogramming in the active and inactive sub-nuclear compartments highlight the importance of high-order genome organization in synchronizing the molecular events following IR.
MeSH term(s)	Humans ; Radiation, Ionizing ; DNA Repair/genetics ; Radiation, Nonionizing ; Biological Transport ; Glioblastoma/genetics ; Glioblastoma/radiotherapy
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25020970
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Article: Inactivation kinetics of selected pathogenic and non-pathogenic bacteria by aqueous ozone to validate minimum usage in purified water.

Lou, Yuqian / Kasler, David R / Hawkins, Zach L / Li, Zhen / Sannito, Dan / Fritz, Ronald D / Yousef, Ahmed E

Frontiers in microbiology

2024 Volume 14, Page(s) 1258381

Abstract: Ozone is often used as an antimicrobial agent at the final step in purified water processing. When used in purified bottled water manufacturing, residual ozone should not exceed 0.4 mg/L, per US-FDA regulations. These regulations require the control ... ...

Abstract	Ozone is often used as an antimicrobial agent at the final step in purified water processing. When used in purified bottled water manufacturing, residual ozone should not exceed 0.4 mg/L, per US-FDA regulations. These regulations require the control of
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1258381
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Article ; Online: A low-cost Arduino-based datalogger with cellular modem and FTP communication for irrigation water use monitoring to enable access to CropManage

Gerardo M. Spinelli / Zach L. Gottesman

HardwareX, Vol 6, Iss , Pp - (2019)

2019

Abstract: The Resource Conservation District of Santa Cruz County implemented a project to improve irrigation management through providing field assistance to growers. A web-based decision support tool called CropManage (https://v3.cropmanage.ucanr.edu) developed ... ...

Abstract	The Resource Conservation District of Santa Cruz County implemented a project to improve irrigation management through providing field assistance to growers. A web-based decision support tool called CropManage (https://v3.cropmanage.ucanr.edu) developed by the University of California Cooperative Extension (UCCE) of Monterey County aids growers with irrigation scheduling. However, CropManage requires a flowmeter and a monitoring station to track water use in the field. In this article, we describe a device that was conceived as a low-cost alternative to Campbell Scientific flowmeter-monitoring stations that include data logger, modem, enclosure, battery, solar panel and charge regulator and cost above $2000. The device was designed for low-cost, ease of construction and with the capability of emulating the Campbell Scientific equipment functions and outputs. The devices were enabled with FTP communication to a central FTP server and were built with an Arduino MEGA, an Adafruit Datalogging Shield and an Adafruit FONA cellular modem. A voltage divider was added to monitor the external 12 V battery voltage and a DC/DC converter was used to convert 12 V to 5 V. Each field station, including the device, battery, enclosure and solar panel has a total cost below $300, while the FTP server costs less than $100. The device was tested for two years in filed conditions and gave output equivalent to the Campbell Scientific equipment. The device is a low-cost technology that enables growers to gain access to CropManage cheaply and reliably. Keywords: Arduino, Flowmeter monitoring, Irrigation scheduling, CropManage
Keywords	Science (General) ; Q1-390
Subject code	600
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pyrimidopteridine-catalyzed Photo-mediated Hydroacetoxylation.

Petrosyan, Andranik / Zach, Luisa / Taeufer, Tobias / Mayer, T S / Rabeah, Jabor / Pospech, Jola

Chemistry (Weinheim an der Bergstrasse, Germany)

2022 Volume 28, Issue 57, Page(s) e202201761

Abstract: Herein we report a photo-mediated formal addition of carboxylic acids to activated alkenes catalyzed by a pyrimidopteridine photoredox catalyst. The decarboxylation of aliphatic carboxylic acids upon single-electron oxidation is countered in the presence ...

Abstract	Herein we report a photo-mediated formal addition of carboxylic acids to activated alkenes catalyzed by a pyrimidopteridine photoredox catalyst. The decarboxylation of aliphatic carboxylic acids upon single-electron oxidation is countered in the presence of electron-rich alkenes and a hydroacetoxylation is observed. Mechanistic proposals have been made based on CV measurements, competitive Stern-Volmer quenching and EPR experiments. Evidence that tetra-N-substituted pyrimidopteridines function as dual photoredox and hydrogen atom transfer catalyst was supported by spectroscopic means.
MeSH term(s)	Alkenes/chemistry ; Carboxylic Acids/chemistry ; Catalysis ; Hydrogen/chemistry ; Oxidation-Reduction
Chemical Substances	Alkenes ; Carboxylic Acids ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2022-08-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202201761
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Article ; Online: Linear accelerator stereotactic radiosurgery can modulate the clinical course of Hemangioblastoma: Case series and review of the literature.

Zibly, Z / Cohen, Z R / Peled, A / Zach, L / Nissim, U / Attia, Moshe / Graves, Christian / Camphausen, K / Spiegelman, R

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2020 Volume 82, Issue Pt A, Page(s) 162–165

Abstract: Hemangioblastomas (HB) are benign low grade vascular tumors most frequently occurring in the cerebellum, brain stem, and spinal cord. Often associated with Von Hippel Lindau disease (VHL), the lesions are often multifocal requiring complex resection and ... ...

Abstract	Hemangioblastomas (HB) are benign low grade vascular tumors most frequently occurring in the cerebellum, brain stem, and spinal cord. Often associated with Von Hippel Lindau disease (VHL), the lesions are often multifocal requiring complex resection and are difficult to control. Linear Accelerator (LINAC) Stereotactic Radiosurgery (SRS) has been demonstrated to provide additional tumor control. In this case series, we present our multi-center experience utilizing LINAC SRS in fourteen patients with 23 lesions. We observed a tumor control rate of 87% and found interval changes in the peritumoral enhancement to correlate with treatment outcome. In our study, SRS treatment was also well-tolerated in both cystic and noncystic patients with multifocal disease. Disease control was achieved in all but three patients post-resection and no longitudinal radiation-induced secondary malignancy was observed. SRS response correlated highly with lesion size and radiation dose. We conclude that LINAC SRS is safe and effective for patients with HB and should be considered in addition to surgery in asymptomatic, VHL patients, deep seated lesions and isolated lesions.
MeSH term(s)	Adolescent ; Adult ; Brain Neoplasms/pathology ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/therapy ; Cerebellum/pathology ; Child ; Female ; Hemangioblastoma/pathology ; Hemangioblastoma/radiotherapy ; Hemangioblastoma/surgery ; Humans ; Male ; Middle Aged ; Particle Accelerators ; Radiosurgery ; Spinal Cord/pathology ; Treatment Outcome ; Young Adult ; von Hippel-Lindau Disease/complications
Language	English
Publishing date	2020-11-11
Publishing country	Scotland
Document type	Case Reports ; Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2020.09.026
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Zs.A 3999: Show issues

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Book: VERGLEICH VERSCHIEDENER UNTERSUCHUNGSMETHODEN BEIM LATENTEN MYOFACIALEN DYSFUNKTIONS-SYNDROM

Zach, Ludwig

1980

Size	III, 78 S.
Document type	Book
Note	ERLANGEN, NUERNBERG, UNIV., MED. FAK., DISS., 1980
HBZ-ID	HT002597400
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Article ; Online: Exploratory Analysis of the Relationship between Social Identification and Testosterone Reactivity to Vicarious Combat.

Casto, Kathleen V / Root, Zach L / Geniole, Shawn N / Carré, Justin M / Bruner, Mark W

Human nature (Hawthorne, N.Y.)

2021 Volume 32, Issue 2, Page(s) 509–527

Abstract: Testosterone (T) fluctuates in response to competitive social interactions, with the direction of change typically depending on factors such as contest outcome. Watching a competition may be sufficient to activate T among fans and others who are invested ...

Abstract	Testosterone (T) fluctuates in response to competitive social interactions, with the direction of change typically depending on factors such as contest outcome. Watching a competition may be sufficient to activate T among fans and others who are invested in the outcome. This study explores the change in T associated with vicarious experiences of competition among combat sport athletes viewing a teammate win or lose and assesses how individual differences in social identification with one's team relates to these patterns of T reactivity. Twenty-six male combat athletes completed a social identity questionnaire on a neutral day. Later, salivary samples (assayed for T) were obtained before and after athletes viewed a video of a teammate engaged in a formal contest. T reactivity to viewing a teammate compete varied among participants in both the magnitude and direction of change, independent of contest outcome. Individual differences in cognitive centrality, a core feature of social identification, showed a strong positive relationship with T reactivity, particularly if their teammate won. Initial findings suggest that dominance-linked androgen responses associated with watching a teammate win a competition might depend on the belief that team membership is central to one's own identity. These exploratory results in a small sample of combat athletes should be interpreted with caution. Uncovering the role of social group dynamics in influencing T responses to competition is particularly important in light of the evolutionary history of coalitional combat in humans.
MeSH term(s)	Competitive Behavior ; Humans ; Male ; Saliva ; Social Identification ; Sports ; Surveys and Questionnaires ; Testosterone
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2021-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1020326-6
ISSN	1936-4776 ; 1045-6767
ISSN (online)	1936-4776
ISSN	1045-6767
DOI	10.1007/s12110-021-09407-7
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Zs.A 2973: Show issues

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Article ; Online: Reinterpretation of the electronic absorption spectrum of the methylene amidogen radical (H

Abbott, Adam S / Glick, Zach L / Schaefer, Henry F

The Journal of chemical physics

2018 Volume 149, Issue 9, Page(s) 94302

Abstract: The peculiar electronic absorption spectrum of ... ...

Abstract	The peculiar electronic absorption spectrum of H
Language	English
Publishing date	2018-09-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.5042763
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Article: The Effects of ILeVO and VOTiVO on Root Penetration and Behavior of the Soybean Cyst Nematode, Heterodera glycines.

Beeman, Augustine Q / Njus, Zach L / Pandey, Santosh / Tylka, Gregory L

Plant disease

2019 Volume 103, Issue 3, Page(s) 392–397

Abstract: The objective of this study was to determine the effects of ILeVO (fluopyram) and VOTiVO (Bacillus firmus I-1582) seed treatments on Heterodera glycines second-stage juvenile (J2) root penetration and behavior. In a growth chamber experiment, roots of ... ...

Abstract	The objective of this study was to determine the effects of ILeVO (fluopyram) and VOTiVO (Bacillus firmus I-1582) seed treatments on Heterodera glycines second-stage juvenile (J2) root penetration and behavior. In a growth chamber experiment, roots of soybeans grown from treated or untreated seeds were inoculated with H. glycines J2s at soil depths of 2.5, 5, or 7.5 cm. ILeVO significantly reduced H. glycines root penetration compared with the untreated control, but only when J2s were inoculated at a soil depth of 2.5 cm, which was near the seed. Changes in nematode behavior were assessed by collecting 60-s videos of J2s after 2 h of exposure to exudates from treated seeds or radicles from treated seeds or from soil leachates in which treated seeds were planted. X- and y-coordinates of each of the 13 reference points were recorded every hour for 24 h. A custom program analyzed and transformed the coordinates into nematode motion parameters (speed and total change in curvature). ILeVO, but not VOTiVO, seed exudates significantly reduced J2 speed relative to the untreated control. Soil leachates from ILeVO or VOTiVO treatments had no consistent effect on H. glycines speed or total change in curvature compared with the untreated control. In another experiment, treated or untreated seeds were incubated in wells of 6-well tissue culture plates containing 11.5% Pluronic gel. Seeds were removed after 2 h, and approximately 50 J2s then were pipetted into each well. The plates were scanned every 60 min for 24 h, and the number of J2s in each well that moved a minimum distance of ≥300 µm was determined using another custom software program. ILeVO, but not VOTiVO, significantly reduced the movement of J2 populations relative to control wells in which no seeds were added. And wells that had seeds, treated or not, yielded significantly less J2 movement compared with the no-seed control. The results of these experiments indicate that ILeVO reduces activity on H. glycines J2s but may not affect nematodes beyond a limited area surrounding the treated seed.
MeSH term(s)	Animals ; Bacillus/physiology ; Behavior, Animal/drug effects ; Benzamides/pharmacology ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Plant Roots/drug effects ; Plant Roots/microbiology ; Plant Roots/parasitology ; Pyridines/pharmacology ; Seeds/chemistry ; Glycine max/drug effects ; Glycine max/microbiology ; Glycine max/parasitology ; Tylenchoidea/drug effects ; Tylenchoidea/microbiology
Chemical Substances	Benzamides ; Pyridines ; N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide (F0VT7K5302)
Language	English
Publishing date	2019-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-02-18-0222-RE
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Z 2043: Show issues

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Article ; Online: Prospective Analysis of Radiation-Induced Contrast Enhancement and Health-Related Quality of Life After Proton Therapy for Central Nervous System and Skull Base Tumors.

Lütgendorf-Caucig, Carola / Pelak, Maciej / Hug, Eugen / Flechl, Birgit / Surböck, Birgit / Marosi, Christine / Mock, Ulrike / Zach, Leor / Mardor, Yael / Furman, Orit / Hentschel, Harald / Gora, Joanna / Fossati, Piero / Stock, Markus / Graichen, Uwe / Klee, Sascha / Georg, Petra

International journal of radiation oncology, biology, physics

2024 Volume 118, Issue 5, Page(s) 1206–1216

Abstract: Purpose: Intracerebral radiation-induced contrast enhancement (RICE) can occur after photon as well as proton beam therapy (PBT). This study evaluated the incidence, characteristics, and risk factors of RICE after PBT delivered to, or in direct ... ...

Abstract	Purpose: Intracerebral radiation-induced contrast enhancement (RICE) can occur after photon as well as proton beam therapy (PBT). This study evaluated the incidence, characteristics, and risk factors of RICE after PBT delivered to, or in direct proximity to, the brain and its effect on health-related quality of life (HRQoL). Methods and materials: Four hundred twenty-one patients treated with pencil beam scanning PBT between 2017 and 2021 were included. Follow-up included clinical evaluation and contrast-enhanced magnetic resonance imaging at 3, 6, and 12 months after treatment completion and annually thereafter. RICE was graded according to Common Terminology Criteria for Adverse Events version 4, and HRQoL parameters were assessed via European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30 questionnaires. Results: The median follow-up was 24 months (range, 6-54), and median dose to 1% relative volume of noninvolved central nervous system (D1%CNS) was 54.3 Gy relative biologic effectiveness (RBE; range, 30-76 Gy RBE). The cumulative RICE incidence was 15% (n = 63), of which 10.5% (n = 44) were grade 1, 3.1% (n = 13) were grade 2, and 1.4% (n = 6) were grade 3. No grade 4 or 5 events were observed. Twenty-six of 63 RICE (41.3%) had resolved at the latest follow-up. The median onset after PBT and duration of RICE in patients in whom the lesions resolved were 11.8 and 9.0 months, respectively. On multivariable analysis, D1%CNS > 57.6 Gy RBE, previous in-field radiation, and diabetes mellitus were identified as significant risk factors for RICE development. Previous radiation was the only factor influencing the risk of symptomatic RICE. After PBT, general HRQoL parameters were not compromised. In a matched cohort analysis of 54/50 patients with and without RICE, no differences in global health score or functional and symptom scales were seen. Conclusions: The overall incidence of clinically relevant RICE after PBT is very low and has no significant negative effect on long-term patient QoL.
MeSH term(s)	Humans ; Proton Therapy/adverse effects ; Proton Therapy/methods ; Skull Base Neoplasms/diagnostic imaging ; Skull Base Neoplasms/radiotherapy ; Quality of Life ; Radiation Injuries/pathology ; Radiotherapy Dosage ; Brain/radiation effects
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2024.01.007
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