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  1. Article ; Online: Edward Hickling Bradford (1848-1926): The Founder of Pediatric Orthopedics in America.

    Zachariou, Eleftherios / Galanis, Athanasios / Mavrommatis, Evangelos

    Surgical innovation

    2022  Volume 29, Issue 2, Page(s) 299–300

    Abstract: Edward Hickling Bradford (1848-1926) is considered as 1 of the most important figures in American and world orthopedics during 19th and early 20th century. His teaching ability, his gifted surgical skills and his innovations in orthopedics attracted the ... ...

    Abstract Edward Hickling Bradford (1848-1926) is considered as 1 of the most important figures in American and world orthopedics during 19th and early 20th century. His teaching ability, his gifted surgical skills and his innovations in orthopedics attracted the interest of the world orthopedic's community and gave him a long lasting reputation. But most of all he is considered as the founder of pediatric orthopedics in America.
    MeSH term(s) Child ; Cognition ; History, 19th Century ; History, 20th Century ; Humans ; Male ; Orthopedic Procedures ; Orthopedics ; United States
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2182571-3
    ISSN 1553-3514 ; 1553-3506
    ISSN (online) 1553-3514
    ISSN 1553-3506
    DOI 10.1177/15533506211066426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4269: Show issues Location:
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  2. Article: Maximal Effort Cytoreduction in Epithelial Ovarian Cancer: Perioperative Complications and Survival Outcomes from a Retrospective Cohort.

    Haidopoulos, Dimitrios / Pergialiotis, Vasilios / Zachariou, Eleftherios / Sapantzoglou, Ioakim / Thomakos, Nikolaos / Stamatakis, Emmanouil / Alexakis, Nikolaos

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Splenectomy as Part of Maximal-Effort Cytoreductive Surgery in Advanced Epithelial Ovarian Cancer.

    Pergialiotis, Vasilios / Zachariou, Eleftherios / Lygizos, Vasilios / Vlachos, Dimitrios Efthymios / Stamatakis, Emmanouil / Angelou, Kyveli / Daskalakis, Georgios / Thomakos, Nikolaos / Haidopoulos, Dimitrios

    Cancers

    2024  Volume 16, Issue 4

    Abstract: Introduction: A splenectomy is frequently performed during debulking surgery for advanced ovarian cancer. Its impact on perioperative and survival outcomes remains questionable as current evidence is conflicting. In the present study, we sought to ... ...

    Abstract Introduction: A splenectomy is frequently performed during debulking surgery for advanced ovarian cancer. Its impact on perioperative and survival outcomes remains questionable as current evidence is conflicting. In the present study, we sought to determine the factors that affect survival rates in ovarian cancer patients that undergo a splenectomy as part of maximal-effort cytoreduction.
    Patients and methods: A retrospective chart review was conducted that included all epithelial ovarian cancer patients that had surgical cytoreduction for advanced epithelial ovarian cancer. Differences among splenectomized and non splenectomized patients were evaluated as well as the impact of known risk factors on survival outcomes of splenectomized patients.
    Results: Overall, 245 patients were identified and 223 were included in the present series, of whom 91 had a splenectomy. Recurrence rates as well as death rates were comparable among splenectomized and non-splenectomized patients; however, both the disease-free survival (
    Discussion: The findings of our study support the feasibility of splenectomy in advanced epithelial ovarian cancer; however, its impact on patients' survival is considerable. Therefore, every effort should be made to avoid splenic injury which will result in unintended splenectomy for non-oncological reasons.
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16040790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Laparoscopic versus Vaginal Uterosacral Ligament Suspension in Women with Pelvic Organ Prolapse: A Systematic Review and Meta-analysis of the Literature.

    Douligeris, Athanasios / Kathopoulis, Nikolaos / Zachariou, Eleftherios / Mortaki, Anastasia / Zacharakis, Dimitrios / Kypriotis, Konstantinos / Chatzipapas, Ioannis / Protopapas, Athanasios

    Journal of minimally invasive gynecology

    2024  

    Abstract: Objective: Uterosacral ligament suspension (USLS) is one of the most frequently used operations for the restoration of apical support in women with uterovaginal prolapse. However, existing studies are inconclusive as to whether and which surgical access ...

    Abstract Objective: Uterosacral ligament suspension (USLS) is one of the most frequently used operations for the restoration of apical support in women with uterovaginal prolapse. However, existing studies are inconclusive as to whether and which surgical access route is superior. The aim of the present meta-analysis is tentatively to compare the efficiency and the postoperative complications of laparoscopic USLS (L-USLS) and vaginal USLS (V-USLS), highlighting that current evidence remains inconclusive regarding the superiority of either surgical access route.
    Data sources: We performed a systematic literature review of 5 major databases (Medline, Scopus, Google Scholar Cochrane Central Register of Controlled Trials and Clinicaltrials.gov) from inception till April 2023.
    Methods of study selection: No language restrictions were applied. All comparative studies that compared L-USLS and V-USLS for the management of women with uterovaginal prolapse were included.
    Tabulation, integration, and results: Data from 6 retrospective cohort studies on 856 patients were extracted and analyzed. The methodological quality of the included studies was assessed using the risk of bias in nonrandomized studies of interventions tool and ranged between moderate to serious. The pooled results suggest that L-USLS was associated with a potentially decreased incidence of ureteral compromise (odds ratio [OR], 0.19; 95% confidence interval [CI] 0.04-0.89; p = .04) and seemingly lower objective (OR 0.47; 95% CI 0.23-0.97; p = .04) and subjective recurrence rates (OR 0.46; 95% CI 0.23-0.92; p = .03). There were no significant differences between the rates of postoperative pain from USLS sutures, postoperative pelvic hematomas, the suture exposure/granulation tissue formation, and the prolapse recurrence retreatment among the 2 groups.
    Conclusion: The present meta-analysis indicates that L-USLS is possibly associated with significantly fewer ureteral compromise rates and decreased subjective and objective recurrences rates compared to V-USLS. Nevertheless, given the limitations in data quality and heterogeneity of the included studies, these findings should be interpreted with caution. Large-scale randomized studies are essential to more definitively determine the relative merits of the laparoscopic versus vaginal approach.
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2024.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4205: Show issues Location:
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  5. Article ; Online: Tumor free distance from serosa and survival rates of endometrial cancer patients: A meta-analysis.

    Pergialiotis, Vasilios / Zachariou, Eleftherios / Vlachos, Dimitrios Efthymios / Vlachos, Athanasios / Goula, Kalliroi / Thomakos, Nikolaos / Rodolakis, Alexandros / Haidopoulos, Dimitrios

    European journal of obstetrics, gynecology, and reproductive biology

    2023  Volume 286, Page(s) 16–22

    Abstract: Myometrial invasion and its extent have been directly associated with the risk of relapse as well as the overall survival of endometrial cancer patients. Tumor free distance from the serosal surface of the uterine wall has been investigated the last ... ...

    Abstract Myometrial invasion and its extent have been directly associated with the risk of relapse as well as the overall survival of endometrial cancer patients. Tumor free distance from the serosal surface of the uterine wall has been investigated the last years by several studies, however, to date, its importance remains unknown. The present meta-analysis is based on a systematic search of the Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar databases and has been designed according to the PRISMA guidelines. Nine studies were included in the present systematic review that recruited pathology slides from 1,598 endometrial cancer patients and their meta-analysis indicated that TFD was significantly associated with the progression free survival of patients with endometrial cancer (OR 0.36, 95% CI 0.20, 0.65). The disease specific survival was not affected by the TFD (OR 0.30, 95% CI 0.09, 1.01). Sensitivity analyses revealed, however, that both the progression free and overall survival rates were associated with TFD. Significant discrepancies were observed in terms of histological subtypes and stage of the disease among included patients, hence, the actual importance of TFD in specific subgroups remains unknown. Future studies must evaluate the importance of this pathology marker particularly in patients with endometrioid subtypes and early-stage disease, as it is believed that in this group its importance will be more predictive as it will not be skewed by the presence of more important factors such as more aggressive histology and advanced stage disease.
    MeSH term(s) Female ; Humans ; Survival Rate ; Neoplasm Recurrence, Local/pathology ; Neoplasm Invasiveness/pathology ; Endometrial Neoplasms/pathology ; Serous Membrane/pathology ; Disease-Free Survival
    Language English
    Publishing date 2023-05-08
    Publishing country Ireland
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 837: Show issues Location:
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  6. Article ; Online: Fertility outcomes after treatment with intraperitoneal chemotherapy.

    Papageorgiou, Dimitrios / Diakosavvas, Michail / Angelou, Kyveli / Kathopoulis, Nikolaos / Voros, Charalambos / Zachariou, Eleftherios / Papadatou, Konstantina / Papapanagiotou, Ioannis K / Papakonstantinou, Katerina

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

    2022  Volume 42, Issue 6, Page(s) 1626–1634

    Abstract: Intraperitoneal chemotherapy (IPC) administration has been added to the therapeutic protocols of cancers, confined to the abdominal cavity. Since, a survival benefit in patients treated with adjuvant IPC has been demonstrated, fertility questions are ... ...

    Abstract Intraperitoneal chemotherapy (IPC) administration has been added to the therapeutic protocols of cancers, confined to the abdominal cavity. Since, a survival benefit in patients treated with adjuvant IPC has been demonstrated, fertility questions are raised in these patients. A comprehensive search of the English literature of PubMed/MEDLINE, EmBase and Google Scholar databases was conducted, from their inception until April 2021, following the MOOSE guidelines. Twelve out of 473 studies were included in the final review and analysis. After treatment with IPC for peritoneal carcinomatosis, 19 women, who underwent fertility-sparing surgery, with 20 successful pregnancies were reported. The mean interval time between IPC and pregnancy was 38.4 months (range 9-168 months). In 16 cases, conception was spontaneous, three required
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Cytoreduction Surgical Procedures/methods ; Female ; Fertility Preservation/methods ; Humans ; Peritoneal Neoplasms/surgery ; Pregnancy
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604639-3
    ISSN 1364-6893 ; 0144-3615
    ISSN (online) 1364-6893
    ISSN 0144-3615
    DOI 10.1080/01443615.2022.2055453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2461: Show issues Location:
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  7. Article ; Online: sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies-A Review of the Literature.

    Sapantzoglou, Ioakeim / Rouvali, Angeliki / Koutras, Antonios / Chatziioannou, Maria Ioanna / Prokopakis, Ioannis / Fasoulakis, Zacharias / Zachariou, Eleftherios / Douligeris, Athanasios / Mortaki, Anastasia / Perros, Paraskevas / Ntounis, Thomas / Pergialiotis, Vasilios / Domali, Ekaterini / Athanasiou, Stavros / Daskalakis, George / Rodolakis, Alexandros / Panagopoulos, Periklis / Pappa, Kalliopi I

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 7

    Abstract: Twin pregnancies demonstrate a 2-3-fold higher chance of developing PE compared to singletons, and recent evidence has demonstrated that the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, as well as imminent deliveries due ... ...

    Abstract Twin pregnancies demonstrate a 2-3-fold higher chance of developing PE compared to singletons, and recent evidence has demonstrated that the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, as well as imminent deliveries due to PE complications. The primary objective of this systematic review was to summarise the available data on the levels of sFLT1, PlGF and their ratios in twin pregnancies and to investigate their association with the development of PE, adverse pregnancy outcomes and the timing of the delivery. A systematic search of Ovid Embase, Web of Science, Science Direct, PubMed, Ovid Medline, Google Scholar and CINAHL was carried out. sFLT1 levels and the sFLT1/PIGF ratio appeared higher in twins compared to singleton pregnancies, especially in the third trimester, while PlGF levels appeared higher up until the third trimester, with their values showing no difference or being even lower than in singletons thereafter. The sFLT1/PIGF ratio has been reported to be an independent marker of adverse outcomes related to pre-eclampsia and is associated with the mean time until delivery in an inverse manner. Further research is required in order to establish the optimal sFLT1/PIGF cut-off values and to stratify the risk of adverse outcomes in twin pregnancies.
    MeSH term(s) Female ; Humans ; Pregnancy ; Biomarkers ; Placenta Growth Factor ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/etiology ; Pregnancy, Twin ; Vascular Endothelial Growth Factor Receptor-1
    Chemical Substances Biomarkers ; FLT1 protein, human (EC 2.7.10.1) ; Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1) ; PGF protein, human
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59071232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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