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  1. Article ; Online: Teaching Trans-Centric Curricular Content Using Modified Jigsaw.

    Zheng, Cynthia / D'Costa, Zoee / Zachow, Rob J / Lebeau, Robert / Bachmann, Gloria A

    MedEdPORTAL : the journal of teaching and learning resources

    2022  Volume 18, Page(s) 11257

    Abstract: Introduction: Transgender (trans) individuals have unique medical needs and difficulty accessing quality health care, exacerbated by inadequate provider knowledge. Incorporation of trans health care into medical school curricula has increased recently ... ...

    Abstract Introduction: Transgender (trans) individuals have unique medical needs and difficulty accessing quality health care, exacerbated by inadequate provider knowledge. Incorporation of trans health care into medical school curricula has increased recently to address this gap. Jigsaw activities emphasize positive interdependence through structured cooperative learning, resulting in increased interest and self-confidence. We implemented a voluntary 2-hour modified jigsaw exercise on trans health care with changes designed to optimize the structure for medical students.
    Methods: The session was implemented both in person and virtually over 2 years with preclerkship medical students at the end of their endocrine/reproduction physiology course. The session featured a knowledge test with answer discussion followed by a clinical correlation-either a case discussion or video discussion. A pre- and posttest design compared students' knowledge, attitudes, and beliefs.
    Results: Eighty-nine students participated. Their initial attitudes and beliefs regarding trans health care were highly positive and remained elevated. Participants showed increases in knowledge and self-confidence discussing gender identity and clinical care postsession. All expressed interest in further training and felt the session enhanced their understanding of trans health and reproductive physiology. On 1-year follow-up, students showed decreased knowledge and self-confidence in discussing trans health; however, scores remained higher than presession. Student surveys suggested formal integration of more trans health education into the curriculum.
    Discussion: Medical students increased their knowledge and self-confidence regarding trans medicine and felt the modified jigsaw exercise was an effective teaching method. The results suggest that ongoing education is an important tool in optimizing trans health care.
    MeSH term(s) Curriculum ; Female ; Gender Identity ; Humans ; Learning ; Male ; Schools, Medical ; Students, Medical
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article
    ISSN 2374-8265
    ISSN (online) 2374-8265
    DOI 10.15766/mep_2374-8265.11257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effects of hepatocyte growth factor on cyclic nucleotide-dependent signaling and steroidogenesis in rat ovarian granulosa cells in vitro.

    Zachow, Rob J / Woolery, Jennifer K

    Biology of reproduction

    2002  Volume 67, Issue 2, Page(s) 454–459

    Abstract: Hepatocyte growth factor (HGF) down-modulates FSH-dependent estradiol-17beta (E(2)) production in ovarian granulosa cells in vitro. The mechanisms of action underlying the antiestrogenic effects of HGF are vague, although evidence indicates that HGF may ... ...

    Abstract Hepatocyte growth factor (HGF) down-modulates FSH-dependent estradiol-17beta (E(2)) production in ovarian granulosa cells in vitro. The mechanisms of action underlying the antiestrogenic effects of HGF are vague, although evidence indicates that HGF may affect cAMP signal transduction in rat granulosa cells. The present study investigated the effects of HGF on FSH-induced steroidogenesis in the presence and absence of insulin-like growth factor I (IGF-I), as well as the actions of HGF within cyclic nucleotide-dependent signal transduction cascades in granulosa cells. Immature rat granulosa cells were incubated with FSH, IGF-I, and HGF. HGF impaired the production of FSH-stimulated and FSH + IGF-I-stimulated E(2) synthesis, as well as FSH + IGF-I-dependent estrone production. Progesterone synthesis was not altered by HGF. HGF suppressed FSH-dependent cAMP content at 24 h, but not at 36 h; cGMP content was stimulated by HGF with and without FSH at 24 h. In the presence of the cyclic nucleotide phosphodiesterase (PDE) inhibitor, 3-isobutyl-1-methylxanthine (IBMX), FSH-dependent cAMP accumulation was not affected by HGF. The suppressive effect of HGF on FSH-dependent E(2) production was alleviated by IBMX, whereas the HGF-dependent block in FSH + IGF-I-supported E(2) production was not prevented by IBMX. The effects of HGF on cyclic nucleotide PDE activities were manifested in a time-dependent and hormone-dependent manner. FSH-induced cAMP PDE was suppressed by HGF at 24 h but not at 36 h, whereas FSH-dependent cGMP PDE was impaired at 36 h, but not at 24 h. HGF prevented the IGF-I-dependent reduction in FSH-stimulated cAMP-PDE activity at 24 and 36 h, and lowered FSH + IGF-I-stimulated cGMP-PDE activity at 36 h, concomitant with an HGF-dependent increase in cGMP content at 24 h. These data indicate that HGF affects cAMP-directed and cGMP-directed signaling pathways at multiple sites in granulosa cells. These HGF-dependent effects may provide insight for mechanisms of action whereby HGF reduces E(2) secretion by granulosa cells.
    MeSH term(s) 1-Methyl-3-isobutylxanthine/pharmacology ; 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; 3',5'-Cyclic-GMP Phosphodiesterases/metabolism ; Animals ; Cyclic AMP/metabolism ; Cyclic AMP/physiology ; Cyclic GMP/metabolism ; Cyclic GMP/physiology ; Estradiol/biosynthesis ; Female ; Follicle Stimulating Hormone/physiology ; Granulosa Cells/drug effects ; Granulosa Cells/metabolism ; Hepatocyte Growth Factor/pharmacology ; Humans ; Insulin-Like Growth Factor I/physiology ; Male ; Ovary/cytology ; Ovary/drug effects ; Ovary/metabolism ; Phosphodiesterase Inhibitors/pharmacology ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Steroids/biosynthesis
    Chemical Substances Phosphodiesterase Inhibitors ; Recombinant Proteins ; Steroids ; Estradiol (4TI98Z838E) ; Hepatocyte Growth Factor (67256-21-7) ; Insulin-Like Growth Factor I (67763-96-6) ; Follicle Stimulating Hormone (9002-68-0) ; Cyclic AMP (E0399OZS9N) ; 3',5'-Cyclic-AMP Phosphodiesterases (EC 3.1.4.17) ; 3',5'-Cyclic-GMP Phosphodiesterases (EC 3.1.4.35) ; Cyclic GMP (H2D2X058MU) ; 1-Methyl-3-isobutylxanthine (TBT296U68M)
    Language English
    Publishing date 2002-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1095/biolreprod67.2.454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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