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  1. AU="Zafar, Mohammad A"
  2. AU=Owens Michael D
  3. AU="Kuveždić, D."
  4. AU="John, Shannon"
  5. AU="O'Shaughnessy, R F L"
  6. AU="AlHarfoush, Enmar"
  7. AU="Savill, Edward"
  8. AU="Pavel P. Polyakov"
  9. AU="Robert Haennel"
  10. AU="Robert W. Crawford"
  11. AU="Figueroa, Andres V"
  12. AU="Racca, C."
  13. AU="Slavu, Diana-Maria"
  14. AU="Talbert, Emily"
  15. AU=Abdelnour Loay H
  16. AU=Meisburger Steve P.
  17. AU="Silveira, Fernando A. O."
  18. AU="Toru Nabika"
  19. AU="Vojkovic, Marina"
  20. AU="Gaier, Eric D"
  21. AU="Chandler Crews"
  22. AU="Comte, Marie-Hélène"
  23. AU="Cohen, Or"
  24. AU="Abdellatifi, Mohamed"
  25. AU="Luebbe, Elizabeth"
  26. AU="Emidio, Adriana"
  27. AU=Masmejan Sophie
  28. AU="Samantha Ridley"
  29. AU="Moghaddam-Alvandi, Arash"
  30. AU="Khanolkar, Amey R."
  31. AU="Vasquez Martinez, Rodolfo"
  32. AU="Morgan, E"

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  1. Artikel ; Online: Natural History and Intervention Thresholds for Ascending Thoracic Aortic Aneurysm-Not an Easy Nut to Crack.

    Zafar, Mohammad A / Elefteriades, John A

    JAMA cardiology

    2023  Band 8, Heft 5, Seite(n) 512

    Mesh-Begriff(e) Humans ; Nuts ; Aortic Aneurysm, Thoracic/surgery
    Sprache Englisch
    Erscheinungsdatum 2023-03-21
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.0153
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Nonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta.

    Elefteriades, John A / Ziganshin, Bulat A / Zafar, Mohammad A

    Aorta (Stamford, Conn.)

    2023  Band 11, Heft 2, Seite(n) 71–86

    Abstract: For decades, aortic surgery has relied on size criteria for intervention on the ascending aorta. While diameter has served well, diameter alone falls short of an ideal criterion. Herein, we examine the potential application of other, nondiameter criteria ...

    Abstract For decades, aortic surgery has relied on size criteria for intervention on the ascending aorta. While diameter has served well, diameter alone falls short of an ideal criterion. Herein, we examine the potential application of other, nondiameter criteria in aortic decision-making. These findings are summarized in this review. We have conducted multiple investigations of specific alternate nonsize criteria by leveraging our extensive database, which includes complete, verified anatomic, clinical, and mortality data on 2,501 patients with thoracic aortic aneurysm (TAA) and dissections (198 Type A, 201 Type B, and 2102 TAAs). We examined 14 potential intervention criteria. Each substudy had its own specific methodology, reported individually in the literature. The overall findings of these studies are presented here, with a special emphasis on how the findings can be incorporated into enhanced aortic decision-making-above and beyond sheer diameter. The following nondiameter criteria have been found useful in decision-making regarding surgical intervention. (1) Pain: In the absence of other specific cause, substernal chest pain mandates surgery. Well-developed afferent neural pathways carry warning signals to the brain. (2) Aortic length/tortuosity: Length is emerging as a mildly better predictor of impending events than diameter. (3) Genes: Specific genetic aberrations provide a powerful predictor of aortic behavior; malignant genetic variants obligate earlier surgery. (4) Family history: Aortic events closely follow those in relatives with a threefold increase in likelihood of aortic dissection for other family members once an index family dissection has occurred. (5) Bicuspid aortic valve: Previously thought to increase aortic risk (as a "Marfan light" situation), current data show that bicuspid valve is not a predictor of higher risk. (6) Diabetes actually protects against aortic events, via mural thickening and fibrosis. (7) Biomarkers: A specialized "RNA signature test" identifies aneurysm-bearing patients in the general population and promises to predict impending dissection. (8) Aortic stress: Blood pressure (BP) elevation from anxiety/exertion precipitates dissection, especially with high-intensity weightlifting. (9) Root dilatation imposes higher dissection risk than supracoronary ascending aneurysm. (10) Inflammation on positron emission tomography (PET) imaging implies high rupture risk and merits surgical intervention. (11) A
    Sprache Englisch
    Erscheinungsdatum 2023-05-12
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 2325-4637
    ISSN 2325-4637
    DOI 10.1055/s-0043-1766114
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Decision-making in aortic disease.

    Wu, Jinlin / Zafar, Mohammad A / Elefteriades, John A

    European heart journal

    2023  Band 45, Heft 8, Seite(n) 633–634

    Mesh-Begriff(e) Humans ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Aortic Diseases/therapy ; Clinical Decision-Making ; Decision Making ; Transcatheter Aortic Valve Replacement
    Sprache Englisch
    Erscheinungsdatum 2023-11-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad699
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  4. Artikel ; Online: Intricacies of aortic risk assessment studies: not a simple matter.

    Zafar, Mohammad A / Wu, Jinlin / Elefteriades, John A

    European heart journal

    2023  Band 45, Heft 9, Seite(n) 735–736

    Sprache Englisch
    Erscheinungsdatum 2023-12-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad795
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  5. Artikel: The natural history of aortic root aneurysms.

    Ziganshin, Bulat A / Kargin, Nicole / Zafar, Mohammad A / Elefteriades, John A

    Annals of cardiothoracic surgery

    2023  Band 12, Heft 3, Seite(n) 213–224

    Abstract: The aortic root has a different embryologic origin from all other segments of the human aorta, a feature that likely confers unique susceptibilities, anatomical patterns, and clinical behavior of aneurysm disease in this vital location. In this ... ...

    Abstract The aortic root has a different embryologic origin from all other segments of the human aorta, a feature that likely confers unique susceptibilities, anatomical patterns, and clinical behavior of aneurysm disease in this vital location. In this manuscript, we review the natural history of ascending aortic aneurysm, with a specific focus on the aortic root. The specific central message is that root dilatation is more malignant than ascending dilatation.
    Sprache Englisch
    Erscheinungsdatum 2023-05-18
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2023-avs1-20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Nonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta

    Elefteriades, John A. / Ziganshin, Bulat A. / Zafar, Mohammad A.

    AORTA

    2023  Band 11, Heft 02, Seite(n) 71–86

    Abstract: For decades, aortic surgery has relied on size criteria for intervention on the ascending aorta. While diameter has served well, diameter alone falls short of an ideal criterion. Herein, we examine the potential application of other, nondiameter criteria ...

    Abstract For decades, aortic surgery has relied on size criteria for intervention on the ascending aorta. While diameter has served well, diameter alone falls short of an ideal criterion. Herein, we examine the potential application of other, nondiameter criteria in aortic decision-making. These findings are summarized in this review. We have conducted multiple investigations of specific alternate nonsize criteria by leveraging our extensive database, which includes complete, verified anatomic, clinical, and mortality data on 2,501 patients with thoracic aortic aneurysm (TAA) and dissections (198 Type A, 201 Type B, and 2102 TAAs). We examined 14 potential intervention criteria. Each substudy had its own specific methodology, reported individually in the literature. The overall findings of these studies are presented here, with a special emphasis on how the findings can be incorporated into enhanced aortic decision-making—above and beyond sheer diameter. The following nondiameter criteria have been found useful in decision-making regarding surgical intervention. (1) Pain: In the absence of other specific cause, substernal chest pain mandates surgery. Well-developed afferent neural pathways carry warning signals to the brain. (2) Aortic length/tortuosity: Length is emerging as a mildly better predictor of impending events than diameter. (3) Genes: Specific genetic aberrations provide a powerful predictor of aortic behavior; malignant genetic variants obligate earlier surgery. (4) Family history: Aortic events closely follow those in relatives with a threefold increase in likelihood of aortic dissection for other family members once an index family dissection has occurred. (5) Bicuspid aortic valve: Previously thought to increase aortic risk (as a “Marfan light” situation), current data show that bicuspid valve is not a predictor of higher risk. (6) Diabetes actually protects against aortic events, via mural thickening and fibrosis. (7) Biomarkers: A specialized “RNA signature test” identifies aneurysm-bearing patients in the general population and promises to predict impending dissection. (8) Aortic stress: Blood pressure (BP) elevation from anxiety/exertion precipitates dissection, especially with high-intensity weightlifting. (9) Root dilatation imposes higher dissection risk than supracoronary ascending aneurysm. (10) Inflammation on positron emission tomography (PET) imaging implies high rupture risk and merits surgical intervention. (11) A KIF6 p.Trp719Arg variant elevates aortic dissection risk nearly two-fold. (12) Female sex confers some increased risk, which can be largely accommodated by using body-size-based nomograms (especially height nomograms). (13) Fluoroquinolones predispose to catastrophic dissection events and should be avoided rigorously in aneurysm patients. (14) Advancing age makes the aorta more vulnerable, increasing likelihood of dissection. In conclusion, nondiameter criteria can beneficially be brought to bear on the decision to observe or operate on specific TAA.
    Schlagwörter aorta ; diameter ; aortic surgery ; thoracic aorta ; ascending aorta ; chest pain
    Sprache Englisch
    Erscheinungsdatum 2023-04-01
    Verlag Thieme Medical Publishers, Inc.
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ISSN 2325-4637
    ISSN (online) 2325-4637
    DOI 10.1055/s-0043-1766114
    Datenquelle Thieme Verlag

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  7. Artikel: Clinical Experience with "Stand-Alone" Elephant Trunk Procedure for Descending Aortic Aneurysms.

    Kumbasar, Ulas / Zafar, Mohammad A / Ziganshin, Bulat A / Elefteriades, John A

    Aorta (Stamford, Conn.)

    2022  Band 10, Heft 2, Seite(n) 52–56

    Abstract: Background:  Both open and endovascular treatments of descending thoracic aortic aneurysms require a secure proximal landing zone. This may be difficult to achieve when the dilatation extends proximally to the left subclavian level. Clamping above the ... ...

    Abstract Background:  Both open and endovascular treatments of descending thoracic aortic aneurysms require a secure proximal landing zone. This may be difficult to achieve when the dilatation extends proximally to the left subclavian level. Clamping above the aneurysm may be difficult. In the case of an endovascular approach, achieving a suitable landing zone may require extensive extra-anatomic debranching, which is not without complications and limitations.
    Methods:  We describe a modification of the traditional elephant trunk procedure that represents a "stand-alone" elephant trunk. Under deep hypothermic circulatory arrest, the aorta is transected between the left carotid and left subclavian arteries. A simple, noninverted elephant trunk is placed through the distal cut aorta. The two ends are sewn back together, incorporating the lip of the elephant trunk in the anastomosis. We review our experience in five patients who underwent this procedure.
    Results:  All 5 patients (4 males, 1 female) aged 41 to 68 (mean, 57 years) tolerated the Stage 1 stand-alone elephant trunk procedure well, without mortality, stroke, or bleeding. The Stage 2 descending aortic replacements were performed at a mean of 6.7 months after Stage 1. There was no Stage 2 mortality, stroke, or bleeding. One patient died 8 years later of cardiac cause, and the remaining are alive and well.
    Conclusion:  A stand-alone elephant trunk procedure is safe and straightforward and provides an excellent proximal foundation for subsequent open (or potentially endovascular) descending aortic replacement.
    Sprache Englisch
    Erscheinungsdatum 2022-08-07
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 2325-4637
    ISSN 2325-4637
    DOI 10.1055/s-0042-1743535
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Toward standard abbreviations and acronyms for use in articles on aortic disease.

    Perez, Zachary G / Zafar, Mohammad A / Ziganshin, Bulat A / Elefteriades, John A

    JTCVS open

    2022  Band 10, Seite(n) 34–38

    Abstract: Objectives: Academic medical literature is fraught with complex article-specific acronyms and abbreviations that can impair communication and make reading arduous. Our goal is to ease frustration with bespoke, inconsistent, and variable sets of ... ...

    Abstract Objectives: Academic medical literature is fraught with complex article-specific acronyms and abbreviations that can impair communication and make reading arduous. Our goal is to ease frustration with bespoke, inconsistent, and variable sets of abbreviations that currently exist for common aorta-related terminology (eg, anatomy, imaging, disease, and therapy). We hope to ease reading and improve communication in the aortic sphere of cardiovascular literature.
    Methods: We reviewed a total of 205 published references related to aortic disease, including a systematic review of aorta-related articles in the
    Results: We present suggested acronyms and abbreviations for common terminology related to the aorta. It is anticipated that this standard list will evolve over time as the literature and technology of the field grows and develops.
    Conclusions: A proposed standard set of acronyms and abbreviations for aorta-related terminology is provided that, if found useful, could be implemented broadly in the aortic literature.
    Sprache Englisch
    Erscheinungsdatum 2022-04-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2022.04.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Getting to the root of aortic dissection in congenital heart disease.

    Zafar, Mohammad A / Ziganshin, Bulat A / Elefteriades, John A

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Band 61, Heft 2, Seite(n) 318–319

    Mesh-Begriff(e) Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/surgery ; Aortic Aneurysm, Thoracic/surgery ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/surgery ; Humans
    Sprache Englisch
    Erscheinungsdatum 2021-10-30
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab464
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Machine learning: principles and applications for thoracic surgery.

    Ostberg, Nicolai P / Zafar, Mohammad A / Elefteriades, John A

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2021  Band 60, Heft 2, Seite(n) 213–221

    Abstract: Objectives: Machine learning (ML) has experienced a revolutionary decade with advances across many disciplines. We seek to understand how recent advances in ML are going to specifically influence the practice of surgery in the future with a particular ... ...

    Abstract Objectives: Machine learning (ML) has experienced a revolutionary decade with advances across many disciplines. We seek to understand how recent advances in ML are going to specifically influence the practice of surgery in the future with a particular focus on thoracic surgery.
    Methods: Review of relevant literature in both technical and clinical domains.
    Results: ML is a revolutionary technology that promises to change the way that surgery is practiced in the near future. Spurred by an advance in computing power and the volume of data produced in healthcare, ML has shown remarkable ability to master tasks that had once been reserved for physicians. Supervised learning, unsupervised learning and reinforcement learning are all important techniques that can be leveraged to improve care. Five key applications of ML to cardiac surgery include diagnostics, surgical skill assessment, postoperative prognostication, augmenting intraoperative performance and accelerating translational research. Some key limitations of ML include lack of interpretability, low quality and volumes of relevant clinical data, ethical limitations and difficulties with clinical implementation.
    Conclusions: In the future, the practice of cardiac surgery will be greatly augmented by ML technologies, ultimately leading to improved surgical performance and better patient outcomes.
    Mesh-Begriff(e) Humans ; Machine Learning ; Thoracic Surgery
    Sprache Englisch
    Erscheinungsdatum 2021-03-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezab095
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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