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Article ; Online: Endoscopic treatment of scarred polyps with a non-thermal device (Endorotor): A review of the literature‎.

Zaghloul, Mariam / Rehman, Hameed / Sansone, Stefano / Argyriou, Konstantinos / Parra-Blanco, Adolfo

2024 Volume 30, Issue 12, Page(s) 1706–1713

Abstract: Endoscopic resection (ER) of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic devices. ER procedures have evolved ...

Abstract	Endoscopic resection (ER) of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic devices. ER procedures have evolved over the past few years from endoscopic mucosal resection (EMR) to more advanced techniques, such as endoscopic submucosal dissection and endo-scopic full-thickness resection. Complete resection and disease eradication are the ultimate goals of ER-based techniques, and novel devices have been developed to achieve these goals. The EndoRotor
MeSH term(s)	Humans ; Female ; Cicatrix ; Colonic Polyps/surgery ; Endoscopy ; Disease Eradication ; Endometriosis
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v30.i12.1706
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Article: Cardiovascular Risk Assessment After Sofosbuvir And Daclatasvir Regimen For Chronic Hepatitis C Virus Infection.

Maher, Kareem Ali / Biomy, Reda / Youssef, Mahmoud Mohammed / Zaghloul, Mariam Salah / Haseeb, Wael Anwar

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73Suppl 4, Issue 4, Page(s) S136–S141

Abstract: Objectives: To assess cardiovascular risk after sofosbuvir and daclatasvir antiviral combination therapy in chronic hepatitis C virus patients.: Method: The prospective cohortstudy was conducted at the Kafrelsheikh University Hospital, Egypt, from ... ...

Abstract	Objectives: To assess cardiovascular risk after sofosbuvir and daclatasvir antiviral combination therapy in chronic hepatitis C virus patients. Method: The prospective cohortstudy was conducted at the Kafrelsheikh University Hospital, Egypt, from December 2019 to December 2021, and comprised adult patients of either gender with chronic hepatitis C virus and with minimum ejection fraction 40%. They were classified into groups according to their cardiovascular risk. Group 1 had individuals with no risk factors, Group 2 had patients with many risk factors, Group 3 had patients with only hypertension, Group 4 had those with diabetes alone, and Group 5 comprised smokers. All the patients were evaluated for the risk of major cardiovascular events at baseline and at the end of 12-week of antiviral combination therapy of sofosbuvir 400 mg once daily dose and daclatasvir 60 mg once daily dose. Data was analysed with SPSS version 23. Results: Of the 200 patients, there were 96(48%) males and 104(52%) females. The age ranged 34-81 years. There were 78(39%) patients in Group 1; 20(25.6%) males and 58(74.4%) females with mean age 54.4±10.45 years. Group 2 had 60(30%) patients; 40(66.6%) males and 20(33.3%) females with mean age 59.57±9.1 years. Group 3 had 25(12.5%) patients; 3(12%) males and 22(88%) females with mean age 61.4±7.8 years. Group 4 had 13(6.5%) patients; 10(77%) males and 3(23%) females with mean age 55.4±10.4 years. Group 5 had 24(12%) patients who were all (100%) males with mean age 60.7±5.7 years. There were non-significant changes in the incidence of angina, arrhythmias or progression of dyspnoea (p>0.05). Echocardiography follow-up results showed non-significant changes in mean ejection fraction, global longitudinal strain and pulmonary artery pressure (p>0.05). Conclusions: Sofosbuvir and daclatasvir combination therapy wasfound to be safe in chronic hepatitis C virus patients regarding cardiac risks.
MeSH term(s)	Adult ; Male ; Female ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Sofosbuvir/therapeutic use ; Hepatitis C, Chronic/drug therapy ; Prospective Studies ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/epidemiology ; Treatment Outcome ; Risk Factors ; Antiviral Agents/adverse effects ; Pyrrolidines/therapeutic use ; Drug Therapy, Combination ; Heart Disease Risk Factors ; Hepacivirus ; Genotype
Chemical Substances	Sofosbuvir (WJ6CA3ZU8B) ; daclatasvir (LI2427F9CI) ; Antiviral Agents ; Pyrrolidines
Language	English
Publishing date	2023-07-24
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.EGY-S4-28
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Article: Evaluation Of Left Ventricular Function After Sofosbuvir And Daclatasvir Regimen For Chronic Hepatitis C.

Maher, Kareem Ali / Biomy, Reda / Youssef, Mahmoud Mohammed / Haseeb, Wael Anwar / Zaghloul, Mariam Salah

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73Suppl 4, Issue 4, Page(s) S131–S135

Abstract: Objectives: To assess left ventricular functions by echocardiography after 12 weeks of sofosbuvir-daclatasvir combination therapy.: Method: The prospective cohort study was conducted from December 2019 to December 2021 at Kafrelsheikh University ... ...

Abstract	Objectives: To assess left ventricular functions by echocardiography after 12 weeks of sofosbuvir-daclatasvir combination therapy. Method: The prospective cohort study was conducted from December 2019 to December 2021 at Kafrelsheikh University Hospital, Egypt, and comprised adult patients of either gender who had been referred to the Cardiovascular Department for cardiac evaluation and were found to be eligible forsofosbuvir-daclatasvir combination therapy. The patients were classified into five groups according to cardiovascular risk factors. Group 1 had no risk factors; Group 2 had many risk factors; Group 3 had only hypertension; Group 4 had diabetes only; and Group 5 had smoking as the only risk. All patients were assessed at baseline and at the end of the 12-week of antiviral combination therapy sofosbuvir 400 mg once daily dose and daclatasvir 60 mg once daily dose. Parameters checked were left ventricular ejection fraction, global longitudinalstrain, wall motion abnormalities and diastolic function. Data was analysed using SPSS 23. Results: Of the 200 patients, 104(52%) were females and 96(48%) were males. The age range was 34-81 years, and 18(9%) patients were aged >70 years. There were 78(39%) patientsin Group 1, 60(30%) in Group 2, 25(12.5%) in Group 3, Group 4 had 13(6.5%) and Group 5 had 24(12%) patients. There were no significant changes in mean ejection fraction, global longitudinal strain and wall motion abnormalities (p>0.05). Diastolic function had some significant parameters in each of the 5 groups (p<0.05). Conclusions: Sofosbuvir-daclatasvir combination therapy did not affect or impair left ventricular systolic or diastolic functions.
MeSH term(s)	Adult ; Male ; Female ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Sofosbuvir/therapeutic use ; Hepatitis C, Chronic/drug therapy ; Prospective Studies ; Ventricular Function, Left ; Stroke Volume ; Hepacivirus ; Drug Therapy, Combination ; Antiviral Agents/adverse effects ; Pyrrolidines/therapeutic use ; Treatment Outcome
Chemical Substances	Sofosbuvir (WJ6CA3ZU8B) ; daclatasvir (LI2427F9CI) ; Antiviral Agents ; Pyrrolidines
Language	English
Publishing date	2023-07-24
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.EGY-S4-27
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Article: Efficacy of Nitazoxanide, Nitazoxanide-Garlic Combination and Tinidazole in Treatment of

Abdo, Sarah M / Ghallab, Marwa Mohamed Ibrahim / Zaghloul, Mariam S / Elhadad, Heba

Iranian journal of parasitology

2022 Volume 18, Issue 1, Page(s) 48–55

Abstract: Background: Giardia duodenalis: Methods: Stool samples were collected from 390 children and microscopically examined using formalin-ethyl acetate concentration and culturing on Jones' medium for : Results: Cure rate was significantly higher in TIN ...

Abstract	Background: Giardia duodenalis Methods: Stool samples were collected from 390 children and microscopically examined using formalin-ethyl acetate concentration and culturing on Jones' medium for Results: Cure rate was significantly higher in TIN treated groups (75.5% and 96.6%) than NTZ (57.7% and 40%) or NTZ plus garlic treated groups (55.5% and 43%) in both Conclusion: TIN, once, is more efficacious than NTZ or NTZ plus garlic in the treatment of
Language	English
Publishing date	2022-09-29
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388453-8
ISSN	2008-238X ; 1735-7020
ISSN (online)	2008-238X
ISSN	1735-7020
DOI	10.18502/ijpa.v18i1.12379
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Article: Choledocho-nodal Fistula: Uncommon Cause of Obstructive Jaundice in a Patient with HCC Diagnosed by Combined ERCP/EUS.

Emara, Mohamed H / Zaghloul, Mariam S / Mahros, Aya M / Ema, Emad H

Journal of clinical imaging science

2021 Volume 11, Page(s) 32

Abstract: A 58-year-old male patient presented with advanced hepatocellular carcinoma underwent transarterial chemoembolization (TACE) for hepatic focal lesions followed by TACE for a solitary hilar nodal metastasis combined with regorafenib therapy. One month ... ...

Abstract	A 58-year-old male patient presented with advanced hepatocellular carcinoma underwent transarterial chemoembolization (TACE) for hepatic focal lesions followed by TACE for a solitary hilar nodal metastasis combined with regorafenib therapy. One month later, the patient developed progressive jaundice. Work-up showed obstructive jaundice with intrahepatic biliary radicles dilatation. The diagnosis and treatment was achieved by combining endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography and showed uncommon cause of obstructive jaundice due to common bile duct compression by a choledocho-nodal fistula following TACE of a metastatic hilar lymph node.
Language	English
Publishing date	2021-06-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2601233-9
ISSN	2156-5597 ; 2156-7514
ISSN (online)	2156-5597
ISSN	2156-7514
DOI	10.25259/JCIS_57_2021
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Article ; Online: Different patterns of esophageal motility disorders among patients with dysphagia and normal endoscopy: A 2-center experience.

Zaghloul, Mariam S / Elshaer, Yasmine A / Ramadan, Mohamed E / ElBatae, Hassan E

Medicine

2022 Volume 101, Issue 38, Page(s) e30573

Abstract: Esophageal motility disorders (EMDs) are the main etiology of nonobstructive dysphagia (NOD), but they are underestimated in Egypt. High-resolution manometry (HRM) with Chicago Classification version 3.0 (CC v3.0) is the current gold standard diagnostic ... ...

Abstract	Esophageal motility disorders (EMDs) are the main etiology of nonobstructive dysphagia (NOD), but they are underestimated in Egypt. High-resolution manometry (HRM) with Chicago Classification version 3.0 (CC v3.0) is the current gold standard diagnostic modality to assess EMD in patients with NOD. In this HRM-based study, we aimed to classify EMD among Egyptian patients and explore the relationship between the severity of symptoms and the various groups of EMD. From January 2020 to January 2021, patients with dysphagia were subjected to diagnostic workup, which included symptom questionnaire for Eckardt score, esophagogastroduodenoscopy, barium esophagogram, and HRM. All patients were categorized based on the HRM results using CC version 3.0 after exclusion of those with obstructive esophageal lesions. Of 252 patients with dysphagia, 55 patients with NOD were analyzed according to CC version 3.0. Achalasia was diagnosed in 31 patients (56.4%) (type I: 18 [58.06%]; type II: 9 [29.03%], and type III: 4 [12.9%]), 3 patients (5.5%) with esophagogastric junction outflow obstruction, 2 patients (3.6%) with absent contractility, 4 patients (7.3%) with distal esophageal spasm, 7 patients (12.7%) with ineffective esophageal motility, and 8 patients (14.5%) with normal manometry. Patients with achalasia experienced significantly high regurgitation (96.8% vs 70.8%; P = .016) compared with those without achalasia. Achalasia was the most common EMD in Egyptian patients with NOD. Eckardt score was higher in patients with outflow obstruction and major motor disorder, but it could not differentiate different categories of CC of EMD. HRM is effective in characterization of EMD.
MeSH term(s)	Barium ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Endoscopy, Gastrointestinal/adverse effects ; Esophageal Achalasia/complications ; Esophageal Motility Disorders/complications ; Esophagogastric Junction ; Humans ; Manometry/methods
Chemical Substances	Barium (24GP945V5T)
Language	English
Publishing date	2022-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030573
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Article ; Online: Serum midkine is a more sensitive predictor for hepatocellular carcinoma than Dickkopf-1 and alpha-L-fucosidase in cirrhotic HCV patients.

El-Shayeb, Ayman F / El-Habachi, Nihal M / Mansour, Amal R / Zaghloul, Mariam S

Medicine

2021 Volume 100, Issue 17, Page(s) e25112

Abstract: Abstract: Alpha fetoprotein (AFP) level is the gold standard diagnostic tool for detection and monitoring hepatocellular carcinoma (HCC) but with low sensitivity. Thus, the identification of alternative or combined serum markers of HCC is highly needed. ...

Abstract	Abstract: Alpha fetoprotein (AFP) level is the gold standard diagnostic tool for detection and monitoring hepatocellular carcinoma (HCC) but with low sensitivity. Thus, the identification of alternative or combined serum markers of HCC is highly needed. Therefore, the aim of this work was to verify the value of serum midkine (MDK), Dickkopf-related protein 1 (DKK1), and alpha-L-fucosidase (AFU) in detection of HCC.We recruited 244 subjects to the present study; 89 with liver cirrhosis, 86 cirrhotic hepatitis C virus (HCV) induced HCC, and 69 apparently healthy volunteers as controls. Serum AFP, MDK, DKK1, and AFU were measured by ELISA.Patients with HCC showed significantly higher serum MDK, DKK1, and AFU levels compared with those patients with liver cirrhosis and healthy controls (X2 = 179.56, 153.94, and 90.07 respectively) (P < .001 in all). In HCC cases, neither of MDK, DKK1, or AFU was correlated with tumor number. On the other hand, only serum DKK1 was significantly higher in lesions >5 cm, those with portal vein thrombosis and advanced HCC stage. Receiver operator characteristic (ROC) curve analysis showed that serum MDK levels discriminated between cirrhosis and HCC at a sensitivity of 100%, a specificity of 90% at cut-off value of >5.1 ng/mL.Although our results showed that serum MDK, DKK-1, and AFU are increased in HCC cases only MDK may be considered as the most promising serological marker for the prediction of the development of HCC in cirrhotic HCV patients.
MeSH term(s)	Biomarkers, Tumor/blood ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/virology ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Hepacivirus ; Hepatitis C/blood ; Hepatitis C/complications ; Hepatitis C/virology ; Humans ; Intercellular Signaling Peptides and Proteins/blood ; Liver Cirrhosis/blood ; Liver Cirrhosis/complications ; Liver Cirrhosis/virology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/virology ; Male ; Middle Aged ; Midkine/blood ; Predictive Value of Tests ; ROC Curve ; Sensitivity and Specificity ; alpha-L-Fucosidase/blood
Chemical Substances	Biomarkers, Tumor ; DKK1 protein, human ; Intercellular Signaling Peptides and Proteins ; MDK protein, human ; Midkine (137497-38-2) ; alpha-L-Fucosidase (EC 3.2.1.51)
Language	English
Publishing date	2021-04-22
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000025112
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Article: Changes in the co-expressions of interleukin 29 (IL-29), IFN-inducible protein 10 (IP-10) and monokine induced by IFNγ (MIG) genes in chronic hepatitis C Egyptian patients untreated and treated with DAAs.

Gaballah, Ahmed / Naga, Iman Salah / Zaghloul, Mariam Salah / Mostafa, Hanan Mostafa / Noby, Ahmed

Acta virologica

2021 Volume 65, Issue 2, Page(s) 141–148

Abstract: Direct acting antiviral agents (DAAs) are a group of antiviral drugs that inhibit specific non-structural proteins of the virus and disrupt viral replication and infection. DAAs regimens for hepatitis C virus (HCV) infection provide a particular event to ...

Abstract	Direct acting antiviral agents (DAAs) are a group of antiviral drugs that inhibit specific non-structural proteins of the virus and disrupt viral replication and infection. DAAs regimens for hepatitis C virus (HCV) infection provide a particular event to tackle mechanistic intracellular relationships between the innate immunity and HCV, potentially providing perceptions about the rate of the viral replication and complex decay. Interleukin 29 (IL-29) prevents the replication of HCV. IFN-inducible protein 10 (IP-10) plays a significant role in the pathogenesis of HCV infection. MIG/CXCL9 are produced by inﬂammatory and stromal cells such as hepatocytes following either stimulation by interferon lambda (IFNγ) or viral infection. This study aimed to evaluate the co-expression of IL-29, IP-10 and MIG in peripheral blood mononuclear cells (PBMCs) from untreated and treated chronic HCV patients with DAAs. This study included group of twenty naïve HCV patients, group of twenty sustained viral response (SVR) patients and a control group that consisted of 10 healthy subjects. All subjects were tested for liver enzymes, serum albumin level, total serum bilirubin, platelet count, prothrombin activity and viral load. Relative gene expression of IL-29, IP-10, and MIG in PBMCs from all subjects was determined using real time PCR. The mean value of IL-29, IP-10 and MIG gene expression significantly increased in both naïve HCV and SVR groups of patients as compared to normal subjects. The corresponding value was significantly lower in patients with SVR compared to naïve HCV patients. Infection with HCV significantly trigged the co-expression of IL-29, IP-10, and CXCL9 (MIG) genes in PBMCs of chronic hepatitis C patients and significantly down-regulated in those who achieved SVR after successful DAAs therapy. Keywords: IP10; MIG; IL29; HCV; DAAs; gene expression.
MeSH term(s)	Antiviral Agents/therapeutic use ; Chemokine CXCL10/genetics ; Egypt ; Hepacivirus ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/genetics ; Humans ; Interleukins/genetics ; Leukocytes, Mononuclear ; Monokines/therapeutic use
Chemical Substances	Antiviral Agents ; Chemokine CXCL10 ; Interleukins ; Monokines
Language	English
Publishing date	2021-06-15
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	210452-0
ISSN	1336-2305 ; 0001-723X
ISSN (online)	1336-2305
ISSN	0001-723X
DOI	10.4149/av_2021_209
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Article ; Online: Does gallbladder wall thickness measurement predict esophageal varices in cirrhotic patients with portal hypertension?

Elkerdawy, Mahmoud A / Ahmed, Mohamed H / Zaghloul, Mariam S / Haseeb, Mona T / Emara, Mohamed H

European journal of gastroenterology & hepatology

2021 Volume 33, Issue 6, Page(s) 917–925

Abstract: Background and study aim: Endoscopy is the gold standard investigation for diagnosis of gastroesophageal varices (GOVs), yet it is invasive, associated with complications. Many noninvasive parameters were investigated to predict the presence of GOVs. ... ...

Abstract	Background and study aim: Endoscopy is the gold standard investigation for diagnosis of gastroesophageal varices (GOVs), yet it is invasive, associated with complications. Many noninvasive parameters were investigated to predict the presence of GOVs. The current study investigated gallbladder wall thickening (GBWT) measurement as a noninvasive predictor of GOVs in posthepatitic cirrhotic patients with portal hypertension. Patients and methods: In this cross-sectional study, 105 cirrhotic patients were divided into, group I and II according to the presence or absence of GOVs, respectively. Group I subdivided into, groups A and B according to the grade of GOVs either nonadvanced (grades I and II) or advanced (grades III and IV), respectively. Complete history taking, full clinical examination, full investigations, upper endoscopy and abdominal ultrasonography were performed to examine all patients. Results: Both groups were comparable in their baseline characteristics except for AST to Platelet Ratio Index and Fibrosis-4 scores, which were significantly higher in group I. GBWT, portal vein diameter and spleen length were significantly associated not only with GOVs but also with its advanced grades. GBWT at a cutoff level >3.1 mm can predict the presence of GOVs with 54.29% sensitivity, 97.14% specificity, 97.4% positive predictive value (PPV), 51.5% negative predictive value (NPV) and 68.5% accuracy. GBWT can predict advanced grades of GOVs at a cutoff level >3.5 mm, with 45% sensitivity, 90% specificity, 64.3% PPV, 80.4% NPV and 77.1% accuracy. Conclusion: GBWT was associated with the presence of GOVs, and with advanced GOVs in posthepatitis cirrhotic patients with portal hypertension.
MeSH term(s)	Cross-Sectional Studies ; Esophageal and Gastric Varices/diagnostic imaging ; Esophageal and Gastric Varices/etiology ; Gallbladder/pathology ; Humans ; Hypertension, Portal/diagnosis ; Hypertension, Portal/diagnostic imaging ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology ; Predictive Value of Tests
Language	English
Publishing date	2021-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002024
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Article: Non-pulmonary involvement in COVID-19: A systemic disease rather than a pure respiratory infection.

El-Kassas, Mohamed / Alboraie, Mohamed / Elbadry, Mohamed / El Sheemy, Reem / Abdellah, Mohamed / Afify, Shimaa / Madkour, Ahmad / Zaghloul, Mariam / Awad, Abeer / Wifi, Mohamed-Naguib / Al Balakosy, Amira / Eltabbakh, Mohamed

World journal of clinical cases

2023 Volume 11, Issue 3, Page(s) 493–505

Abstract: During the early phase of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), diagnosis was difficult due to the diversity in symptoms and imaging findings and the variability of ... ...

Abstract	During the early phase of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), diagnosis was difficult due to the diversity in symptoms and imaging findings and the variability of disease presentation. Pulmonary manifestations are reportedly the main clinical presentations of COVID-19 patients. Scientists are working hard on a myriad of clinical, epidemiological, and biological aspects to better understand SARS-CoV-2 infection, aiming to mitigate the ongoing disaster. Many reports have documented the involvement of various body systems and organs apart from the respiratory tract including the gastrointestinal, liver, immune system, renal, and neurological systems. Such involvement will result in diverse presentations related to effects on these systems. Other presentations such as coagulation defects and cutaneous manifestation may also occur. Patients with specific comorbidities including obesity, diabetes, and hypertension have increased morbidity and mortality risks with COVID-19.
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i3.493
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