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  1. Article ; Online: Positive Association between Autoantibodies Against Oxidized LDL and HDL-C: A Novel Mechanism for HDL Cardioprotection?

    Nunez, Carla Evelyn Coimbra / Oliveira, Joaquim Barreto / Barros-Mazon, Silvia de / Zago, Vanessa H S / Kaplan, Denise Beheregaray / Nakamura, Ruy T / Gidlund, Magnus Ake / Gomes, Erica I L / Cazita, Patricia Miralda / Nakandakare, Edna / Carmo, Helison R / Sposito, Andrei C / Faria, Eliana Cotta de

    Arquivos brasileiros de cardiologia

    2022  

    Abstract: Background: In the atherosclerotic plaque microenvironment, oxidized phospholipids expressed in the oxidized low-density lipoprotein (oxLDL) surface bind to scavenger receptors of macrophages eliciting foam cell formation and plaque progression. Auto- ... ...

    Title translation Associação Positiva entre Autoanticorpos contra LDL Oxidada e HDL-C: Um Novo Mecanismo para Cardioproteção de HDL?
    Abstract Background: In the atherosclerotic plaque microenvironment, oxidized phospholipids expressed in the oxidized low-density lipoprotein (oxLDL) surface bind to scavenger receptors of macrophages eliciting foam cell formation and plaque progression. Auto-antibodies against oxLDL (oxLDL-Ab) interact with oxidative epitopes leading to the formation of immune complexes that are unable to interact with macrophage receptors, thus abrogating atherogenesis. Release of oxLDL-Ab by B cells involves interleukin 5 and Th2 response, which in turn are potentiated by HDL. Thereby, we hypothesized that individuals with higher levels of HDL-C may plausibly display elevated titers of oxLDL-Ab.
    Objective: To evaluate the relationship between HDL-C and oxLDL-Ab levels.
    Methods: Asymptomatic individuals (n = 193) were grouped according to their HDL-C concentration to one of three categories: low (< 68 mg/dL), intermediate (68 to 80 mg/dL) or high (> 80 mg/dL). P values < 0.05 were considered statistically significant.
    Results: Our analysis included 193 individuals (mean age: 47 years; male: 26.3%). Compared to individuals in the lowest HDL-C tertile, those in the highest tertile were older (36 versus 53 years; p = 0.001) and less frequently male (42.6% versus 20.9%; p = 0.001). Mean values of oxLDL-Ab increased as the HDL-C group escalated (0.31, 0.33 and 0.43 units, respectively; p = 0.001 for trend). Simple linear regression found a significant, positive relationship between the independent variable, HDL-C, and the dependent variable, oxLDL-Ab (R = 0.293; p = 0.009). This relation remained significant (R = 0.30; p = 0.044), after adjustment by covariates. Apolipoprotein AI levels were also related to oxLDL-Ab in both simple and adjusted linear regression models.
    Conclusion: HDL-C and oxLDL-Ab are independently related.
    Language English
    Publishing date 2022-09-02
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20210796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 548: Show issues Location:
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  2. Article: Lipase C, Hepatic Type −250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil

    Zago, Vanessa H. S. / Parra, Eliane S. / Virgínio, Vítor W. M. / Vendrame, Felipe / Gomes, Érica I. L. / Scherrer, Daniel Z. / Marson, Fernando A. L. / de Faria, Eliana C.

    Lipids. 2020 May, v. 55, no. 3

    2020  

    Abstract: The common genetic variant in the promoter region of the hepatic lipase gene [LIPC −250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 ... ...

    Abstract The common genetic variant in the promoter region of the hepatic lipase gene [LIPC −250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 with carotid atherosclerosis, plasma lipids, and parameters of reverse cholesterol transport. A total of 285 normolipidemic and asymptomatic participants from an initial sample of 598,288 individuals (inclusion criteria: LDL‐C ≤130 mg/dL and triglycerides ≤150 mg/dL; age: 20–75 years, both genders; confirmation of clinical, anthropometric and laboratory data; attended all visits; DNA was achieved to perform genetic analysis) were enrolled and the rs2070895 variant was genotyped by TaqMan® OpenArray® Plataform. Carotid intima‐media thickness and the screening of atherosclerotic plaques were determined by B‐mode ultrasonography. The rs2070895 genotype frequencies were 0.44, 0.41, and 0.15 (GG, GA, and AA, respectively). Logistic regression analysis showed that the risk of having plaques was increased in participants carrying the AA or AG genotypes (OR = 3.90; 95% CI = 1.54–10.33), despite an increase in high‐density lipoprotein cholesterol levels, HDL diameter and apolipoprotein A‐I, as compared to the GG genotype. Hepatic lipase and endogenous lecithin cholesterol acyl transferase activities were reduced (38% and 19%, respectively) and lipoprotein lipase was increased by 30% (AA vs GG). Our results provide evidence that the AA or AG genotypes of the rs2070895 were associated with carotid atherosclerosis in apparently healthy participants, probably as a consequence of reduced reverse cholesterol transport and accumulation of HDL subfraction 2 rich in triglycerides and depleted in cholesteryl esters that could become dysfunctional.
    Keywords DNA ; apolipoprotein A-I ; atherosclerosis ; genes ; genetic analysis ; genotype ; genotyping ; high density lipoprotein cholesterol ; lecithins ; lipoprotein lipase ; promoter regions ; regression analysis ; risk ; ultrasonography ; Brazil
    Language English
    Dates of publication 2020-05
    Size p. 225-237.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12232
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 645: Show issues Location:
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  3. Article ; Online: Lipase C, Hepatic Type -250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil.

    Zago, Vanessa H S / Parra, Eliane S / Virgínio, Vítor W M / Vendrame, Felipe / Gomes, Érica I L / Scherrer, Daniel Z / Marson, Fernando A L / de Faria, Eliana C

    Lipids

    2020  Volume 55, Issue 3, Page(s) 225–237

    Abstract: The common genetic variant in the promoter region of the hepatic lipase gene [LIPC -250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 ... ...

    Abstract The common genetic variant in the promoter region of the hepatic lipase gene [LIPC -250G/A(rs2070895)] has an ambiguous association with cardiovascular disease. In this context, our study was performed to identify the relationships between the rs2070895 with carotid atherosclerosis, plasma lipids, and parameters of reverse cholesterol transport. A total of 285 normolipidemic and asymptomatic participants from an initial sample of 598,288 individuals (inclusion criteria: LDL-C ≤130 mg/dL and triglycerides ≤150 mg/dL; age: 20-75 years, both genders; confirmation of clinical, anthropometric and laboratory data; attended all visits; DNA was achieved to perform genetic analysis) were enrolled and the rs2070895 variant was genotyped by TaqMan® OpenArray® Plataform. Carotid intima-media thickness and the screening of atherosclerotic plaques were determined by B-mode ultrasonography. The rs2070895 genotype frequencies were 0.44, 0.41, and 0.15 (GG, GA, and AA, respectively). Logistic regression analysis showed that the risk of having plaques was increased in participants carrying the AA or AG genotypes (OR = 3.90; 95% CI = 1.54-10.33), despite an increase in high-density lipoprotein cholesterol levels, HDL diameter and apolipoprotein A-I, as compared to the GG genotype. Hepatic lipase and endogenous lecithin cholesterol acyl transferase activities were reduced (38% and 19%, respectively) and lipoprotein lipase was increased by 30% (AA vs GG). Our results provide evidence that the AA or AG genotypes of the rs2070895 were associated with carotid atherosclerosis in apparently healthy participants, probably as a consequence of reduced reverse cholesterol transport and accumulation of HDL subfraction 2 rich in triglycerides and depleted in cholesteryl esters that could become dysfunctional.
    MeSH term(s) Adult ; Aged ; Asymptomatic Diseases ; Brazil ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/genetics ; Cholesterol/blood ; Female ; Genetic Association Studies ; Humans ; Lipase/genetics ; Lipids/blood ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult
    Chemical Substances LIPC protein, human ; Lipids ; Cholesterol (97C5T2UQ7J) ; Lipase (EC 3.1.1.3)
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 645: Show issues Location:
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  4. Article ; Online: Oxidized low-density lipoproteins and their antibodies: relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseases.

    Ferreira, Paolla F C / Zago, Vanessa H S / D'Alexandri, Fabio L / Panzoldo, Natália B / Gidlund, Magnus A / Nakamura, Rui T / Schreiber, Roberto / Parra, Eliane S / Santiago, Fernanda D / Nakandakare, Edna R / Quintão, Eder C R / de Faria, Eliana C

    Clinica chimica acta; international journal of clinical chemistry

    2012  Volume 413, Issue 19-20, Page(s) 1472–1478

    Abstract: Background: Metabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial.: Methods: In 107 adults without atherosclerotic manifestations, we measured oxLDL and ... ...

    Abstract Background: Metabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial.
    Methods: In 107 adults without atherosclerotic manifestations, we measured oxLDL and oxLDL Ab, and also the activities of CETP, PLTP, lipases and the carotid intima-media thickness (cIMT). Comparisons were performed for the studied parameters between the lowest and the highest tertile of oxLDL and oxLDL Ab, and the relationships between studied variables were evaluated.
    Results: Subjects with higher oxLDL Ab present reduced hepatic lipase activity and borderline increased cIMT. In the highest oxLDL tertile, besides the higher levels of total cholesterol, LDL-C and apoB100, we found reduced CETP activity and higher cIMT. A significant correlation between oxLDL Ab and cIMT, independent of oxLDL, and a borderline correlation between oxLDL and cIMT independent of oxLDL Ab were found. In the multivariate analysis, apoAI was a significant predictor of oxLDL Ab, in contrast to regulation of oxLDL by apoB100, PLTP and inverse of CETP.
    Conclusions: In adults without atherosclerotic disease, the metabolic regulation and carotid atherosclerosis of oxLDL Ab and oxLDL groups, characterized a dual trait in oxLDL Ab, as a contributor to carotid atherosclerosis, much less so than oxidized LDL, and with a modest atheroprotective role.
    MeSH term(s) Adult ; Aged ; Analysis of Variance ; Antibodies/blood ; Apolipoprotein B-100/blood ; Biological Transport ; Carotid Arteries/metabolism ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/physiopathology ; Carotid Intima-Media Thickness ; Cholesterol/blood ; Cholesterol Ester Transfer Proteins/metabolism ; Cholesterol, LDL/blood ; Female ; Humans ; Lipase/metabolism ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/immunology ; Liver/metabolism ; Middle Aged ; Phospholipid Transfer Proteins/metabolism ; Risk Factors
    Chemical Substances Antibodies ; Apolipoprotein B-100 ; CETP protein, human ; Cholesterol Ester Transfer Proteins ; Cholesterol, LDL ; Lipoproteins, LDL ; PLTP protein, human ; Phospholipid Transfer Proteins ; oxidized low density lipoprotein ; Cholesterol (97C5T2UQ7J) ; Lipase (EC 3.1.1.3) ; hepatic lipase, human (EC 3.1.1.3)
    Language English
    Publishing date 2012-10-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2012.05.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.173: Show issues Location:
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  5. Article ; Online: Impact of seasonality on the prevalence of dyslipidemia: a large population study.

    Moura, Filipe A / Dutra-Rodrigues, Marcelo S / Cassol, Angela S / Parra, Eliane S / Zago, Vanessa H S / Panzoldo, Natalia B / Alexandre, Fernanda / Vieira, Isabela C / Vendrame, Felipe / Virginio, Vitor W / Castanho, Vera S / Danelon, Mirian R G / Nunes, Valeria S / Leança, Camila C / Saraiva, Francisco K / Coelho, Otavio R / Nakandakare, Edna / Quintão, Eder C R / de Faria, Eliana Cotta /
    Sposito, Andrei C

    Chronobiology international

    2013  Volume 30, Issue 8, Page(s) 1011–1015

    Abstract: Assessment of lipid profile parameters has been considered a cornerstone in classifying individuals and populations at risk for cardiovascular disease. Recently, however, preliminary data have raised the possibility of seasonal variations in these ... ...

    Abstract Assessment of lipid profile parameters has been considered a cornerstone in classifying individuals and populations at risk for cardiovascular disease. Recently, however, preliminary data have raised the possibility of seasonal variations in these parameters, which may cause under- or overestimation. Biological rhythms and seasonal variation of lipid profile was investigated in 227 359 consecutive individuals who underwent health checkups in primary care centers between 2008 and 2010. Plasma low-density lipoprotein cholesterol (LDL-C) >130 mg/dL was 8% more prevalent during winter than summer, with a larger difference among women and middle-aged adults (p < 0.001). High-density lipoprotein cholesterol (HDL-C) <40 mg/dL and triglycerides (TG) >150 mg/dL were respectively 9% and 5% more prevalent during the summer (p < 0.001). Variation amplitude was 3.4 ± 0.3 mg/dL for HDL-C (p = 0.005), 7 ± 2 mg/dL for LDL-C (p = 0.047), and 12 ± 9 mg/dL for TG (p = 0.058). Based on a large population sample, this study confirms the existence of biological rhythms and seasonal variation in lipid profile. This finding must be particularly accounted for in cross-sectional analyses of relative risk, prevalence, or the rate of goal achievement for lipid parameters.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Brazil/epidemiology ; Child ; Child, Preschool ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cross-Sectional Studies ; Dyslipidemias/blood ; Dyslipidemias/diagnosis ; Dyslipidemias/epidemiology ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Nonlinear Dynamics ; Periodicity ; Prevalence ; Risk Factors ; Seasons ; Sex Distribution ; Sex Factors ; Time Factors ; Triglycerides/blood ; Young Adult
    Chemical Substances Biomarkers ; Cholesterol, HDL ; Cholesterol, LDL ; Triglycerides
    Language English
    Publishing date 2013-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998996-1
    ISSN 1525-6073 ; 0742-0528
    ISSN (online) 1525-6073
    ISSN 0742-0528
    DOI 10.3109/07420528.2013.793698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2068: Show issues Location:
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