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  1. Article ; Online: Sarcome de kaposi et myélome multiple: s´agit-il d´une association causée par le HHV-8?

    Kahouli, Sophia / Zahid, Hafid / Benkirane, Majid / Messaoudi, Nezha

    The Pan African medical journal

    2020  Volume 36, Page(s) 85

    Abstract: Kaposi´s sarcoma is a tumor characterized by purple or brownish lesions affecting the skin. It is most commonly associated with human herpes virus type 8 (HHV-8) infection and may be secondary to malignant hemopathy, including lymphomas. We here report a ...

    Title translation IAssociation between Kaposi´s sarcoma and multiple myeloma: is it caused by HHV-8?
    Abstract Kaposi´s sarcoma is a tumor characterized by purple or brownish lesions affecting the skin. It is most commonly associated with human herpes virus type 8 (HHV-8) infection and may be secondary to malignant hemopathy, including lymphomas. We here report a new case of a very rare combination: Kaposi´s disease-multiple myeloma. The study involved Mr. aged 67 years, treated for Kaposi´s disease in the Department of Dermatology. Serological test for HHV-8 was positive; it was associated with stage I multiple myeloma IgG Lambda with a poor prognosis. We here report this 21
    MeSH term(s) Aged ; Herpesvirus 8, Human/isolation & purification ; Humans ; Male ; Multiple Myeloma/pathology ; Multiple Myeloma/virology ; Neoplasm Staging ; Prognosis ; Sarcoma, Kaposi/pathology ; Sarcoma, Kaposi/virology
    Language French
    Publishing date 2020-06-12
    Publishing country Uganda
    Document type Case Reports
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2020.36.85.22407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bone pain, splenomegaly and microcytic anemia in a young woman.

    Mahtat, El Mehdi / Hasnaoui, Naoual / Zahid, Hafid

    European journal of internal medicine

    2020  Volume 78, Page(s) 129–130

    MeSH term(s) Anemia, Hypochromic ; Female ; Gaucher Disease ; Humans ; Pain ; Splenomegaly/diagnostic imaging ; Splenomegaly/etiology
    Language English
    Publishing date 2020-07-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2020.06.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Cold agglutinins revealed by abnormalities to the cell blood count: a case report.

    Zahid, Hafid / Hadef, Rachid / Labrini, Faycal / Yahyaoui, Anass / Messaoudi, Nezha

    The Pan African medical journal

    2021  Volume 38, Page(s) 328

    Abstract: Cold agglutinin are erythrocyte antibodies which possess the property of agglutinating red blood cells at temperatures of below 37°C, this phenomenon is reversible after heating. This is usually immunoglobulin M (IgM) class. Their pathogenicity is much ... ...

    Abstract Cold agglutinin are erythrocyte antibodies which possess the property of agglutinating red blood cells at temperatures of below 37°C, this phenomenon is reversible after heating. This is usually immunoglobulin M (IgM) class. Their pathogenicity is much more related to their temperature range of activity than their title. As we report in this observation, cold hemagglutination makes it difficult to interpret certain immunological tests such as ABO Rh blood grouping or searching for irregular antibodies (SAI). The discovery of cold agglutinins can be fortuitous revealing itself by disturbances and aberrations in the results of blood count or as part of a suggestive clinical or laboratory table cold hemagglutinin disease. The search for a lymphoid hematological at their diagnosis should be systematic.
    MeSH term(s) Anemia, Hemolytic, Autoimmune/diagnosis ; Anemia, Hemolytic, Autoimmune/immunology ; Blood Cell Count ; Cryoglobulins/immunology ; Humans ; Immunoglobulin M/immunology ; Male ; Middle Aged
    Chemical Substances Cryoglobulins ; Immunoglobulin M ; cold agglutinins
    Language English
    Publishing date 2021-04-06
    Publishing country Uganda
    Document type Case Reports
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2021.38.328.9100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Un cas marocain d’érythrophagocytose blastique et LAL T de novo sans anomalie cytogénétique.

    Kahouli, Sophia / Zahid, Hafid / Khorassani, Mohamed El / Kabbaj, Saâd El / Benkirane, Majid / Messaoudi, Nezha

    The Pan African medical journal

    2020  Volume 36, Page(s) 202

    Abstract: Erythrophagocytosis by blast cells is due to hyperactivation of blast cells. Erythrophagocytosis is associated with T cell myeloid hemopathies (8;16). This study shows an exceptional case of erythrophagocytosis by blast cells in a patient with acute T- ... ...

    Title translation Erythrophagocytosis by blast cells and de novo T cell LAL without cytogenetic abnormalities in a Moroccan patient.
    Abstract Erythrophagocytosis by blast cells is due to hyperactivation of blast cells. Erythrophagocytosis is associated with T cell myeloid hemopathies (8;16). This study shows an exceptional case of erythrophagocytosis by blast cells in a patient with acute T-lymphoblastic leukemia without cytogenetic abnormalities. We here report the case of A.Z, aged 19 years presenting with febrile syndrome with dizziness and phosphenes, tumor syndrome with amygdala and gingival hypertrophy. Blood count revealed hyperleukocytosis (399.5 G/L), with aregenerative anemia (Hb: 9.3 g/dl) and thrombocytopenia (platelet count: 40 g/L). Myelogram showed 90% of blast cells (MPO-negative) with erythrophagocytosis by blast cells images. Immunophenotyping confirmed T-cell LAL. Cytogenetic analysis was normal. Erythrophagocytosis by blast cells in patients with T-cell LAL appears to be a separate entity, hence the importance of images on diagnosis, prognosis and treatment of T-cell LAL.
    MeSH term(s) Erythrocytes/cytology ; Female ; Fever/etiology ; Humans ; Morocco ; Myelography ; Phagocytosis/physiology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Prognosis ; Young Adult
    Language French
    Publishing date 2020-07-22
    Publishing country Uganda
    Document type Case Reports
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2020.36.202.24477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effect of CYP2C9, VKORC1, CYP4F2, and GGCX gene variants and patient characteristics on acenocoumarol maintenance dose: Proposal for a dosing algorithm for Moroccan patients.

    Elkhazraji, Abdelhak / Bouaiti, El Arbi / Boulahyaoui, Hassan / Nahmtchougli, Christiana Philippa / Zahid, Hafid / Bensaid, Mounia / Ibrahimi, Azeddine / Messaoudi, Nezha

    Drug discoveries & therapeutics

    2018  Volume 12, Issue 2, Page(s) 68–76

    Abstract: We investigated the impact of non-genetics factors, and single nucleotide polymorphisms (SNPs) in VKORC1, CYP2C9, CYP4F2, and GGCX on acenocoumarol dosage in Moroccan adult's patients, in order to develop an algorithm to predict acenocoumarol dose for ... ...

    Abstract We investigated the impact of non-genetics factors, and single nucleotide polymorphisms (SNPs) in VKORC1, CYP2C9, CYP4F2, and GGCX on acenocoumarol dosage in Moroccan adult's patients, in order to develop an algorithm to predict acenocoumarol dose for Moroccan patients. Our study consisted of 217 Moroccan patients taking a maintenance dose of acenocoumarol for various indications. The patients were genotyped for VKORC1 -1639 G>A, VKORC1 1173 C>T, CYP2C9*2, CYP2C9*3, CYP4F2 1347 G>A and GGCX 12970 C>G SNPs. The statistical analysis was performed using the SPSS software. The age and SNPs in VKORC1 and CYP2C9 were significantly associated with the weekly acenocoumarol dose requirement (p = 0.023, p = 0.0001 and p = 0.001 respectively). There was no association found between the weekly acenocoumarol dose and the CYP4F2 or GGCX variants (p-value > 0.05). Non-parametric analysis confirmed the accumulate effect of variant alleles at VKORC1 -1639 G>A, VKORC1 1173 C>T and CYP2C9 SNPs on the acenocoumarol dose requirement. With 90.24% less dose required for one patient carrying homozygote variant at VKORC1 -1173 (TT) and CYP2C9 *x/*x haplotype. The multiple linear regression analysis showed that mutation in VKORC1 -1639, VKORC1 1173 SNPs, or in CYP2C9 haplotype reduces the mean acenocoumarol weekly dose to 25.4%, 23.4% and 6.2%, respectively. The R2 for multiple regression analysis final model was found to be 35.9%. In this work we were able to establish the factors influencing interindividual sensitivity to the anticoagulant therapy that can help physicians to predict optimal dose requirement for long term therapy.
    MeSH term(s) Acenocoumarol/administration & dosage ; Acenocoumarol/therapeutic use ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; Carbon-Carbon Ligases/genetics ; Cytochrome P-450 CYP2C9/genetics ; Cytochrome P450 Family 4/genetics ; Drug Dosage Calculations ; Female ; Humans ; Linear Models ; Maintenance Chemotherapy ; Male ; Middle Aged ; Morocco ; Pharmacogenomic Variants ; Polymorphism, Single Nucleotide ; Vitamin K Epoxide Reductases/genetics ; Young Adult
    Chemical Substances CYP2C9 protein, human (EC 1.14.13.-) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Cytochrome P450 Family 4 (EC 1.14.14.1) ; CYP4F2 protein, human (EC 1.14.14.78) ; VKORC1 protein, human (EC 1.17.4.4) ; Vitamin K Epoxide Reductases (EC 1.17.4.4) ; Carbon-Carbon Ligases (EC 6.4.-) ; glutamyl carboxylase (EC 6.4.-) ; Acenocoumarol (I6WP63U32H)
    Language English
    Publishing date 2018-05-14
    Publishing country Japan
    Document type Journal Article
    ISSN 1881-7831
    ISSN 1881-7831
    DOI 10.5582/ddt.2017.01063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Severe hemolytic disease of the premature newborn due to RH1 incompatibility: a case report.

    Uwingabiye, Jean / Zahid, Hafid / Labrini, Fayçal / El Khazraji, Abdelhak / Yahyaoui, Anass / Hadef, Rachid / Messaoudi, Nezha

    Clujul medical (1957)

    2016  Volume 89, Issue 4, Page(s) 565–568

    Abstract: We report a case of dramatic outcome of severe hemolytic disease in a newborn due to RH1 incompatibility. A newborn with A RH1 blood group was admitted in the Mohammed V Military Teaching Hospital for the problem of hydrops fetalis associated with RH1 ... ...

    Abstract We report a case of dramatic outcome of severe hemolytic disease in a newborn due to RH1 incompatibility. A newborn with A RH1 blood group was admitted in the Mohammed V Military Teaching Hospital for the problem of hydrops fetalis associated with RH1 incompatibility. The blood group of his mother, aged 31, was AB RH1-negative and that of his 37 year old father was A RH1. The mother had a history of 4 term deliveries, 3 abortions, and 1 living child. There was no prevention by anti-D immunoglobulin postpartum. The mother's irregular agglutinin test was positive and the pregnancy was poorly monitored. The laboratory tests of the newborn showed a high total serum bilirubin level (30 mg/L) and macrocytic regenerative anemia (Hemoglobin=4 g/dL, mean corpuscular volume = 183 fL, reticulocytes count =176600/m
    Language English
    Publishing date 2016-10-20
    Publishing country Romania
    Document type Case Reports
    ZDB-ID 419197-3
    ISSN 2066-8872 ; 1222-2119 ; 1224-550X
    ISSN (online) 2066-8872
    ISSN 1222-2119 ; 1224-550X
    DOI 10.15386/cjmed-578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2836: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Rare and unusual case of anti-factor XI antibodies in patient with plasma cell leukemia.

    Uwingabiye, Jean / Zahid, Hafid / El Amrani, Mohamed / Labrini, Fayçal / Elkhazraji, Abdelhak / El Kabbaj, Driss / Benyahia, Mohammed / Yahyaoui, Anass / Hadef, Rachid / Messaoudi, Nezha

    BMC hematology

    2018  Volume 18, Page(s) 18

    Abstract: Background: The acquired inhibitors of coagulation have been observed in very rare cases of monoclonal gammopathies. We report a very rare case of anti-factor XI antibodies in patient with plasma cell leukemia (PCL).: Case presentation: This is a 59- ... ...

    Abstract Background: The acquired inhibitors of coagulation have been observed in very rare cases of monoclonal gammopathies. We report a very rare case of anti-factor XI antibodies in patient with plasma cell leukemia (PCL).
    Case presentation: This is a 59-year-old male patient without pathological history, admitted to the nephrology department for management of renal insufficiency and anemia syndrome. The history and physical examination revealed stigmata of hemorrhagic syndrome including hemothorax and hemoptysis. The hemostasis assessment showed an isolated prolonged activated partial thromboplastin time (APTT) with APTT ratio = 2.0.The index of circulating anticoagulant (37.2%) revealed the presence of circulating anticoagulants. The normalized dilute Russell viper venom time ratio of 0.99 has highlighted the absence of lupus anticoagulants. The coagulation factors assay objectified the decrease of the factor XI activity corrected by the addition of the control plasma confirming the presence of anti-factor XI autoantibodies. In addition, the blood count showed bicytopenia with non-regenerative normocytic normochromic anemia and thrombocytopenia. The blood smear demonstrated a plasma cell count of 49% (2842/mm3) evoking PCL. The bone marrow was invaded up to 90% by dystrophic plasma cells. The biochemical assessment suggested downstream renal and electrolyte disturbances from exuberant light chain production with abnormalities including hyperuricemia, hypercalcemia, elevated lactate dehydrogenase, non nephrotic-range proteinuria and high level of C reactive protein. The serum protein electrophoresis showed the presence of a monoclonal peak. The serum immunofixation test detects the presence of monoclonal free lambda light chains. He was treated with velcade, thalidomide and dexamethasone. The patient died after 2 weeks despite treatment.
    Conclusion: Both PCL and anti-factor XI inhibitors are two very rare entities. To the best of our knowledge, this is the first reported case of a factor XI inhibitor arising in the setting of PCL. Factor inhibitors should be suspected in patients whose monoclonal gammopathies are accompanied by bleeding manifestations.
    Language English
    Publishing date 2018-08-10
    Publishing country England
    Document type Case Reports
    ZDB-ID 2744433-8
    ISSN 2052-1839
    ISSN 2052-1839
    DOI 10.1186/s12878-018-0100-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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