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  1. AU="Zahra POURPAK"
  2. AU="Su, Yingying"
  3. AU="Bayat, Alireza R"
  4. AU="Subramanian, Harshith"
  5. AU="Hasib, Al"
  6. AU="Gao, Hongyang"
  7. AU="Bedrosian, P. A."
  8. AU="Hotujac, Ljubomir"
  9. AU="Falato, C"
  10. AU="Mayrink, Marcelo Oliveira"
  11. AU="Davidoff, Dahlia F"
  12. AU=Endo A
  13. AU="Chunlei Yu"
  14. AU="Nagao, Asuteka"
  15. AU="Derwael, Céline" AU="Derwael, Céline"
  16. AU="Yao, Yang"
  17. AU=Strutz Frank
  18. AU="Won-Sang Lee"
  19. AU="the ICHseq Investigators" AU="the ICHseq Investigators"
  20. AU="Green, J G"
  21. AU="Xinguang Yang"
  22. AU="Masamed, Rinat"
  23. AU="Flores-Estrada, Diana"
  24. AU="Castellanos, Jason A"
  25. AU="Kiberd, Bryce A"
  26. AU="Kaushal, Deepak"
  27. AU="Rouzaire, Paul"
  28. AU="Mohammed A. S. Abourehab"
  29. AU="Basa, S."
  30. AU="Rohner, Eliane"
  31. AU="Abu-Mahfouz, Adnan M"
  32. AU="Falanti, Andrea"
  33. AU="Yujing Dang"
  34. AU="Clare Duncan"
  35. AU="Calvo Soto, Andrea Patricia"
  36. AU="Joanna I. Olszewska"
  37. AU="Francesco Cavallieri"
  38. AU="Betaieb, Ehssen"
  39. AU="Fan, Xiaoyu"
  40. AU="Riveros-Magaña, Alma Rocío"
  41. AU="Zhang, Wei-Fen"
  42. AU="Ciuca, Catrinel"
  43. AU="Friend, James R"
  44. AU="Colin R. Jackson"
  45. AU="Messina, Claudia"
  46. AU="Faircloth, Chelsey"
  47. AU="Md. Zabirul Islam" AU="Md. Zabirul Islam"
  48. AU="Butcher, Xochitl"
  49. AU="Espay, Alberto J."

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  1. Artikel ; Online: Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity

    Maryam Nourizadeh / Elham Feizabadi / Milad Mirmoghtadaei / Ashraf Mohammadi / Mohammad Reza Fazlollahi / Leila Moradi / Zahra Pourpak

    Iranian Journal of Immunology, Vol 20, Iss 4, Pp 400-

    2023  Band 409

    Abstract: Background: Few studies have evaluated COVID-19 vaccine efficacy in patients with inborn errors of immunity (IEI).Objective: To evaluate the levels of antibody (Ab) production and function after COVID-19 vaccination in IEI patients with phagocytic, ... ...

    Abstract Background: Few studies have evaluated COVID-19 vaccine efficacy in patients with inborn errors of immunity (IEI).Objective: To evaluate the levels of antibody (Ab) production and function after COVID-19 vaccination in IEI patients with phagocytic, complement, and Ab deficiencies and their comparison with healthy controls.Methods: Serum samples were collected from 41 patients and 32 healthy controls at least one month after the second dose of vaccination, while clinical evaluations continued until the end of the third dose. Levels of specific anti-receptor-binding domain (RBD) IgG and anti-RBD neutralizing antibodies were measured using EUROIMMUN and ChemoBind kits, respectively. Conventional SARS-CoV-2 neutralization test (cVNT) was also performed. Cutoff values of ≤20, 20-80, and ≥80 (for cVNT and Chemobined) and 0.8-4.2, 4.2-8.5, and ≥8.5 (for EUROIMMUN) were defined as negative/weak, positive/moderate, and positive/significant, respectively.Results: A considerable distinction was observed between the Ab-deficient patients and the controls for Ab concentration (EUROIMMUN, p<0.01) and neutralization (ChemoBind, p<0.001). However, there was no significant difference compared with the other patient groups. A near-zero cVNT in Ab-deficient patients was found compared to the controls (p<0.01). A significant correlation between the two kits was found using the whole data (R2=0.82, p<0.0001).Conclusion: Despite varying degrees of Ab production, all Ab deficient patients, as well as almost half of those with complement and phagocytic defects, did not effectively neutralize the virus (cVNT). In light of the decreased production and efficiency of the vaccine, a revised immunization plan may be needed in IEI.
    Schlagwörter covid-19 vaccines ; immunologic deficiency syndromes ; neutralization tests ; viral antibodies ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Shiraz University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement

    Zahra Alizadeh / Nastaran Keyhanian / Sara Ghaderkhani / Simin Dashti-Khavidaki / Raheleh Shokouhi Shoormasti / Zahra Pourpak

    Iranian Journal of Allergy, Asthma and Immunology, Vol 20, Iss

    2021  Band 4

    Abstract: No effective antiviral drugs and vaccines are available for the treatment of patients with severe coronavirus 2019 (COVID-19). Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for ... ...

    Abstract No effective antiviral drugs and vaccines are available for the treatment of patients with severe coronavirus 2019 (COVID-19). Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation. We did a randomized, single-blind study in Imam Khomeini Hospital between June 30, 2020, and August 5, 2020. Mild to moderate COVID-19 patients aged 25-65 years were eligible to enter the study based on chest CT scan, clinical symptoms, and physician diagnosis. The intervention group was prescribed 6 mg of oral melatonin for 2 weeks, which consumed half an hour before bedtime every night in low light conditions. Clinical symptoms and C-reactive protein (CRP) were measured before and after treatment in the melatonin received and control (regular medications) groups. Among screened patients with COVID-19, 14 patients were assigned to receive melatonin, and 17 patients were considered as controls. A significant difference (p=0.005) between CRP 1 and CRP 2 levels (before and after using melatonin) was found in the melatonin group while this difference (p=0.069) was not significant in the control group. Also, the percentage of recovery (based on symptoms) in patients who took melatonin was higher than that of patients in the control group (85.7% VS 47.1%). The result of this study confirmed the effectiveness of melatonin in mild to moderate outpatients with COVID-19. More clinical trials on elderly, diabetic, obese patients and severe cases are suggested in future studies.
    Schlagwörter COVID-19 ; Inflammation ; Melatonin ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Meatal Stenosis and Atopic Condition

    Nastaran Sabetkish / Zahra Pourpak / Abdol-Mohammad Kajbafzadeh / Raheleh Shokouhi Shoormasti / Mahsa Jafari

    Iranian Journal of Allergy, Asthma and Immunology, Vol 20, Iss

    A Pilot Study Demonstrating a Possible Unidentified Etiology

    2021  Band 5

    Abstract: Meatal stenosis (MS) is known as one of the most frequent complications of circumcision. In the present study, we aimed to find any possible relationship between MS and allergic disorders. A total of 36 children with a mean±SD age of 5.84±2.03 years were ...

    Abstract Meatal stenosis (MS) is known as one of the most frequent complications of circumcision. In the present study, we aimed to find any possible relationship between MS and allergic disorders. A total of 36 children with a mean±SD age of 5.84±2.03 years were referred with MS and an atopic background even in themselves or in one of their family members (Group A). There were also age-matched controls with a mean±SD age of 5.70±2.17 years who were referred to our center with allergic symptoms and no urinary complaints (Group B, n=17). The RIDA qLine allergy and allergy explorer (ALEX) tests were performed for all patients to find possible allergen sensitization. Laboratory findings revealed that IgE-sensitization to the main food and aeroallergens in Group A (with the chief complaint of MS in whom a mild atopic condition was found during concise medical history taking) were very similar to the control group with no significant difference (except for ryegrass which was higher in the control group). Although total IgE level was considerably higher in group B compared to group A, food sensitization to cow’s milk and ß-lactoglobulin was higher in asthmatic patients of group A compared to the controls. It seems that not all patients with MS should be considered as a complication of circumcision and undergo a surgical procedure for correction of the stenosis. Further investigations are required to determine the role of concise medical history taking and proper treatment of the allergic disorder to reduce failed surgical attempts in atopic boys with MS.
    Schlagwörter Asthma ; Atopic dermatitis ; Food hypersensitivity ; Male circumcision ; Urology ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Biological and Immunological Aspects of Iron Deficiency Anemia in Cancer Development: A Narrative Review

    Zohora, Fatema / Katayoon Bidad / Mostafa Moin / Zahra Pourpak

    Nutrition and cancer. 2018 May 19, v. 70, no. 4

    2018  

    Abstract: Iron Deficiency Anemia (IDA) is a universal health problem and a risk factor for the development of cancer. IDA changes the microenvironment of the human body by affecting both the biological and immunological systems. It increases DNA damage and genomic ...

    Abstract Iron Deficiency Anemia (IDA) is a universal health problem and a risk factor for the development of cancer. IDA changes the microenvironment of the human body by affecting both the biological and immunological systems. It increases DNA damage and genomic instability by different mechanisms. IDA is one of the leading causes of the imbalance between different antioxidant enzymes as well as enzymes involved in DNA damage and DNA repair systems of the body. It can affect the biogenesis/expression of microRNAs. IDA interrupts the oxidative phosphorylation energy metabolism and intestinal Cytochrome-P450 systems. It also disturbs multicellular signaling pathways involved in cell survival and helps in tumor angiogenesis. Moreover, IDA is also responsible for the functional deterioration of innate and adaptive immune systems that lead to immunological dysfunctions against invading pathogens. Genomic instability and immunological dysfunctions are the hallmarks of cancer development. In this review, we will review the evidence linking IDA to increased cancer risk.
    Schlagwörter angiogenesis ; antioxidants ; biogenesis ; carcinogenesis ; cell viability ; DNA damage ; DNA repair ; enzymes ; genomics ; humans ; iron ; iron deficiency anemia ; microRNA ; neoplasms ; nutrient deficiencies ; oxidative phosphorylation ; pathogens ; risk factors ; signal transduction
    Sprache Englisch
    Erscheinungsverlauf 2018-0519
    Umfang p. 546-556.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 2025822-7
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2018.1460685
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Osteoimmunology and Nutritional Science

    Mahshid Sirjani / Zahra Pourpak

    Iranian Journal Of Allergy, Asthma and Immunology, Vol 12, Iss 3, Pp 290-

    2013  Band 291

    Schlagwörter Nutrition ; Osteoimmunology ; Immunologic diseases. Allergy ; RC581-607 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Allergy and Immunology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Englisch
    Erscheinungsdatum 2013-07-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Identification of Antibodies against Neutrophil Surface Antigens in Two Iranian Patients with Autoimmune Neutropenia

    Behnaz Esmaeili / Behnaz Bayat / Mohamad Reza Fazlollahi / Leila Moradi / Arash Kalantari / Seyed Mohammad Kazem Nourbakhsh / Zahra Pourpak

    Iranian Journal of Allergy, Asthma and Immunology, Vol 20, Iss

    2021  Band 6

    Abstract: Autoimmune neutropenia is a type of immune-mediated neutropenia, caused by antibody-induced neutrophil destruction. Here we report two cases (3-year-old boy and 9-year-old girl) with suspected autoimmune neutropenia. The presence of neutrophil antibodies ...

    Abstract Autoimmune neutropenia is a type of immune-mediated neutropenia, caused by antibody-induced neutrophil destruction. Here we report two cases (3-year-old boy and 9-year-old girl) with suspected autoimmune neutropenia. The presence of neutrophil antibodies in sera of these patients was investigated using standard neutrophil antibody screening tests such as granulocyte immunofluorescence test (GIFT), granulocyte agglutination test (GAT), and lymphocyte immunofluorescence test (LIFT). A positive reactivity with two panel cells was found in GIFT. No reactivities with panel cells were observed in GAT and LIFT. To the best of our knowledge, this is the first report for detecting the neutrophil reactive antibodies using genotyped neutrophils in patients with autoimmune neutropenia in Iran. The final diagnosis of our patients was primary autoimmune neutropenia for the boy and autoimmune neutropenia associated with familial Mediterranean fever for the girl.
    Schlagwörter Agglutination test ; Autoimmunity ; Indirect immunofluorescence ; Neutropenia ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Osteoimmunology and Nutritional Science

    Mahshid Sirjani / Zahra Pourpak

    Iranian Journal of Allergy, Asthma and Immunology, Vol 12, Iss

    2013  Band 3

    Abstract: LETTER TO THE ... ...

    Abstract LETTER TO THE EDITOR
    Schlagwörter NO Keywords ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2013-09-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: Determining Laboratory Reference Values of TREC and KREC in Different Age Groups of Iranian Healthy Individuals

    Leila Shakerian / Zahra Pourpak / Somayeh Shamlou / Erna Domsgen / Anoshirvan Kazemnejad / Hossein Dalili / Maryam Nourizadeh

    Iranian Journal of Allergy, Asthma and Immunology, Vol 18, Iss

    2019  Band 2

    Abstract: Assessment of the number of T-cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) copies has been recently described as biomarkers of newly formed T and B cells respectively. In this study, we aimed to explore ... ...

    Abstract Assessment of the number of T-cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) copies has been recently described as biomarkers of newly formed T and B cells respectively. In this study, we aimed to explore the effects of demographic variables including age, gender, weight, height and ethnicity on these two episomal DNA molecules. Second, for the first time in our country, we determined the reference values of TREC and KREC copy numbers in different age groups of Iranian healthy individuals as a threshold for identifying T cell and B cell lymphopenia. The TREC and KREC copy numbers were evaluated in 251 dried blood spot (DBS) samples from healthy volunteers (age range: 0-60 years). Six primary immunodeficiency (PID) patients were included as disease controls. TREC and KREC copies were markedly reduced with increasing age. Although the levels of TREC and KREC were higher in females than males, this difference did not reach statistical significance. These findings suggest that demographic variables including age should be considered for interpretation results of the TREC/KREC assay.
    Schlagwörter Immunodeficiency ; Kappa-deleting recombination excision circles ; Reference value ; T-cell receptor excision circles ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: In Vitro Analysis of Nine MicroRNAs in CD8+ T Cells of Asthmatic Patients and the Effects of Two FDA-approved Drugs

    Mohsen Badalzadeh / Marzieh Mazinani / Zahra Pourpak / Hassan Heidarnazhad / Esmaeil Mortaz / Mostafa Moin / Ali Farazmand

    Iranian Journal of Allergy, Asthma and Immunology, Vol 18, Iss

    2019  Band 4

    Abstract: In this study, we first tried to determine whether the expression level of 9 miRNAs in the peripheral blood CD8+ T cells of asthmatic patients varies from that of controls, and secondly, we investigated the effects of fluticasone furoate and vilanterol ... ...

    Abstract In this study, we first tried to determine whether the expression level of 9 miRNAs in the peripheral blood CD8+ T cells of asthmatic patients varies from that of controls, and secondly, we investigated the effects of fluticasone furoate and vilanterol on the expression level of these miRNAs. Fifteen subjects including 8 healthy individuals and 7 asthmatic patients were included in this study. CD8+T cells were isolated from participants' peripheral blood by a negative selection method using magnetic-activated cell sorting (MACS). The expression of 9 miRNAs was examined between the healthy individuals and asthmatic patients. Then the expression level of 9 miRNAs before and after treatment with the drugs was examined by quantitative real-time PCR. No significant changes in the expression level of 9 miRNAs were observed in asthmatic patients compared to the healthy controls. Fluticasone and vilanterol, in combination, had the greatest effect on miRNA expression. MiR-150 and miR-106a were the most and the least miRNAs, respectively, present in CD8+ T cells of patients and controls. MiR-106a and miR-126 had a positive correlation in CD8+ cells of asthmatic patients. Although no significant difference in the expression level of studies miRNAs was observed, the correlations among miRNAs were significant. Therefore, we suggest that the correlation between miRNAs would be a very important factor in physiological and pathological conditions in healthy individuals and asthmatic patients. Such a miRNA-miRNA correlation network can be even more critical than any changes in the variation of their expression in the CD8+ T cells.
    Schlagwörter Fluticasone furoate ; MicroRNAs ; Vilanterol ; CD8 T cells ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-08-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Recent Advances in Gene Therapy and Modeling of Chronic Granulomatous Disease

    Arefeh Jafarian / Gelareh Shokri / Mahdieh Shokrollahi Barough / Mostafa Moin / Zahra Pourpak / Masoud Soleimani

    Iranian Journal of Allergy, Asthma and Immunology, Vol 18, Iss

    2019  Band 2

    Abstract: The Chronic granulomatous disease (CGD) is a primary immunodeficiency that characterized by mutations in phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, resulting in deficient antimicrobial activity of phagocytic cells and ... ...

    Abstract The Chronic granulomatous disease (CGD) is a primary immunodeficiency that characterized by mutations in phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, resulting in deficient antimicrobial activity of phagocytic cells and recurrent childhood infections. Hematopoietic stem cell transplantation (HSCT) is a curative option for patients with human leukocyte antigen (HLA) matched donor, when conventional cares and therapies fail. However, in many cases when the patients have not an HLA-matched donor, they need to a method to recapitulate the function of the affected gene within the patient’s own cells. Gene therapy is a promising approach for CGD. While, the success of retroviral or lentiviral vectors in gene therapy for CGD has been hampered by random integration and insertional activation of proto-oncogenes. These serious adverse events led to improvement and generations of viral vectors with increased safety characteristics. Gene therapy continues to progress and the advent of new technologies, such as engineered endonucleases that have shown a great promise for the treatment of genetic disease. This review focuses on the application of gene therapy for the CGD, the limitations encountered in current clinical trials, advantages and disadvantages of endonucleases in gene correction and modeling with CRISPR/Cas9 approach.
    Schlagwörter Chronic granulomatous disease ; Endonucleases ; Gene editing ; NADPH oxidases ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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