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  1. Article ; Online: Persistent Fever and Rising CRP in a Patient With Pustular Psoriasis Deceived the Medical Team to Consider Her as a Case of COVID-19 During the Pandemic

    Zahra Saffarian / Shahin Hamzelou / Fateme Shirzad Moghadam

    Acta Medica Iranica, Vol 59, Iss

    2021  Volume 8

    Abstract: Generalized pustular psoriasis is a rare variant of pustular psoriasis. During the pandemic of COVID-19, every patient referred to medical centers with fever or other flu-like symptoms would be first evaluated for COVID-19. Here, we report a case of ... ...

    Abstract Generalized pustular psoriasis is a rare variant of pustular psoriasis. During the pandemic of COVID-19, every patient referred to medical centers with fever or other flu-like symptoms would be first evaluated for COVID-19. Here, we report a case of pustular psoriasis who were under biologic immunosuppressive treatment (Infliximab) and was admitted to take her every eight weeks injection of infliximab. During evaluations before the injection, persistent fever and high CRP was detected. Due to these findings, she was suspected of having COVID-19, and this suspicion delayed routine medical care and infliximab infusion for her main disease, pustular psoriasis. After two negative results of the COVID-19 PCR test, Infliximab infusion was done, and surprisingly the fever disappeared, and CRP level decreased.
    Keywords Psoriasis ; COVID-19 ; Biological Treatment ; Infliximab ; Medicine (General) ; R5-920
    Subject code 630
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Role of Social Cognition in Predicting the Social Functioning in Patients With Chronic Schizophrenia

    Zahra Saffarian / Behrouz Doulatshahi / Abbas Pourshabaz / Najmeh Rasti Kerdar

    Iranian Rehabilitation Journal, Vol 16, Iss 3, Pp 239-

    2018  Volume 246

    Abstract: Objectives: Patients with schizophrenia are characterized with deficiencies in various aspects of social functioning. Given the relationship between social functioning deficits and relapse in these patients, identification of underlying factors is of ... ...

    Abstract Objectives: Patients with schizophrenia are characterized with deficiencies in various aspects of social functioning. Given the relationship between social functioning deficits and relapse in these patients, identification of underlying factors is of significant importance. Thus, in this study, the contribution of each dimension of social cognition (Emotion Perception [EP], Theory of Mind [ToM] and Attributional Style [AS]) in predicting the social function of schizophrenic patients were examined. Methods: The statistical population included all patients with chronic schizophrenia hospitalized in Shiraz chronic healthcare centers. Of them, a total of 62 patients with schizophrenia disorder were selected based on purposive sampling method from three chronic care centers and were evaluated using social cognition tools (Hinting Task, Face Emotion Identification Task, and The Ambiguous Intentions and Hostility Questionnaire) and the Social Functioning Scale (SFS). Results: The results showed that ToM and EP predicted social functioning in people with schizophrenia but attributional style was not associated with social functioning. Discussion: On the whole, ToM and EP are general abilities contributing in explaining social functioning. However, the importance of attributional bias is significant when evaluating the performance of a person in specific areas such as aggressive behaviors.
    Keywords Social cognition ; Theory of mind ; Emotion perception ; Attributional style ; Social function ; Medicine ; R ; Vocational rehabilitation. Employment of people with disabilities ; HD7255-7256
    Subject code 300
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher Negah Institute for Scientific Communication
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Whole transcriptome–based skin virome profiling in typical epidermodysplasia verruciformis reveals α-, β-, and γ-HPV infections

    Amir Hossein Saeidian / Leila Youssefian / Mahtab Naji / Hamidreza Mahmoudi / Samantha M. Barnada / Charles Huang / Karim Naghipoor / Amir Hozhabrpour / Jason S. Park / Flavia Manzo Margiotta / Fatemeh Vahidnezhad / Zahra Saffarian / Kambiz Kamyab-Hesari / Mohammad Tolouei / Niloofar Faraji / Seyyede Zeinab Azimi / Ghazal Namdari / Parvin Mansouri / Jean-Laurent Casanova /
    Vivien Béziat / Emmanuelle Jouanguy / Jouni Uitto / Hassan Vahidnezhad

    JCI Insight, Vol 8, Iss

    2023  Volume 5

    Abstract: HPVs are DNA viruses include approximately 450 types that are classified into 5 genera (α-, β-, γ-, μ-, and ν-HPV). The γ- and β-HPVs are present in low copy numbers in healthy individuals; however, in patients with an inborn error of immunity, certain ... ...

    Abstract HPVs are DNA viruses include approximately 450 types that are classified into 5 genera (α-, β-, γ-, μ-, and ν-HPV). The γ- and β-HPVs are present in low copy numbers in healthy individuals; however, in patients with an inborn error of immunity, certain species of β-HPVs can cause epidermodysplasia verruciformis (EV), manifesting as recalcitrant cutaneous warts and skin cancer. EV presents as either typical or atypical. Manifestations of typical EV are limited to the skin and are caused by abnormal keratinocyte-intrinsic immunity to β-HPVs due to pathogenic sequence variants in TMC6, TMC8, or CIB1. We applied a transcriptome-based computational pipeline, VirPy, to RNA extracted from normal-appearing skin and wart samples of patients with typical EV to explore the viral and human genetic determinants. In 26 patients, 9 distinct biallelic mutations were detected in TMC6, TMC8, and CIB1, 7 of which are previously unreported to our knowledge. Additionally, 20 different HPV species, including 3 α-HPVs, 16 β-HPVs, and 1 γ-HPV, were detected, 8 of which are reported here for the first time to our knowledge in patients with EV (β-HPV-37, -47, -80, -151, and -159; α-HPV-2 and -57; and γ-HPV-128). This study expands the TMC6, TMC8, and CIB1 sequence variant spectrum and implicates new HPV subtypes in the pathogenesis of typical EV.
    Keywords Dermatology ; Genetics ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Prediction of Severity of Delusion Based on Jumping-to-Conclusion Bias in Schizophrenia Patients

    Zahra Saffarian / Mohammad Ali Goodarzi / Maryam Abbasian / Javad Molazadeh / Habib Hadianfard

    Iranian Rehabilitation Journal, Vol 14, Iss 1, Pp 69-

    2016  Volume 73

    Abstract: Objectives: New cognitive theories of delusions have proposed that deficit or bias in inferencestage (a stage of normal belief formation) is significant in delusion formation. The aim of thisstudy was predicting the severity of delusions based on jumping- ...

    Abstract Objectives: New cognitive theories of delusions have proposed that deficit or bias in inferencestage (a stage of normal belief formation) is significant in delusion formation. The aim of thisstudy was predicting the severity of delusions based on jumping-to-conclusion bias in patientswith schizophrenia. Methods: The sample consisted of 60 deluded patients with schizophrenia who were selectedfrom the Ebnesina and Razi hospitals in Shiraz using convenience sampling method. TheSimilarity Task was used to measure the jumping-to-conclusion biases. Results: Its results have shown that the jumping-to-conclusion biases could predict a great partof the variance of delusions. Discussion: These results generally indicated that the jumping to conclusion biases mayprovide a more useful explanation for the delusion formation.
    Keywords Jumping–to-conclusion bias ; Delusion ; Similarity task ; Medicine ; R ; Vocational rehabilitation. Employment of people with disabilities ; HD7255-7256
    Subject code 150
    Language English
    Publishing date 2016-03-01T00:00:00Z
    Publisher Negah Institute for Scientific Communication
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Whole-transcriptome sequencing–based concomitant detection of viral and human genetic determinants of cutaneous lesions

    Amir Hossein Saeidian / Leila Youssefian / Charles Y. Huang / Fahimeh Palizban / Mahtab Naji / Zahra Saffarian / Hamidreza Mahmoudi / Azadeh Goodarzi / Soheila Sotoudeh / Fatemeh Vahidnezhad / Maliheh Amani / Narjes Tavakoli / Ali Ajami / Samaneh Mozafarpoor / Mehrdad Teimoorian / Saeed Dorgaleleh / Sima Shokri / Mohammad Shenagari / Nima Abedi /
    Sirous Zeinali / Paolo Fortina / Vivien Béziat / Emmanuelle Jouanguy / Jean-Laurent Casanova / Jouni Uitto / Hassan Vahidnezhad

    JCI Insight, Vol 7, Iss

    2022  Volume 8

    Abstract: Severe viral infections of the skin can occur in patients with inborn errors of immunity (IEI). We report an all-in-one whole-transcriptome sequencing–based method by RNA-Seq on a single skin biopsy for concomitantly identifying the cutaneous virome and ... ...

    Abstract Severe viral infections of the skin can occur in patients with inborn errors of immunity (IEI). We report an all-in-one whole-transcriptome sequencing–based method by RNA-Seq on a single skin biopsy for concomitantly identifying the cutaneous virome and the underlying IEI. Skin biopsies were obtained from healthy and lesional skin from patients with cutaneous infections suspected to be of viral origin. RNA-Seq was utilized as the first-tier strategy for unbiased human genome-wide rare variant detection. Reads unaligned to the human genome were utilized for the exploration of 926 viruses in a viral genome catalog. In 9 families studied, the patients carried pathogenic variants in 6 human IEI genes, including IL2RG, WAS, CIB1, STK4, GATA2, and DOCK8. Gene expression profiling also confirmed pathogenicity of the human variants and permitted genome-wide homozygosity mapping, which assisted in identification of candidate genes in consanguineous families. This automated, online, all-in-one computational pipeline, called VirPy, enables simultaneous detection of the viral triggers and the human genetic variants underlying skin lesions in patients with suspected IEI and viral dermatosis.
    Keywords Genetics ; Infectious disease ; Medicine ; R
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Use of Intense Pulsed Light (IPL) for the Treatment of Vascular Lesions

    Sara Zamani / Behrooz Barikbin / Azin Ayatollahi / Zahra Saffarian / Somayeh Hejazi

    Journal of Lasers in Medical Sciences, Vol 2, Iss 2, Pp 73-

    2011  Volume 81

    Abstract: According to the English literature, various lasers and light sources (i,g. argon ion lasers, pulsed KTP lasers, diode lasers and Nd:YAG lasers, pulsed dye laser(PDL), intense pulsed light sources (IPLS) are applicable for the treatment of different ... ...

    Abstract According to the English literature, various lasers and light sources (i,g. argon ion lasers, pulsed KTP lasers, diode lasers and Nd:YAG lasers, pulsed dye laser(PDL), intense pulsed light sources (IPLS) are applicable for the treatment of different vascular lesions. These conditions are the most important indication for laser therapy. This review summarizes the current literature on IPL with regard to the treatment of vascular lesions
    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-06-01T00:00:00Z
    Publisher Laser Application in Medical Sciences Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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