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  1. Article: Patient-matched analysis identifies deregulated networks in prostate cancer to guide personalized therapeutic intervention.

    Kumar, Akinchan / Kasikci, Yasenya / Badredine, Alaa / Azzag, Karim / Quintyn Ranty, Marie L / Zaidi, Falek / Aragou, Nathalie / Mazerolles, Catherine / Malavaud, Bernard / Mendoza-Parra, Marco A / Vandel, Laurence / Gronemeyer, Hinrich

    American journal of cancer research

    2021  Volume 11, Issue 11, Page(s) 5299–5318

    Abstract: Prostate cancer (PrCa) is the second most common malignancy in men. More than 50% of advanced prostate cancers display the TMPRSS2-ERG fusion. Despite extensive cancer genome/transcriptome data, little is known about the impact of mutations and altered ... ...

    Abstract Prostate cancer (PrCa) is the second most common malignancy in men. More than 50% of advanced prostate cancers display the TMPRSS2-ERG fusion. Despite extensive cancer genome/transcriptome data, little is known about the impact of mutations and altered transcription on regulatory networks in the PrCa of individual patients. Using patient-matched normal and tumor samples, we established somatic variations and differential transcriptome profiles of primary ERG-positive prostate cancers. Integration of protein-protein interaction and gene-regulatory network databases defined highly diverse patient-specific network alterations. Different components of a given regulatory pathway were altered by novel and known mutations and/or aberrant gene expression, including deregulated ERG targets, and were validated by using a novel
    Language English
    Publishing date 2021-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hippocampal expression of a virus-derived protein impairs memory in mice.

    Bétourné, Alexandre / Szelechowski, Marion / Thouard, Anne / Abrial, Erika / Jean, Arnaud / Zaidi, Falek / Foret, Charlotte / Bonnaud, Emilie M / Charlier, Caroline M / Suberbielle, Elsa / Malnou, Cécile E / Granon, Sylvie / Rampon, Claire / Gonzalez-Dunia, Daniel

    Proceedings of the National Academy of Sciences of the United States of America

    2018  Volume 115, Issue 7, Page(s) 1611–1616

    Abstract: The analysis of the biology of neurotropic viruses, notably of their interference with cellular signaling, provides a useful tool to get further insight into the role of specific pathways in the control of behavioral functions. Here, we exploited the ... ...

    Abstract The analysis of the biology of neurotropic viruses, notably of their interference with cellular signaling, provides a useful tool to get further insight into the role of specific pathways in the control of behavioral functions. Here, we exploited the natural property of a viral protein identified as a major effector of behavioral disorders during infection. We used the phosphoprotein (P) of Borna disease virus, which acts as a decoy substrate for protein kinase C (PKC) when expressed in neurons and disrupts synaptic plasticity. By a lentiviral-based strategy, we directed the singled-out expression of P in the dentate gyrus of the hippocampus and we examined its impact on mouse behavior. Mice expressing the P protein displayed increased anxiety and impaired long-term memory in contextual and spatial memory tasks. Interestingly, these effects were dependent on P protein phosphorylation by PKC, as expression of a mutant form of P devoid of its PKC phosphorylation sites had no effect on these behaviors. We also revealed features of behavioral impairment induced by P protein expression but that were independent of its phosphorylation by PKC. Altogether, our findings provide insight into the behavioral correlates of viral infection, as well as into the impact of virus-mediated alterations of the PKC pathway on behavioral functions.
    MeSH term(s) Animals ; Borna Disease/metabolism ; Borna Disease/pathology ; Borna Disease/virology ; Borna disease virus/physiology ; Cells, Cultured ; Cognition Disorders/etiology ; Cognition Disorders/metabolism ; Cognition Disorders/pathology ; Dentate Gyrus/metabolism ; Dentate Gyrus/pathology ; Dentate Gyrus/virology ; Hippocampus/metabolism ; Hippocampus/pathology ; Hippocampus/virology ; Memory, Long-Term/physiology ; Mice ; Mutation ; Neuronal Plasticity ; Neurons/metabolism ; Neurons/pathology ; Neurons/virology ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Viral Structural Proteins/genetics ; Viral Structural Proteins/metabolism
    Chemical Substances P protein, Borna disease virus ; Phosphoproteins ; Viral Structural Proteins ; Protein Kinase C (EC 2.7.11.13)
    Language English
    Publishing date 2018--13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1711977115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Sphingosine Kinase 1 urothelial expression is increased in patients with neurogenic detrusor overactivity.

    Ballouhey, Quentin / Panicker, Jalesh N / Mazerolles, Catherine / Roumiguie, Mathieu / Zaidi, Falek / Rischmann, Pascal / Malavaud, Bernard / Game, Xavier

    International braz j urol : official journal of the Brazilian Society of Urology

    2015  Volume 41, Issue 6, Page(s) 1141–1147

    Abstract: Unlabelled: To evaluate the expression of sphingosine kinase 1 (SPK1) in the bladder wall in patients with neurogenic lower urinary tract dysfunction and its association with clinical, urodynamic and pathological features.: Materials and methods: The ...

    Abstract Unlabelled: To evaluate the expression of sphingosine kinase 1 (SPK1) in the bladder wall in patients with neurogenic lower urinary tract dysfunction and its association with clinical, urodynamic and pathological features.
    Materials and methods: The expression of SPK1 was studied in bladder wall specimens obtained from cystectomy using immunohistochemistry in ten patients with spinal cord injury (n=8) or multiple sclerosis (n=2) with urodynamically proven neuropathic bladder dysfunction, and in controls (n=5). Inflammation and fibrosis were analysed with histological criteria and SPK1 expression was determined by individual immunohistochemical staining.
    Results: Significant increased SPK1 urothelial immunoreactivity was shown in patients compared to control group (p=0.03). By contrast, SPK1 immunoreactivity in patients was significantly decreased in the sub-urothelium, muscles and nerves, p=0.02; 0.01 and 0.003, respectively. Patients with neurogenic detrusor overactivity (NDO) had higher SPK1 urothelium expression than those without any DO (p=0.04).
    Conclusions: SPK1 is expressed in the human bladder wall, specifically the urothelium, in bladder specimens from patients with NDO. The role of SPK1 in the pathophysiology of NDO needs further elucidation.
    MeSH term(s) Adult ; Aged ; Biopsy ; Female ; Fibrosis ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Multiple Sclerosis/complications ; Phosphotransferases (Alcohol Group Acceptor)/analysis ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Spinal Cord Injuries/complications ; Urinary Bladder/pathology ; Urinary Bladder, Overactive/enzymology ; Urinary Bladder, Overactive/etiology ; Urinary Bladder, Overactive/pathology ; Urodynamics ; Urothelium/pathology
    Chemical Substances Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; sphingosine kinase (EC 2.7.1.-)
    Language English
    Publishing date 2015-11
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2206649-4
    ISSN 1677-6119 ; 1677-5538
    ISSN (online) 1677-6119
    ISSN 1677-5538
    DOI 10.1590/S1677-5538.IBJU.2014.0676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6174: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress.

    Laurent, Victor / Toulet, Aurélie / Attané, Camille / Milhas, Delphine / Dauvillier, Stéphanie / Zaidi, Falek / Clement, Emily / Cinato, Mathieu / Le Gonidec, Sophie / Guérard, Adrien / Lehuédé, Camille / Garandeau, David / Nieto, Laurence / Renaud-Gabardos, Edith / Prats, Anne-Catherine / Valet, Philippe / Malavaud, Bernard / Muller, Catherine

    Molecular cancer research : MCR

    2019  Volume 17, Issue 3, Page(s) 821–835

    Abstract: Prostate gland is surrounded by periprostatic adipose tissue (PPAT), which is increasingly believed to play a paracrine role in prostate cancer progression. Our previous work demonstrates that adipocytes promote homing of prostate cancer cells to PPAT ... ...

    Abstract Prostate gland is surrounded by periprostatic adipose tissue (PPAT), which is increasingly believed to play a paracrine role in prostate cancer progression. Our previous work demonstrates that adipocytes promote homing of prostate cancer cells to PPAT and that this effect is upregulated by obesity. Here, we show that once tumor cells have invaded PPAT (mimicked by an
    MeSH term(s) Adipose Tissue/physiopathology ; Animals ; Cell Culture Techniques ; Humans ; Male ; Mice ; Obesity/complications ; Oxidative Stress ; Prostatic Neoplasms/etiology ; Prostatic Neoplasms/pathology ; Transfection
    Language English
    Publishing date 2019-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2098788-2
    ISSN 1557-3125 ; 1541-7786
    ISSN (online) 1557-3125
    ISSN 1541-7786
    DOI 10.1158/1541-7786.MCR-18-0748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5744: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.

    Laurent, Victor / Guérard, Adrien / Mazerolles, Catherine / Le Gonidec, Sophie / Toulet, Aurélie / Nieto, Laurence / Zaidi, Falek / Majed, Bilal / Garandeau, David / Socrier, Youri / Golzio, Muriel / Cadoudal, Thomas / Chaoui, Karima / Dray, Cedric / Monsarrat, Bernard / Schiltz, Odile / Wang, Yuan Yuan / Couderc, Bettina / Valet, Philippe /
    Malavaud, Bernard / Muller, Catherine

    Nature communications

    2016  Volume 7, Page(s) 10230

    Abstract: Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this ...

    Abstract Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells. In obesity, higher secretion of CCL7 by adipocytes facilitates extraprostatic extension. The observed increase in migration associated with obesity is totally abrogated when the CCR3/CCL7 axis is inhibited. In human prostate cancer tumours, expression of the CCR3 receptor is associated with the occurrence of aggressive disease with extended local dissemination and a higher risk of biochemical recurrence, highlighting the potential benefit of CCR3 antagonists in the treatment of prostate cancer.
    MeSH term(s) Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adipocytes/metabolism ; Adipose Tissue/cytology ; Adult ; Aged ; Animals ; Cell Line, Tumor ; Cell Movement ; Chemokine CCL7/metabolism ; Disease Progression ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Humans ; Immunohistochemistry ; Male ; Mass Spectrometry ; Mice ; Middle Aged ; Neoplasm Recurrence, Local/metabolism ; Obesity/metabolism ; Prognosis ; Prostate ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Receptors, CCR3/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
    Chemical Substances Chemokine CCL7 ; Receptors, CCR3
    Language English
    Publishing date 2016-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2041-1723
    ISSN (online) 2041-1723
    DOI 10.1038/ncomms10230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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