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  1. Article ; Online: Terminal Schwann Cells Lead Synapse Remodelling following Injury(1,2).

    Zainul, Zarin

    eNeuro

    2014  Volume 1, Issue 1

    Abstract: This commentary article describes the importance and significance of the article recently published by the Kang and colleagues in The Journal of Neuroscience in 2014. Kang and colleagues provided new features of injury induced synapse remodelling. ...

    Abstract This commentary article describes the importance and significance of the article recently published by the Kang and colleagues in The Journal of Neuroscience in 2014. Kang and colleagues provided new features of injury induced synapse remodelling.
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Journal Article
    ISSN 2373-2822
    ISSN (online) 2373-2822
    DOI 10.1523/ENEURO.0028-14.2014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Dark nights behind the white clouds - risks of tobacco smoking on human health besides the oral health and malignancy.

    Zainul, Zarin

    EXCLI journal

    2011  Volume 10, Page(s) 69–84

    Abstract: Tobacco smoking is the common practice in a large percentage of the population worldwide, and the incidence is continuously increasing. Tobacco smoking is the most preventable cause of lung cancer, and it also impairs oral health. People are aware of the ...

    Abstract Tobacco smoking is the common practice in a large percentage of the population worldwide, and the incidence is continuously increasing. Tobacco smoking is the most preventable cause of lung cancer, and it also impairs oral health. People are aware of the carcinogenic effects of tobacco smoking on the lungs and oral cavity, but it is also a risk factor for many other harmful diseases. This review article covers most of the diseases that are associated with tobacco smoking, such as coronary artery disease (CAD), diabetes, chronic obstructive pulmonary disease (COPD), arthritis, impotency, infertility, tuberculosis, and Alzheimer's disease. The association of these diseases with tobacco smoking is discussed in detail in this review, along with their possible pathophysiology. This article focuses on the ongoing research of these diseases, and aims to raise awareness of the hazards of tobacco smoking, and to promote anti-smoking awareness programs.
    Language English
    Publishing date 2011-05-12
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1611-2156
    ISSN 1611-2156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel roles of phentolamine in protecting axon myelination, muscle atrophy, and functional recovery following nerve injury.

    Zainul, Zarin / Ma, Bo / Koka, Mert / Wilkerson, Jenny L / Ortiz, Yuma T / Kerosuo, Laura / Chandran, Vijayendran

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3344

    Abstract: Incomplete functional recovery after peripheral nerve injury (PNI) often results in devastating physical disabilities in human patients. Despite improved progress in surgical and non-surgical approaches, achieving complete functional recovery following ... ...

    Abstract Incomplete functional recovery after peripheral nerve injury (PNI) often results in devastating physical disabilities in human patients. Despite improved progress in surgical and non-surgical approaches, achieving complete functional recovery following PNI remains a challenge. This study demonstrates that phentolamine may hold a significant promise in treating nerve injuries and denervation induced muscle atrophy following PNI. In a sciatic nerve crush injury mouse model, we found that phentolamine treatment enhanced motor and functional recovery, protected axon myelination, and attenuated injury-induced muscle atrophy in mice at 14 days post-injury (dpi) compared to saline treatment. In the soleus of phentolamine treated animals, we observed the downregulation of phosphorylated signal transducer and activator of transcription factor 3 (p-STAT3) as well as muscle atrophy-related genes Myogenin, muscle ring finger 1 (MuRF-1), and Forkhead box O proteins (FoxO1, FoxO3). Our results show that both nerve and muscle recovery are integral components of phentolamine treatment-induced global functional recovery in mice at 14 dpi. Moreover, phentolamine treatment improved locomotor functional recovery in the mice after spinal cord crush (SCC) injury. The fact that phentolamine is an FDA approved non-selective alpha-adrenergic blocker, clinically prescribed for oral anesthesia reversal, hypertension, and erectile dysfunction makes this drug a promising candidate for repurposing in restoring behavioral recovery following PNI and SCC injuries, axonal neuropathy, and muscle wasting disorders.
    MeSH term(s) Animals ; Axons/metabolism ; Humans ; Male ; Mice ; Muscle, Skeletal/pathology ; Muscular Atrophy/pathology ; Nerve Regeneration ; Peripheral Nerve Injuries ; Phentolamine/therapeutic use ; Recovery of Function/physiology ; Sciatic Nerve/injuries ; Sciatic Neuropathy
    Chemical Substances Phentolamine (Z468598HBV)
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07253-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Maintenance of pluripotency in the entire ectoderm enables neural crest formation.

    Pajanoja, Ceren / Hsin, Jenny / Olinger, Bradley / Schiffmacher, Andrew / Abrams, Shaun / Dapkunas, Arvydas / Zainul, Zarin / Doyle, Andrew D / Martin, Daniel / Kerosuo, Laura

    Research square

    2023  

    Abstract: The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell ...

    Abstract The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell potential to generate mesodermal- and endodermal-like cells is obtained. We monitored transcriptional changes from gastrulation to neurulation using single-cell-Multiplex-Spatial-Transcriptomics (scMST) complemented with RNA-sequencing. Unexpectedly, we find maintenance of undecided Nanog/Oct4-PouV/Klf4-positive pluripotent-like pan-ectodermal stem-cells spanning the entire ectoderm late in the neurulation process with ectodermal patterning completed only at the end of neurulation when pluripotency becomes restricted to NC, challenging our understanding of gastrulation. Furthermore, broad ectodermal pluripotency is found at all axial levels unrelated to the NC lineage the cells later commit to, suggesting a general role in stemness enhancement and proposing a mechanism by which the NC acquires its ability to form derivatives beyond "ectodermal-capacity" in chick and mouse embryos.
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2285117/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential.

    Pajanoja, Ceren / Hsin, Jenny / Olinger, Bradley / Schiffmacher, Andrew / Yazejian, Rita / Abrams, Shaun / Dapkunas, Arvydas / Zainul, Zarin / Doyle, Andrew D / Martin, Daniel / Kerosuo, Laura

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 5941

    Abstract: The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell ...

    Abstract The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell potential to generate mesodermal- and endodermal-like derivatives is obtained. Here, we monitor transcriptional changes from gastrulation to neurulation using single-cell-Multiplex-Spatial-Transcriptomics (scMST) complemented with RNA-sequencing. We show maintenance of pluripotency-like signature (Nanog, Oct4/PouV, Klf4-positive) in undecided pan-ectodermal stem-cells spanning the entire ectoderm late during neurulation with ectodermal patterning completed only at the end of neurulation when the pluripotency-like signature becomes restricted to NC, challenging our understanding of gastrulation. Furthermore, broad ectodermal pluripotency-like signature is found at multiple axial levels unrelated to the NC lineage the cells later commit to, suggesting a general role in stemness enhancement and proposing a mechanism by which the NC acquires its ability to form derivatives beyond "ectodermal-capacity" in chick and mouse embryos.
    MeSH term(s) Animals ; Mice ; Ectoderm ; Neural Crest ; Neural Stem Cells ; Germ Layers ; Chickens
    Language English
    Publishing date 2023-09-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-41384-6
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  6. Article ; Online: Correct expression and localization of collagen XIII are crucial for the normal formation and function of the neuromuscular system.

    Härönen, Heli / Zainul, Zarin / Naumenko, Nikolay / Sormunen, Raija / Miinalainen, Ilkka / Shakirzyanova, Anastasia / Santoleri, Sabrina / Kemppainen, Antti V / Giniatullin, Rashid / Pihlajaniemi, Taina / Heikkinen, Anne

    The European journal of neuroscience

    2019  Volume 49, Issue 11, Page(s) 1491–1511

    Abstract: Transmembrane collagen XIII has been linked to maturation of the musculoskeletal system. Its absence in mice ( ... ...

    Abstract Transmembrane collagen XIII has been linked to maturation of the musculoskeletal system. Its absence in mice (Col13a1
    MeSH term(s) Animals ; Axons/metabolism ; Collagen Type XIII/genetics ; Collagen Type XIII/metabolism ; Diaphragm/metabolism ; Mice ; Mice, Knockout ; Muscle, Skeletal/metabolism ; Neuromuscular Junction/genetics ; Neuromuscular Junction/metabolism ; Receptors, Cholinergic/genetics ; Receptors, Cholinergic/metabolism ; Synaptic Transmission/physiology ; Synaptic Vesicles/metabolism
    Chemical Substances Collagen Type XIII ; Receptors, Cholinergic
    Language English
    Publishing date 2019-02-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.14346
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2548: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury.

    Zainul, Zarin / Heikkinen, Anne / Koivisto, Hennariikka / Rautalahti, Iina / Kallio, Mika / Lin, Shuo / Härönen, Heli / Norman, Oula / Rüegg, Markus A / Tanila, Heikki / Pihlajaniemi, Taina

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2018  Volume 38, Issue 17, Page(s) 4243–4258

    Abstract: Collagen XIII occurs as both a transmembrane-bound and a shed extracellular protein and is able to regulate the formation and function of neuromuscular synapses. Its absence results in myasthenia: presynaptic and postsynaptic defects at the neuromuscular ...

    Abstract Collagen XIII occurs as both a transmembrane-bound and a shed extracellular protein and is able to regulate the formation and function of neuromuscular synapses. Its absence results in myasthenia: presynaptic and postsynaptic defects at the neuromuscular junction (NMJ), leading to destabilization of the motor nerves, muscle regeneration and atrophy. Mutations in
    MeSH term(s) Animals ; Collagen Type XIII/genetics ; Collagen Type XIII/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Regeneration ; Neuromuscular Junction/metabolism ; Neuromuscular Junction/physiology ; Peripheral Nerve Injuries/metabolism ; Peripheral Nerve Injuries/physiopathology ; Recovery of Function
    Chemical Substances Collagen Type XIII
    Language English
    Publishing date 2018-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.3119-17.2018
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    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse.

    Härönen, Heli / Zainul, Zarin / Tu, Hongmin / Naumenko, Nikolay / Sormunen, Raija / Miinalainen, Ilkka / Shakirzyanova, Anastasia / Oikarainen, Tuomo / Abdullin, Azat / Martin, Paula / Santoleri, Sabrina / Koistinaho, Jari / Silman, Israel / Giniatullin, Rashid / Fox, Michael A / Heikkinen, Anne / Pihlajaniemi, Taina

    Human molecular genetics

    2017  Volume 26, Issue 11, Page(s) 2076–2090

    Abstract: Both transmembrane and extracellular cues, one of which is collagen XIII, regulate the formation and function of the neuromuscular synapse, and their absence results in myasthenia. We show that the phenotypical changes in collagen XIII knock-out mice are ...

    Abstract Both transmembrane and extracellular cues, one of which is collagen XIII, regulate the formation and function of the neuromuscular synapse, and their absence results in myasthenia. We show that the phenotypical changes in collagen XIII knock-out mice are milder than symptoms in human patients, but the Col13a1-/- mice recapitulate major muscle findings of congenital myasthenic syndrome type 19 and serve as a disease model. In the lack of collagen XIII neuromuscular synapses do not reach full size, alignment, complexity and function resulting in reduced muscle strength. Collagen XIII is particularly important for the preterminal integrity, and when absent, destabilization of the motor nerves results in muscle regeneration and in atrophy especially in the case of slow muscle fibers. Collagen XIII was found to affect synaptic integrity through binding the ColQ tail of acetylcholine esterase. Although collagen XIII is a muscle-bound transmembrane molecule, it also undergoes ectodomain shedding to become a synaptic basal lamina component. We investigated the two forms' roles by novel Col13a1tm/tm mice in which ectodomain shedding is impaired. While postsynaptic maturation, terminal branching and neurotransmission was exaggerated in the Col13a1tm/tm mice, the transmembrane form's presence sufficed to prevent defects in transsynaptic adhesion, Schwann cell invagination/retraction, vesicle accumulation and acetylcholine receptor clustering and acetylcholinesterase dispersion seen in the Col13a1-/- mice, pointing to the transmembrane form as the major conductor of collagen XIII effects. Altogether, collagen XIII secures postsynaptic, synaptic and presynaptic integrity, and it is required for gaining and maintaining normal size, complexity and functional capacity of the neuromuscular synapse.
    MeSH term(s) Acetylcholinesterase/metabolism ; Animals ; Basement Membrane/metabolism ; Cell Adhesion/physiology ; Collagen/metabolism ; Collagen Type XIII/genetics ; Collagen Type XIII/metabolism ; Mice ; Mice, Knockout ; Muscle Proteins/metabolism ; Muscle, Skeletal/metabolism ; Neuromuscular Junction/metabolism ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptors, Cholinergic/metabolism ; Synapses/metabolism ; Synaptic Transmission
    Chemical Substances Collagen Type XIII ; Muscle Proteins ; Receptors, Cholinergic ; Collagen (9007-34-5) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Acetylcholinesterase (EC 3.1.1.7)
    Language English
    Publishing date 2017-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddx101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3469: Show issues Location:
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