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  1. Article: Kletochnye tekhnologii kak osnova razrabotki regeneratornykh printsipov lecheniya zabolevanii sleznoi zhelezy.

    Safonova, T N / Zaitseva, G V

    Vestnik oftalmologii

    2024  Volume 140, Issue 2. Vyp. 2, Page(s) 158–165

    Abstract: The lacrimal gland (LG) is a tubuloacinar exocrine gland composed of acinar, ductal, and myoepithelial cells. Three-dimensional distribution of acinar lobules, ducts, and myoepithelial cells is necessary for the effective functioning of the organ. LG is ... ...

    Title translation Cell technologies as a basis for the development of regenerative principles for the treatment of lacrimal gland diseases.
    Abstract The lacrimal gland (LG) is a tubuloacinar exocrine gland composed of acinar, ductal, and myoepithelial cells. Three-dimensional distribution of acinar lobules, ducts, and myoepithelial cells is necessary for the effective functioning of the organ. LG is the main organ of immune surveillance of the ocular surface system. The embryogenesis of the gland is regulated by the interaction of genetic mechanisms, internal epigenetic (enzyme systems, hormones) and exogenous factors. There is no doubt that there is a clear genetic program for the implementation of the complex process of embryonic development. The mechanisms regulating LG organogenesis initiate the work of a huge number of structural oncogenes, transcription and growth factors, etc. Studying the expression and selective activity of regulatory genes during organ development, their participation in the differentiation of different cell types is a current trend at the nexus of clinical genetics, molecular biology, embryology and immunocytochemistry. Due to its relatively simple structure and accessibility, human LG is a suitable object for potential application in regenerative medicine. Development of a universal protocol for obtaining functional differentiated secretory epithelium of LG capable of expressing tissue-specific markers is an urgent task. Determining the nature and origin of stem cells and progenitor cells will allow the isolation and multiplication of these cells in culture. After obtaining a functionally active culture of LG cells, it is possible to create a model of autoimmune diseases.
    MeSH term(s) Humans ; Regenerative Medicine/methods ; Lacrimal Apparatus/embryology ; Lacrimal Apparatus/physiology ; Lacrimal Apparatus Diseases/therapy ; Lacrimal Apparatus Diseases/physiopathology ; Cell Differentiation/physiology
    Language Russian
    Publishing date 2024-04-30
    Publishing country Russia (Federation)
    Document type Journal Article ; Review ; English Abstract
    ZDB-ID 962921-x
    ISSN 0042-465X
    ISSN 0042-465X
    DOI 10.17116/oftalma2024140022158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prediktivnaya znachimost' geneticheskogo analiza razvitiya sindroma «sukhogo glaza» razlichnogo geneza.

    Safonova, T N / Zaitseva, G V / Loginov, V I / Burdennyy, A M

    Vestnik oftalmologii

    2024  Volume 139, Issue 6, Page(s) 13–18

    Abstract: One of the etiological causes of dry eye disease (DED) is systemic autoimmune diseases (AID): primary Sjögren's syndrome (PSS), rheumatoid arthritis (RA); their manifestation may begin with ophthalmic symptoms. The relationship of PSS and RA with genetic ...

    Title translation Predictive significance of genetic analysis of the development of dry eye disease of different origin.
    Abstract One of the etiological causes of dry eye disease (DED) is systemic autoimmune diseases (AID): primary Sjögren's syndrome (PSS), rheumatoid arthritis (RA); their manifestation may begin with ophthalmic symptoms. The relationship of PSS and RA with genetic factors is proven. The contribution of polymorphic markers of the genes
    Purpose: The aim of the study was to determine the prognostic significance of a panel of polymorphic gene markers in the development of dry eye syndrome in patients with primary Sjögren's syndrome and rheumatoid arthritis over a five-year follow-up period.
    Material and methods: Patients with a verified diagnosis of PSS and RA without signs of DED were examined (
    Results: Dry eye disease had developed in groups of patients with AID with predisposing genotypes of polymorphic markers of the genes
    Conclusion: Genetic research methods are essential for minimally invasive early diagnosis of dry eye disease, and can subsequently become the basis for a personalized approach to its treatment.
    MeSH term(s) Humans ; Sjogren's Syndrome/genetics ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/genetics ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/genetics ; Genotype ; Prognosis ; Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics
    Chemical Substances PTPN22 protein, human (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 (EC 3.1.3.48)
    Language Russian
    Publishing date 2024-01-18
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 962921-x
    ISSN 0042-465X
    ISSN 0042-465X
    DOI 10.17116/oftalma202313906113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Rol' mikroRNK v patogeneze zabolevanii, svyazannykh s narusheniem funktsii sleznoi zhelezy.

    Safonova, T N / Zaitseva, G V / Burdenny, A M

    Vestnik oftalmologii

    2023  Volume 139, Issue 3, Page(s) 112–118

    Abstract: At this time, the mechanism causing lacrimal gland dysfunction is not understood completely. In diseases associated with lacrimal gland involvement (Sjogren's syndrome, sarcoidosis, IgG4-associated disease, etc.) patients have been observed to experience ...

    Title translation The role of miRNA in the pathogenesis of diseases associated with functional dysregulation of the lacrimal gland.
    Abstract At this time, the mechanism causing lacrimal gland dysfunction is not understood completely. In diseases associated with lacrimal gland involvement (Sjogren's syndrome, sarcoidosis, IgG4-associated disease, etc.) patients have been observed to experience elevated cellular apoptosis, active production of autoantibodies to glandular tissue, increased level of pro-inflammatory cytokines, functional disruption of signaling molecules leading to changes in tear production. Difficulties in differential diagnosis of lacrimal gland dysfunction in above-listed diseases are associated, on the one hand, with similarity of the clinical picture of ophthalmological manifestations, and on the other hand - with complicated morphological interpretation of changes in the glandular tissues. In this view, miRNA is a promising diagnostic and prognostic marker that would help with differential diagnosis as well as with choosing the treatment tactics. Methods of molecular profiling and identification of "molecular phenotypes" of lacrimal gland and ocular surface damage will allow the use of miRNA as biomarkers and prognostic factors for personalized treatment.
    MeSH term(s) Humans ; Lacrimal Apparatus/pathology ; MicroRNAs/genetics ; MicroRNAs/therapeutic use ; Sjogren's Syndrome/complications ; Lacrimal Apparatus Diseases/etiology ; Lacrimal Apparatus Diseases/genetics ; Cytokines
    Chemical Substances MicroRNAs ; Cytokines
    Language Russian
    Publishing date 2023-06-28
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 962921-x
    ISSN 0042-465X
    ISSN 0042-465X
    DOI 10.17116/oftalma2023139031112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Evolyutsiya metodov diagnostiki sindroma sukhogo glaza.

    Safonova, T N / Zaitseva, G V / Kintyukhina, N P

    Vestnik oftalmologii

    2023  Volume 139, Issue 3. Vyp. 2, Page(s) 81–89

    Abstract: This article reviews modern functional and instrumental examination methods included in the diagnostic algorithm for dry eye disease. The described methods can serve as an objective criterion for the effectiveness of the therapy. ...

    Title translation Evolution of dry eye disease diagnostics.
    Abstract This article reviews modern functional and instrumental examination methods included in the diagnostic algorithm for dry eye disease. The described methods can serve as an objective criterion for the effectiveness of the therapy.
    MeSH term(s) Humans ; Dry Eye Syndromes/diagnosis ; Tears
    Language Russian
    Publishing date 2023-05-05
    Publishing country Russia (Federation)
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 962921-x
    ISSN 0042-465X
    ISSN 0042-465X
    DOI 10.17116/oftalma202313903281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Molekuliarno-geneticheskie issledovaniia v prognoze techeniia sukhogo keratokon''iunktivita.

    Safonova, T N / Zaitseva, G V

    Vestnik oftalmologii

    2018  Volume 134, Issue 3, Page(s) 108–115

    Abstract: The article reviews the results of Russian and foreign studies concerning the search of susceptibility genes for widespread multifactorial diseases: Sjogren's syndrome and rheumatoid arthritis. Studying regularity patterns of genome changes in autoimmune ...

    Title translation Molecular genetic examination for dry eye syndrome prognosis.
    Abstract The article reviews the results of Russian and foreign studies concerning the search of susceptibility genes for widespread multifactorial diseases: Sjogren's syndrome and rheumatoid arthritis. Studying regularity patterns of genome changes in autoimmune processes with ophthalmic manifestations and their correlation with the severity of dry keratoconjunctivitis will contribute to a better understanding of the etiology and pathogenesis of eye manifestations of the diseases, and will also allow the development of new effective methods of diagnosis and targeted therapy.
    MeSH term(s) Dry Eye Syndromes/diagnosis ; Humans ; Keratoconjunctivitis ; Prognosis ; Russia ; Sjogren's Syndrome
    Language Russian
    Publishing date 2018-07-19
    Publishing country Russia (Federation)
    Document type Journal Article ; Review
    ZDB-ID 962921-x
    ISSN 0042-465X
    ISSN 0042-465X
    DOI 10.17116/oftalma20181343108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Assotsiatsiya polimorfnykh markerov rs7947461 gena TRIM21 i rs33996649 gena PTPN22 s riskom razvitiya sindroma sukhogo glaza ekzogennoi etiologii.

    Safonova, T N / Zaitseva, G V / Burdennyy, A M / Loginov, V I

    Vestnik oftalmologii

    2021  Volume 137, Issue 5. Vyp. 2, Page(s) 217–223

    Abstract: In this age of technological advancement, an increasing number of people is being exposed to external risk factors of damaging their ocular surface (wearing contact lenses, electromagnetic radiation from computers, mobile devices, etc.). However, the ... ...

    Title translation Association of polymorphic markers rs7947461 of the TRIM21 gene and rs33996649 of the PTPN22 gene with the risk of developing exogenous dry eye syndrome.
    Abstract In this age of technological advancement, an increasing number of people is being exposed to external risk factors of damaging their ocular surface (wearing contact lenses, electromagnetic radiation from computers, mobile devices, etc.). However, the presence of external factors does not lead to a 100% risk of developing the dry eye disease (DED). The trigger mechanism in the development of autoimmune lesions of the ocular environment in some systemic diseases is known to be associated with molecular genetic factors. The search for molecular genetic disorders is based on the analysis of polymorphic markers of a number of genes responsible for the state of the eye surface.
    Purpose: To study the relationship of polymorphic markers rs7947461 of the
    Material and methods: The study included 57 people with exogenous risk factors for DED development. The control group included volunteers without a history of ophthalmic pathologies (
    Results: In the course of the study, 31 patients of the main group were diagnosed with DED and separated into the 1st subgroup; DED diagnosis was not confirmed in 26 patients, who were put into the 2nd subgroup. The 1st subgroup showed a significant increase in the frequency of predisposing genotypes of the
    Conclusion: The revealed association of polymorphic markers rs7947461 of the
    MeSH term(s) Biomarkers ; Contact Lenses ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/genetics ; Genotype ; Humans ; Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics ; Ribonucleoproteins/genetics ; Risk Factors
    Chemical Substances Biomarkers ; Ribonucleoproteins ; SS-A antigen ; PTPN22 protein, human (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 (EC 3.1.3.48)
    Language Russian
    Publishing date 2021-09-07
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 962921-x
    ISSN 0042-465X
    ISSN 0042-465X
    DOI 10.17116/oftalma2021137052217
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  7. Article: Polimorfnye markery nekotorykh genov v razvitii sukhogo keratokon''iunktivita u patsientov s revmatoidnym artritom i sindromom Shegrena.

    Safonova, T N / Zaitseva, G V / Burdenniy, A M

    Vestnik oftalmologii

    2019  Volume 135, Issue 5. Vyp. 2, Page(s) 254–259

    Abstract: The article reviews literature on relationships between polymorphic variants of the genes THBS1, GTF2I, MUC1, TRIM21, STAT4, PTPN22 with clinical features of dry keratoconjunctivitis in rheumatoid arthritis and Sjogren's syndrome. The development and ... ...

    Title translation Polymorphic markers of certain genes in the development of dry keratoconjunctivitis in patients with rheumatoid arthritis and Sjogren's syndrome.
    Abstract The article reviews literature on relationships between polymorphic variants of the genes THBS1, GTF2I, MUC1, TRIM21, STAT4, PTPN22 with clinical features of dry keratoconjunctivitis in rheumatoid arthritis and Sjogren's syndrome. The development and implementation of a method for analyzing polymorphic gene variants used to diagnose dry keratoconjunctivitis in rheumatoid arthritis and Sjogren's syndrome will allow assessment of the possibility of developing dry keratoconjunctivitis and/or its progression in patients with autoimmune diseases or in people at risk. Determination of clinical and morphological regularities of dry keratoconjunctivitis in accordance with the revealed molecular and genetic changes will contribute to better understanding of the etiology and pathogenesis of ophthalmological manifestations of autoimmune diseases, and will also help improve the diagnostics and prognosis of dry keratoconjunctivitis.
    MeSH term(s) Arthritis, Rheumatoid ; Biomarkers ; Humans ; Keratoconjunctivitis ; Prognosis ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 ; Sjogren's Syndrome
    Chemical Substances Biomarkers ; PTPN22 protein, human (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 22 (EC 3.1.3.48)
    Language Russian
    Publishing date 2019-11-06
    Publishing country Russia (Federation)
    Document type Journal Article ; Review
    ZDB-ID 962921-x
    ISSN 0042-465X
    ISSN 0042-465X
    DOI 10.17116/oftalma2019135052254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Role of Polymorphic Markers rs1478604, rs2292305, and rs2228262 in THBS1 Gene in the Development of Autoimmune Dry Eye Syndrome.

    Safonova, T N / Surnina, Z V / Zaitseva, G V / Burdennyi, A M / Loginov, V I

    Bulletin of experimental biology and medicine

    2020  Volume 169, Issue 5, Page(s) 707–709

    Abstract: An association of polymorphic marker rs2228262 in the THBS1 gene with the risk of developing dry eye in Sjögren syndrome was revealed. Confocal microscopy data suggest that this polymorphic marker is responsible for the high probability of corneal nerve ... ...

    Abstract An association of polymorphic marker rs2228262 in the THBS1 gene with the risk of developing dry eye in Sjögren syndrome was revealed. Confocal microscopy data suggest that this polymorphic marker is responsible for the high probability of corneal nerve fiber lesion in Sjögren syndrome even in the absence of clinical and functional signs of dry eye syndrome. A significant correlation was established between polymorphic markers rs1478604, rs2228262 in THBS1 gene and the coefficients of anisotropy and orientation symmetry of corneal nerve fibers. These results allow considering these polymorphic markers as a genetic factor of predisposition to dry eye syndrome in patients with Sjögren syndrome.
    MeSH term(s) Adult ; Aged ; Cornea/metabolism ; Cornea/pathology ; Dry Eye Syndromes/metabolism ; Dry Eye Syndromes/pathology ; Female ; Humans ; Male ; Microscopy, Confocal ; Middle Aged ; Sjogren's Syndrome/metabolism ; Sjogren's Syndrome/pathology ; Thrombospondin 1/genetics ; Thrombospondin 1/metabolism
    Chemical Substances Thrombospondin 1 ; thrombospondin-1, human
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390407-6
    ISSN 1573-8221 ; 0007-4888 ; 0365-9615
    ISSN (online) 1573-8221
    ISSN 0007-4888 ; 0365-9615
    DOI 10.1007/s10517-020-04960-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Vzaimosviaz' polimorfizmov gena TRIM21 s tiazhest'iu sukhogo keratokon''iunktivita pri revmatoidnom artrite i bolezni Shegrena.

    Safonova, T N / Zaitseva, G V / Loginov, V I / Burdenniy, A M / Lukina, S S

    Vestnik oftalmologii

    2019  Volume 135, Issue 5. Vyp. 2, Page(s) 192–198

    Abstract: Ophthalmologic manifestation of Sjogren's disease (SD) and rheumatoid arthritis (RA) is dry keratoconjunctivitis (dry eye disease; DED).: Purpose: To study the relationship of polymorphic markers rs7947461 (C/T), rs915956 (C/T), rs4144331 (C/A) of the ...

    Title translation Association of polymorphisms of the TRIM21 gene with the severity of dry keratoconjunctivitis in rheumatoid arthritis and Sjogren's disease.
    Abstract Ophthalmologic manifestation of Sjogren's disease (SD) and rheumatoid arthritis (RA) is dry keratoconjunctivitis (dry eye disease; DED).
    Purpose: To study the relationship of polymorphic markers rs7947461 (C/T), rs915956 (C/T), rs4144331 (C/A) of the TRIM21 gene with the severity of DED in patients with RA and SD.
    Material and methods: The study included 70 patients with RA (n=27) and SD (n=43). The control group consisted of volunteers without a history of RA or SD (n=35). Alleles of the polymorphic marker C660T rs7947461 of the TRIM21 gene were identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method; alleles of the polymorphic marker rs915956 (C/T) and rs4144331 (C/A) of the TRIM21 gene were identified by analyzing DNA melting curves.
    Results: An association was found between the predisposing genotype (TT) of rs7947461 polymorphic marker and the risk of developing severe DED. The AA genotype of rs4144331 polymorphic marker was found only in severe DED (c
    Conclusion: An association was established between rs7947461 (rs660) and rs4144331 and the risk of developing severe DED.
    MeSH term(s) Alleles ; Arthritis, Rheumatoid/genetics ; Genetic Predisposition to Disease ; Genotype ; Humans ; Keratoconjunctivitis/genetics ; Polymorphism, Genetic ; Ribonucleoproteins/genetics ; Sjogren's Syndrome/genetics
    Chemical Substances Ribonucleoproteins ; SS-A antigen
    Language Russian
    Publishing date 2019-11-06
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 962921-x
    ISSN 0042-465X
    ISSN 0042-465X
    DOI 10.17116/oftalma2019135052192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Protivovirusnaia aktivnost' 2'-dezoksi-2'-ftorguanozina v otnoshenii virusov grippa i prostogo gerpesa v kul'turakh kletok.

    Boreko, I / Pavlova, N I / Zaĭtseva, G V / Mikhaĭlopulo, I A

    Voprosy virusologii

    2001  Volume 46, Issue 5, Page(s) 40–42

    Abstract: High antiviral activity of 2'-deoxy-2'fluoroguanosine (2'-D-2'-FG) was observed in chicken embryo cells infected with FPV/Rostock/34 (H7N1) influenza virus and herpes simplex virus (HSV) type I (strain 1C). 50% inhibitory concentration (IC50) of 2'-D-2'- ... ...

    Title translation Antiviral activity of 2'-deoxy-2'-fluoroguanosine against influenza and herpes simplex viruses in cultured cells.
    Abstract High antiviral activity of 2'-deoxy-2'fluoroguanosine (2'-D-2'-FG) was observed in chicken embryo cells infected with FPV/Rostock/34 (H7N1) influenza virus and herpes simplex virus (HSV) type I (strain 1C). 50% inhibitory concentration (IC50) of 2'-D-2'-FG was 1.44 microM for FPV and 0.093 microM for HSV. IC50 of remantadine hydrochloride, ribavirin (FPV), and acycloguanosine (HSV) were < 0.46, 14.4, and 0.08 microM, respectively. Anti-HSV activity was confirmed in Vero cells: IC50 < 0.34 microM for 2'-D-2'-FG and IC50 < 0.044 microM for acycloguanosine.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Cercopithecus aethiops ; Chick Embryo ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/pharmacology ; Herpesvirus 1, Human/drug effects ; Microbial Sensitivity Tests ; Orthomyxoviridae/drug effects ; Vero Cells
    Chemical Substances Antiviral Agents ; 2'-deoxy-2'-fluoroguanosine (78842-13-4) ; Deoxyguanosine (G9481N71RO)
    Language Russian
    Publishing date 2001-09
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 201241-8
    ISSN 0507-4088
    ISSN 0507-4088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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