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Article: Letter to: Endometriosis of the rectosigmoid colon mimicking gastrointestinal stromal tumor.

Baharuddin, Dg Marshitah Pg / Hayati, Firdaus / Azizan, Nornazirah / Zakaria, Andee Dzulkarmaen

Turkish journal of surgery

2021 Volume 37, Issue 4, Page(s) 420–421

Language	English
Publishing date	2021-12-31
Publishing country	Turkey
Document type	Journal Article
ISSN	2564-6850
ISSN	2564-6850
DOI	10.47717/turkjsurg.2021.5297
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Article: Hospital-Acquired COVID-19 Infection Increases Morbidity and Mortality: A Case Report of Post-Surgical Challenge of Duodenal Ulcer Repair During COVID-19 Era.

Ghanayem, Jamil F / Zakaria, Andee Dzulkarnaen / Wan Zain, Wan Zainira / Al-Chalabi, Muath Mamdouh Mahmod

Cureus

2022 Volume 14, Issue 2, Page(s) e22646

Abstract: Hospital-acquired infections are nosocomially acquired infections that are not present or incubating at the time of admission to a hospital. During the COVID-19 pandemic, many hospitals became sources of the infection, creating a great challenge for ... ...

Abstract	Hospital-acquired infections are nosocomially acquired infections that are not present or incubating at the time of admission to a hospital. During the COVID-19 pandemic, many hospitals became sources of the infection, creating a great challenge for health care providers and uninfected patients who visited these hospitals seeking medical or surgical advice. We are presenting a middle-aged man who complained of abdominal pain associated with poor oral intake during the COVID-19 pandemic in January 2021. After being diagnosed with a perforated duodenal ulcer, he underwent laparoscopic repair. He was postoperatively referred to interventional radiology for central line insertion. However, as one of the pre-procedure perquisites during the COVID-19 pandemic, he underwent a nasopharyngeal swab real-time PCR test, which was positive for COVID-19 infection to be considered hospital-acquired. This article shows how the pandemic may complicate the post-surgical condition, increasing patient morbidity and mortality.
Language	English
Publishing date	2022-02-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.22646
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Article ; Online: Down Regulated Expression Levels of miR-27b and miR-451a as a Potential Biomarker for Triple Negative Breast Cancer Patients Undergoing TAC Chemotherapy.

Abdul Aziz, Ahmad Aizat / Md Salleh, Md Salzihan / Yahya, Maya Mazuwin / Zakaria, Andee Dzulkarnaen / Ankathil, Ravindran

Asian Pacific journal of cancer prevention : APJCP

2022 Volume 23, Issue 3, Page(s) 1053–1059

Abstract: Background: Triple negative breast cancer (TNBC) is associated with poor prognosis, aggressive phenotype(s) of tumours, partial chemotherapy response, and lack of clinically proven therapies. MicroRNAs (miRNAs) can target and modulate key genes that are ...

Abstract	Background: Triple negative breast cancer (TNBC) is associated with poor prognosis, aggressive phenotype(s) of tumours, partial chemotherapy response, and lack of clinically proven therapies. MicroRNAs (miRNAs) can target and modulate key genes that are involved in TNBC chemotherapy. Deregulated miRNA expression is highly involved in anti-cancer drug resistance phenotype and thus, miRNAs tend to be promising candidates for prediction of chemotherapy response and recurrence. Aim: This study aimed to investigate the expression levels of selected miRNAs (miR-21, miR-27b, miR-34a, miR-182, miR-200c and miR-451a) in cancerous and normal adjacent tissues of TNBC patients and to correlate with the clinicopathological data. Methods: Forty-one (41) FFPE tissue block of histopathologically confirmed TNBC patients was collected. Total RNA from the cancerous and adjacent non-cancerous tissues were isolated, transcribed, and pre-amplified. The relative expression level of miRNAs in tumour and normal adjacent tissues of TNBC patients was analysed using qRT-PCR. Results: Out of six miRNAs studied, the relative expression of miR-27b and miR-451a were found to be significantly lower in cancerous as compared to normal adjacent tissues of TNBC patients. In addition, a significant down regulation of miR-451a was also observed in infiltrating ductal carcinoma subtype, stages I and II, in both grade II and III, premenopausal and postmenopausal as well as in those with positive axillary lymph node metastases. Conclusion: The results suggest the possible utilization of miR-27b and miR-451a expression levels as potential predictive risk markers for TNBC patients undergoing TAC chemotherapy.
MeSH term(s)	Biomarkers, Tumor/genetics ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; MIRN27 microRNA, human ; MIRN451 microRNA, human ; MicroRNAs
Language	English
Publishing date	2022-03-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2022.23.3.1053
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Article: Pneumaturia and faecaluria: Symptoms leading to a life-saving diagnosis.

Wynn, Aye Aye / Yin, Khine San / Mya, Nang Khin / Azizan, Nornazirah / Zakaria, Andee Dzulkarnaen / Hayati, Firdaus

Annals of medicine and surgery (2012)

2022 Volume 79, Page(s) 103967

Abstract: Background: Colonic diverticulosis is often asymptomatic, but it can complicate bleeding, abscess and stricture. Pneumaturia and faecaluria are unexpected manifestations of colonic diverticulitis complicated by colovesical fistula formation.: Case ... ...

Abstract	Background: Colonic diverticulosis is often asymptomatic, but it can complicate bleeding, abscess and stricture. Pneumaturia and faecaluria are unexpected manifestations of colonic diverticulitis complicated by colovesical fistula formation. Case presentation: This case report highlighted a 57-year-old man who presented with lower abdominal pain which was associated with pneumaturia and fecaluria. He was diagnosed with colovesical fistula after being misdiagnosed with other diseases from various clinic visits. Direct fluoroscopy was performed and a diverticular fistula of the sigmoid colon was confirmed by computed tomography of the abdomen. Hartmann's procedure and resection of the posterior wall of the bladder were resected. Conclusion: Pneumaturia and faecaluria are common but distinct manifestations of complicated diverticular diseases. Attention should be paid to general practitioners to achieve proper referral, hence early treatment and prevention of disease-related complications.
Language	English
Publishing date	2022-06-11
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2022.103967
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Article ; Online: Diagnostic Value of Preoperative Haemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score in Predicting Tumour Budding in Colorectal Cancer.

Hidrus, Aizuddin / Abdul Rahim, Syed Sharizman Syed / Zakaria, Andee Dzulkarnaen / Hayati, Firdaus

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2022 Volume 32, Issue 11, Page(s) 1514–1515

Abstract: Null. ...

Abstract	Null.
MeSH term(s)	Humans ; Prognosis ; Lymphocytes/pathology ; Albumins ; Hemoglobins/analysis ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/pathology ; Retrospective Studies
Chemical Substances	Albumins ; Hemoglobins
Language	English
Publishing date	2022-09-07
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2022.11.1514
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Article ; Online: Identification of AOC3 and LRRC17 as Colonic Fibroblast Activation Markers and Their Potential Roles in Colorectal Cancer Progression.

Ahmad Zawawi, Sahira Syamimi / Mohd Azram, Nur Azlien Shahira / Sulong, Sarina / Zakaria, Andee Dzulkarnaen / Lee, Yeong Yeh / Che Jalil, Nur Asyilla / Musa, Marahaini

Asian Pacific journal of cancer prevention : APJCP

2023 Volume 24, Issue 9, Page(s) 3099–3107

Abstract: Background: Accumulation of cancer-associated fibroblasts (CAFs) in the tumor stroma is linked to poor prognosis in colorectal cancer (CRC). CAF-cancer cell interplay, facilitated by secretomes including transforming growth factor-beta 1 (TGF-β1), ... ...

Abstract	Background: Accumulation of cancer-associated fibroblasts (CAFs) in the tumor stroma is linked to poor prognosis in colorectal cancer (CRC). CAF-cancer cell interplay, facilitated by secretomes including transforming growth factor-beta 1 (TGF-β1), supports fibroblast activation, drives colorectal carcinogenesis, and contributes to CRC aggressive phenotypes. Although widely used, traditional CAF biomarkers are found to have heterogeneous and non-specific expression. Amine oxidase copper containing 3 (AOC3) and leucine-rich repeat-containing 17 (LRRC17) have been reported to be emerging markers of myofibroblasts. Aim: Our objective was to investigate the potential of AOC3 and LRRC17 as biomarkers for fibroblast activation thus predicting their roles in CRC progression. Methods: Immunofluorescence (IF) staining of AOC3 and LRRC17 was performed on myofibroblast line (CCD-112CoN), primary fibroblasts from colorectal tumor (CAFs), and adjacent normal tissue (normal fibroblasts-NFs). SW620 (epithelial CRC cell line) was used as a control. Conventional CAF biomarker (alpha-smooth muscle actin - α-SMA) was included in the IF analysis. Fluorescence intensity was compared between groups using ImageJ software. Proliferation and contractility of treated cells were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and collagen gel contraction assays, respectively. Fibroblast contraction under TGF-β1 treatment was compared to those treated with complete medium (addition of 10% serum) and serum free (SF) medium. Results: Positive AOC3, LRRC17, and α-SMA expression were observed in colonic fibroblasts, more prominent in CAFs, whereas negative staining was found in SW620. Significant downregulation of AOC3, and upregulations in LRRC17 and α-SMA expression was found in TGF-β1-treated fibroblasts compared to SF medium treatment (p-value<0.05). All fibroblasts exhibited higher proliferation in complete medium and under treatment with conditioned medium from SW620 than SF medium. Significant contraction of NFs was recorded in complete medium and TGF-β1 (p-value<0.01). Conclusion: Our results demonstrate AOC3 and LRRC17 as the potential markers of CAF activation which promote CRC progression.
MeSH term(s)	Humans ; Transforming Growth Factor beta1/metabolism ; Fibroblasts/pathology ; Colorectal Neoplasms/pathology ; Actins/metabolism ; Biomarkers/metabolism ; Cancer-Associated Fibroblasts/metabolism
Chemical Substances	Transforming Growth Factor beta1 ; Actins ; Biomarkers
Language	English
Publishing date	2023-09-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2023.24.9.3099
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Article ; Online: Genetic Association of CYP1B1 4326 C>G Polymorphism with Disease-Free Survival in TNBC Patients Undergoing TAC Chemotherapy Regimen.

Abdul Aziz, Ahmad Aizat / Md Salleh, Md Salzihan / Yahya, Maya Mazuwin / Zakaria, Andee Dzulkarnaen / Ankathil, Ravindran

Asian Pacific journal of cancer prevention : APJCP

2021 Volume 22, Issue 4, Page(s) 1319–1324

Abstract: Background: Triple negative breast cancer (TNBC) which is treated with taxane, adriamycin and cyclophosphamide (TAC) chemotherapy regimen show variation in treatment response. CYP1B1 4326 C>G polymorphism has been implicated in contributing to the ... ...

Abstract	Background: Triple negative breast cancer (TNBC) which is treated with taxane, adriamycin and cyclophosphamide (TAC) chemotherapy regimen show variation in treatment response. CYP1B1 4326 C>G polymorphism has been implicated in contributing to the differences in treatment response in various types of cancers. Aim: The objective of the present study was to investigate whether this polymorphism modulate the risk of disease recurrence in TNBC patients undergoing TAC chemotherapy regimen. Methods: Blood samples of 76 immunohistochemistry confirmed TNBC patients were recruited. The genotyping of CYP1B1 4326 C>G polymorphism was carried out using PCR-RFLP technique. The genotype patterns were categorized into homozygous wildtype, heterozygous and homozygous variant. Kaplan-Meier analysis followed by Cox proportional hazard regression model were performed to evaluate the TNBC patients' recurrence risk. Results: Out of 76 TNBC patients, 25 (33.0%) showed disease recurrence after one-year evaluation. Kaplan Meier analysis showed that TNBC patients who are carriers of CYP1B1 4326 GG variant genotypes (37.0%) had a significantly lower probability of disease-free rates as compared to TNBC patients who are carriers of CYP1B1 4326 CC/CG genotypes (71.0%). Univariate and multivariate Cox analysis demonstrated that TNBC patients who carried CYP1B1 4326 GG variant genotype had a significantly higher risk of recurrence with HR: 2.50 and HR: 4.18 respectively, even after adjustment as compared to TNBC patients who were carriers of CYP1B1 4326 CC and CG genotypes. Conclusion: Our results demonstrate the potential use of CYP1B1 4325 GG variant genotype as a candidate biomarker in predicting risk of recurrence in TNBC patients undergoing TAC chemotherapy regimen.
MeSH term(s)	Adult ; Antineoplastic Agents/therapeutic use ; Bridged-Ring Compounds/therapeutic use ; Cyclophosphamide/therapeutic use ; Cytochrome P-450 CYP1B1/genetics ; Disease-Free Survival ; Doxorubicin/therapeutic use ; Female ; Genotype ; Humans ; Malaysia ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/genetics ; Polymorphism, Single Nucleotide/genetics ; Taxoids/therapeutic use ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/mortality
Chemical Substances	Antineoplastic Agents ; Bridged-Ring Compounds ; Taxoids ; taxane (1605-68-1) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; CYP1B1 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP1B1 (EC 1.14.14.1)
Language	English
Publishing date	2021-04-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2021.22.4.1319
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Article ; Online: Traumatic Neck Injury: An Accidental Impalement by a Needlefish.

Ali, Aishath Azna / Gurung, Rajan / Hayati, Firdaus / Zakaria, Andee Dzulkarnaen / Mohamad, Irfan / Ching, Fui Fui

Wilderness & environmental medicine

2021 Volume 32, Issue 4, Page(s) 517–521

Abstract: Encounters between marine animals and humans can result in critical injury and fatal complications. We highlight a 20-y-old male who sustained a penetrating injury to the neck as a result of impalement by needlefish (Tylosurus sp) while snorkeling. He ... ...

Abstract	Encounters between marine animals and humans can result in critical injury and fatal complications. We highlight a 20-y-old male who sustained a penetrating injury to the neck as a result of impalement by needlefish (Tylosurus sp) while snorkeling. He sustained a penetrating injury in the posterior triangle of the neck. On presentation, he was stabilized and received empirical antibiotics, analgesia, and antitetanus toxoid injection before being transferred to a tertiary center. On presentation to the tertiary hospital, the patient was hemodynamically stable with no clinical evidence of injury to surrounding neck structures, and this was confirmed using computed tomography. The patient underwent local wound exploration and retrieval of the needlefish beak under general anesthesia. The wound was left open to heal by secondary intention. The patient was discharged with oral antibiotics and went on to make a complete recovery.
MeSH term(s)	Animals ; Beloniformes ; Humans ; Male ; Neck Injuries/etiology ; Tomography, X-Ray Computed ; Wounds, Penetrating/etiology ; Wounds, Penetrating/surgery
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	1238909-2
ISSN	1545-1534 ; 1080-6032
ISSN (online)	1545-1534
ISSN	1080-6032
DOI	10.1016/j.wem.2021.07.006
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Article: Twisted Mesenteric Leiomyoma Mimicking Acute Appendicitis.

Mohd Isa, Mohammad Izwan / Zakaria, Andee Dzulkarnaen / Wan Zain, Wan Zainira / Wan Ab Rahman, Wan Suriza / Awg Isa, Junaidi

Cureus

2022 Volume 14, Issue 5, Page(s) e25260

Abstract: Leiomyoma is a benign tumor of smooth muscles and can essentially arise from any part of the body that contains smooth muscles. It is more commonly found in the uterus, while those from the gastrointestinal tract are rare. The spectrum of clinical ... ...

Abstract	Leiomyoma is a benign tumor of smooth muscles and can essentially arise from any part of the body that contains smooth muscles. It is more commonly found in the uterus, while those from the gastrointestinal tract are rare. The spectrum of clinical presentation is rather wide, from a vague abdominal discomfort or acute abdomen mimicking more common diagnoses such as acute appendicitis or acute gastroenteritis to features of intestinal obstruction and gastrointestinal bleeding. Here, we share our experience with a case of a young woman whose symptoms and signs were typical of acute appendicitis, which intraoperatively turned out to be a twisted mesenteric tumor located at 70 cm from duodenojejunal flexure. The tumor was managed by segmental resection and anastomosis. She had an uneventful recovery postoperatively, and histopathological examination of the surgical specimen was consistent with an infarcted mesenteric leiomyoma. The rarity of this entity mimicking appendicitis is highlighted, and should it never get twisted, it would have probably remained unnoticed for the rest of her life. In the current era of laparoscopy, it is always wise to never skip a thorough examination of the whole length of the small bowel in order to locate this type of pathology.
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.25260
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Article: Giant solitary juvenile polyp: from obstructed defecation syndrome to incontinence.

Teoh, Zhan Huai / Soh, Jien Yen / Mohamad, Nasibah / Zawawi, Norzaliana / Zakaria, Andee Dzulkarnaen / Zakaria, Zaidi / Wong, Michael Pak-Kai

Annals of coloproctology

2022

Abstract: Juvenile polyps (JPs) are the most common polyps in pediatric patients. We present the case of an 18-year-old male patient with a giant solitary JP resembling solitary rectal ulcer syndrome (SRUS). The presenting history was rectal bleeding and symptoms ... ...

Abstract	Juvenile polyps (JPs) are the most common polyps in pediatric patients. We present the case of an 18-year-old male patient with a giant solitary JP resembling solitary rectal ulcer syndrome (SRUS). The presenting history was rectal bleeding and symptoms of obstructed defecation syndrome. Colonoscopy revealed a polypoidal mass at the anorectal junction, with biopsy-confirmed SRUS. The symptoms worsened, and a protruding mass from the anus caused fecal incontinence. Pelvic magnetic resonance imaging showed a huge pedunculated mass occupying the low rectum with local compression of the urinary bladder. Transanal excision of the anal tumor was performed due to bleeding. A histopathological examination showed a JP with high-grade dysplasia. A histological examination to differentiate JPs and SRUS could be challenging based on a superficial forceps biopsy. Therefore, an excision biopsy is usually warranted with the understanding that adenomatous or malignant transformation is found in 5.6% to 12% of all JPs.
Language	English
Publishing date	2022-11-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2711906-3
ISSN	2287-9722 ; 2287-9714
ISSN (online)	2287-9722
ISSN	2287-9714
DOI	10.3393/ac.2022.00549.0078
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