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  1. Article: Sirolimus

    Ahmed, Faiza / Zakaria, Faiza / Enebong Nya, Godsgift / Mouchli, Mohamad

    World journal of gastrointestinal surgery

    2022  Volume 14, Issue 8, Page(s) 862–866

    Abstract: Liver transplantation (LT) withstands as the most preferred therapeutic option for patients afflicted with hepatocellular carcinoma (HCC) and cirrhosis. To improve prognosis post-transplant, as well as to prevent the occurrence of rejection, a life-long ... ...

    Abstract Liver transplantation (LT) withstands as the most preferred therapeutic option for patients afflicted with hepatocellular carcinoma (HCC) and cirrhosis. To improve prognosis post-transplant, as well as to prevent the occurrence of rejection, a life-long immunosuppression strategy is implemented. The following letter to the editor highlights and provides novel evidence from recently published literature on topics discussed within the review article titled "Trends of rapamycin in survival benefits of liver transplantation for hepatocellular carcinoma" in
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v14.i8.862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association between sex and Huntington's disease: an updated review on symptomatology and prognosis of neurodegenerative disorders.

    Hasnain, Nimra / Arif, Taha Bin / Shafaut, Roha / Zakaria, Faiza / Fatima, Syeda Zainab / Haque, Ibtehaj Ul

    Wiener medizinische Wochenschrift (1946)

    2022  Volume 174, Issue 5-6, Page(s) 87–94

    Abstract: Huntington's disease is a rare autosomal dominant disorder presenting with chorea, rigidity, hypo-/akinesia, cognitive decline, and psychiatric disturbances. Numerous risk factors have been defined in the onset of this disease. However, the number of CAG ...

    Title translation Zusammenhang zwischen Geschlecht und Huntington-Chorea: aktualisierte Übersicht zur Symptomatologie und Prognose neurodegenerativer Erkrankungen.
    Abstract Huntington's disease is a rare autosomal dominant disorder presenting with chorea, rigidity, hypo-/akinesia, cognitive decline, and psychiatric disturbances. Numerous risk factors have been defined in the onset of this disease. However, the number of CAG repeats in the genes are the most crucial factor rendering patients susceptible to the disease. Studies have shown significant differences in onset and disease presentation among the sexes, which prompts analysis of the impact of different sexes on disease etiology and progression. This article therefore discusses the evidence-based role of sex in aspects of symptomatology, pathogenesis, biomarkers, progression, and prognosis of Huntington's disease, with a secondary review of sex-linked differences in Alzheimer's and Parkinson's disease.
    MeSH term(s) Humans ; Huntington Disease/diagnosis ; Huntington Disease/genetics ; Huntington Disease/psychology ; Prognosis
    Language English
    Publishing date 2022-06-20
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-022-00941-2
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  3. Article: Home Isolated COVID-19 Patients Adhering To Recommended Guidelines: A Cross Sectional Survey In Karachi.

    Luxmi, Shobha / Obaid, Munazza / Zia, Sadaf / Siddiqui, Fatima Zulfiqar / Barry, Musfirah Danyal / Zaheer, Saba / Zakaria, Faiza

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73, Issue 11, Page(s) 2157–2160

    Abstract: Objectives: To assess compliance level of coronavirus disease-2019 patients with recommended isolation guidelines.: Methods: The cross-sectional phone-based survey was conducted in Karachi, from March to October 2020 after approval from the ethics ... ...

    Abstract Objectives: To assess compliance level of coronavirus disease-2019 patients with recommended isolation guidelines.
    Methods: The cross-sectional phone-based survey was conducted in Karachi, from March to October 2020 after approval from the ethics review board of Dow University of Health Sciences, Karachi, and comprised patients of either gender who had been tested positive and were advised home isolation due to mild/asymptomatic nature of their infection. Data was collected using a predesigned 42-item questionnaire in the light of the guidelines issued by the National Institutes of Health, Islamabad, Pakistan. Data was analysed using SPSS 20.
    Results: Of the 450 patients approached, 305(68%) responded; 176(57.7%) females and 129(41.1%) males. The overall mean age was 35.16±14.15 years (range: 13-78 years). Of the total, 9(2.95%) patients did not isolate themselves at all, 51(16.7%) came into contact with other people, 75(24.6%) broke the home isolation and 69(22.6%) were sharing their rooms with other family members. Overall, 260(85.2%) participants were keeping themselves updated with the changes in the guidelines through conventional and social media.
    Conclusions: Coronavirus disease-2019 patients who were advised home isolation adhered to some but not all of the recommendations.
    MeSH term(s) Male ; Female ; Humans ; Young Adult ; Adult ; Middle Aged ; COVID-19 ; Cross-Sectional Studies ; SARS-CoV-2 ; Pakistan/epidemiology ; Family
    Language English
    Publishing date 2023-11-27
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.6821
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  4. Article ; Online: Meta-Analysis of Racial Disparity in Utilization of Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation.

    Shahid, Izza / Usman, Muhammad Shariq / Siddiqi, Tariq Jamal / Zakaria, Faiza / Alkhouli, Mohamad

    The American journal of cardiology

    2021  Volume 153, Page(s) 147–149

    MeSH term(s) African Americans/statistics & numerical data ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; European Continental Ancestry Group/statistics & numerical data ; Factor Xa Inhibitors/therapeutic use ; Healthcare Disparities/ethnology ; Humans ; Stroke/etiology ; Stroke/prevention & control
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Letter ; Meta-Analysis
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2021.05.008
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  5. Article: The Frequency of Refractory Status Epilepticus and Its Outcome in a Tertiary Care Hospital in Pakistan: A Retrospective Study.

    Mansoor, Aisha / Kumar, Sahlish / Malik, Laraib / Razak, Sufyan / Sulaiman, Reem / Fatima, Qandeel / Zakaria, Faiza / Iqbal, Ayman / Yasmin, Farah / Malik, Farheen

    Cureus

    2022  Volume 14, Issue 9, Page(s) e29149

    Abstract: Background Refractory status epilepticus (RSE) is a common neurologic emergency with refractory cases leading to increased rates of morbidity and mortality in patients. The lack of previous studies on the incidence, causes, and management of refractory ... ...

    Abstract Background Refractory status epilepticus (RSE) is a common neurologic emergency with refractory cases leading to increased rates of morbidity and mortality in patients. The lack of previous studies on the incidence, causes, and management of refractory status epilepticus in the pediatric population from our region prompted us to investigate further in this study. Methods We included retrospective data of all patients admitted to the pediatric intensive care unit (PICU) with a provisional diagnosis of RSE at a tertiary care hospital in Karachi from February 2019 to February 2021. No personal identification data was used, and confidentiality of the data was maintained throughout the analysis. The Statistical Package for the Social Sciences (SPSS) software version 22.0 (IBM SPSS Statistics, Armonk, NY, USA) was used to pool data and perform a descriptive analysis. Results Among the 687 patients who presented to the PICU with seizures, 50 (7.27%) patients were eventually diagnosed with RSE during the two-year period. The majority of the patients were male and less than one year of age. Infectious causes predominated our data cohort, and a four-drug regimen consisting of phenytoin, levetiracetam, valproic acid, and midazolam was able to terminate RSE in the majority of the patients in our setting (70%). The mortality rate was noted to be 22% among patients with RSE. Conclusion Morbidity and mortality among pediatric RSE patients are high in our settings. Urgent emergency services and timely cause-directed intervention could improve outcomes.
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.29149
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  6. Article ; Online: Cystic Fibrosis Transmembrane Conductance Regulator Protein Modulators in Children and Adolescents with different CF Genotypes - Systematic Review and Meta-Analysis.

    Yousif Hamdan, Alaa Hassan / Zakaria, Faiza / Lourdes Pormento, Maria Kezia / Lawal, Odunayo Susan / Opiegbe, Adaugo / Zahid, Samina / Guntipalli, Prathima / Nasr, Ujala / Hasan Rizvi, Syed Asad

    Current reviews in clinical and experimental pharmacology

    2023  

    Abstract: Objective: To determine the efficacy of the first triple CFTR protein modulators in children and adolescents with cystic fibrosis.: Methods: Systematic review and meta-analysis were conducted, following PRISMA guidelines. The following databases were ...

    Abstract Objective: To determine the efficacy of the first triple CFTR protein modulators in children and adolescents with cystic fibrosis.
    Methods: Systematic review and meta-analysis were conducted, following PRISMA guidelines. The following databases were searched extensively: PubMed/Medline, Clinical trials.gov, Google Scholar, Scopus, Embase, and Europe PMC using the keywords: "Ivacaftor," "Elexacaftor," "Tezacaftor," VX_661", VX_770", "VX_445", "cystic fibrosis". A total of ten randomized clinical trials were included in our analysis. Primary outcomes included: Absolute change in predicted FEV1 from baseline, Absolute change in sweat chloride test from baseline, Absolute change in BMI from baseline, Absolute change in CF-QR from baseline, and Adverse Events.
    Results: Among primary findings, significant absolute change in predictive FEV1 from baseline through 4 weeks favoured the triple CFTR protein modulators. [MD=11.80,95%CI=8.47_15.12, p value=<0.00001]; as well as CF_QR score [MD=0.00,95%CI=-2.50_2.50, p value=1.00], and BMI kg/m² change [MD=16.90,95%CI=12.73_21.06, p value=<0.00001]. No significant change was noted for CFTR channels activity in the treatment group when compared to placebo or VX_770/VX_661 [MD= -12.57,95%CI=-94.46_69.32, p value=0.76].
    Conclusion: In children aged ≥ 6 y old and adolescents with F508del_CFTR mutation, Elexacaftor-Tezacaftor-Ivacaftor tend to be more effective than first-generation therapy, demonstrating promising results by exhibiting significant improvement in lung function, body weight, and respiratory-related quality of life.
    Language English
    Publishing date 2023-02-01
    Publishing country Netherlands
    Document type Meta-Analysis
    ISSN 2772-4336
    ISSN (online) 2772-4336
    DOI 10.2174/2772432818666230201094115
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  7. Article: Information Seeking Practices and Availability of Smart Devices Among Healthcare Professionals in a Lower-Middle-Income Country: An Analysis From Pakistan.

    Razak, Sufyan / Bai, Shilpa / Zakaria, Faiza / Ali, Mustafa / Rashmi, Fnu / Sulaiman, Reem / Jangda, Ayesha Altaf / Tyagi, Ashish / Nima, Fnu / Rizvi, Syed Asad Hasan

    Cureus

    2022  Volume 14, Issue 10, Page(s) e30771

    Abstract: Introduction Evidence-based medicine (EBM) is a principle that integrates clinical experience with relevant information available to provide adequate healthcare. It requires access to current medical literature. This paper analyzes the information ... ...

    Abstract Introduction Evidence-based medicine (EBM) is a principle that integrates clinical experience with relevant information available to provide adequate healthcare. It requires access to current medical literature. This paper analyzes the information requirements of a lower-middle-income country (LMIC) and the resources available and preferred by medical professionals. Methods A survey-based cross-sectional study was carried out among 160 participants, ranging in expertise from students to attending physicians in Karachi, Pakistan. The survey comprised questions to assess the clinical background, technology access, need for health-related information, and the preference for resources to obtain that information in different scenarios. They were also asked if they use PubMed and their recommended methods to improve information access. Statistical Package for the Social Sciences (SPSS; IBM, NY, USA) software was used for all analyses. Results A basic mobile phone (with limited internet connectivity) was the most common device used at home (n=159; 99.4%) and work (n=141; 88.1%). No smart devices were available to 28 (17.5%) participants at work. Internet connectivity was available for 155 (96.9%) participants at home but only for 118 (73.7%) participants at work. About one-third (n=49; 30.6%) experienced questions arising in practice two to four times a day, and half of the participants (n=80; 50%) were very likely to look up a reference. The most common resource for the majority of given clinical scenarios was a senior colleague. At the same time, medical websites (Medscape, Up-to-Date, WebMD) were the first choice for a non-specific general medical query. About 68.75% (n=110) of participants claimed to use PubMed in daily practice. The most common reason for not using PubMed was the ease of using other search engines (like Google). Conclusions Improved access to the internet and well-reputed journals can enhance the practice of EBM in Pakistan. Limitations of technological access must be considered while designing information resources in lower-middle-income countries.
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.30771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Influence of Tomographic Corneal Characteristics on Epithelial Thickness Profile.

    Hashmani, Nauman / Hashmani, Maria / Hashmani, Sharif / Fatima, Kiran / Farid, Neha / Zakaria, Faiza / Qazi, Mujtaba A

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11731

    Abstract: Purpose To understand the influence of tomographic corneal characteristics on the epithelium of normal eyes. Methods We scanned a total of 98 eyes of 98 individuals using anterior segment tomography and a spectral-domain optical coherence tomography (OCT) ...

    Abstract Purpose To understand the influence of tomographic corneal characteristics on the epithelium of normal eyes. Methods We scanned a total of 98 eyes of 98 individuals using anterior segment tomography and a spectral-domain optical coherence tomography (OCT) epithelial mapping tool. Only eyes with no previous pathology were included, with a refractive range of +5 diopters (D) to -6 D, intraocular pressure of < 22 mmHg, and no evidence of dry eye (Schirmer's test 2 value > 5 mm). Corneal curvature metrics were statistically correlated with regional epithelial thickness parameters. Results The anterior and posterior corneal surface flat and steep axis, the maximum and minimum curvature, corneal topographic astigmatism, astigmatism polar values, and corneal volume had no statistically significant correlation (p>0.05) with the epithelial thickness. Similarly, anterior corneal surface asphericity had no significant correlation. Posterior surface asphericity had a statistically significant moderate correlation with the epithelium in all areas. Similar results were seen in the multivariate analysis. Conclusions None of the front or back surface parameters had any influence on the corneal epithelium except for the posterior surface asphericity. This statistically significant yet clinically insignificant correlation may be enhanced in diseased populations like keratoconus and could indicate epithelial remodeling with early posterior corneal changes.
    Language English
    Publishing date 2020-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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