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Article ; Online: Letter to the Editor Regarding "Safety Analysis of Bilateral Laser Interstitial Thermal Therapy for Treatment of Butterfly Glioma".

Zakaria, Rasheed / Prabhu, Sujit S

2021 Volume 147, Page(s) 236–237

MeSH term(s)	Animals ; Butterflies ; Glioma/surgery ; Humans ; Hyperthermia, Induced ; Lasers
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.10.161
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Article ; Online: Letter: Estimating the baseline local recurrence rate for a brain metastasis after neurosurgical resection.

Suppree, Joshua S / Kannan, Siddarth / Hughes, David M / Jenkinson, Michael D / Zakaria, Rasheed

Clinical & experimental metastasis

2024 Volume 41, Issue 2, Page(s) 155–157

Abstract: Brain metastases represent a growing healthcare challenge with a rising incidence attributed to earlier detection and improved systemic cancer treatments. We conducted a systematic review and meta-analysis to investigate the local recurrence rate ... ...

Abstract	Brain metastases represent a growing healthcare challenge with a rising incidence attributed to earlier detection and improved systemic cancer treatments. We conducted a systematic review and meta-analysis to investigate the local recurrence rate following surgical resection of a brain metastasis without adjuvant therapy. The analysis included four studies with a total of 235 cases. It was found that the rate of local recurrence by 12-months was 48.1% (95% CI 41.2-58.9). These findings underscore the high rate of patients who will experience local recurrence within 12-months of surgery, emphasising the need for vigilant surveillance when omitting adjuvant radiotherapy in favour of systemic treatments with potential but unproven CNS penetrance. The analysis highlights unmet needs in this patient population.
MeSH term(s)	Humans ; Brain Neoplasms/secondary ; Radiotherapy, Adjuvant ; Combined Modality Therapy ; Radiosurgery ; Neoplasm Recurrence, Local/surgery ; Retrospective Studies
Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Letter
ZDB-ID	604952-7
ISSN	1573-7276 ; 0262-0898
ISSN (online)	1573-7276
ISSN	0262-0898
DOI	10.1007/s10585-024-10274-6
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Zs.A 1855: Show issues

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Article ; Online: Challenges Associated with Reoperation in Patients with Glioma.

Zakaria, Rasheed / Weinberg, Jeffrey S

Neurosurgery clinics of North America

2020 Volume 32, Issue 1, Page(s) 129–135

Abstract: Reoperation for glioma is increasingly common but there is neither firm agreement on the indications nor unequivocally proven benefit from clinical trials. Patient and tumor factors should be considered when offering reoperation and a clear surgical goal ...

Abstract	Reoperation for glioma is increasingly common but there is neither firm agreement on the indications nor unequivocally proven benefit from clinical trials. Patient and tumor factors should be considered when offering reoperation and a clear surgical goal set. Reoperation is challenging because of placement of previous incisions, wound devascularization by preceding radiotherapy and/or chemotherapy, chronic steroid use, the need for further adjuvant therapy, and adherent and defective dura. This article reviews indications, challenges, and recommendations for repeat surgery in the patient with glioma.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Brain Neoplasms/diagnosis ; Brain Neoplasms/drug therapy ; Brain Neoplasms/surgery ; Combined Modality Therapy ; Glioma/diagnosis ; Glioma/drug therapy ; Glioma/surgery ; Humans ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/surgery ; Reoperation
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2020-11-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1196855-2
ISSN	1558-1349 ; 1042-3680
ISSN (online)	1558-1349
ISSN	1042-3680
DOI	10.1016/j.nec.2020.09.004
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Se 1200: Show issues

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Article ; Online: Response to "The reliability of routine clinical post-processing software in assessing potential diffusion weighted MRI biomarkers in brain metastases: common mistake".

Zakaria, Rasheed

Magnetic resonance imaging

2014 Volume 32, Issue 9, Page(s) 1162–1163

MeSH term(s)	Algorithms ; Brain Neoplasms/pathology ; Brain Neoplasms/secondary ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Image Interpretation, Computer-Assisted/methods ; Pattern Recognition, Automated/methods ; Software
Language	English
Publishing date	2014-08-08
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	604885-7
ISSN	1873-5894 ; 0730-725X
ISSN (online)	1873-5894
ISSN	0730-725X
DOI	10.1016/j.mri.2014.08.003
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Zs.A 1817: Show issues

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Article: Clinical Presentation and Prognosis.

Millward, Christopher P / Keshwara, Sumirat / Islim, Abdurrahman I / Zakaria, Rasheed / Jenkinson, Michael D

Advances in experimental medicine and biology

2023 Volume 1416, Page(s) 5–20

Abstract: Over the past three decades, the care for patients with meningioma has steadily improved as a result of a better understanding of the natural history, molecular biology, and classification of these tumors. Surgical frameworks for management have been ... ...

Abstract	Over the past three decades, the care for patients with meningioma has steadily improved as a result of a better understanding of the natural history, molecular biology, and classification of these tumors. Surgical frameworks for management have been established and validated with more options for adjuvant and salvage treatment available for patients with residual or recurrent disease. Overall these advances have improved clinical outcomes and prognosis.Alongside the improved clinical management has come an increase in biological understanding of these tumors. The number of publications within the field of meningioma research continues to expand and biological studies identifying molecular factors at the cytogenic and genomic level offer exciting potential for more personalized management strategies. As survival and understanding have increased, treatment outcomes are moving from traditional metrics, which describe the morbidity and mortality to more patient-centered measures. The subjective experiences of patients with meningioma are gaining interest among clinical researchers and it is recognized that even supposedly mild symptoms arising from meningioma can have a significant effect on a patient's quality of life.This chapter reviews the varied clinical presentations of meningioma, which in the modern era of widespread brain imaging must include a discussion of incidental meningioma. The second part examines prognosis and the clinical, pathological, and molecular factors that can be used to predict outcomes.
MeSH term(s)	Humans ; Meningioma/diagnosis ; Meningioma/genetics ; Meningioma/therapy ; Quality of Life ; Adjuvants, Immunologic ; Benchmarking ; Meningeal Neoplasms
Chemical Substances	Adjuvants, Immunologic
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/978-3-031-29750-2_2
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Zs.A 3192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article ; Online: Commentary: preconceptions about the neurosurgical management of brain metastases.

Zakaria, Rasheed / Jenkinson, Michael D

British journal of neurosurgery

2017 Volume 31, Issue 3, Page(s) 295

MeSH term(s)	Brain ; Brain Neoplasms/secondary ; Humans ; Neurosurgical Procedures ; Radiosurgery
Language	English
Publishing date	2017-03-15
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2017.1302074
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Zs.A 2210: Show issues

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Article ; Online: Genomic Alterations and the Incidence of Brain Metastases in Advanced and Metastatic NSCLC: A Systematic Review and Meta-Analysis.

Gillespie, Conor S / Mustafa, Mohammad A / Richardson, George E / Alam, Ali M / Lee, Keng Siang / Hughes, David M / Escriu, Carles / Zakaria, Rasheed

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2023 Volume 18, Issue 12, Page(s) 1703–1713

Abstract: Introduction: Brain metastases (BMs) in patients with advanced and metastatic NSCLC are linked to poor prognosis. Identifying genomic alterations associated with BM development could influence screening and determine targeted treatment. We aimed to ... ...

Abstract	Introduction: Brain metastases (BMs) in patients with advanced and metastatic NSCLC are linked to poor prognosis. Identifying genomic alterations associated with BM development could influence screening and determine targeted treatment. We aimed to establish prevalence and incidence in these groups, stratified by genomic alterations. Methods: A systematic review and meta-analysis compliant with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses were conducted (PROSPERO identification CRD42022315915). Articles published in MEDLINE, EMBASE, and Cochrane Library between January 2000 and May 2022 were included. Prevalence at diagnosis and incidence of new BM per year were obtained, including patients with EGFR, ALK, KRAS, and other alterations. Pooled incidence rates were calculated using random effects models. Results: A total of 64 unique articles were included (24,784 patients with NSCLC with prevalence data from 45 studies and 9058 patients with NSCLC having incidence data from 40 studies). Pooled BM prevalence at diagnosis was 28.6% (45 studies, 95% confidence interval [CI]: 26.1-31.0), and highest in patients that are ALK-positive (34.9%) or with RET-translocations (32.2%). With a median follow-up of 24 months, the per-year incidence of new BM was 0.13 in the wild-type group (14 studies, 95% CI: 0.11-0.16). Incidence was 0.16 in the EGFR group (16 studies, 95% CI: 0.11-0.21), 0.17 in the ALK group (five studies, 95% CI: 0.10-0.27), 0.10 in the KRAS group (four studies, 95% CI: 0.06-0.17), 0.13 in the ROS1 group (three studies, 95% CI: 0.06-0.28), and 0.12 in the RET group (two studies, 95% CI: 0.08-0.17). Conclusions: Comprehensive meta-analysis indicates a higher prevalence and incidence of BM in patients with certain targetable genomic alterations. This supports brain imaging at staging and follow-up, and the need for targeted therapies with brain penetrance.
MeSH term(s)	Humans ; Lung Neoplasms/epidemiology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Incidence ; Protein-Tyrosine Kinases ; Proto-Oncogene Proteins p21(ras) ; Proto-Oncogene Proteins/genetics ; Carcinoma, Non-Small-Cell Lung/epidemiology ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Genomics ; Brain Neoplasms/epidemiology ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Receptor Protein-Tyrosine Kinases/genetics ; ErbB Receptors/genetics
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2023.06.017
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Zs.A 6664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 652: Show issues

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Article ; Online: Immune checkpoint inhibitor treatment of brain metastasis associated with a less invasive growth pattern, higher T-cell infiltration and raised tumor ADC on diffusion weighted MRI.

Zakaria, Rasheed / Jenkinson, Michael D / Radon, Mark / Das, Kumar / Poptani, Harish / Rathi, Nitika / Rudland, Philip S

Cancer immunology, immunotherapy : CII

2023 Volume 72, Issue 10, Page(s) 3387–3393

Abstract: Background: Brain metastases are the most common intracranial tumors with an increasing incidence. They are an important cause of morbidity and mortality in patients with solid organ cancer and a focus of recent clinical research and experimental ... ...

Abstract	Background: Brain metastases are the most common intracranial tumors with an increasing incidence. They are an important cause of morbidity and mortality in patients with solid organ cancer and a focus of recent clinical research and experimental interest. Immune checkpoint inhibitors are being increasingly used to treat solid organ cancers. Methods: To determine whether immune checkpoint inhibitors were biologically effective in the brain, we compared melanoma brain metastasis samples where treatment with ipilimumab had occurred preoperatively to those who had not received any immune modulating therapy and looked for histopathological (invasion, vascularity, metastasis inducing proteins, matrix metalloproteinases, immune cell infiltration, tissue architecture) and advanced MRI differences (diffusion weighted imaging). Results: Co-localized tissue samples from the same regions as MRI regions of interest showed significantly lower vascularity (density of CD34 + vessels) in the core and higher T-cell infiltration (CD3 + cells) in the leading edge for ipilimumab-treated brain metastasis samples than for untreated cases and this correlated with a higher tumor ADC signal at post-treatment/preoperative MRI brain. Conclusions: Treatment of a melanoma brain metastasis with ipilimumab appears to cause measurable biological changes in the tumor that can be correlated with post-treatment diffusion weighted MRI imaging, suggesting both a mechanism of action and a possible surrogate marker of efficacy.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Ipilimumab/therapeutic use ; T-Lymphocytes ; Diffusion Magnetic Resonance Imaging/methods ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Melanoma/diagnostic imaging ; Melanoma/drug therapy ; Melanoma/secondary
Chemical Substances	Immune Checkpoint Inhibitors ; Ipilimumab
Language	English
Publishing date	2023-07-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-023-03499-z
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Article ; Online: Extent of resection predicts risk of progression in adult pilocytic astrocytoma.

Nelson, Andrew J / Zakaria, Rasheed / Jenkinson, Michael D / Brodbelt, Andrew R

British journal of neurosurgery

2019 Volume 33, Issue 3, Page(s) 343–347

Abstract: Object: ...

Abstract	Object:
MeSH term(s)	Adolescent ; Adult ; Aged ; Astrocytoma/mortality ; Astrocytoma/pathology ; Astrocytoma/surgery ; Biopsy ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Disease Progression ; Disease-Free Survival ; Female ; Headache/surgery ; Humans ; Hydrocephalus/mortality ; Hydrocephalus/pathology ; Hydrocephalus/surgery ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Seizures/surgery ; Ventriculostomy/methods ; Ventriculostomy/mortality ; Young Adult
Language	English
Publishing date	2019-01-17
Publishing country	England
Document type	Journal Article ; Video-Audio Media
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2018.1549315
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Zs.A 2210: Show issues

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Article ; Online: The management of incidental meningioma: An unresolved clinical conundrum.

Islim, Abdurrahman I / Millward, Christopher P / Mills, Samantha J / Fountain, Daniel M / Zakaria, Rasheed / Pathmanaban, Omar N / Mathew, Ryan K / Santarius, Thomas / Jenkinson, Michael D

Neuro-oncology advances

2023 Volume 5, Issue Suppl 1, Page(s) i26–i34

Abstract: The widespread availability and use of brain magnetic resonance imaging and computed tomography has led to an increase in the frequency of incidental meningioma diagnoses. Most incidental meningioma are small, demonstrate indolent behavior during follow- ... ...

Abstract	The widespread availability and use of brain magnetic resonance imaging and computed tomography has led to an increase in the frequency of incidental meningioma diagnoses. Most incidental meningioma are small, demonstrate indolent behavior during follow-up, and do not require intervention. Occasionally, meningioma growth causes neurological deficits or seizures prompting surgical or radiation treatment. They may cause anxiety to the patient and present a management dilemma for the clinician. The questions for both patient and clinician are "will the meningioma grow and cause symptoms such that it will require treatment within my lifetime?" and "will deferment of treatment result in greater treatment-related risks and lower chance of cure?." International consensus guidelines recommend regular imaging and clinical follow-up, but the duration is not specified. Upfront treatment with surgery or stereotactic radiosurgery/radiotherapy may be recommended but this is potentially an overtreatment, and its benefits must be balanced against the risk of related adverse events. Ideally, treatment should be stratified based on patient and tumor characteristics, but this is presently hindered by low-quality supporting evidence. This review discusses risk factors for meningioma growth, proposed management strategies, and ongoing research in the field.
Language	English
Publishing date	2023-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdac109
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