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  1. Article ; Online: The "double rectum" sign.

    Igic, Aleksa / Bulatovic, Dusan / Masulovic, Dragan / Filipovic, Aleksandar / Zakosek, Milos

    Abdominal radiology (New York)

    2024  

    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-024-04258-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1262: Show issues Location:
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  2. Article ; Online: Emphysematous Pancreatitis as a Life-Threatening Condition: A Case Report and Review of the Literature.

    Filipović, Aleksandar / Mašulović, Dragan / Bulatović, Dušan / Zakošek, Miloš / Igić, Aleksa / Filipović, Tamara

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 3

    Abstract: Emphysematous pancreatitis represents the presence of gas within or around the pancreas on the ground of necrotizing pancreatitis due to superinfection with gas-forming bacteria. This entity is diagnosed on clinical grounds and on the basis of radiologic ...

    Abstract Emphysematous pancreatitis represents the presence of gas within or around the pancreas on the ground of necrotizing pancreatitis due to superinfection with gas-forming bacteria. This entity is diagnosed on clinical grounds and on the basis of radiologic findings. Computed tomography is the preferred imaging modality used to detect this life-threating condition. The management of emphysematous pancreatitis consists of conservative measures, image-guided percutaneous catheter drainage or endoscopic therapy, and surgical intervention, which is delayed as long as possible and undertaken only in patients who continue to deteriorate despite conservative management. Due to its high mortality rate, early and prompt recognition and treatment of emphysematous pancreatitis are crucial and require individualized treatment with the involvement of a multidisciplinary team. Here, we present a case of emphysematous pancreatitis as an unusual occurrence and discuss disease features and treatment options in order to facilitate diagnostics and therapy.
    MeSH term(s) Humans ; Drainage ; Emphysema/diagnostic imaging ; Emphysema/therapy ; Pancreas/surgery ; Pancreatitis, Acute Necrotizing/diagnosis ; Pancreatitis, Acute Necrotizing/diagnostic imaging ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Review ; Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60030406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The "comma" sign.

    Igic, Aleksa / Masulovic, Dragan / Filipovic, Aleksandar / Zakosek, Milos / Bulatovic, Dusan

    Abdominal radiology (New York)

    2022  Volume 48, Issue 2, Page(s) 818–819

    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-022-03704-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1262: Show issues Location:
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  4. Article ; Online: A case of primary hepatic lymphoma and a review of the literature

    Mašulović Dragan / Filipović Aleksandar / Zakošek Miloš / Bulatović Dušan / Stojadinović Milica

    Srpski Arhiv za Celokupno Lekarstvo, Vol 148, Iss 11-12, Pp 749-

    2020  Volume 752

    Abstract: Introduction. Primary hepatic lymphoma (PHL) is a rare disease and represents lymphoproliferative disorder confined to the liver parenchyma. This condition is difficult to distinguish from other liver diseases. Histopathology is essential and confirms ... ...

    Abstract Introduction. Primary hepatic lymphoma (PHL) is a rare disease and represents lymphoproliferative disorder confined to the liver parenchyma. This condition is difficult to distinguish from other liver diseases. Histopathology is essential and confirms the diagnosis. Treatment options for PHL include surgery, chemotherapy, radiation, or combinations of these modalities. The objective of this this report is to present a case of PHL and to discuss disease features and treatment options in order to facilitate diagnostics and therapy. Case outline. A 72-year-old female was presented with abdominal pain, nausea, weight loss, and fatigue. Computed tomography (CT) revealed hypoattenuating solitary lesion in liver segment VIII. The detected liver lesion showed elevated 2-[fluorine 18] fluoro-2-deoxy-D-glucose uptake on positron emission tomography/CT examination. Extrahepatic disease was not detected. The tumor board opted for surgery, and atypical resection of liver segments VII and VIII was performed. Pathohistological examination of the resected tumor demonstrated liver infiltration with non-Hodgkin’s lymphoma, diffuse large B-cell type. Postoperative recovery was complicated by fluid collections in the right subphrenic space, successfully managed by percutaneous drainage. Subsequently, the patient was treated with chemotherapy and attained a complete remission documented by negative CT findings. Conclusion. PHL can easily be misdiagnosed as another more frequent primary liver tumor due to its non-specific clinical manifestations, laboratory and imaging findings, and therefore should be considered in the differential diagnosis of a hepatic lesion.
    Keywords chemotherapy ; drainage ; liver ; operative ; tumor ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Serbian Medical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Effect of Percutaneous Biliary Drainage on Enzyme Activity of Serum Matrix Metalloproteinase-9 in Patients with Malignant Hilar Obstructive Hyperbilirubinemia.

    Filipović, Aleksandar / Mašulović, Dragan / Gopčević, Kristina / Galun, Danijel / Igić, Aleksa / Bulatović, Dušan / Zakošek, Miloš / Filipović, Tamara

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Matrix Metalloproteinase 9 ; Prospective Studies ; Cholestasis/therapy ; Neoplasms ; Bilirubin ; Drainage/methods ; Hyperbilirubinemia ; Stents ; Treatment Outcome
    Chemical Substances Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020336
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  6. Article ; Online: A Rare Case of Isolated Hepatocellular Carcinoma Metastasis in Left Mandibular Region in a Patient with Hepatitis C Virus Liver Cirrhosis Diagnosed after the Onset of COVID-19 Infection.

    Mašulović, Dragan / Igić, Aleksa / Filipović, Aleksandar / Zakošek, Miloš / Bulatović, Dušan / Mijović, Ksenija / Micev, Marjan / Galun, Danijel

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 11

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Female ; Humans ; Aged ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Hepacivirus ; COVID-19/complications ; Hepatitis C/complications ; Liver Cirrhosis/complications
    Language English
    Publishing date 2023-11-13
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59111992
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  7. Article ; Online: Total Fluoroscopy Time Reduction During Ultrasound- and Fluoroscopy-Guided Percutaneous Transhepatic Biliary Drainage Procedure: Importance of Adjusting the Puncture Angle.

    Filipović, Aleksandar N / Mašulović, Dragan / Zakošek, Miloš / Filipović, Tamara / Galun, Danijel

    Medical science monitor : international medical journal of experimental and clinical research

    2021  Volume 27, Page(s) e933889

    Abstract: BACKGROUND The purpose of this observational cohort study was to assess patient and operator-dependent factors which could have an impact on total fluoroscopy time during ultrasound and fluoroscopy-guided percutaneous transhepatic biliary drainage (PTBD). ...

    Abstract BACKGROUND The purpose of this observational cohort study was to assess patient and operator-dependent factors which could have an impact on total fluoroscopy time during ultrasound and fluoroscopy-guided percutaneous transhepatic biliary drainage (PTBD). MATERIAL AND METHODS Between October 2016 and November 2020, 127 patients with malignant biliary obstruction underwent ultrasound- and fluoroscopy-guided PTBD with the right-sided intercostal approach. The initial bile duct puncture was ultrasound-guided in all patients, and the puncture angle was measured by ultrasound. Any subsequent steps of the procedure were performed under continuous fluoroscopy (15 fps). The patients were divided in 2 groups based on the puncture angle: ≤30° (group I) and >30° (group II). In a retrospective analysis, both groups were compared for inter- and intragroup variability, technical success, total fluoroscopy time, and complications. RESULTS In group II, the recorded total fluoroscopy time (232.20±140.94 s) was significantly longer than that in group I (83.44±52.61 s) (P<0.001). In both groups, total fluoroscopy time was significantly longer in cases with a lesser degree of bile duct dilatation, intrahepatic bile duct tortuosity, presence of liver metastases, and multiple intrahepatic bile duct strictures. CONCLUSIONS The initial bile duct puncture angle was identified as an operator-dependent factor with the possible impact on total fluoroscopy time. The puncture angle of less than 30° was positively correlated with overall procedure efficacy and total fluoroscopy time reduction.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bile Ducts/diagnostic imaging ; Cholestasis/diagnostic imaging ; Cholestasis/therapy ; Cohort Studies ; Drainage ; Female ; Fluoroscopy/methods ; Humans ; Male ; Middle Aged ; Radiography, Interventional/methods ; Retrospective Studies ; Time Factors ; Ultrasonography, Interventional/methods
    Language English
    Publishing date 2021-11-21
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/MSM.933889
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4924: Show issues Location:
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  8. Article: Prognostic Nutritional Index (PNI) and Neutrophil to Lymphocyte Ratio (NLR) as Predictors of Short-Term Survival in Patients with Advanced Malignant Biliary Obstruction Treated with Percutaneous Transhepatic Biliary Drainage.

    Zakosek, Milos / Bulatovic, Dusan / Pavlovic, Vedrana / Filipovic, Aleksandar / Igic, Aleksa / Galun, Danijel / Jovanovic, Darko / Sisevic, Jelena / Masulovic, Dragan

    Journal of clinical medicine

    2022  Volume 11, Issue 23

    Abstract: Background: Effective biliary tree decompression plays a central role in the palliation of malignant biliary obstruction (MBO). When endoscopic drainage is unfeasible or unsuccessful, percutaneous transhepatic biliary drainage (PTBD) is the method of ... ...

    Abstract Background: Effective biliary tree decompression plays a central role in the palliation of malignant biliary obstruction (MBO). When endoscopic drainage is unfeasible or unsuccessful, percutaneous transhepatic biliary drainage (PTBD) is the method of choice and preferred treatment approach in advanced hilar MBO. The prognostic nutritional index (PNI) reflects the patient's immunonutritional status, while the neutrophil to lymphocyte ratio (NLR) reflects the patient's inflammation status. The aim of the present study was to evaluate the prognostic value of preprocedural PNI and NLR on short-term survival in the advanced stage MBO population threatened with PTBD and to characterize the differences in immunonutritional and inflammatory status between 60-day survivors and non-survivors, as well as analyze other variables influencing short-term survival.
    Methods: This single-center retrospective study was conducted on patients undergoing palliative PTBD caused by MBO as a definitive therapeutic treatment between March 2020 and February 2022. After the procedure, patients were followed until the end of August 2022.
    Results: A total of 136 patients with malignant biliary obstruction were included in the study. Based on receiver operating characteristic (ROC) curve analysis, optimal cut off-values for NLR (3) and PNI (36.7) were determined. In univariate regression analysis, age, absolute neutrophil count, albumin level, NLR ≤ 3, and PNI ≥ 36.7 were significant predictors of 60-day survival. Level of obstruction and PNI ≥ 36.7 were statistically significant independent predictors of 60-day survival in a multivariate regression model. Using PNI ≥ 36.7 as a significant coefficient from the multivariate regression model with the addition of NLR ≤ 3 from univariate analysis, a 60-day survival score was developed.
    Conclusions: PNI and NLR are easy to calculate from routine blood analysis, which is regularly conducted for cancer patients. As such, they represent easily available, highly reproducible, and inexpensive tests capable of expressing the severity of systemic inflammatory responses in patients with cancer. Our study highlights that preprocedural PNI and NLR values provide predictors of short-term survival in patients with MBO treated with palliative PTBD. In addition, the proposed 60-day survival score can contribute to better selection of future candidates for PTBD and recognition of high-risk patients with expected poor outcomes.
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11237055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of the COVID-19 Pandemic on the Outcomes of Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma: A Single Center Experience from a Developing Country.

    Filipović, Aleksandar / Mašulović, Dragan / Živanović, Marko / Filipović, Tamara / Bulatović, Dušan / Zakošek, Miloš / Nikolić, Dejan / Galun, Danijel

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 12

    Abstract: Background and Objectives: Treatment of cancer patients during the COVID-19 pandemic has been a challenge worldwide. In accordance with the current recommendations for hepatocellular carcinoma (HCC) management during the COVID-19 pandemic, loco-regional ... ...

    Abstract Background and Objectives: Treatment of cancer patients during the COVID-19 pandemic has been a challenge worldwide. In accordance with the current recommendations for hepatocellular carcinoma (HCC) management during the COVID-19 pandemic, loco-regional therapy such as transarterial chemoembolization (TACE) was proposed with the purpose of achieving local tumor control and improving overall survival. The aim of this prospective cohort study was to evaluate the outcomes of TACE treatment in patients with HCC during the COVID-19 pandemic in comparison with the outcomes of patients treated in the pre-pandemic period. Materials and Methods: Between September 2018 and December 2021, 154 patients were managed by serial TACE procedures for different liver tumors. Ninety-seven patients met the study criteria and were divided into two groups: the study group n = 49 (patients treated from May 2020 to December 2021); the control group n = 48 (patients treated from September 2018 to May 2020). Results: The mean waiting time for TACE was significantly longer in the study group compared to the control group (p < 0.001). No significant difference in survival between the groups is noted (log-rank test p = 0.823). In multivariate analysis, the MELD score (HR 1.329, 95% CI 1.140−1.548, p < 0.001) remained a significant predictor of mortality. Conclusions: COVID-19 pandemic did not affect the final outcome of TACE treatment.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/therapy ; Liver Neoplasms/pathology ; Pandemics ; Prospective Studies ; Developing Countries ; Treatment Outcome ; Chemoembolization, Therapeutic/adverse effects ; COVID-19/therapy ; Retrospective Studies
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58121701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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