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  1. Article: Over-diagnosis, Overtreatment or Oversurveillance of Melanoma: Is There a Way Out?

    Zalaudek, Iris

    Dermatology practical & conceptual

    2023  Volume 13, Issue 4

    Language English
    Publishing date 2023-10-01
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1304a250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; E-Book: Dermoscopy

    Soyer, H. Peter / Argenziano, Giuseppe / Hofmann-Wellenhof, Rainer / Zalaudek, Iris

    the essentials

    2020  

    Abstract: Dermoscopy: The Essentials presents the practical guidance you need to master this highly effective, more economical, and less invasive alternative to biopsy. Drs. Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, and Iris Zalaudek explain all ...

    Author's details Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, Iris Zalaudek
    Abstract "Dermoscopy: The Essentials presents the practical guidance you need to master this highly effective, more economical, and less invasive alternative to biopsy. Drs. Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, and Iris Zalaudek explain all aspects of performing dermoscopy and interpreting results. With approximately 30% new clinical and dermoscopic images, valuable pearls and checklists, and online access to the fully searchable and downloadable text, you'll have everything you need to diagnose earlier and more accurately"--Publisher's description.
    MeSH term(s) Skin Neoplasms/diagnosis. ; Melanoma/diagnosis. ; Microscopy/methods.
    Keywords Skin/Cancer/Diagnosis
    Subject code 616.99477
    Language English
    Dates of publication 2020-2020
    Size 1 online resource :, color illustrations
    Edition Third edition.
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-7020-6883-7 ; 0-7020-6882-9 ; 978-0-7020-6883-6 ; 978-0-7020-6882-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: How to detect high-performing individuals and groups: Decision similarity predicts accuracy

    Kurvers, Ralf / Hertwig, Ralph / Krause, Jens / Argenziano, Giuseppe / Zalaudek, Iris

    Science advances, 5(11):eaaw9011

    2019  

    Abstract: Distinguishing between high- and low-performing individuals and groups is of prime importance in a wide range of high-stakes contexts. While this is straightforward when accurate records of past performance exist, these records are unavailable in most ... ...

    Institution Leibniz-Institut für Gewässerökologie und Binnenfischerei
    Abstract Distinguishing between high- and low-performing individuals and groups is of prime importance in a wide range of high-stakes contexts. While this is straightforward when accurate records of past performance exist, these records are unavailable in most real-world contexts. Focusing on the class of binary decision problems, we use a combined theoretical and empirical approach to develop and test a approach to this important problem. First, we use a general mathematical argument and numerical simulations to show that the similarity of an individual’s decisions to others is a powerful predictor of that individual’s decision accuracy. Second, testing this prediction with several large datasets on breast and skin cancer diagnostics, geopolitical forecasting, and a general knowledge task, we find that decision similarity robustly permits the identification of high-performing individuals and groups. Our findings offer a simple, yet broadly applicable, heuristic for improving real-world decision-making systems.
    Language English
    Document type Article
    Database Repository for Life Sciences

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  4. Article ; Online: Treatment of menopausal skin - A narrative review of existing treatments, controversies, and future perspectives.

    Merzel Šabović, Eva K / Kocjan, Tomaž / Zalaudek, Iris

    Post reproductive health

    2024  , Page(s) 20533691241233440

    Abstract: Menopause is a state of estrogen deficiency that affects numerous estrogen-dependent tissues in the female body. Skin is one of the most affected organs. Many consider menopausal skin changes to be merely an aesthetic problem; however, they can ... ...

    Abstract Menopause is a state of estrogen deficiency that affects numerous estrogen-dependent tissues in the female body. Skin is one of the most affected organs. Many consider menopausal skin changes to be merely an aesthetic problem; however, they can significantly affect women's quality of life. Currently, there are no approved effective treatments to prevent or alleviate skin changes associated with estrogen deficiency. Standard systemic hormone replacement therapy used to treat menopausal symptoms may be effective to some degree for skin treatment. In addition, compounded bioidentical hormone replacement therapy, selective estrogen receptor modulators, and phytoestrogens could also be used for skin treatment, although this is only hypothetical due to lack of data. Many questions therefore remain unanswered. On the other hand, topical, low-dose estrogen that would act only on the skin without systemic effects could be a possible option, as could be skin-only acting topical phytoestrogens. Such topical products without systemic effects could play a role in the treatment of menopausal skin. However, they are not currently approved because there is insufficient data on their safety and efficacy. A healthy lifestyle could have a positive effect on the menopausal skin. In this review, we provide an overview of the characteristics of menopausal skin, an outlook on the future treatment of menopausal skin with estrogens and other approaches, and the associated controversies and speculations. Overall, the importance of menopausal skin changes should not be neglected, and high-quality research is needed to gain new insights into the treatment of menopausal skin.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2753537-X
    ISSN 2053-3705 ; 2053-3691
    ISSN (online) 2053-3705
    ISSN 2053-3691
    DOI 10.1177/20533691241233440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5557: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Dermoscopy to differentiate clinically similar inflammatory and neoplastic skin lesions.

    Bazzacco, Giulia / Zalaudek, Iris / Errichetti, Enzo

    Italian journal of dermatology and venereology

    2024  Volume 159, Issue 2, Page(s) 135–145

    Abstract: Introduction: Over the few last decades, dermoscopy has become an invaluable and popular imaging technique that complements the diagnostic armamentarium of dermatologists, being employed for both tumors and inflammatory diseases. Whereas distinction ... ...

    Abstract Introduction: Over the few last decades, dermoscopy has become an invaluable and popular imaging technique that complements the diagnostic armamentarium of dermatologists, being employed for both tumors and inflammatory diseases. Whereas distinction between neoplastic and inflammatory lesions is often straightforward based on clinical data, there are some scenarios that may be troublesome, e.g., solitary inflammatory lesions or tumors superimposed to a widespread inflammatory condition that may share macroscopic morphological findings.
    Evidence acquisition: We reviewed the literature to identify dermoscopic clues to support the differential diagnosis of clinically similar inflammatory and neoplastic skin lesions, also providing the histological background of such dermoscopic points of differentiation.
    Evidence synthesis: Dermoscopic differentiating features were identified for 12 relatively common challenging scenarios, including Bowen's disease and basal cell carcinoma vs. psoriasis and dermatitis, erythroplasia of Queyrat vs. inflammatory balanitis, mammary and extramammary Paget's disease vs. inflammatory mimickers, actinic keratoses vs. discoid lupus erythematosus, squamous cell carcinoma vs. hypertrophic lichen planus and lichen simplex chronicus, actinic cheilitis vs. inflammatory cheilitis, keratoacanthomas vs. prurigo nodularis, nodular lymphomas vs. pseudolymphomas and inflammatory mimickers, mycosis fungoides vs. parapsoriasis and inflammatory mimickers, angiosarcoma vs granuloma faciale, and Kaposi sarcoma vs pseudo-Kaposi.
    Conclusions: Dermoscopy may be of aid in differentiating clinically similar inflammatory and neoplastic skin lesions.
    MeSH term(s) Dermoscopy/methods ; Humans ; Diagnosis, Differential ; Skin Neoplasms/pathology ; Skin Neoplasms/diagnostic imaging ; Dermatitis/pathology ; Dermatitis/diagnostic imaging ; Skin Diseases/pathology ; Skin Diseases/diagnostic imaging ; Psoriasis/diagnostic imaging ; Psoriasis/pathology
    Language English
    Publishing date 2024-04-22
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.24.07825-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 119: Show issues Location:
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  6. Article: Epidemiology and Risk Factors of Melanoma: A Review.

    Conforti, Claudio / Zalaudek, Iris

    Dermatology practical & conceptual

    2021  Volume 11, Issue Suppl 1, Page(s) e2021161S

    Abstract: We are currently witnessing a worldwide increase in the incidence of melanoma. Incidence in Europe is about 25 cases per 100,000 population, while in Australia it reaches a rate of 60 new cases per 100,000. While the epidemiological curves of the 1980's ... ...

    Abstract We are currently witnessing a worldwide increase in the incidence of melanoma. Incidence in Europe is about 25 cases per 100,000 population, while in Australia it reaches a rate of 60 new cases per 100,000. While the epidemiological curves of the 1980's and 1990's suggested an increase in the incidence of melanoma across all age groups, the last 10 years' data indicates a 5% reduction in the incidence of thin melanoma in young individuals aged between 15 and 24. This suggests a positive impact of primary prevention campaigns [1-2]. The risk factors associated with melanoma are different and multifactorial: on one hand there is a genetic predisposition, as evidenced by the increased risk in patients with dysplastic nevus syndrome, with familial melanoma or familial melanoma syndromes; on the other hand, the unprotected interaction between UV rays and phototypes I-II increases the risk of developing melanoma, especially in case of sunburns in pediatric age. This review aims to summarize melanoma epidemiology and risk factors.
    Language English
    Publishing date 2021-07-01
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.11S1a161S
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Dramatic Response to Second-Line Nivolumab and Ipilimumab in BRAF-V600-Mutated Metastatic Melanoma.

    Fedele, Dahlia / Moroso, Stefano / Turoldo, Angelo / Bazzocchi, Gabriele / Conforti, Claudio / Zalaudek, Iris / Guglielmi, Alessandra

    Case reports in oncology

    2024  Volume 17, Issue 1, Page(s) 161–168

    Abstract: Introduction: Current treatment options for BRAF V600-mutated unresectable stage III/IV melanoma include anti-PD-1 monotherapy or combination with anti-CTLA-4 or anti-LAG-3 agents, BRAF/MEK inhibitors, and clinical trials. The strategy of combination ... ...

    Abstract Introduction: Current treatment options for BRAF V600-mutated unresectable stage III/IV melanoma include anti-PD-1 monotherapy or combination with anti-CTLA-4 or anti-LAG-3 agents, BRAF/MEK inhibitors, and clinical trials. The strategy of combination immunotherapy with nivolumab and ipilimumab has shown promising results, achieving higher response rates, longer duration of response, improved progression-free survival, and enhanced overall survival. The optimal sequence of treatments remains a topic of interest, with preliminary data suggesting a greater effectiveness of immunotherapy as the first-line approach. Preclinical trials have indicated that the efficacy of this sequence may be due to the modification of the immune environment by BRAF kinase inhibitors, leading to immune escape by tumor cells and resistance to immune checkpoint inhibitors.
    Case presentation: We present a case of a 72-year-old woman with high-burden metastatic melanoma who failed to respond to prior targeted therapy with BRAF/MEK inhibitors and exhibited a successful response to the second-line treatment with ipilimumab and nivolumab. We discuss the potential reasons for this positive outcome contributing to the current debate concerning treatment sequences, resistance mechanisms, and biomarkers predictive of response to immune checkpoint inhibitors in metastatic melanoma.
    Conclusion: We believe that in few years the therapeutic algorithms in BRAF V600-mutated unresectable stage III/IV melanoma will be more complex since they will define clearly the correct therapeutic sequences with the inclusion of new immune checkpoint inhibitor drugs and multiple predictive biomarkers of response to better select patients eligible to immunotherapy.
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000535902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lichen Striatus Post-COVID-19 Infection: Clinical and Dermoscopic Presentations.

    Chersi, Filippo / Conforti, Claudio / Zalaudek, Iris / di Meo, Nicola

    Dermatology practical & conceptual

    2023  Volume 13, Issue 1

    Language English
    Publishing date 2023-01-01
    Publishing country Austria
    Document type Letter
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1301a6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Bullous pemphigoid triggered by dulaglutide: a case report and a review of the literature.

    Sonego, Benedetta / Zelin, Enrico / Zalaudek, Iris / di Meo, Nicola

    Dermatology reports

    2023  Volume 15, Issue 3, Page(s) 9676

    Abstract: Bullous pemphigoid (BP) is an autoimmune disease with a chronic relapsing course, predominantly affecting elderly people. Drugs are one of the possible triggers. A class of antidiabetic drugs often associated with the development of BP are inhibitors of ... ...

    Abstract Bullous pemphigoid (BP) is an autoimmune disease with a chronic relapsing course, predominantly affecting elderly people. Drugs are one of the possible triggers. A class of antidiabetic drugs often associated with the development of BP are inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins), while less known is the association with glucagon-like-peptide-1 receptor agonists. We describe a case of BP caused by dulaglutide and summarize the other few cases described in the literature. As a class of drugs widely used in clinical practice, it is important to know about this possible adverse event.
    Language English
    Publishing date 2023-06-06
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2568735-9
    ISSN 2036-7406 ; 2036-7392
    ISSN (online) 2036-7406
    ISSN 2036-7392
    DOI 10.4081/dr.2023.9676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Adamantiades-Behçet's disease therapy: current treatment options and recommendations with regard to the COVID-19 pandemic.

    Trevisini, Sara / Trevisan, Giusto / Zalaudek, Iris / Bonin, Serena

    Dermatologic therapy

    2022  Volume 35, Issue 3, Page(s) e15286

    Abstract: Adamantiades-Behçet's disease (ABD) is a chronic, idiopathic, relapsing immune-mediate disease that may involve multiple organs. It is characterized by recurrent oral and genital ulcers, skin lesions, ocular, gastrointestinal, vascular, neurological and ... ...

    Abstract Adamantiades-Behçet's disease (ABD) is a chronic, idiopathic, relapsing immune-mediate disease that may involve multiple organs. It is characterized by recurrent oral and genital ulcers, skin lesions, ocular, gastrointestinal, vascular, neurological and joint involvement. It can lead to significant morbidity and mortality. Due to its heterogeneity in clinical findings and physiopathology, its treatment can be various as ABD manifestations in different organs may differently respond to the same drug. The cornerstone of therapy for inducing remission is systemic corticosteroid, whereas immunomodulatory and immunosuppressive agents such as colchicine, azathioprine, cyclosporine-A, interferon-alpha, and cyclophosphamide are used as steroid-sparing agents and to prevent relapses. For aggressive, refractory or frequently relapsing cases, tumor necrosis factor (TNF) alpha inhibitors (infliximab, adalimumab, etanercept) have been reported beneficial. Herein, we describe our experience of 7 patients treated with TNF-alpha inhibitors with recommendations regarding treatment choice during the COVID-19 era.
    MeSH term(s) Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; COVID-19/drug therapy ; Etanercept/therapeutic use ; Humans ; Pandemics ; SARS-CoV-2
    Chemical Substances Etanercept (OP401G7OJC)
    Language English
    Publishing date 2022-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5181: Show issues Location:
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