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  1. Article ; Online: Klassifikation indolenter B-Zell-Lymphome : Neuigkeiten und offene Fragen.

    Anagnostopoulos, Ioannis / Zamò, Alberto

    Pathologie (Heidelberg, Germany)

    2023  Volume 44, Issue 3, Page(s) 154–165

    Abstract: The 5th edition of the WHO classification (WHO-HAEM5) and the International Consensus Classification (ICC) have considerable overlap but also some distinct differences in categorizing indolent B‑cell lymphomas. Most differences with the expected impact ... ...

    Title translation Classification of indolent B-cell lymphomas : Novelties and open questions.
    Abstract The 5th edition of the WHO classification (WHO-HAEM5) and the International Consensus Classification (ICC) have considerable overlap but also some distinct differences in categorizing indolent B‑cell lymphomas. Most differences with the expected impact on the daily diagnostic routine relate to follicular lymphoma (FL). Grading of FL remains mandatory only in the ICC; a diffuse growth pattern in an FL with > 15 blasts per high-power field (FL grade 3A) is not automatically classified as DLBCL according to WHO-HAEM5, and an FL subtype with unusual morphology (blastoid or large centrocyte) and biology is recognized as an entity only in the WHO-HAEM5. With the exception of B‑prolymphocytic leukemia, which is no longer acknowledged in WHO-HAEM5, there are only minor differences between both classifications and include updated names of entities, improved diagnostic criteria, and upgrades from provisional to definite entities.
    MeSH term(s) Humans ; Lymphoma, B-Cell/diagnosis ; Lymphoma, Follicular/diagnosis
    Language German
    Publishing date 2023-04-24
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-023-01186-5
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  2. Article: Targeted panel sequencing in the routine diagnosis of mature T- and NK-cell lymphomas: report of 128 cases from two German reference centers.

    Böck, Julia / Maurus, Katja / Gerhard-Hartmann, Elena / Brändlein, Stephanie / Kurz, Katrin S / Ott, German / Anagnostopoulos, Ioannis / Rosenwald, Andreas / Zamò, Alberto

    Frontiers in oncology

    2023  Volume 13, Page(s) 1231601

    Abstract: Diagnosing any of the more than 30 types of T-cell lymphomas is considered a challenging task for many pathologists and currently requires morphological expertise as well as the integration of clinical data, immunophenotype, flow cytometry and clonality ... ...

    Abstract Diagnosing any of the more than 30 types of T-cell lymphomas is considered a challenging task for many pathologists and currently requires morphological expertise as well as the integration of clinical data, immunophenotype, flow cytometry and clonality analyses. Even considering all available information, some margin of doubt might remain using the current diagnostic procedures. In recent times, the genetic landscape of most T-cell lymphomas has been elucidated, showing a number of diagnostically relevant mutations. In addition, recent data indicate that some of these genetic alterations might bear prognostic and predictive value. Extensive genetic analyses, such as whole exome or large panel sequencing are still expensive and time consuming, therefore limiting their application in routine diagnostic. We therefore devoted our effort to develop a lean approach for genetic analysis of T-cell lymphomas, focusing on maximum efficiency rather than exhaustively covering all possible targets. Here we report the results generated with our small amplicon-based panel that could be used routinely on paraffin-embedded and even decalcified samples, on a single sample basis in parallel with other NGS-panels used in our routine diagnostic lab, in a relatively short time and with limited costs. We tested 128 available samples from two German reference centers as part of our routine work up (among which 116 T-cell lymphomas), which is the largest routine diagnostic series reported to date. Our results showed that this assay had a very high rate of technical success (97%) and could detect mutations in the majority (79%) of tested T-cell lymphoma samples.
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1231601
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  3. Article ; Online: Classical Hodgkin lymphoma cells may promote an IL-17-enriched microenvironment.

    Ferrarini, Isacco / Rigo, Antonella / Zamò, Alberto / Vinante, Fabrizio

    Leukemia & lymphoma

    2019  Volume 60, Issue 14, Page(s) 3395–3405

    Abstract: In classical Hodgkin lymphoma (cHL), the significance of the interplay between Hodgkin and Reed-Sternberg cells (HRS) and reactive T cells remains poorly defined. By immunohistochemistry on bioptic cHL specimens, we found that HRS and surrounding T ... ...

    Abstract In classical Hodgkin lymphoma (cHL), the significance of the interplay between Hodgkin and Reed-Sternberg cells (HRS) and reactive T cells remains poorly defined. By immunohistochemistry on bioptic cHL specimens, we found that HRS and surrounding T lymphocytes stained positive for IL-17 in 40% of cases. IL-17 was detectable in a similar proportion of patients' sera and correlated with disease burden. Supernatants of KM-H2 and HDLM-2 cHL cell lines guided preferential chemotaxis of CCR6
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Apoptosis ; CD30 Ligand/immunology ; CD30 Ligand/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Movement ; Cell Proliferation ; Female ; Follow-Up Studies ; Hodgkin Disease/immunology ; Hodgkin Disease/metabolism ; Hodgkin Disease/pathology ; Humans ; Interleukin-17/immunology ; Interleukin-17/metabolism ; Ki-1 Antigen/immunology ; Ki-1 Antigen/metabolism ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Male ; Middle Aged ; Prognosis ; Reed-Sternberg Cells ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Tumor Microenvironment/immunology ; Young Adult
    Chemical Substances CD30 Ligand ; IL17A protein, human ; Interleukin-17 ; Ki-1 Antigen ; TNFSF8 protein, human
    Language English
    Publishing date 2019-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2019.1636983
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    Zs.A 2997: Show issues Location:
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  4. Article ; Online: Unusual case of iron overload with cancer-mimicking abdominal splenosis.

    Marchi, Giacomo / Avesani, Giacomo / Zamò, Alberto / Girelli, Domenico

    BMJ case reports

    2018  Volume 2018

    Abstract: A 48-year-old man, former alcohol abuser and drug addicted, was referred to our tertiary referral centre for iron disorders because of marked hyperferritinaemia. His clinical history revealed chronic hepatitis C, ß-thalassaemia trait and post-traumatic ... ...

    Abstract A 48-year-old man, former alcohol abuser and drug addicted, was referred to our tertiary referral centre for iron disorders because of marked hyperferritinaemia. His clinical history revealed chronic hepatitis C, ß-thalassaemia trait and post-traumatic splenectomy at age of 22. MRI-estimated liver iron content was markedly elevated, while first-line genetic test for haemochromatosis was negative. Alpha-fetoprotein was increased but liver ultrasonography did not reveal focal liver lesions. Multiphasic contrast-enhanced CT confirmed this result but showed two abdominal masses (diameter of 9 cm and 7 cm, respectively) among bowel loops, strongly suspicious for cancer. However, biopsy of one of the masses led to the final diagnosis of abdominal splenosis.
    MeSH term(s) Abdominal Neoplasms/diagnosis ; Diagnosis, Differential ; Humans ; Iron Overload/diagnosis ; Liver/diagnostic imaging ; Liver/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Splenectomy/adverse effects ; Splenosis/diagnosis ; Splenosis/etiology ; Stomach Diseases/diagnosis
    Language English
    Publishing date 2018-05-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-223410
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  5. Article ; Online: Epstein-Barr virus infection patterns in nodular lymphocyte-predominant Hodgkin lymphoma.

    Gerhard-Hartmann, Elena / Jöhrens, Korinna / Schinagl, Lisa-Marie / Zamó, Alberto / Rosenwald, Andreas / Anagnostopoulos, Ioannis / Rosenfeldt, Mathias

    Histopathology

    2022  Volume 80, Issue 7, Page(s) 1071–1080

    Abstract: Aims: To investigate Epstein-Barr virus (EBV) latency types in 19 cases of EBV-positive nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), as such information is currently incomplete.: Methods and results: Immunohistochemistry (IHC) for CD20, ... ...

    Abstract Aims: To investigate Epstein-Barr virus (EBV) latency types in 19 cases of EBV-positive nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), as such information is currently incomplete.
    Methods and results: Immunohistochemistry (IHC) for CD20, CD79a, PAX5, OCT2, CD30, CD15, CD3 and programmed cell death protein 1 was performed. For EBV detection, in-situ hybridisation (ISH) for EBV-encoded RNA (EBER) was employed combined with IHC for EBV-encoded latent membrane protein (LMP)-1, EBV-encoded nuclear antigen (EBNA)-2, and EBV-encoded BZLF1. In 95% of the cases, neoplastic cells with features of Hodgkin and Reed-Sternberg (HRS) cells were present, mostly showing expression of CD30. In all cases, the B-cell phenotype was largely intact, and delineation from classic Hodgkin lymphoma (CHL) was further supported by myocyte enhancer factor 2B (MEF2B) detection. All tumour cells were EBER-positive except in two cases. EBV latency type II was most frequent (89%) and type I was rare. Cases with latency type I were CD30-negative. Five cases contained some BZLF1-positive and/or EBNA-2-positive bystander lymphocytes.
    Conclusions: As HRS morphology of neoplastic cells and CD30 expression are frequent features of EBV-positive NLPHL, preservation of the B-cell transcription programme, MEF2B expression combined with NLPHL-typical architecture and background composition facilitate distinction from CHL. EBER ISH is the method of choice to identify these cases. The majority present with EBV latency type II, and only rare cases present with latency type I, which can be associated with missing CD30 expression. The presence of occasional bystander lymphocytes expressing BZLF1 and/or EBNA-2 and the partial EBV infection of neoplastic cells in some cases could indicate that EBV is either not primarily involved or is only a transient driver in the pathogenesis of EBV-positive NLPHL.
    MeSH term(s) Epstein-Barr Virus Infections/pathology ; Herpesvirus 4, Human/genetics ; Hodgkin Disease/pathology ; Humans ; Ki-1 Antigen/metabolism ; Lymphocytes/pathology ; Reed-Sternberg Cells/metabolism
    Chemical Substances Ki-1 Antigen
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14652
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  6. Article ; Online: Routine application of the Lymph2Cx assay for the subclassification of aggressive B-cell lymphoma: report of a prospective real-world series.

    Zamò, Alberto / Gerhard-Hartmann, Elena / Ott, German / Anagnostopoulos, Ioannis / Scott, David W / Rosenwald, Andreas / Rauert-Wunderlich, Hilka

    Virchows Archiv : an international journal of pathology

    2022  Volume 481, Issue 6, Page(s) 935–943

    Abstract: The subclassification of diffuse large B-cell lymphoma (DLBCL) into germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtypes has become mandatory in the 2017 update of the WHO classification of lymphoid neoplasms and will continue to be ...

    Abstract The subclassification of diffuse large B-cell lymphoma (DLBCL) into germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtypes has become mandatory in the 2017 update of the WHO classification of lymphoid neoplasms and will continue to be used in the WHO 5
    MeSH term(s) Humans ; In Situ Hybridization, Fluorescence ; Prospective Studies ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/genetics ; Germinal Center/pathology ; RNA/metabolism ; RNA/therapeutic use
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-10-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-022-03420-6
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  7. Article ; Online: Aggressive B-cell lymphomas with a primary bone marrow presentation.

    Zamò, Alberto / Johnston, Peter / Attygalle, Ayoma D / Laurent, Camille / Arber, Daniel A / Fend, Falko

    Histopathology

    2020  Volume 77, Issue 3, Page(s) 369–379

    Abstract: Aggressive B-cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging in terms of diagnostic classification and clinical handling, owing to limited architectural information. Aggressive ...

    Abstract Aggressive B-cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging in terms of diagnostic classification and clinical handling, owing to limited architectural information. Aggressive B-cell lymphomas can be subdivided into entities that typically present primarily in the BM, and cases with BM involvement in which the bulk of disease is present in other organs. One main topic at the 2018 BM workshop of the European Association of Haematopathology/Society of Hematopathology was therefore aggressive B-cell lymphomas with a primary BM presentation. The spectrum of cases submitted to this topic gave a good overview of commonly encountered problems, as well as unusual manifestations, and highlighted areas of imprecise disease definitions and diagnostic grey zones. The categories submitted to the workshop included cases of Burkitt lymphoma (BL) with unusual features, high-grade B-cell lymphomas (HG-BCLs) with and without so-called double/triple-hit, and diffuse large B-cell lymphomas (DLBCLs) with a primary BM presentation. Areas of difficulties included the morphological boundaries of HG-BCL not otherwise specified, cases with MYC and bcl-2 or bcl-6 translocations and terminal deoxynucleotidyl transferase (TdT) expression, which were categorised as B-cell lymphoblastic leukaemia/lymphoma if most cells showed TdT positivity, and the clinicopathological overlap between intravascular large B-cell lymphoma, CD5-positive DLBCL, and DLBCL with primary presentations in the BM, spleen, and liver. This review summarises our understanding of the main aggressive B-cell lymphoma categories with a common primary BM presentation and potential problem areas, and makes suggestions for the immunophenotypic and genetic work-up, illustrated by the interesting and challenging cases submitted to the workshop.
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14124
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  8. Article ; Online: Challenges and limitations in the primary diagnosis of T-cell and natural killer cell/T-cell lymphoma in bone marrow biopsy.

    Attygalle, Ayoma D / Zamò, Alberto / Fend, Falko / Johnston, Peter / Arber, Daniel A / Laurent, Camille

    Histopathology

    2020  Volume 77, Issue 1, Page(s) 2–17

    MeSH term(s) Biopsy ; Bone Marrow/pathology ; Humans ; Killer Cells, Natural/pathology ; Lymphoma, T-Cell/diagnosis ; Lymphoma, T-Cell/pathology
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14093
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  9. Article ; Online: Diagnosis of classic Hodgkin lymphoma on bone marrow biopsy.

    Laurent, Camille / Arber, Daniel A / Johnston, Peter / Fend, Falko / Zamo, Alberto / Attygalle, Ayoma D

    Histopathology

    2020  Volume 76, Issue 7, Page(s) 934–941

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Bone Marrow/pathology ; Female ; Hodgkin Disease/diagnosis ; Hodgkin Disease/pathology ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Letter
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14085
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  10. Article ; Online: Correction to: Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop.

    Di Napoli, Arianna / Soma, Lori / Quintanilla-Martinez, Leticia / de Leval, Laurence / Leoncini, Lorenzo / Zamò, Alberto / Ng, Siok-Bian / Ondrejka, Sarah L / Climent, Fina / Wotherspoon, Andrew / Dirnhofer, Stefan

    Virchows Archiv : an international journal of pathology

    2023  Volume 483, Issue 3, Page(s) 435

    Language English
    Publishing date 2023-09-25
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03664-w
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