LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article: Blood biomarker for Parkinson disease: peptoids.

    Yazdani, Umar / Zaman, Sayed / Hynan, Linda S / Brown, L Steven / Dewey, Richard B / Karp, David / German, Dwight C

    NPJ Parkinson's disease

    2016  Volume 2

    Abstract: Parkinson disease (PD) is the second most common neurodegenerative disease. Because dopaminergic neuronal loss begins years before motor symptoms appear, a biomarker for the early identification of the disease is critical for the study of putative ... ...

    Abstract Parkinson disease (PD) is the second most common neurodegenerative disease. Because dopaminergic neuronal loss begins years before motor symptoms appear, a biomarker for the early identification of the disease is critical for the study of putative neuroprotective therapies. Brain imaging of the nigrostriatal dopamine system has been used as a biomarker for early disease along with cerebrospinal fluid analysis of α-synuclein, but a less costly and relatively non-invasive biomarker would be optimal. We sought to identify an antibody biomarker in the blood of PD patients using a combinatorial peptoid library approach. We examined serum samples from 75 PD patients, 25
    Language English
    Publishing date 2016-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/npjparkd.2016.12
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder.

    Singh, Sarika / Yazdani, Umar / Gadad, Bharathi / Zaman, Sayed / Hynan, Linda S / Roatch, Nichole / Schutte, Claire / Marti, C Nathan / Hewitson, Laura / German, Dwight C

    Journal of neuroinflammation

    2017  Volume 14, Issue 1, Page(s) 113

    Abstract: Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys ( ... ...

    Abstract Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys (n = 30/group) were screened for differences in 110 proteins using a multiplex immunoassay.
    Results: Eleven proteins were found that together could confirm ASD with modest accuracy using multiple training and test sets. Two of the 11 proteins identified here were further tested using a different detection platform and with a larger sample of ASD and TD boys. The two proteins, thyroid-stimulating hormone (TSH) and interleukin-8 (IL-8), have been previously identified as putative biomarkers for ASD. TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated. The diagnostic accuracy for ASD based upon TSH or IL-8 levels alone varied from 74 to 76%, but using both proteins together, the diagnostic accuracy increased to 82%. In addition, TSH levels were negatively correlated with the Autism Diagnostic Observation Schedule subdomain scores.
    Conclusions: These data suggest that a panel of proteins may be useful as a putative blood biomarker for ASD.
    MeSH term(s) Autism Spectrum Disorder/blood ; Child ; Child, Preschool ; Humans ; Interleukin-8/blood ; Luminescent Measurements ; Male ; ROC Curve ; Regression Analysis ; Severity of Illness Index ; Thyrotropin/blood
    Chemical Substances Interleukin-8 ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2017--02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1742-2094
    ISSN (online) 1742-2094
    DOI 10.1186/s12974-017-0888-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: A Search for Blood Biomarkers for Autism: Peptoids.

    Zaman, Sayed / Yazdani, Umar / Deng, Yan / Li, Wenhao / Gadad, Bharathi S / Hynan, Linda / Karp, David / Roatch, Nichole / Schutte, Claire / Nathan Marti, C / Hewitson, Laura / German, Dwight C

    Scientific reports

    2016  Volume 6, Page(s) 19164

    Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, and restricted, repetitive patterns of behavior. In order to identify individuals with ASD and initiate interventions at ...

    Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, and restricted, repetitive patterns of behavior. In order to identify individuals with ASD and initiate interventions at the earliest possible age, biomarkers for the disorder are desirable. Research findings have identified widespread changes in the immune system in children with autism, at both systemic and cellular levels. In an attempt to find candidate antibody biomarkers for ASD, highly complex libraries of peptoids (oligo-N-substituted glycines) were screened for compounds that preferentially bind IgG from boys with ASD over typically developing (TD) boys. Unexpectedly, many peptoids were identified that preferentially bound IgG from TD boys. One of these peptoids was studied further and found to bind significantly higher levels (>2-fold) of the IgG1 subtype in serum from TD boys (n = 60) compared to ASD boys (n = 74), as well as compared to older adult males (n = 53). Together these data suggest that ASD boys have reduced levels (>50%) of an IgG1 antibody, which resembles the level found normally with advanced age. In this discovery study, the ASD1 peptoid was 66% accurate in predicting ASD.
    MeSH term(s) Autism Spectrum Disorder/blood ; Autism Spectrum Disorder/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Autoantibodies/metabolism ; Biomarkers ; Child ; Child, Preschool ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Male ; Peptoids/metabolism ; Protein Binding
    Chemical Substances Autoantibodies ; Biomarkers ; Immunoglobulin G ; Peptoids
    Language English
    Publishing date 2016-01-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep19164
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates.

    Quan, Jiexia / Lakhanpal, Akshai / Reddy, M Muralidhar / Zaman, Sayed / Li, Quan-Zhen / German, Dwight C / Olsen, Nancy J / Kodadek, Thomas / Karp, David R

    Journal of immunological methods

    2013  Volume 402, Issue 1-2, Page(s) 23–34

    Abstract: Antibodies to a wide range of self-antigens, including those directed against nucleic acids or nucleic acid-binding proteins are the essential biomarkers for diseases such as systemic lupus erythematosus (SLE). Highly complex libraries of nonamers ... ...

    Abstract Antibodies to a wide range of self-antigens, including those directed against nucleic acids or nucleic acid-binding proteins are the essential biomarkers for diseases such as systemic lupus erythematosus (SLE). Highly complex libraries of nonamers consisting of N-substituted glycines (peptoids) were screened for compounds that bound IgG from patients with SLE and earlier, incomplete autoimmune syndromes. Peptoids were identified that could identify subjects with SLE and related syndromes with a high sensitivity (70%) and specificity (97.5%). Immobilized peptoids were used to isolate IgG from both healthy subjects and SLE patients that reacted with known RNA-binding proteins. In the case of SLE patients, the peptoid-purified IgG reacted with several autoantigens, suggesting that the peptoids are capable of interacting with multiple, structurally similar molecules. These results show that the measurement of IgG binding to peptoids can identify subjects with high levels of pathogenic autoantibodies.
    MeSH term(s) Autoantibodies/blood ; Autoantigens/blood ; Autoantigens/immunology ; Biomarkers/blood ; Case-Control Studies ; Humans ; Immunoglobulin G/blood ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/immunology ; Peptide Library ; Peptoids/immunology ; Reproducibility of Results
    Chemical Substances Autoantibodies ; Autoantigens ; Biomarkers ; Immunoglobulin G ; Peptide Library ; Peptoids
    Language English
    Publishing date 2013-11-20
    Publishing country Netherlands
    Document type Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2013.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 795: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top