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  1. Article ; Online: An automated reminder for perioperative glucose regulation improves protocol compliance.

    Polderman, Jorinde A W / de Groot, Fleur A / Zamanbin, Alaleh / Hollmann, Markus W / Holleman, Frits / Preckel, Benedikt / Hermanides, Jeroen

    Diabetes research and clinical practice

    2016  Volume 116, Page(s) 80–82

    Abstract: A growing proportion of patients presenting for surgery have diabetes. Unfortunately, perioperative diabetes protocol compliance is low. Using digitalization of the perioperative environment, an automated reminder in the preoperative assessment platform ... ...

    Abstract A growing proportion of patients presenting for surgery have diabetes. Unfortunately, perioperative diabetes protocol compliance is low. Using digitalization of the perioperative environment, an automated reminder in the preoperative assessment platform proved to increase compliance and we advocate its use throughout the perioperative process.
    MeSH term(s) Analysis of Variance ; Blood Glucose/analysis ; Diabetes Mellitus/drug therapy ; Guideline Adherence/standards ; Humans ; Perioperative Care/methods ; Prospective Studies ; Reminder Systems
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2016-06
    Publishing country Ireland
    Document type Journal Article ; Observational Study
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2016.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity.

    Kunne, Cindy / Acco, Alexandra / Hohenester, Simon / Duijst, Suzanne / de Waart, Dirk R / Zamanbin, Alaleh / Oude Elferink, Ronald P J

    Hepatology (Baltimore, Md.)

    2013  Volume 57, Issue 4, Page(s) 1509–1517

    Abstract: Unlabelled: The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient rehydroxylation of deoxycholic acid. The aim of this study was to characterize bile ... ...

    Abstract Unlabelled: The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient rehydroxylation of deoxycholic acid. The aim of this study was to characterize bile formation in a mouse model (Hrn mice) with hepatic disruption of the cytochrome p450 (CYP) oxidoreductase gene, encoding the single electron donor for all CYPs. Bile formation was studied after acute BS infusion or after feeding a BS-supplemented diet for 3 weeks. Fecal BS excretion in Hrn mice was severely reduced to 7.6% ± 1.8% of wild-type (WT), confirming strong reduction of (CYP-mediated) BS synthesis. Hrn bile contained 48% ± 18% dihydroxy BS, whereas WT bile contained only 5% ± 1% dihydroxy BS. Upon tauroursodeoxycholate infusion, biliary BS output was equal in WT versus Hrn, indicating that canalicular secretion capacity was normal. In contrast, taurodeoxycholic acid (TDC) infusion led to markedly impaired bile flow and BS output, suggesting onset of cholestasis. Feeding a cholate-supplemented diet (0.1%) resulted in a completely restored bile salt pool in Hrn mice, with 50% ± 9% TDC and 42% ± 10% taurocholic acid in bile, as opposed to 2% ± 1% and 80% ± 3% in WT mice, respectively. Under these conditions, biliary cholesterol secretion was strongly increased in Hrn mice, whereas serum alanine aminotransferase levels were decreased.
    Conclusion: Hrn mice have strongly impaired bile salt synthesis and (re)hydroxylation capacity and are more susceptible to acute TDC-induced cholestasis. In this mouse model, a more-human BS pool can be instilled by BS feeding, without hepatic damage, which makes Hrn mice an attractive model to study the effects of human BS.
    MeSH term(s) Animals ; Bile Acids and Salts/metabolism ; Cholesterol/metabolism ; Cytochrome P-450 Enzyme System/deficiency ; Disease Models, Animal ; Hydroxylation ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Diseases/genetics ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oxidoreductases/deficiency ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Phospholipids/metabolism ; Taurocholic Acid/pharmacology
    Chemical Substances Bile Acids and Salts ; Phospholipids ; Taurocholic Acid (5E090O0G3Z) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Cholesterol (97C5T2UQ7J) ; Oxidoreductases (EC 1.-)
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.26133
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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