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  1. Article ; Online: Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions.

    Zamani Rarani, Fahimeh / Zamani Rarani, Mohammad / Hamblin, Michael R / Rashidi, Bahman / Hashemian, Seyed Mohammad Reza / Mirzaei, Hamed

    Cellular & molecular biology letters

    2022  Volume 27, Issue 1, Page(s) 63

    Abstract: The pandemic outbreak of coronavirus disease 2019 (COVID-19) has created health challenges in all parts of the world. Understanding the entry mechanism of this virus into host cells is essential for effective treatment of COVID-19 disease. This virus can ...

    Abstract The pandemic outbreak of coronavirus disease 2019 (COVID-19) has created health challenges in all parts of the world. Understanding the entry mechanism of this virus into host cells is essential for effective treatment of COVID-19 disease. This virus can bind to various cell surface molecules or receptors, such as angiotensin-converting enzyme 2 (ACE2), to gain cell entry. Respiratory failure and pulmonary edema are the most important causes of mortality from COVID-19 infections. Cytokines, especially proinflammatory cytokines, are the main mediators of these complications. For normal respiratory function, a healthy air-blood barrier and sufficient blood flow to the lungs are required. In this review, we first discuss airway epithelial cells, airway stem cells, and the expression of COVID-19 receptors in the airway epithelium. Then, we discuss the suggested molecular mechanisms of endothelial dysfunction and blood vessel damage in COVID-19. Coagulopathy can be caused by platelet activation leading to clots, which restrict blood flow to the lungs and lead to respiratory failure. Finally, we present an overview of the effects of immune and non-immune cells and cytokines in COVID-19-related respiratory failure.
    MeSH term(s) COVID-19 ; Cytokines ; Humans ; Peptidyl-Dipeptidase A ; Respiratory Insufficiency ; SARS-CoV-2
    Chemical Substances Cytokines ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2108724-6
    ISSN 1689-1392 ; 1689-1392
    ISSN (online) 1689-1392
    ISSN 1689-1392
    DOI 10.1186/s11658-022-00363-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparison of TGF-β3 and avocado/soybean unsaponifiable on chondrogenesis of human adipose-derived stem cells on poly (lactic-co-glycolic) acid/ hyaluronic acid hybrid scaffold.

    Pourentezari, Majid / Sharifian, Zeinolabedin / Mardani, Mohammad / Valiani, Ali / Zamani Rarani, Mohammad / Setayeshmehr, Mohsen / Eini, Fatemeh / Hashemibeni, Batool

    Iranian journal of basic medical sciences

    2020  Volume 24, Issue 1, Page(s) 24–29

    Abstract: Objectives: Avocado/soybean unsaponifible (ASU) possesses properties including chondroprotective, anticatabolic, and anabolic. The goal behind this research was to detect the effect of ASU and TGF-β3 on the chondrogenesis of human adipose-derived stem ... ...

    Abstract Objectives: Avocado/soybean unsaponifible (ASU) possesses properties including chondroprotective, anticatabolic, and anabolic. The goal behind this research was to detect the effect of ASU and TGF-β3 on the chondrogenesis of human adipose-derived stem cells (hADSCs) on poly (lactic-co-glycolic) acid (PLGA)/ hyaluronic acid (PLGA/HA) hybrid scaffold.
    Materials and methods: First hADSCs were seeded in PLGA/Hyaluronic acid scaffold and cultured in chondrogenic media. These cells were assigned into 4 groups: control, TGFβ-3, ASU, and TGFβ-3+ASU. The viability was assessed separately by MTT. Real-time PCR was used to quantify the expression of chondrogenic specific genes [
    Results: These findings indicated a significant increase in the proliferation and survival of hADSCs differentiated cells by ASU compared with the control group (
    Conclusion: Using the synergist form TGFβ-3, ASU induces chondrogenesis in hADSCs in PLGA/HA composite scaffold. This can be deduced with reduction of special markers of hyaline cartilage in comparison with ASU and decreased hypertrophic marker compared with TGF-β3.
    Language English
    Publishing date 2020-09-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2500485-2
    ISSN 2008-3874 ; 2008-3866
    ISSN (online) 2008-3874
    ISSN 2008-3866
    DOI 10.22038/ijbms.2020.44409.10391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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