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  1. Article ; Online: Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.

    Zagorulya, Maria / Yim, Leon / Morgan, Duncan M / Edwards, Austin / Torres-Mejia, Elen / Momin, Noor / McCreery, Chloe V / Zamora, Izabella L / Horton, Brendan L / Fox, James G / Wittrup, K Dane / Love, J Christopher / Spranger, Stefani

    Immunity

    2023  Volume 56, Issue 2, Page(s) 386–405.e10

    Abstract: Local environmental factors influence ... ...

    Abstract Local environmental factors influence CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Interferon-gamma ; Lung Neoplasms ; T-Lymphocytes, Cytotoxic ; T-Lymphocytes, Regulatory
    Chemical Substances Interferon-gamma (82115-62-6) ; IFNG protein, human
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  2. Article: Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response.

    Chen, Jonathan H / Nieman, Linda T / Spurrell, Maxwell / Jorgji, Vjola / Richieri, Peter / Xu, Katherine H / Madhu, Roopa / Parikh, Milan / Zamora, Izabella / Mehta, Arnav / Nabel, Christopher S / Freeman, Samuel S / Pirl, Joshua D / Lu, Chenyue / Meador, Catherine B / Barth, Jaimie L / Sakhi, Mustafa / Tang, Alexander L / Sarkizova, Siranush /
    Price, Colles / Fernandez, Nicolas F / Emanuel, George / He, Jiang / Raay, Katrina Van / Reeves, Jason W / Yizhak, Keren / Hofree, Matan / Shih, Angela / Sade-Feldman, Moshe / Boland, Genevieve M / Pelka, Karin / Aryee, Martin / Korsunsky, Ilya / Mino-Kenudson, Mari / Gainor, Justin F / Hacohen, Nir

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially-localized multicellular 'immunity hubs' defined by expression of the T cell-attracting ... ...

    Abstract The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially-localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.04.535379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy.

    Chen, Jonathan H / Nieman, Linda T / Spurrell, Maxwell / Jorgji, Vjola / Elmelech, Liad / Richieri, Peter / Xu, Katherine H / Madhu, Roopa / Parikh, Milan / Zamora, Izabella / Mehta, Arnav / Nabel, Christopher S / Freeman, Samuel S / Pirl, Joshua D / Lu, Chenyue / Meador, Catherine B / Barth, Jaimie L / Sakhi, Mustafa / Tang, Alexander L /
    Sarkizova, Siranush / Price, Colles / Fernandez, Nicolas F / Emanuel, George / He, Jiang / Van Raay, Katrina / Reeves, Jason W / Yizhak, Keren / Hofree, Matan / Shih, Angela / Sade-Feldman, Moshe / Boland, Genevieve M / Pelka, Karin / Aryee, Martin J / Mino-Kenudson, Mari / Gainor, Justin F / Korsunsky, Ilya / Hacohen, Nir

    Nature immunology

    2024  Volume 25, Issue 4, Page(s) 644–658

    Abstract: The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we ... ...

    Abstract The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we examined immunity hubs in human pre-immunotherapy lung cancer specimens and found an association with beneficial response to PD-1 blockade. Critically, we discovered the stem-immunity hub, a subtype of immunity hub strongly associated with favorable PD-1-blockade outcome. This hub is distinct from mature tertiary lymphoid structures and is enriched for stem-like TCF7
    MeSH term(s) Humans ; Lung Neoplasms ; CD8-Positive T-Lymphocytes ; Programmed Cell Death 1 Receptor ; Chemokines/metabolism ; Immunotherapy/methods ; Tumor Microenvironment
    Chemical Substances Programmed Cell Death 1 Receptor ; Chemokines
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-024-01792-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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