Article ; Online: Noncanonical-NF-κB activation and DDX3 inhibition reduces the HIV-1 reservoir by elimination of latently infected cells
2023 Volume 12, Issue 1, Page(s) e0318023
Abstract: Importance: HIV-1 continues to be a major global health challenge. Current HIV-1 treatments are effective but need lifelong adherence. An HIV-1 cure should eliminate the latent viral reservoir that persists in people living with HIV-1. Different methods ...
| Abstract | Importance: HIV-1 continues to be a major global health challenge. Current HIV-1 treatments are effective but need lifelong adherence. An HIV-1 cure should eliminate the latent viral reservoir that persists in people living with HIV-1. Different methods have been investigated that focus on reactivation and subsequent elimination of the HIV-1 reservoir, and it is becoming clear that a combination of compounds with different mechanisms of actions might be more effective. Here, we target two host factors, inhibitor of apoptosis proteins that control apoptosis and the DEAD-box helicase DDX3, facilitating HIV mRNA transport/translation. We show that targeting of these host factors with SMAC mimetics and DDX3 inhibitors induce reversal of viral latency and eliminate HIV-1-infected cells |
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| MeSH term(s) | Humans ; HIV-1 ; NF-kappa B/metabolism ; HIV Infections/drug therapy ; HIV Infections/genetics ; CD4-Positive T-Lymphocytes ; Gene Expression Regulation ; Virus Latency |
| Chemical Substances | NF-kappa B |
| Language | English |
| Publishing date | 2023-12-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2807133-5 |
| ISSN | 2165-0497 ; 2165-0497 |
| ISSN (online) | 2165-0497 |
| ISSN | 2165-0497 |
| DOI | 10.1128/spectrum.03180-23 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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