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Article ; Online: Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta.

Barbosa, Felipe Lukacievicz / Ehrenfried, Carlos Augusto / Radulski, Débora Rasec / Oliveira, Cristhian Santos / Stefanello, Maria Élida Alves / Zampronio, Aleksander Roberto

Inflammopharmacology

2024 Volume 32, Issue 2, Page(s) 1263–1275

Abstract: This study evaluated the composition and the antinociceptive and anti-inflammatory activity of the crude extracts and two isolated compounds, anamarine (ANA) and 10-epi-olguine (eOL), obtained from the leaves of Cantinoa stricta (Lamiaceae). Crude ... ...

Abstract	This study evaluated the composition and the antinociceptive and anti-inflammatory activity of the crude extracts and two isolated compounds, anamarine (ANA) and 10-epi-olguine (eOL), obtained from the leaves of Cantinoa stricta (Lamiaceae). Crude ethanolic extract (EEt) and dichloromethane extract (DCM), selected based on NMR data, were submitted to pharmacological tests in male Swiss mice. The oral administration of EEt and DCM significantly reduced the second phase of formalin-induced nociception (60%), lipopolysaccharide (LPS)-induced mechanical hyperalgesia (90%), and carrageenan (Cg)-induced edema (25%). ANA and eOL, the major compounds in EEt and DCM extracts, administered orally or locally (in the paw), also reduced the LPS-induced mechanical hyperalgesia (Oral ID
MeSH term(s)	Male ; Female ; Mice ; Animals ; Hyperalgesia/metabolism ; Pyrones/adverse effects ; Lipopolysaccharides ; Anti-Inflammatory Agents/therapeutic use ; Analgesics/therapeutic use ; Carrageenan ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Edema/chemically induced ; Edema/drug therapy ; Epinephrine ; Epoxy Compounds
Chemical Substances	olguine ; Pyrones ; Lipopolysaccharides ; Anti-Inflammatory Agents ; Analgesics ; Carrageenan (9000-07-1) ; Plant Extracts ; Epinephrine (YKH834O4BH) ; Epoxy Compounds
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01444-9
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Zs.A 3274: Show issues

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Article ; Online: Neuroscience-Based Nomenclature (NbN): the Portuguese version of the new classification for psychopharmacological drugs.

Galduroz, José Carlos Fernandes / Zampronio, Aleksander Roberto / Vital, Maria Aparecida Barbato Frazão / Sallet, Paulo Clemente / Zohar, Joseph / Andreatini, Roberto

Trends in psychiatry and psychotherapy

2024

Abstract: Neuroscience-Based Nomenclature (NbN) is a proposal to provide a nomenclature based on neuroscience and pharmacology instead of the old disease-based classification. NbN is based on the mechanism of action and pharmacological target and aims to assist in ...

Abstract	Neuroscience-Based Nomenclature (NbN) is a proposal to provide a nomenclature based on neuroscience and pharmacology instead of the old disease-based classification. NbN is based on the mechanism of action and pharmacological target and aims to assist in rational prescription, reduce stigma, and increase treatment adherence. Currently, NbN is endorsed by many psychiatric associations, adopted by several relevant journals, and included in major psychiatry textbooks. Therefore, it is important that NbN is known to psychiatrists.
Language	English
Publishing date	2024-01-18
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2708374-3
ISSN	2238-0019 ; 2238-0019
ISSN (online)	2238-0019
ISSN	2238-0019
DOI	10.47626/2237-6089-2023-0771
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Article ; Online: Involvement of cannabinoid receptors and neuroinflammation in early sepsis: Implications for posttraumatic stress disorder.

Matias, Maycon Eduardo / Radulski, Débora Rasec / Rodrigues da Silva, Thiago / Raymundi, Ana Maria / Stern, Cristina Aparecida Jark / Zampronio, Aleksander Roberto

International immunopharmacology

2023 Volume 123, Page(s) 110745

Abstract: Sepsis is associated with several comorbidities in survivors, such as posttraumatic stress disorder (PTSD). This study investigated whether rats that survive sepsis develop the generalization of fear memory as a model of PTSD. Responses to interventions ... ...

Abstract	Sepsis is associated with several comorbidities in survivors, such as posttraumatic stress disorder (PTSD). This study investigated whether rats that survive sepsis develop the generalization of fear memory as a model of PTSD. Responses to interventions that target the endothelin-1 (ET-1)/cannabinoid system and glial activation in the initial stages of sepsis were evaluated. As a control, we evaluated hyperalgesia before fear conditioning. Sepsis was induced by cecal ligation and puncture (CLP) in Wistar rats. CLP-induced sepsis with one or three punctures resulted in fear generalization in the survivors 13 and 20 days after the CLP procedure, a process that was not associated with hyperalgesia. Septic animals were intracerebroventricularly treated with vehicle, the endothelin receptor A (ET
MeSH term(s)	Rats ; Animals ; Receptors, Cannabinoid ; Stress Disorders, Post-Traumatic/drug therapy ; Rats, Wistar ; Neuroinflammatory Diseases ; Minocycline ; Hyperalgesia ; Cannabinoids/pharmacology ; Cannabinoids/therapeutic use ; Sepsis/metabolism
Chemical Substances	Receptors, Cannabinoid ; Minocycline (FYY3R43WGO) ; Cannabinoids
Language	English
Publishing date	2023-08-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110745
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Zs.A 5408: Show issues

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Article ; Online: Fever Induced by Zymosan A and Polyinosinic-Polycytidylic Acid in Female Rats: Influence of Sex Hormones and the Participation of Endothelin-1.

Coelho, L C M / Cruz, J V / Maba, I K / Zampronio, Aleksander Roberto

Inflammation

2020 Volume 44, Issue 1, Page(s) 321–333

Abstract: Sex differences in the immune response can also affect the febrile response, particularly the fever induced by lipopolysaccharide (LPS). However, other pathogen-associated molecular patterns, such as zymosan A (Zym) and polyinosinic-polycytidylic acid ( ... ...

Abstract	Sex differences in the immune response can also affect the febrile response, particularly the fever induced by lipopolysaccharide (LPS). However, other pathogen-associated molecular patterns, such as zymosan A (Zym) and polyinosinic-polycytidylic acid (Poly I:C), also induce fever in male rats with a different time course of cytokine release and different mediators such as endothelin-1 (ET-1). This study investigated whether female sex hormones affect Zym- and Poly I:C-induced fever and the involvement of ET-1 in this response. The fever that was induced by Zym and Poly I:C was higher in ovariectomized (OVX) female rats compared with sham-operated female rats. Estrogen replacement in OVX females reduced Zym- and Poly I:C-induced fever. The ET
MeSH term(s)	Animals ; Endothelin-1/antagonists & inhibitors ; Endothelin-1/metabolism ; Female ; Fever/chemically induced ; Fever/metabolism ; Gonadal Steroid Hormones/metabolism ; Injections, Intraventricular ; Male ; Ovariectomy/trends ; Poly I-C/administration & dosage ; Poly I-C/toxicity ; Rats ; Rats, Wistar ; Zymosan/administration & dosage ; Zymosan/toxicity
Chemical Substances	Endothelin-1 ; Gonadal Steroid Hormones ; Zymosan (9010-72-4) ; Poly I-C (O84C90HH2L)
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-020-01335-5
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Zs.A 1401: Show issues

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Article ; Online: Role of central endothelin-1 in hyperalgesia, anhedonia, and hypolocomotion induced by endotoxin in male rats.

Lomba, Luís Alexandre / Cruz, Juliana Varella / Coelho, Letícia Costa Mastrangelo / Leite-Avalca, Mariane Cristina Guttervill / Correia, Diego / Zampronio, Aleksander Roberto

Experimental brain research

2020 Volume 239, Issue 1, Page(s) 267–277

Abstract: Sickness syndrome is an adaptive response that can be distinguished by specific signs and symptoms, such as fever and generalized hyperalgesia. Endothelin-1 (ET-1) is produced by inflammatory stimuli, including lipopolysaccharide, and involved in the ... ...

Abstract	Sickness syndrome is an adaptive response that can be distinguished by specific signs and symptoms, such as fever and generalized hyperalgesia. Endothelin-1 (ET-1) is produced by inflammatory stimuli, including lipopolysaccharide, and involved in the pathogenesis of inflammation and pain by acting through ET
MeSH term(s)	Anhedonia ; Animals ; Endothelin-1/toxicity ; Endotoxins ; Hyperalgesia/chemically induced ; Male ; Rats ; Receptor, Endothelin B
Chemical Substances	Endothelin-1 ; Endotoxins ; Receptor, Endothelin B
Language	English
Publishing date	2020-11-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1201-4
ISSN	1432-1106 ; 0014-4819
ISSN (online)	1432-1106
ISSN	0014-4819
DOI	10.1007/s00221-020-05929-1
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Zs.A 278: Show issues

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Article ; Online: Toll-like receptor 4 (TLR4) signaling in the trigeminal ganglion mediates facial mechanical and thermal hyperalgesia in rats.

Araya, Erika Ivanna / Barroso, Amanda Ribeiro / Turnes, Joelle de Melo / Radulski, Débora Rasec / Jaganaught, Jovia-Roy Ashley / Zampronio, Aleksander Roberto / Chichorro, Juliana Geremias

Physiology & behavior

2020 Volume 226, Page(s) 113127

Abstract: There is increasing evidence that the toll-like receptor 4 (TLR4) signaling pathway contribute to development of hyperalgesia in the trigeminal system. The aim of the present study was to investigate the role of TLR4 in the trigeminal ganglion (TG) in ... ...

Abstract	There is increasing evidence that the toll-like receptor 4 (TLR4) signaling pathway contribute to development of hyperalgesia in the trigeminal system. The aim of the present study was to investigate the role of TLR4 in the trigeminal ganglion (TG) in facial hyperalgesia induced by injection of Lipopolysaccharide (LPS) or intraoral mucosal incision, which is an orofacial postoperative pain model, in male Wistar rats. The TLR4 antagonist (LPS-RS, 20 µg/10 µL) was administrated 30 min before LPS injection into the TG (10 µg/10 µL) or oral mucosa (10 µg/50 µL). In the postoperative pain model, rats were treated with LPS-RS (20 µg/10 µL) into the TG for three consecutive days after the incision. Facial heat and mechanical hyperalgesia were assessed hourly after LPS injection or intraoral incision. In addition, expression of NFκB was assessed in the TG on day 3 after intraoral incision. Our results showed that blockade of TLR4 in the TG attenuated facial heat and mechanical hyperalgesia induced by LPS or by mucosal incision, and that both conditions are associated to increase of phosphorylated NFκB in the TG. In conclusion, the present study suggests that activation of TLR4-NFκB signaling pathway in the TG contributes to the development of facial heat and mechanical hyperalgesia and may contribute to pain in inflammatory oral conditions.
MeSH term(s)	Animals ; Hyperalgesia ; Male ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Signal Transduction ; Toll-Like Receptor 4 ; Trigeminal Ganglion
Chemical Substances	Tlr4 protein, rat ; Toll-Like Receptor 4
Language	English
Publishing date	2020-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2020.113127
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Zs.A 747: Show issues

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Article: Toll-like receptor 4 (TLR4) signaling in the trigeminal ganglion mediates facial mechanical and thermal hyperalgesia in rats

Araya, Erika Ivanna / Barroso, Amanda Ribeiro / Turnes, Joelle de Melo / Radulski, Débora Rasec / Jaganaught, Jovia-Roy Ashley / Zampronio, Aleksander Roberto / Chichorro, Juliana Geremias

Physiology & behavior. 2020 Nov. 01, v. 226

2020

Abstract	There is increasing evidence that the toll-like receptor 4 (TLR4) signaling pathway contribute to development of hyperalgesia in the trigeminal system. The aim of the present study was to investigate the role of TLR4 in the trigeminal ganglion (TG) in facial hyperalgesia induced by injection of Lipopolysaccharide (LPS) or intraoral mucosal incision, which is an orofacial postoperative pain model, in male Wistar rats. The TLR4 antagonist (LPS-RS, 20 µg/10 µL) was administrated 30 min before LPS injection into the TG (10 µg/10 µL) or oral mucosa (10 µg/50 µL). In the postoperative pain model, rats were treated with LPS-RS (20 µg/10 µL) into the TG for three consecutive days after the incision. Facial heat and mechanical hyperalgesia were assessed hourly after LPS injection or intraoral incision. In addition, expression of NFκB was assessed in the TG on day 3 after intraoral incision. Our results showed that blockade of TLR4 in the TG attenuated facial heat and mechanical hyperalgesia induced by LPS or by mucosal incision, and that both conditions are associated to increase of phosphorylated NFκB in the TG. In conclusion, the present study suggests that activation of TLR4-NFκB signaling pathway in the TG contributes to the development of facial heat and mechanical hyperalgesia and may contribute to pain in inflammatory oral conditions.
Keywords	Toll-like receptor 4 ; antagonists ; behavior ; ganglia ; heat ; lipopolysaccharides ; males ; models ; mucosa ; pain ; somatosensory disorders
Language	English
Dates of publication	2020-1101
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2020.113127
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Central mediators of the zymosan-induced febrile response.

Bastos-Pereira, Amanda Leite / Fraga, Daniel / Dreifuss, Arturo Alejandro / Zampronio, Aleksander Roberto

Journal of basic and clinical physiology and pharmacology

2017 Volume 28, Issue 6, Page(s) 555–562

Abstract: Background: Zymosan is a fungal cell wall protein-carbohydrate complex that is known to activate inflammatory pathways through the Toll-like receptors and is commonly used to induce fever. Nevertheless, the central mediators that are involved in the ... ...

Abstract	Background: Zymosan is a fungal cell wall protein-carbohydrate complex that is known to activate inflammatory pathways through the Toll-like receptors and is commonly used to induce fever. Nevertheless, the central mediators that are involved in the zymosan-induced febrile response are only partially known. Methods: The present study evaluated the participation of prostaglandins, substance P, endothelin-1 (ET-1), and endogenous opioids (eOPs) in the zymosan-induced febrile response by using inhibitors and antagonists in male Wistar rats. Results: Both nonselective (indomethacin) and selective (celecoxib) cyclooxygenase inhibitors reduced the febrile response induced by an intraperitoneal (i.p.) injection of zymosan. Indomethacin also blocked the increase in the prostaglandin E2 levels in the cerebrospinal fluid. An intracerebroventricular injection of the neurokinin-1, ETB, and μ-opioid receptor antagonists also reduced the febrile response induced by the i.p. injected zymosan. Moreover, the μ-opioid receptor antagonist CTAP also reduced the febrile response induced by intra-articular injection of zymosan. Conclusions: These results demonstrate that prostaglandins, substance P, ET-1, and eOPs are central mediators of the zymosan-induced febrile response.
MeSH term(s)	Animals ; Body Temperature/drug effects ; Celecoxib/pharmacology ; Dinoprostone/cerebrospinal fluid ; Fever/chemically induced ; Fever/prevention & control ; Indomethacin/pharmacology ; Infusions, Intraventricular ; Injections, Intra-Articular ; Injections, Intraperitoneal ; Male ; Oligopeptides/administration & dosage ; Oligopeptides/pharmacology ; Peptide Fragments/administration & dosage ; Peptide Fragments/pharmacology ; Piperidines/administration & dosage ; Piperidines/pharmacology ; Rats ; Somatostatin/administration & dosage ; Somatostatin/pharmacology ; Tropanes/administration & dosage ; Tropanes/pharmacology ; Zymosan/administration & dosage ; Zymosan/antagonists & inhibitors
Chemical Substances	CTAP octapeptide ; Oligopeptides ; Peptide Fragments ; Piperidines ; SR140333B ; Tropanes ; BQ 788 (44OLL8XEJ4) ; Somatostatin (51110-01-1) ; Zymosan (9010-72-4) ; Celecoxib (JCX84Q7J1L) ; Dinoprostone (K7Q1JQR04M) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2017-11-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2017-0061
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Zs.A 3207: Show issues

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Article ; Online: Immune-mediated febrile response in female rats: Role of central hypothalamic mediators.

Brito, Haissa Oliveira / Radulski, Débora / Wilhelms, Daniel Björk / Stojakovic, Andrea / Brito, Luciane Maria Oliveira / Gil da Costa, Rui Miguel / Trindade, Edvaldo / Engblom, David / Franco, Celia Regina Cavichiolo / Zampronio, Aleksander Roberto

Scientific reports

2020 Volume 10, Issue 1, Page(s) 4073

Abstract: Lipopolysaccharide (LPS) induces fever through cytokines like receptor-activator of nuclear factor κB ligand (RANKL), triggering mediators like prostaglandins (PG), endothelin-1 (ET-1), corticotrophin-releasing factor (CRF), substance P (SP) and ... ...

Abstract	Lipopolysaccharide (LPS) induces fever through cytokines like receptor-activator of nuclear factor κB ligand (RANKL), triggering mediators like prostaglandins (PG), endothelin-1 (ET-1), corticotrophin-releasing factor (CRF), substance P (SP) and endogenous opioids. LPS-induced fever is reduced in females compared with males except in ovariectomized (OVX) females which show increased fever mediated by PG. The present study aimed to identify the mediators involved in fever in intact and OVX female rats. Fever was induced with LPS (50 μg/kg) intraperitoneally or CRF (2.5 μg), ET-1 (1 pg), morphine (10 μg) and SP (500 ng) intracerebroventricularly in sham-operated and OVX rats. The role of RANKL was evaluated with osteoprotegerin (OPG, 1 μg, intracerebroventricularly). Expression of RANK, CRF
MeSH term(s)	Analgesics, Opioid/metabolism ; Animals ; Corticotropin-Releasing Hormone/metabolism ; Cytokines/metabolism ; Endothelin-1/metabolism ; Female ; Fever/etiology ; Fever/metabolism ; Fever/pathology ; Hypothalamus/drug effects ; Hypothalamus/immunology ; Hypothalamus/metabolism ; Lipopolysaccharides/toxicity ; Ovariectomy/adverse effects ; Prostaglandins/metabolism ; RANK Ligand/metabolism ; Rats ; Rats, Wistar ; Substance P/metabolism
Chemical Substances	Analgesics, Opioid ; Cytokines ; Endothelin-1 ; Lipopolysaccharides ; Prostaglandins ; RANK Ligand ; Substance P (33507-63-0) ; Corticotropin-Releasing Hormone (9015-71-8)
Language	English
Publishing date	2020-03-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-61210-z
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Article ; Online: Evidence of substance P autocrine circuitry that involves TNF-α, IL-6, and PGE2 in endogenous pyrogen-induced fever.

Brito, Haissa Oliveira / Barbosa, Felipe L / Reis, Renata Cristiane Dos / Fraga, Daniel / Borges, Beatriz S / Franco, Celia R C / Zampronio, Aleksander Roberto

Journal of neuroimmunology

2016 Volume 293, Page(s) 1–7

Abstract: Substance P (SP) is involved in fever that is induced by lipopolysaccharide (LPS) but not by interleukin-1β or macrophage inflammatory protein-1α. Intracerebroventricular (i.c.v.) administration of the neurokinin-1 (NK1) receptor antagonist SR140333B in ... ...

Abstract	Substance P (SP) is involved in fever that is induced by lipopolysaccharide (LPS) but not by interleukin-1β or macrophage inflammatory protein-1α. Intracerebroventricular (i.c.v.) administration of the neurokinin-1 (NK1) receptor antagonist SR140333B in rats reduced fever that was induced by an i.c.v. injection of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2), corticotropin-releasing factor (CRF), endothelin-1 (ET-1), and morphine (MOR). Furthermore, an i.c.v. injection of SP induced a febrile response that was inhibited by indomethacin concomitant with an increase in PGE2 levels in cerebrospinal fluid. Lipopolysaccharide and PGE2 caused higher expression and internalization of NK1 receptors in the hypothalamus which were prevented by SR140333B. These data suggest that SP is an important mediator of fever, in which it induces a prostaglandin-dependent response and is released after TNF-α, IL-6, PGE2, CRF, endogenous opioids, and ET-1.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Body Temperature/drug effects ; Corticotropin-Releasing Hormone/pharmacology ; Dinoprostone/cerebrospinal fluid ; Fever/chemically induced ; Fever/prevention & control ; Gene Expression Regulation/drug effects ; Hypothalamus/drug effects ; Hypothalamus/metabolism ; Indomethacin/pharmacology ; Interleukin-6/administration & dosage ; Interleukin-6/metabolism ; Male ; Morphine/pharmacology ; Polysaccharides/toxicity ; Pyrogens ; Rats ; Rats, Wistar ; Receptors, Neurokinin-1/metabolism ; Substance P/metabolism ; Substance P/pharmacology ; Time Factors ; Tropanes/pharmacology ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Interleukin-6 ; Polysaccharides ; Pyrogens ; Receptors, Neurokinin-1 ; SR140333B ; Tropanes ; Tumor Necrosis Factor-alpha ; Substance P (33507-63-0) ; Morphine (76I7G6D29C) ; Corticotropin-Releasing Hormone (9015-71-8) ; Dinoprostone (K7Q1JQR04M) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2016-01-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2016.01.016
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Zs.A 1646: Show issues

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