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Article ; Online: Gold nanoparticles (AuNPs) decrease the viability of cervical cancer cells by inducing the BAX gene and activating antioxidant enzymes.

Kamil Shareef, Noor Alhuda / Zandsalimi, Farshid / Tavoosidana, Gholamreza

2024 Volume 51, Issue 1, Page(s) 287

Abstract: Background: Cervical Cancer (CC), a leading cause of female mortality worldwide, demonstrates a direct association with high-risk human papillomavirus (HPV) infections. However, not all CC patients exhibit HPV infection, suggesting additional ... ...

Abstract	Background: Cervical Cancer (CC), a leading cause of female mortality worldwide, demonstrates a direct association with high-risk human papillomavirus (HPV) infections. However, not all CC patients exhibit HPV infection, suggesting additional predisposing factors. Recently, disturbances in the oxidant-antioxidant balance have been implicated in CC development. This study explores the impact of gold nanoparticles (AuNPs) on the survival and antioxidant capacity of HeLa cells, aiming to contribute to novel CC therapy approaches. Methods and results: Synthesized and characterized AuNPs (25.5 nm, uniform distribution according to the DLS analysis) were administered to HeLa cells at varying concentrations. After 24 h, cell viability was assessed using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2 H-tetrazolium bromide) (MTT) assay. Real-time PCR measured expression levels of apoptosis-related genes (BCL2 associated X (BAX) and p53). Catalase and superoxide dismutase (SOD) activities, key antioxidant enzymes, were also evaluated post-AuNP treatment. AuNPs dose-dependently reduced HeLa cell viability, with an IC Conclusions: AuNPs demonstrated the potential to induce HeLa cell death by upregulating pro-apoptotic BAX gene expression and altering antioxidant system enzyme activities. These findings underscore the promise of AuNPs as a therapeutic avenue for CC, emphasizing their impact on crucial cellular processes involved in cancer progression.
MeSH term(s)	Humans ; Female ; Uterine Cervical Neoplasms/genetics ; Gold/pharmacology ; Antioxidants ; HeLa Cells ; bcl-2-Associated X Protein/genetics ; Metal Nanoparticles
Chemical Substances	Gold (7440-57-5) ; Antioxidants ; bcl-2-Associated X Protein
Language	English
Publishing date	2024-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09253-7
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Article ; Online: A review on colorimetric assays for DNA virus detection.

Abdolhosseini, Mansoreh / Zandsalimi, Farshid / Moghaddam, Fahimeh Salasar / Tavoosidana, Gholamreza

Journal of virological methods

2022 Volume 301, Page(s) 114461

Abstract: Early detection is one of the ways to deal with DNA virus widespread prevalence, and it is necessary to know new diagnostic methods and techniques. Colorimetric assays are one of the most advantageous methods in detecting viruses. These methods are based ...

Abstract	Early detection is one of the ways to deal with DNA virus widespread prevalence, and it is necessary to know new diagnostic methods and techniques. Colorimetric assays are one of the most advantageous methods in detecting viruses. These methods are based on color change, which can be seen either with the naked eye or with special devices. The aim of this study is to introduce and evaluate effective colorimetric methods based on amplification, nanoparticle, CRISPR/Cas, and Lateral flow in the diagnosis of DNA viruses and to discuss the effectiveness of each of the updated methods. Compared to the other methods, colorimetric assays are preferred for faster detection, high efficiency, cheaper cost, and high sensitivity and specificity. It is expected that the spread of these viruses can be prevented by identifying and developing new methods.
MeSH term(s)	Colorimetry/methods ; DNA ; DNA Viruses ; Nucleic Acid Amplification Techniques/methods ; Sensitivity and Specificity
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2022-01-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2022.114461
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Article ; Online: Bacillus subtilis supernatant improves the efficacy of radiation therapy in rat intestinal epithelial cells by upregulation of bax and caspase-3 genes.

Nazari, Niloofar / Zandsalimi, Farshid / Abdolhosseini, Mansoreh / Ghahremani, Mohammad Hossein / Motevaseli, Elahe

Molecular biology reports

2023 Volume 50, Issue 9, Page(s) 7639–7647

Abstract: Background: Colorectal Cancer (CC) is among the most prevalent cancers in elderly persons. Radiotherapy is usually prescribed as CC develops, however, radiation beams indiscriminately affect normal cells. Previous studies nominated that probiotics and ... ...

Abstract	Background: Colorectal Cancer (CC) is among the most prevalent cancers in elderly persons. Radiotherapy is usually prescribed as CC develops, however, radiation beams indiscriminately affect normal cells. Previous studies nominated that probiotics and their metabolites can be used to minimize the side effects of radiotherapy. Hereby, the aim of this study was to investigate the probable correlation between cell-free supernatant of Bacillus subtilis and radiation response in normal and cancerous cell lines. Methods and results: IEC-18 and SW-48 cells were treated with different concentrations of B. subtilis supernatant. To evaluate the effect of probiotic treatments under radiation and the normal situation, the cytotoxicity of the treatments was measured using the MTT method. The cell cycle status was analyzed by flow cytometry. The expression levels of Bax, Bcl-2, and Caspase 3 genes were also determined by real-time (RT) PCR. B. subtilis supernatant increased the viability of normal cells under radiation treatment, although this effect was not significant. 40% v/v of this mixture could amplify the lethal effect of radiation and decreased the viability of cancer cells. SW-48 cells that received 40% v/v of the supernatant had a significantly higher rate of apoptosis. Probiotic supernatant effectively induced the expression of proapoptotic Bax and Caspase 3 genes. Conclusion: Presented results confirmed that the supernatant of B. subtilis can be supposed as a clue to improve the efficacy of radiation therapy in CC patients as it increased the sensitivity of cancerous cells and protected normal epithelial cells from detrimental effects of radiation.
MeSH term(s)	Rats ; Animals ; Bacillus subtilis/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; Up-Regulation ; Epithelial Cells/metabolism ; Apoptosis ; Probiotics/pharmacology
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; bcl-2-Associated X Protein
Language	English
Publishing date	2023-08-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08694-w
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Article ; Online: A review on colorimetric assays for DNA virus detection

Abdolhosseini, Mansoreh / Zandsalimi, Farshid / Moghaddam, Fahimeh Salasar / Tavoosidana, Gholamreza

Journal of Virological Methods. 2022 Mar., v. 301 p.114461-

2022

Abstract	Early detection is one of the ways to deal with DNA virus widespread prevalence, and it is necessary to know new diagnostic methods and techniques. Colorimetric assays are one of the most advantageous methods in detecting viruses. These methods are based on color change, which can be seen either with the naked eye or with special devices. The aim of this study is to introduce and evaluate effective colorimetric methods based on amplification, nanoparticle, CRISPR/Cas, and Lateral flow in the diagnosis of DNA viruses and to discuss the effectiveness of each of the updated methods. Compared to the other methods, colorimetric assays are preferred for faster detection, high efficiency, cheaper cost, and high sensitivity and specificity. It is expected that the spread of these viruses can be prevented by identifying and developing new methods.
Keywords	DNA ; DNA viruses ; color ; colorimetry ; nanoparticles ; LAMP ; SDA ; RCA ; HPV ; LF ; NP ; QD ; AuNP ; AgNP ; LSPR ; UCNP ; LRET ; FRET ; PEI ; AMC-SDA ; CRISPR ; RPA ; LFIA ; NALFA ; Colorimetric assay ; Nanoparticle ; Loop-mediated isothermal amplification ; CRISPR/Cas ; Lateral flow
Language	English
Dates of publication	2022-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2022.114461
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Article: Denovo designing: a novel signal peptide for tat translocation pathway to transport activin A to the periplasmic space of E. coli

Zandsalimi, Farshid / Hajihassan, Zahra / Hamidi, Roghaye

Biotechnology letters. 2020 Jan., v. 42, no. 1

2020

Abstract: OBJECTIVES: The twin-arginine translocation (Tat) pathway is one of the bacterial secretory strategies which exports folded proteins across the cytoplasmic membrane. RESULTS: In the present study, we designed a novel Tat-signal peptide for secretion of ... ...

Abstract	OBJECTIVES: The twin-arginine translocation (Tat) pathway is one of the bacterial secretory strategies which exports folded proteins across the cytoplasmic membrane. RESULTS: In the present study, we designed a novel Tat-signal peptide for secretion of human activin A used as a recombinant protein model here. In doing so, Haloferax volcanii, Halobacterium salinarum, and Escherichia coli Tat specific signal peptides were aligned by ClustalW program to determine conserved and more frequently used residues. After making the initial signal peptide sequence and doing some mutations, efficiency of this designed signal peptide was evaluated using a set of well-known software programs such as TatP, PRED-TAT, and Phobius. Then the best complex between TatC as an initiator protein in Tat secretory machine and the new designed signal peptide connected to activin A with the lowest binding energy was constructed by HADDOCK server, and ΔΔG value of − 5.5 kcal/mol was calculated by FoldX module. After that, efficiency of this novel signal peptide for secretion of human activin A to the periplasmic space of E. coli Rosetta-gami (DE3) strain was experimentally evaluated; to scrutinize the activity of the novel signal peptide, Iranian Bacillus Licheniformis α-Amylase enzyme signal peptide as a Sec pathway signal peptide was used as a positive control. The quantitative analysis of western blotting bands by ImageJ software confirmed the high secretion ability of the new designed signal peptide; translocation of 69% of the produced recombinant activin A to the periplasmic space of E. coli. Circular Dichroism (CD) spectroscopy technique also approved the proper secondary structure of activin A secreted to the periplasmic space. The biological activity of activin A was also confirmed by differentiation of K562 erythroleukemia cells to the red blood cell by measuring the amount of hemoglobin or Fe2+ ion using ICP method. CONCLUSIONS: In conclusion, this novel designed signal peptide can be used to secrete any other recombinant proteins to the periplasmic space of E. coli efficiently.
Keywords	alpha-amylase ; Bacillus licheniformis ; bioactive properties ; circular dichroism spectroscopy ; computer software ; erythrocytes ; Escherichia coli ; hemoglobin ; humans ; iron ; quantitative analysis ; recombinant proteins ; secretion ; signal peptide ; Western blotting
Language	English
Dates of publication	2020-01
Size	p. 45-55.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-019-02752-9
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Article ; Online: Determination of melamine contamination in milk with various packaging: a risk assessment study.

Ghanati, Kiandokht / Eghbaljoo, Hadi / Akbari, Nader / Mazaheri, Yeganeh / Aghebat-Bekheir, Saeed / Mahmoodi, Babak / Zandsalimi, Farshid / Basaran, Burhan / Sadighara, Parisa

Environmental monitoring and assessment

2023 Volume 195, Issue 9, Page(s) 1095

Abstract: Melamine is one type of monomer used as starting substance in manufacturing packaging lining in many countries worldwide. Environmental and food contamination is an issue constantly discussed. In the present study, the melamine content in milk samples ... ...

Abstract	Melamine is one type of monomer used as starting substance in manufacturing packaging lining in many countries worldwide. Environmental and food contamination is an issue constantly discussed. In the present study, the melamine content in milk samples with three package types was measured by HPLC/UV. Melamine is not a lipophilic compound. Therefore, the selected samples were low-fat milk. The melamine content in various packaged milk, including packet, polyethylene bags, and plastic packaging, is 790 ± 39.8, 50.7 ± 13, and 57.7 ± 24.54 ppb, respectively. According to the existing standards, the measured values in all the milk samples were lower than the permitted limits. The risk assessment for adults and children showed that the HQ value for both age groups was less than 1. Therefore, milk consumption will not pose a health risk in terms of contamination with melamine.
MeSH term(s)	Adult ; Child ; Humans ; Animals ; Milk ; Environmental Monitoring ; Polyethylene ; Risk Assessment
Chemical Substances	melamine (N3GP2YSD88) ; Polyethylene (9002-88-4)
Language	English
Publishing date	2023-08-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-023-11737-1
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Article ; Online: Spinal Muscular Atrophy with Progressive Myoclonic Epilepsy (SMA-PME): three new cases and review of the mutational spectrum.

Najafi, Ali / Tasharrofi, Behnoosh / Zandsalimi, Farshid / Rasulinezhad, Maryam / Ghahvechi Akbari, Masood / Zamani, Gholamreza / Ashrafi, Mahmoud Reza / Heidari, Morteza

Italian journal of pediatrics

2023 Volume 49, Issue 1, Page(s) 64

Abstract: Background: Spinal muscular atrophy (SMA) could be classified as 5q and non-5q, based on the chromosomal location of causative genes. A rare form of non-5q SMA is an autosomal-recessive condition called spinal muscular atrophy with progressive myoclonic ...

Abstract	Background: Spinal muscular atrophy (SMA) could be classified as 5q and non-5q, based on the chromosomal location of causative genes. A rare form of non-5q SMA is an autosomal-recessive condition called spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME), phenotypically characterized by myoclonic and generalized seizures with progressive neurological deterioration. SMA-PME is a clinically heterogeneous disorder that arises from biallelic pathogenic variants in ASAH1 gene. Methods: Following clinical and primary laboratory assessments, whole-exome sequencing was performed to detect the disease-causing variants in three cases of SMA-PME from different families. Also, Multiplex ligation-dependent probe amplification (MLPA) was employed for determining the copy numbers of SMN1 and SMN2 genes to rule out 5q SMA. Results: Exome sequencing revealed two different homozygous missense mutations (c.109 C > A [p.Pro37Thr] or c.125 C > T [p.Thr42Met]) in exon 2 of the ASAH1 gene in the affected members of the families. Sanger sequencing of the other family members showed the expected heterozygous carriers. In addition, no clinically relevant variant was identified in patients by MLPA. Conclusion: This study describes two different ASAH1 mutations and the clinical picture of 3 SMA-PME patients. In addition, previously reported mutations have been reviewed. This study could help to fortify the database of this rare disease with more clinical and genomic data.
MeSH term(s)	Humans ; Mutation ; Muscular Atrophy, Spinal/diagnosis ; Muscular Atrophy, Spinal/genetics ; Myoclonic Epilepsies, Progressive/genetics ; Mutation, Missense
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-023-01474-z
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Article ; Online: Enhanced periplasmic expression of human activin A in

Hajihassan, Zahra / Khairkhah, Niloofar / Zandsalimi, Farshid

Preparative biochemistry & biotechnology

2019 Volume 50, Issue 2, Page(s) 141–147

Abstract: Activin A is a member of the transforming growth factor-beta (TGF-β) protein superfamily, which acts as a hormone in regulating cell proliferation and differentiation. Structurally, activin is a dimer of two subunits linked by a disulfide bond. Since the ...

Abstract	Activin A is a member of the transforming growth factor-beta (TGF-β) protein superfamily, which acts as a hormone in regulating cell proliferation and differentiation. Structurally, activin is a dimer of two subunits linked by a disulfide bond. Since the correct folding of this protein is essential for its function, we aimed to use a modified signal peptide to target the expressed recombinant protein to the periplasm of
MeSH term(s)	Activins/chemistry ; Activins/genetics ; Activins/isolation & purification ; Chromatography, Affinity ; Escherichia coli/genetics ; Humans ; K562 Cells ; Periplasm/metabolism ; Protein Sorting Signals ; Protein Structure, Secondary ; alpha-Amylases/metabolism
Chemical Substances	Protein Sorting Signals ; activin A ; Activins (104625-48-1) ; alpha-Amylases (EC 3.2.1.1) ; alpha-amylase, Bacillus licheniformis (EC 3.2.1.1)
Language	English
Publishing date	2019-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1322522-4
ISSN	1532-2297 ; 1082-6068
ISSN (online)	1532-2297
ISSN	1082-6068
DOI	10.1080/10826068.2019.1679177
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Article ; Online: Denovo designing: a novel signal peptide for tat translocation pathway to transport activin A to the periplasmic space of E. coli.

Zandsalimi, Farshid / Hajihassan, Zahra / Hamidi, Roghaye

Biotechnology letters

2019 Volume 42, Issue 1, Page(s) 45–55

Abstract: Objectives: The twin-arginine translocation (Tat) pathway is one of the bacterial secretory strategies which exports folded proteins across the cytoplasmic membrane.: Results: In the present study, we designed a novel Tat-signal peptide for secretion ...

Abstract	Objectives: The twin-arginine translocation (Tat) pathway is one of the bacterial secretory strategies which exports folded proteins across the cytoplasmic membrane. Results: In the present study, we designed a novel Tat-signal peptide for secretion of human activin A used as a recombinant protein model here. In doing so, Haloferax volcanii, Halobacterium salinarum, and Escherichia coli Tat specific signal peptides were aligned by ClustalW program to determine conserved and more frequently used residues. After making the initial signal peptide sequence and doing some mutations, efficiency of this designed signal peptide was evaluated using a set of well-known software programs such as TatP, PRED-TAT, and Phobius. Then the best complex between TatC as an initiator protein in Tat secretory machine and the new designed signal peptide connected to activin A with the lowest binding energy was constructed by HADDOCK server, and ΔΔG value of - 5.5 kcal/mol was calculated by FoldX module. After that, efficiency of this novel signal peptide for secretion of human activin A to the periplasmic space of E. coli Rosetta-gami (DE3) strain was experimentally evaluated; to scrutinize the activity of the novel signal peptide, Iranian Bacillus Licheniformis α-Amylase enzyme signal peptide as a Sec pathway signal peptide was used as a positive control. The quantitative analysis of western blotting bands by ImageJ software confirmed the high secretion ability of the new designed signal peptide; translocation of 69% of the produced recombinant activin A to the periplasmic space of E. coli. Circular Dichroism (CD) spectroscopy technique also approved the proper secondary structure of activin A secreted to the periplasmic space. The biological activity of activin A was also confirmed by differentiation of K562 erythroleukemia cells to the red blood cell by measuring the amount of hemoglobin or Fe Conclusions: In conclusion, this novel designed signal peptide can be used to secrete any other recombinant proteins to the periplasmic space of E. coli efficiently.
MeSH term(s)	Activins/chemistry ; Activins/genetics ; Activins/metabolism ; Cell Membrane/enzymology ; Cell Membrane/metabolism ; Circular Dichroism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Halobacterium salinarum/genetics ; Haloferax volcanii/genetics ; Humans ; Periplasm/metabolism ; Protein Folding ; Protein Sorting Signals/genetics ; Protein Transport ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Twin-Arginine-Translocation System/metabolism
Chemical Substances	Protein Sorting Signals ; Recombinant Proteins ; Twin-Arginine-Translocation System ; activin A ; Activins (104625-48-1)
Language	English
Publishing date	2019-11-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	423853-9
ISSN	1573-6776 ; 0141-5492
ISSN (online)	1573-6776
ISSN	0141-5492
DOI	10.1007/s10529-019-02752-9
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Article ; Online: Effect of resveratrol on the radiosensitivity of 5-FU in human breast cancer MCF-7 cells.

Aghamiri, Shahin / Jafarpour, Ali / Zandsalimi, Farshid / Aghemiri, Mehran / Shoja, Mohsen

Journal of cellular biochemistry

2019 Volume 120, Issue 9, Page(s) 15671–15677

Abstract: The aim of this study was to assess the efficacy of resveratrol (Res) on radiosensitivity of 5-fluorouracil (5-FU) in the spheroid culture of MCF-7 breast cancer cell line using colony formation examination. Spheroids on day 9 with 300 µm diameters were ... ...

Abstract	The aim of this study was to assess the efficacy of resveratrol (Res) on radiosensitivity of 5-fluorouracil (5-FU) in the spheroid culture of MCF-7 breast cancer cell line using colony formation examination. Spheroids on day 9 with 300 µm diameters were treated with 20 µM resveratrol and/or 1 µM 5-FU for one volume doubling time (VDT) (42 hours) and then irradiated with 2 Gy gamma radiation (
MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/radiotherapy ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Combined Modality Therapy ; Female ; Fluorouracil/pharmacology ; Gamma Rays ; Humans ; MCF-7 Cells ; Radiation Tolerance/drug effects ; Radiation Tolerance/radiation effects ; Resveratrol/pharmacology ; Spheroids, Cellular/drug effects
Chemical Substances	Resveratrol (Q369O8926L) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2019-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.28836
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