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  1. Article ; Online: MutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study.

    Amaral-Silva, G-K / Dias, L-M / Mariz, B-A / Fonseca, F-P / Rangel, A-L / Zanella, V-G / Castilho, R-M / Martins, M-D / Vargas, P-A / Wagner, V-P

    Medicina oral, patologia oral y cirugia bucal

    2022  Volume 27, Issue 2, Page(s) e164–e173

    Abstract: Background: Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA ... ...

    Abstract Background: Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA mismatch-repair system MutSα (hMSH2-hMSH6) and MutSβ (hMSH2-hMSH3) in a panel comprising the most common benign and malignant salivary gland tumors (SGT), and to determine their association with disease-free survival.
    Material and methods: Ten cases of normal salivary gland (NSG) and 92 of SGT (54 benign and 38 malignant) were retrieved. Immunohistochemistry was performed for hMSH2, hMSH3, hMSH6. Scanned slides were digitally analyzed based on the percentage of positive cells with nuclear staining. Cases were further classified in MutSαhigh and MutSβhigh based on hMSH2-hMSH6 and hMSH3-hMSH6 expression, respectively.
    Results: hMSH3 expression was lower in malignant SGT compared to NSG and benign cases. Adenoid cystic carcinoma (ACC) cases with perineural invasion presented a lower percentage of hMSH3 positive cells. hMSH6 was downregulated in both benign and malignant SGT compared to NSG. Malignant SGT cases with MutSαhigh expression had lower disease-free survival compared to MutSαlow cases. A 10.26-fold increased risk of presenting local recurrence was observed.
    Conclusions: Our findings suggest that a lack of hMSH3 protein function is associated with a more aggressive phenotype (malignancy and perineural invasion) and that MutSα overexpression predicts a poor clinical outcome in malignant SGT.
    MeSH term(s) DNA Repair ; Disease-Free Survival ; Humans ; Immunohistochemistry ; MutS Homolog 2 Protein ; Salivary Gland Neoplasms
    Chemical Substances MutS Homolog 2 Protein (EC 3.6.1.3)
    Language English
    Publishing date 2022-03-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2171573-7
    ISSN 1698-6946 ; 1698-4447
    ISSN (online) 1698-6946
    ISSN 1698-4447
    DOI 10.4317/medoral.25138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Salivary gland cancer in Southern Brazil: a prognostic study of 107 cases.

    Zanella, V-G / Wagner, V-P / Schmidt, T-R / Thieme, S / Correa, C / Fonseca, F-P / Rigon, P / Barra, M-B / Kroef, R-G / Vargas, P-A / Martins, M-D

    Medicina oral, patologia oral y cirugia bucal

    2021  Volume 26, Issue 3, Page(s) e393–e403

    Abstract: Background: Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We performed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from the south of Brazil aiming to determine the ... ...

    Abstract Background: Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We performed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from the south of Brazil aiming to determine the prognostic value of demographic, clinic and pathologic features.
    Material and methods: Cases diagnosed as SGC between 2006 and 2016 were retrospectively collected. Medical records were examined to extract demographic, clinic, pathologic and follow-up information.
    Results: One-hundred and seven cases of SGC were identified. The most common SGC were mucoepidermoid carcinoma (MEC) (n = 39) followed by adenoid cystic carcinoma (AdCC) (n = 29). Among AdCCs, 55.2% of cases were classified as cribriform, 27.6% as tubular and 17.2% as solid. The tubular subtype had the highest percentage of cases with perineural invasion (p=0.01). Among MEC, 61.5% of cases were classified as low grade, 15.4% as intermediate grade and 19.9% as high grade. Low grade MEC had the lowest percentage of cases with perineural invasion (p=0.04). The 5-year survival for loco-regional control, disease-free survival (DFS) and disease-specific survival were 75%, 70% and 84%, respectively. The following features were associated with poor DFS: advanced age (p=0.03), rural residency (p=0.01), being a smoker or former smoker (p=0.01), pain (p=0.03), nodal metastasis (p<0.001), need for chemotherapy (p=0.02), neck dissection (p=0.04), perineural invasion (p=0.01), and being diagnosed with AdCC compared to MEC (p=0.02).
    Conclusions: The clinco-demographic and pathologic features identified as prognostic factors reveal the profile of patients at increased risk of recurrence and who would benefit from closer follow-up.
    MeSH term(s) Brazil/epidemiology ; Humans ; Neoplasm Recurrence, Local ; Prognosis ; Retrospective Studies ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/epidemiology ; Salivary Gland Neoplasms/therapy
    Language English
    Publishing date 2021-05-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2171573-7
    ISSN 1698-6946 ; 1698-4447
    ISSN (online) 1698-6946
    ISSN 1698-4447
    DOI 10.4317/medoral.24248
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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