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  1. Book ; Thesis: Blutgerinnungsstörungen und Progression hämorrhagischer Hirnkontusionen nach isoliertem Schädel-Hirn-Trauma

    Zang, Benedikt

    2015  

    Author's details von Benedikt Zang aus Bad Honnef
    Language German
    Size 122 Blätter, Illustrationen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Dresden, 2016
    HBZ-ID HT019166383
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 E 1786 order for loan Magazin

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  2. Article ; Online: Interdisciplinary risk counseling for hereditary breast and ovarian cancer: real-world data from a specialized center.

    Zang, Benedikt / Helms, Malina / Besch, Laura / Kalmbach, Nanette / Stegen, Stephanie / Blohmer, Jens-Uwe / Speiser, Dorothee

    Archives of gynecology and obstetrics

    2022  Volume 307, Issue 5, Page(s) 1585–1592

    Abstract: Purpose: Hereditary breast and ovarian cancer has long been established to affect a considerable number of patients and their families. By identifying those at risk ideally before they have been diagnosed with breast and/or ovarian cancer, access to ... ...

    Abstract Purpose: Hereditary breast and ovarian cancer has long been established to affect a considerable number of patients and their families. By identifying those at risk ideally before they have been diagnosed with breast and/or ovarian cancer, access to preventive measures, intensified screening and special therapeutic options can be obtained, and thus, prognosis can be altered beneficially. Therefore, a standardized screening and counseling process has been established in Germany under the aegis of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). As one of these specialized clinics, the HBOC-Center at Charité offers genetic counseling as well as genetic analysis based on the GC-HBOC standards. This analysis aims first at depicting this process from screening through counseling to genetic analysis as well as the patient collective and second at correlating the results of genetic analysis performed. Thus, real-world data from an HBOC-Center with a substantial patient collective and a high frequency of pathogenic variants in various genes shall be presented.
    Methods: The data of 2531 people having been counseled at the HBOC-Center at Charité in 2016 and 2017 were analyzed in terms of patient and family history as well as pathogenic variants detected during genetic analysis with the TruRisk
    Results: Genetic analysis was conducted in 59.8% of all cases meeting the criteria for genetic analysis and 286 pathogenic variants were detected among 278 (30.3%) counselees tested using the TruRisk
    Conclusion: Genetic counseling and analysis provide the foundation in the prevention and therapy of hereditary breast and ovarian cancer. The rate of pathogenic variants detected is associated with family history as well as breast cancer subtype and age at diagnosis, and can reach considerable dimensions. Therefore, a standardized process of identification, genetic counseling and genetic analysis deems mandatory.
    MeSH term(s) Humans ; Female ; Triple Negative Breast Neoplasms/genetics ; Genetic Predisposition to Disease ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/prevention & control ; Genes, BRCA2 ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/prevention & control ; Counseling ; Hereditary Breast and Ovarian Cancer Syndrome/diagnosis ; Hereditary Breast and Ovarian Cancer Syndrome/genetics ; Hereditary Breast and Ovarian Cancer Syndrome/prevention & control
    Language English
    Publishing date 2022-10-28
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-022-06819-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Paradigmatic Approach to Support Personalized Counseling With Digital Health (iKNOW).

    Speiser, Dorothee / Heibges, Maren / Besch, Laura / Hilger, Caren / Keinert, Marie / Klein, Katharina / Rauwolf, Gudrun / Schmid, Christine / Schulz-Niethammer, Sven / Stegen, Steffi / Westfal, Viola / Witzel, Isabell / Zang, Benedikt / Kendel, Friederike / Feufel, Markus A

    JMIR formative research

    2023  Volume 7, Page(s) e41179

    Abstract: iKNOW is the first evidence-based digital tool to support personalized counseling for women in Germany with a hereditary cancer risk. The counseling tool is designed for carriers of pathogenic gBRCA (germline breast cancer gene) variants that increase ... ...

    Abstract iKNOW is the first evidence-based digital tool to support personalized counseling for women in Germany with a hereditary cancer risk. The counseling tool is designed for carriers of pathogenic gBRCA (germline breast cancer gene) variants that increase the lifetime risk of breast and ovarian cancer. Carriers of pathogenic variants are confronted with complex, individualized risk information, and physicians must be able to convey this information in a comprehensible way to enable preference-sensitive health decisions. In this paper, we elaborate on the clinical, regulatory, and practical premises of personalized counseling in Germany. By operationalizing these premises, we formulate 5 design principles that, we suggest, are specific enough to develop a digital tool (eg, iKNOW), yet wide-ranging enough to inform the development of counseling tools for personalized medicine more generally: (1) digital counseling tools should implement the current standard of care (eg, based on guidelines); (2) digital counseling tools should help to both standardize and personalize the counseling process (eg, by enabling the preference-sensitive selection of counseling contents from a common information base); (3) digital counseling tools should make complex information easy to access both cognitively (eg, by using evidenced-based risk communication formats) and technically (eg, by means of responsive design for various devices); (4) digital counseling tools should respect the counselee's data privacy rights (eg, through strict pseudonymization and opt-in consent); and (5) digital counseling tools should be systematically and iteratively evaluated with the users in mind (eg, using formative prototype testing to ensure a user-centric design and a summative multicenter, randomized controlled trial). On the basis of these paradigmatic design principles, we hope that iKNOW can serve as a blueprint for the development of more digital innovations to support personalized counseling approaches in cancer medicine.
    Language English
    Publishing date 2023-04-21
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/41179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early hemorrhagic progression of traumatic brain contusions: frequency, correlation with coagulation disorders, and patient outcome: a prospective study.

    Juratli, Tareq A / Zang, Benedikt / Litz, Rainer J / Sitoci, Kerim-Hakan / Aschenbrenner, Ulf / Gottschlich, Birgit / Daubner, Dirk / Schackert, Gabriele / Sobottka, Stephan B

    Journal of neurotrauma

    2014  Volume 31, Issue 17, Page(s) 1521–1527

    Abstract: The focus of this paper is to identify and quantify risk factors for early hemorrhagic progression of brain contusions (HPC) in patients with traumatic brain injury (TBI) and to evaluate their impact on patients' outcome. Further, based on abnormal ... ...

    Abstract The focus of this paper is to identify and quantify risk factors for early hemorrhagic progression of brain contusions (HPC) in patients with traumatic brain injury (TBI) and to evaluate their impact on patients' outcome. Further, based on abnormal values in routine blood tests, the role of trauma-induced coagulopathy is analyzed in detail. Therefore, a prospective study of 153 TBI patients was completed at one institution between January 2008 and June 2012. The collected data included demographics, initial Glasgow Coma Scale pupillary response, initial and 6 h follow-up computed tomography scan findings, coagulation parameters (international normalized ratio, partial thromboplastin time, platelet count, fibrinogen, D-dimer and factor XIII), as well as outcome data using the modified Rankin score at discharge and after one year. The overall rate of early HPC within the first 6 h was 43.5%. The frequency of coagulopathy was 47.1%. When analyzing for risk factors that independently influenced outcome in the form of mRS ≥4 at both points, the following variables appeared: elevated D-dimer level (≥10,000 μg/L), HPC, and initial brain contusions ≥3 cm. Patients sustaining early HPC had a hazard ratio of 5.4 for unfavorable outcome at discharge (p=0.002) and of 3.9 after one year (p=0.006). Overall, patients who developed early HPC were significantly more likely to be gravely disabled or to die. Unfavorable neurological outcome after an isolated TBI is determined largely by early HPC and coagulopathy, which seem to occur very frequently in TBI patients, irrespective of the severity of the trauma.
    MeSH term(s) Adolescent ; Adult ; Aged ; Blood Coagulation Disorders/epidemiology ; Brain Hemorrhage, Traumatic/epidemiology ; Brain Hemorrhage, Traumatic/etiology ; Brain Injuries/complications ; Brain Injuries/mortality ; Disease Progression ; Female ; Glasgow Coma Scale ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Risk Factors ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2014-09-01
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2013.3241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2016: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Conference proceedings: Coagulation disorders in patients with traumatic brain contusions: predictors for progression, frequency, clinical consequences, and long-term outcome

    Juratli, Tareq / Sitoci, Kerim-Hakan / Schackert, Gabriele / Zang, Benedikt / Sobottka, Stephan

    2014  , Page(s) 14dgch238

    Event/congress 131. Kongress der Deutschen Gesellschaft für Chirurgie; Berlin; Deutsche Gesellschaft für Chirurgie; 2014
    Keywords Medizin, Gesundheit
    Publishing date 2014-03-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/14dgch238
    Database German Medical Science

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  6. Conference proceedings: Prior anticoagulation or antiplatelet use affects intracranial hemorrhage pattern and patient's outcome after traumatic brain injuries

    Juratli, Tareq A. / Zang, Benedikt / Litz, Rainer / Sitoci, Kerim-Hakan / Klein, Johann / Schackert, Gabriele / Sobottka, Stephan B

    2015  , Page(s) MO.17.02

    Event/congress 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); Karlsruhe; Deutsche Gesellschaft für Neurochirurgie; 2015
    Keywords Medizin, Gesundheit ; antiplatelet ; anticoagulation ; traumatic brain injuries
    Publishing date 2015-06-02
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/15dgnc079
    Database German Medical Science

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