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Article: Association between Coronary Artery Disease and rs10757278 and rs1333049 Polymorphisms in 9p21 Locus in Iran.

Yaghoubi Hariri, Farbod / Salahshourifar, Iman / Zare Karizi, Shohreh

Reports of biochemistry & molecular biology

2020 Volume 9, Issue 1, Page(s) 58–63

Abstract: Background: Coronary arteries disease (CAD) has been recognized as one of the most common causes of death worldwide, with an estimated seven million deaths annually.: Methods: Two hundred blood samples from Iranian CAD patients and normal healthy ... ...

Abstract	Background: Coronary arteries disease (CAD) has been recognized as one of the most common causes of death worldwide, with an estimated seven million deaths annually. Methods: Two hundred blood samples from Iranian CAD patients and normal healthy controls were collected. CAD and the 9p21 locus variants Results: No significant differences in Conclusion: The inconsistency between the results of this and other studies on different CAD populations may be due to high population, different ethnicities, low prevalence of some alleles in populations, and interactions of different genes.
Language	English
Publishing date	2020-08-14
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2743890-9
ISSN	2322-3480
ISSN	2322-3480
DOI	10.29252/rbmb.9.1.58
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Article ; Online: Designing and determining immunogenicity of a recombinant protein due to producing a new vaccine against Enterotoxigenic Escherichia coli containing CfaE and CotD subunits.

Roghanian, Pooneh / Zare Karizi, Shohreh / Motamedi, Mohammad Javad / Kazemi, Rouhollah / Khoobbakht, Dorna / Amani, Jafar

Journal of immunoassay & immunochemistry

2021 Volume 42, Issue 5, Page(s) 525–542

Abstract: ... ...

Abstract	Enterotoxigenic
MeSH term(s)	Animals ; Antibodies, Bacterial ; Bacterial Toxins ; Enterotoxigenic Escherichia coli/immunology ; Escherichia coli Infections/prevention & control ; Escherichia coli Proteins/genetics ; Escherichia coli Vaccines ; Mice ; Mice, Inbred BALB C ; Recombinant Fusion Proteins/genetics ; Recombinant Proteins
Chemical Substances	Antibodies, Bacterial ; Bacterial Toxins ; Escherichia coli Proteins ; Escherichia coli Vaccines ; Recombinant Fusion Proteins ; Recombinant Proteins
Language	English
Publishing date	2021-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2050610-7
ISSN	1532-4230 ; 1532-1819
ISSN (online)	1532-4230
ISSN	1532-1819
DOI	10.1080/15321819.2021.1906890
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Article ; Online: Expression Patterns of miR181a and miR30d in Patients with Breast Cancer.

Tavakolpournegari, Alireza / Hashemi, Mehrdad / Zare Karizi, Shohreh / Matin Ahmadi, Arash / Bidooki, Seyed Hesamoddin / Banaei, Gooya

Iranian journal of public health

2022 Volume 51, Issue 7, Page(s) 1594–1601

Abstract: Background: One of the important molecular pathways in breast cancer is the PTEN-PI3K-AKT pathway. Any change in the activity of the PTEN gene can alter the PI3K-AKT pathway. Moreover, there are subsets of genes and pathways their expression changes by ... ...

Abstract	Background: One of the important molecular pathways in breast cancer is the PTEN-PI3K-AKT pathway. Any change in the activity of the PTEN gene can alter the PI3K-AKT pathway. Moreover, there are subsets of genes and pathways their expression changes by post-transcriptional regulations. For instance, gene regulation alters by non-coding RNAs such as micro-RNAs as post-transcriptional regulators that prevent the expression of the target transcript. Therefore, it is essential to assess the related alterations in micro-RNA expression patterns to find out the possible causes of conversions in related transcripts and pathways such as the PTENPI3K-AKT pathway in breast cancer. Methods: To determine the expression level of miR-181a and miR-30d in 30 breast tumor samples and 30 adjacent normal samples, the RNA extraction, and cDNA synthesis was performed by RiboEx (GeneAll, Korea). Finally, the Real-Time PCR method was used for quantitative analysis of the expression levels of these miRNAs. all the experimental part of the project in done at Islamic Azad University in 2017. Results: After analyzing comparisons in the expression level of miR-181a and miR-30d in tumor and normal tissues, there was a significant increase in the expression level of miR-181a in tumor samples compared with normal samples. Moreover, the expression level of miR-30d in tumor samples reported a significant decrease in comparison with normal samples ( Conclusion: Upregulation of miR-181a may affect the transcription of the PTEN gene resulting in the cell progress to cancer. The Downregulation of miR-30d may also lead to cancer cell growth, due to a reduction in the affecting on the CREB gene transcript.
Language	English
Publishing date	2022-09-27
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2240935-X
ISSN	2251-6093 ; 2251-6093
ISSN (online)	2251-6093
ISSN	2251-6093
DOI	10.18502/ijph.v51i7.10093
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Article ; Online: Alterations of DNA methylation and expression of genes related to thyroid hormone metabolism in colon epithelium of obese patients.

Shimi, Ghazaleh / Pourvali, Katayoun / Ghorbani, Arman / Nooshin, Sajad / Zare Karizi, Shohreh / Iranirad, Reza / Zand, Hamid

BMC medical genomics

2022 Volume 15, Issue 1, Page(s) 229

Abstract: Background: Colorectal cancer is common among obese individuals. The purpose of the current study was to determine changes in DNA methylation status and mRNA expression of thyroid hormone receptor beta (THRB), as a tumor suppressor, and thyroid hormone ... ...

Abstract	Background: Colorectal cancer is common among obese individuals. The purpose of the current study was to determine changes in DNA methylation status and mRNA expression of thyroid hormone receptor beta (THRB), as a tumor suppressor, and thyroid hormone inactivating enzyme, type 3 deiodinase (DIO3) genes, in human epithelial colon tissues of healthy obese individuals. Methods: Colon biopsies were analyzed by methylation sensitive-high resolution melting (MS-HRM) to investigate promoter methylation of DIO3 and THRB, and by quantitative real-time polymerase chain reaction to assay expression of DIO3 and THRB mRNA on eighteen obese and twenty-one normal-weight healthy men. Results: There was no significant difference in mean methylation levels at the THRB promoter region between the two groups. Nevertheless, obesity decreased THRB expression levels, significantly (P < 0.05; fold change: 0.19). Furthermore, obesity attenuated DNA methylation (P < 0.001) and enhanced mRNA expression of DIO3 (P < 0.05; fold change: 3). Conclusions: Our findings suggest that obesity may alter expression of THRB and DIO3 genes through epigenetic mechanism. Alterations of THRB and DIO3 expressions may predispose colon epithelium of obese patients to neoplastic transformation.
MeSH term(s)	Male ; Humans ; DNA Methylation ; Thyroid Hormone Receptors beta/genetics ; Thyroid Hormone Receptors beta/metabolism ; RNA, Messenger/genetics ; Thyroid Hormones/metabolism ; Obesity/genetics ; Colon/metabolism ; Epithelium/metabolism
Chemical Substances	Thyroid Hormone Receptors beta ; RNA, Messenger ; Thyroid Hormones
Language	English
Publishing date	2022-11-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2411865-5
ISSN	1755-8794 ; 1755-8794
ISSN (online)	1755-8794
ISSN	1755-8794
DOI	10.1186/s12920-022-01387-6
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Article ; Online: Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles.

Mohammad Gholinia Sarpoli, Leila / Zare-Karizi, Shohreh / Heidari, Erfan / Hasanzadeh, Akbar / Bayandori, Mehrdad / Azedi, Fereshteh / Hamblin, Michael R / Karimi, Mahdi

Pharmaceutical development and technology

2022 Volume 27, Issue 7, Page(s) 785–793

Abstract: Purpose: Breast cancer is the second major cause of death worldwide among women. Co-delivery of anticancer drugs and nucleic acids targeting the apoptosis pathway could be a promising new approach.: Methods: In the present study, we synthesized a ... ...

Abstract	Purpose: Breast cancer is the second major cause of death worldwide among women. Co-delivery of anticancer drugs and nucleic acids targeting the apoptosis pathway could be a promising new approach. Methods: In the present study, we synthesized a novel nanostructure for the co-delivery of curcumin and siRNA to breast cancer cells. Curcumin-loaded polylactic-co-glycolic acid (PLGA) was synthesized using an O/W emulsion-solvent diffusion method. It was coated with polyethylenimine (PEI) and subsequently complexed with Bcl-2 siRNA. Also, nanoparticles were characterized such as zeta potential, size distribution and drug encapsulation. Finally, the cytotoxicity of NP and Bcl-2 expression was evaluated. Results: The curcumin-loaded PLGA nanoparticles were 70 nm in size, and increased to 84 nm after incorporation of PEI plus Bcl-2 siRNA. The encapsulation ratio of the drug in our nanoparticle was 78%. Cellular internalization of PLGA-CUR-PEI/Bcl-2 siRNA NPs was confirmed by fluorescence microscopy with the broadcasting of the fluorescence in the cytoplasm and into the nucleus. The results of the cell viability assay revealed that curcumin-loaded PLGA coated with PEI and Bcl-2 siRNA exhibited the highest cytotoxicity against the T47D cell line, while the siRNA decreased the Bcl-2 expression by 90.7%. Conclusion: The co-delivery of curcumin plus Bcl-2 siRNA with the PLGA-PEI nanosystem could be a synergistic drug carrier against breast cancer cells.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Drug Carriers/chemistry ; Emulsions ; Female ; Glycolates ; Humans ; Lactic Acid/chemistry ; Nanoparticles/chemistry ; Polyethyleneimine ; Polyglycolic Acid/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; RNA, Small Interfering/genetics ; Solvents
Chemical Substances	Antineoplastic Agents ; Drug Carriers ; Emulsions ; Glycolates ; RNA, Small Interfering ; Solvents ; glycolic acid (0WT12SX38S) ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT) ; Polyethyleneimine (9002-98-6) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2022-09-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1331774-x
ISSN	1097-9867 ; 1083-7450
ISSN (online)	1097-9867
ISSN	1083-7450
DOI	10.1080/10837450.2022.2120003
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Article ; Online: Immunogenicity Evaluation of Chimeric Subunit Vaccine Comprising Adhesion Coli Surface Antigens from Enterotoxigenic Escherichia coli.

Khoobbakht, Dorna / Zare Karizi, Shohreh / Motamedi, Mohammad Javad / Kazemi, Rouhollah / Roghanian, Pooneh / Amani, Jafar

Journal of molecular microbiology and biotechnology

2020 Volume 29, Issue 1-6, Page(s) 91–100

Abstract: Enterotoxigenic Escherichia coli (ETEC) is the most common agent of diarrhea morbidity in developing countries. ETEC adheres to host intestinal epithelial cells via various colonization factors. The CooD and CotD proteins play a significant role in ... ...

Abstract	Enterotoxigenic Escherichia coli (ETEC) is the most common agent of diarrhea morbidity in developing countries. ETEC adheres to host intestinal epithelial cells via various colonization factors. The CooD and CotD proteins play a significant role in bacteria binding to the intestinal epithelial cells as adhesin tip subunits of CS1 and CS2 pili. The purpose here was to design a new construction containing cooD and cotD genes and use several types of bioinformatics software to predict the structural and immunological properties of the designed antigen. The fusion gene was synthesized with codon bias of E. coli in order to increase the expression level of the protein. The amino acid sequences, protein structure, and immunogenicity properties of potential antigens were analyzed in silico. The chimeric protein was expressed in E. coliBL21 (DE3). The antigenicity of the recombinant proteins was verified by Western blotting and ELISA. In order to assess the induced immunity, the immunized mice were challenged with wild-type ETEC by an intraperitoneal route. Immunological analyses showed the production of a high titer of IgG serum with no sign of serum-mucosal IgA antibody response. The result of the challenge assay showed that 30% of immunized mice survived. The results of this study showed that CooD-CotD recombinant protein can stimulate immunity against ETEC. The designed chimera could be a prototype for the subunit vaccine, which is worthy of further consideration.
MeSH term(s)	Adhesins, Bacterial/immunology ; Animals ; Antigens, Surface/immunology ; Enterotoxigenic Escherichia coli/immunology ; Escherichia coli Proteins/immunology ; Escherichia coli Vaccines/immunology ; Immunogenicity, Vaccine ; Immunoglobulin A ; Immunoglobulin G/blood ; Mice ; Mice, Inbred BALB C ; Nucleic Acid Conformation ; Recombinant Fusion Proteins/immunology ; Vaccines, Subunit
Chemical Substances	Adhesins, Bacterial ; Antigens, Surface ; CooD protein, E coli ; Escherichia coli Proteins ; Escherichia coli Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Recombinant Fusion Proteins ; Vaccines, Subunit
Language	English
Publishing date	2020-07-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2006915-7
ISSN	1660-2412 ; 1464-1801
ISSN (online)	1660-2412
ISSN	1464-1801
DOI	10.1159/000509708
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Article ; Online: Investigation the Role of Autophagy in Non-Small Cell Lung Cancer.

Pargol, Minoo / Zare Karizi, Shima / Akbari, Masoumeh / Nourmohammadi, Bahareh / Shadmehr, Mohammad Behgam / Karimipoor, Morteza / Zare Karizi, Shohreh

Asian Pacific journal of cancer prevention : APJCP

2021 Volume 22, Issue 3, Page(s) 947–955

Abstract: Objective: Recent studies have shown the role of autophagy in different types of cancer including lung cancer. MicroRNAs are considered as key factors in regulation of autophagy related genes. miR-30d, miR-204-5p and miR-20a are regulatory markers which ...

Abstract	Objective: Recent studies have shown the role of autophagy in different types of cancer including lung cancer. MicroRNAs are considered as key factors in regulation of autophagy related genes. miR-30d, miR-204-5p and miR-20a are regulatory markers which can suppress the expression of beclin1, LC3, bcl2 and ULK1 as their target genes and they lead to decrement of autophagy in human cancer cells. Moreover, epigenetic modifications DNA methylation has been indicated in regulation of autophagy in different stages of cancer. Methods: In this study, the expression levels of miR-30d, miR-204-5p and miR-20a as well as their target genes were analyzed in 30 non-small cell lung cancers (NSCLCs) patients sample and adjacent normal tissues by real-time qPCR. In addition, DNA methylation of beclin1, LC3, bcl2 and ULK1 genes were assessed by MS-HRM method. Results: MiR-30d (p value= 0.01) and miR-204-5p (P=0.048) significantly down-regulated in tumor samples compared to normal adjacent tissues, while there was no significant change in expression level of miR-20a. On the other hand, target genes expression level was significantly increased in NSCLC tissues, however methylation pattern of the target gene promoters, did not show any significant alteration. Conclusion: These results indicate roles for miR-30d, miR-204-5p as tumor suppressor genes as well as target genes as oncogenes in NSCLC patients. Although these factors may have a significant role in NSCLC progression, further studies are necessary to investigate the implications of these findings for treatment of lung cancer. .
MeSH term(s)	Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Autophagy/genetics ; Autophagy-Related Protein-1 Homolog/genetics ; Beclin-1/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; DNA Methylation ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; MicroRNAs/genetics ; Microtubule-Associated Proteins/genetics ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/genetics
Chemical Substances	BCL2 protein, human ; BECN1 protein, human ; Beclin-1 ; Intracellular Signaling Peptides and Proteins ; MAP1LC3A protein, human ; MIRN204 microRNA, human ; MIRN20a microRNA, human ; MIRN30d microRNA, human ; MicroRNAs ; Microtubule-Associated Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; ULK1 protein, human (EC 2.7.11.1)
Language	English
Publishing date	2021-03-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2021.22.3.947
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Article: PHBV nanofibers promotes insulin-producing cells differentiation of human induced pluripotent stem cells

Abazari, Mohammad Foad / Zare Karizi, Shohreh / Hajati-Birgani, Nazanin / Norouzi, Sara / Khazeni, Zahraalsadat / Hashemi, Javad / Shafaghi, Lida / Soleimanifar, Fatemeh / Mansour, Reyhaneh Nassiri / Enderami, Seyed Ehsan

Gene. 2021 Feb. 05, v. 768

2021

Abstract: Tissue-engineering associated techniques have long been employed to improve the various elements of the therapeutic approaches toward the more efficient ones in diabetic states. The resultant constructs comprise of the polymeric scaffolds with proper ... ...

Abstract	Tissue-engineering associated techniques have long been employed to improve the various elements of the therapeutic approaches toward the more efficient ones in diabetic states. The resultant constructs comprise of the polymeric scaffolds with proper degradation rates that produce bodily compatible components, and the pluripotent cells that are highly capable of generating islet-like cells. In this study, Poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers were fabricated by the Electrospinning. After validation of its 3-D structure, fibers size and non-toxicity, insulin-producing cells (IPC) differentiation potential of the induced pluripotent stem cells (iPSCs) were evaluated during growing on the PHBV nanofibers in comparison with tissue culture polystyrene (TCPS). SEM analyses confirmed the 3-D and nanofibrous structure of the fabricated scaffold. The survival rate of the iPSCs cultured on the PHBV nanofibers was increased significantly compared to the cells cultured on the TCPS, which is an evidence for the non-toxicity of the nanofibers. Insulin and C-peptide secretion levels significantly increased in the differentiated iPSCs on PHBV nanofibers compared to those cells cultured on TCPS. Moreover, levels of the gene transcription and translation results revealed that insulin, Glut-2, and Pdx-1 genes and insulin protein, in IPC-differentiated iPSCs grown on PHBV nanofibers are significantly higher than those cells grown on TCPS. Taken together, these results go beyond previous reports, showing thatiPSCs-PHBV as a promising cell-copolymer construct, could potentially be applied in the pancreatic tissue engineering applications to diabetic patient treatment.
Keywords	c-peptide ; chemical elements ; degradation ; genes ; induced pluripotent stem cells ; nanofibers ; patients ; polystyrenes ; secretion ; survival rate ; therapeutics ; tissue culture ; tissue engineering ; transcription (genetics)
Language	English
Dates of publication	2021-0205
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2020.145333
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Article: Association of kinase insert domain-containing receptor (KDR) gene polymorphism/ haplotypes with recurrent spontaneous abortion and genetic structure.

Shahsavari, Shiva / Noormohammadi, Zahra / Zare Karizi, Shohreh

International journal of reproductive biomedicine

2016 Volume 13, Issue 12, Page(s) 755–764

Abstract: Background: Recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society. Recently a few numbers of genetic polymorphisms in kinase insert domain-containing ... ...

Abstract	Background: Recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society. Recently a few numbers of genetic polymorphisms in kinase insert domain-containing receptor (KDR) gene are examined that can endanger the life of the fetus in pregnant women. Objective: The risk of KDR gene polymorphisms was investigated in Iranian women with idiopathic recurrent spontaneous abortion (RSA). Materials and methods: A case controlled study was performed. One hundred idiopathic recurrent spontaneous abortion patients with at least two consecutive pregnancy losses before 20 weeks of gestational age with normal karyotypes were included in the study. Also, 100 healthy women with at least one natural pregnancy were studied as control group. Two functional SNPs located in KDR gene; rs1870377 (Q472H), and rs2305948 (V297I) as well as one tag SNP in the intron region (rs6838752) were genotyped by using PCR based restriction fragment length polymorphism (PCR-RFLP) technique. Haplotype frequency was determined for these three SNPs' genotypes. Analysis of genetic STRUCTURE and K means clustering were performed to study genetic variation. Results: Functional SNP (rs1870377) was highly linked to tag SNP (rs6838752) (D´ value=0. 214; χ(2) = 16.44, p<0. 001). K means clustering showed that k = 8 as the best fit for the optimal number of genetic subgroups in our studied materials. This result was in agreement with Neighbor Joining cluster analysis. Conclusion: In our study, the allele and genotype frequencies were not associated with RSA between patient and control individuals. Inconsistent results in different populations with different allele frequencies among RSA patients and controls may be due to ethnic variation and used sample size.
Language	English
Publishing date	2016-01-25
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2898387-7
ISSN	2476-3772 ; 2476-4108
ISSN (online)	2476-3772
ISSN	2476-4108
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Article: Recent findings on the role of microRNAs in genetic kidney diseases

Askari, Hassan / Raeis-Abdollahi, Ehsan / Abazari, Mohammad Foad / Akrami, Hassan / Vakili, Sina / Savardashtaki, Amir / Tajbakhsh, Amir / Sanadgol, Nima / Azarnezhad, Asaad / Rahmati, Leila / Abdullahi, Payman Raise / Zare Karizi, Shohreh / Safarpour, Ali Reza

Molecular biology reports. 2022 July, v. 49, no. 7

2022

Abstract: BACKGROUND: MicroRNAs (miRNAs) are non-coding, endogenous, single-stranded, small (21–25 nucleotides) RNAs. Various target genes at the post-transcriptional stage are modulated by miRNAs that are involved in the regulation of a variety of biological ... ...

Abstract	BACKGROUND: MicroRNAs (miRNAs) are non-coding, endogenous, single-stranded, small (21–25 nucleotides) RNAs. Various target genes at the post-transcriptional stage are modulated by miRNAs that are involved in the regulation of a variety of biological processes such as embryonic development, differentiation, proliferation, apoptosis, inflammation, and metabolic homeostasis. Abnormal miRNA expression is strongly associated with the pathogenesis of multiple common human diseases including cardiovascular diseases, cancer, hepatitis, and metabolic diseases. METHODS AND RESULTS: Various signaling pathways including transforming growth factor-β, apoptosis, and Wnt signaling pathways have also been characterized to play an essential role in kidney diseases. Most importantly, miRNA-targeted pharmaceutical manipulation has represented a promising new therapeutic approach against kidney diseases. Furthermore, miRNAs such as miR-30e-5p, miR-98-5p, miR-30d-5p, miR-30a-5p, miR-194-5p, and miR-192-5p may be potentially employed as biomarkers for various human kidney diseases. CONCLUSIONS: A significant correlation has also been found between some miRNAs and the clinical markers of renal function like baseline estimated glomerular filtration rate (eGFR). Classification of miRNAs in different genetic renal disorders may promote discoveries in developing innovative therapeutic interventions and treatment tools. Herein, the recent advances in miRNAs associated with renal pathogenesis, emphasizing genetic kidney diseases and development, have been summarized.
Keywords	apoptosis ; biomarkers ; embryogenesis ; glomerular filtration rate ; hepatitis ; homeostasis ; humans ; inflammation ; kidneys ; microRNA ; molecular biology ; nucleotides ; pathogenesis ; therapeutics
Language	English
Dates of publication	2022-07
Size	p. 7039-7056.
Publishing place	Springer Netherlands
Document type	Article
Note	Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07620-w
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