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  1. Book ; Online ; E-Book: Rediscovery of Genetic and Genomic Resources for Future Food Security

    Salgotra, Romesh Kumar / Zargar, Sajad Majeed

    2020  

    Abstract: This book describes how the latest genomic resources techniques can be efficiently used in plant breeding programmes to achieve food security in the future. It also shares insights on how to utilize the untapped and unexplored genetic diversity of wild ... ...

    Author's details edited by Romesh Kumar Salgotra, Sajad Majeed Zargar
    Abstract This book describes how the latest genomic resources techniques can be efficiently used in plant breeding programmes to achieve food security in the future. It also shares insights on how to utilize the untapped and unexplored genetic diversity of wild species, wild relatives and landraces for crop improvement. Moreover, the book offers an impressive array of balanced analyses, fresh ideas and perspectives, and thoughtful and realistic proposals regarding the sustainable utilization of plant genetic resources with modern biotechnological techniques. The first book to address the importance of plant genetics and genomic resources for food security, it brings together a group of plant breeders and biotechnologists to investigate the use of genomic resources techniques in plant breeding programmes. Providing essential information on the efficient utilization of genomic resources in precision breeding, it offers a valuable asset for undergraduate and graduate students, teachers and professionals engaged in related fields.
    Keywords Plant breeding ; Plant genetics ; Agriculture ; Nucleic acids ; Plant Breeding/Biotechnology ; Plant Genetics and Genomics ; Nucleic Acid Chemistry
    Subject code 631.53
    Language English
    Size 1 online resource (XXI, 364 p. 18 illus., 16 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-0156-4 ; 981-15-0155-6 ; 978-981-15-0156-2 ; 978-981-15-0155-5
    DOI 10.1007/978-981-15-0156-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Principles of genomics and proteomics

    Mir, Rakeeb Ahmad / Zargar, Sajad Majeed / Shafi, Sheikh Mansoor

    2023  

    Author's details Rakeeb Ahmad Mir, Sheikh Mansoor Shafi, Sajad Majeed Zargar
    MeSH term(s) Genomics/methods ; Proteomics/methods
    Keywords Genomics ; Proteomics
    Subject code 572.86
    Language English
    Size 1 online resource (242 pages)
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-99378-8 ; 9780323990455 ; 978-0-323-99378-4 ; 0323990452
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Neglected and underutilized crops - towards nutritional security and sustainability

    Masi, Antonio / Salgotra, Romesh Kumar / Zargar, Sajad Majeed

    2021  

    Author's details edited by Sajad Majeed Zargar, Antonio Masi, Romesh Kumar Salgotra
    Keywords Sustainable agriculture ; Crop diversification ; Agricultura sostenible ; Conreu
    Subject code 605
    Language English
    Size 1 online resource (278 pages)
    Publisher Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-3876-4 ; 981-16-3875-6 ; 978-981-16-3876-3 ; 978-981-16-3875-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Plant omics and crop breeding

    Zargar, Sajad Majeed / Rai, Vandna

    2017  

    Author's details edited by Sajad Majeed Zargar, Vandna Rai
    Keywords Plant biotechnology/Research. ; Plant breeding/Research.
    Language English
    Size xxi, 468 pages :, illustrations (some color) ;, 25 cm
    Document type Book
    ISBN 9781771884556 ; 177188455X
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Genetic diversity, population structure and genetic relationships in apricot (Prunus armeniaca L.) germplasm of Jammu and Kashmir, India using ISSR markers

    Zargar, Showkat A. / Saggoo, M. I. S. / Wani, Aijaz A. / Zargar, Sajad Majeed

    Genetic resources and crop evolution. 2022 Jan., v. 69, no. 1

    2022  

    Abstract: The collection and characterization of apricot germplasm is an important step for its utilization, conservation, and breeding programs. In the present study, the genetic diversity and population structure of 106 accessions of apricot including 82 ... ...

    Abstract The collection and characterization of apricot germplasm is an important step for its utilization, conservation, and breeding programs. In the present study, the genetic diversity and population structure of 106 accessions of apricot including 82 indigenous and 24 exotic accessions collected from various geographical locations of Jammu and Kashmir, India were evaluated using 14 inter simple sequence repeat markers. The PCR amplification produced 365 loci of which 356 (97.53%) were polymorphic. The average number of alleles, effective number of alleles, expected heterozygosity, Shannon’s information index indicated high level of genetic diversity in the collected apricot accessions, and the polymorphism information content (0.82) revealed that these markers were highly polymorphic. The results of UPGMA dendrogram and model-based STRUCTURE analysis clearly divided the 106 apricot accessions into two main groups; one group included the 78 accessions of Kashmir province and the other included 28 accessions of Jammu province indicating the distinction of two genetic pools of apricot in the region. Nonetheless, PCoA also revealed a similar grouping of accessions except few exotic accessions that formed a small separate group. Moreover, analysis of molecular variance showed high genetic variation within the population (67%) and low among the population (33%). To our knowledge, this study represents the first comprehensive report on the ISSR based genetic diversity, relationship, and the structure of apricot accessions of Jammu and Kashmir. Further, the results of the present study will assist in efficient utilization, conservation, and MAS based breeding programs of apricot.
    Keywords Prunus armeniaca ; apricots ; evolution ; genetic variation ; germplasm ; heterozygosity ; microsatellite repeats ; population structure ; variance ; India
    Language English
    Dates of publication 2022-01
    Size p. 255-270.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1134125-7
    ISSN 0925-9864
    ISSN 0925-9864
    DOI 10.1007/s10722-021-01225-1
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4526: Show issues

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  6. Article: Molecular insights into sensing, regulation and improving of heat tolerance in plants

    Saini, Nupur / Nikalje, Ganesh Chandrakant / Zargar, Sajad Majeed / Suprasanna, Penna

    Plant cell reports. 2022 Mar., v. 41, no. 3

    2022  

    Abstract: Climate-change-mediated increase in temperature extremes has become a threat to plant productivity. Heat stress-induced changes in growth pattern, sensitivity to pests, plant phonologies, flowering, shrinkage of maturity period, grain filling, and ... ...

    Abstract Climate-change-mediated increase in temperature extremes has become a threat to plant productivity. Heat stress-induced changes in growth pattern, sensitivity to pests, plant phonologies, flowering, shrinkage of maturity period, grain filling, and increased senescence result in significant yield losses. Heat stress triggers multitude of cellular, physiological and molecular responses in plants beginning from the early sensing followed by signal transduction, osmolyte synthesis, antioxidant defense, and heat stress-associated gene expression. Several genes and metabolites involved in heat perception and in the adaptation response have been isolated and characterized in plants. Heat stress responses are also regulated by the heat stress transcription factors (HSFs), miRNAs and transcriptional factors which together form another layer of regulatory circuit. With the availability of functionally validated candidate genes, transgenic approaches have been applied for developing heat-tolerant transgenic maize, tobacco and sweet potato. In this review, we present an account of molecular mechanisms of heat tolerance and discuss the current developments in genetic manipulation for heat tolerant crops for future sustainable agriculture.
    Keywords antioxidant activity ; corn ; gene expression ; genetic engineering ; heat ; heat stress ; heat tolerance ; metabolites ; microRNA ; shrinkage ; signal transduction ; sustainable agriculture ; sweet potatoes ; temperature ; tobacco ; transcription (genetics)
    Language English
    Dates of publication 2022-03
    Size p. 799-813.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 8397-5
    ISSN 1432-203X ; 0721-085X ; 0721-7714
    ISSN (online) 1432-203X
    ISSN 0721-085X ; 0721-7714
    DOI 10.1007/s00299-021-02793-3
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 85/705: Show issues

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  7. Article ; Online: Molecular insights into sensing, regulation and improving of heat tolerance in plants.

    Saini, Nupur / Nikalje, Ganesh Chandrakant / Zargar, Sajad Majeed / Suprasanna, Penna

    Plant cell reports

    2021  Volume 41, Issue 3, Page(s) 799–813

    Abstract: Climate-change-mediated increase in temperature extremes has become a threat to plant productivity. Heat stress-induced changes in growth pattern, sensitivity to pests, plant phonologies, flowering, shrinkage of maturity period, grain filling, and ... ...

    Abstract Climate-change-mediated increase in temperature extremes has become a threat to plant productivity. Heat stress-induced changes in growth pattern, sensitivity to pests, plant phonologies, flowering, shrinkage of maturity period, grain filling, and increased senescence result in significant yield losses. Heat stress triggers multitude of cellular, physiological and molecular responses in plants beginning from the early sensing followed by signal transduction, osmolyte synthesis, antioxidant defense, and heat stress-associated gene expression. Several genes and metabolites involved in heat perception and in the adaptation response have been isolated and characterized in plants. Heat stress responses are also regulated by the heat stress transcription factors (HSFs), miRNAs and transcriptional factors which together form another layer of regulatory circuit. With the availability of functionally validated candidate genes, transgenic approaches have been applied for developing heat-tolerant transgenic maize, tobacco and sweet potato. In this review, we present an account of molecular mechanisms of heat tolerance and discuss the current developments in genetic manipulation for heat tolerant crops for future sustainable agriculture.
    MeSH term(s) Crops, Agricultural/genetics ; Crops, Agricultural/metabolism ; Gene Expression Regulation, Plant/genetics ; Heat Shock Transcription Factors/genetics ; Heat-Shock Response/genetics ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants, Genetically Modified/metabolism ; Stress, Physiological/genetics ; Thermotolerance/genetics
    Chemical Substances Heat Shock Transcription Factors ; Plant Proteins
    Language English
    Publishing date 2021-10-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8397-5
    ISSN 1432-203X ; 0721-085X ; 0721-7714
    ISSN (online) 1432-203X
    ISSN 0721-085X ; 0721-7714
    DOI 10.1007/s00299-021-02793-3
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    In stock of ZB MED Bonn / Germany

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  8. Article ; Online: Insights into role of STP13 in sugar driven signaling that leads to decrease in photosynthesis in dicot legume crop model (Phaseolus vulgaris L.) under Fe and Zn stress.

    Urwat, Uneeb / Zargar, Sajad Majeed / Ahmad, Syed Mudasir / Ganai, Nazir Ahmad

    Molecular biology reports

    2021  Volume 48, Issue 3, Page(s) 2527–2531

    Abstract: Mineral (Fe/Zn) stress significantly affects fundamental metabolic and physiological responses in plants that results in reduction of plant growth and development. Deficiency of these micronutrients leads to inhibition of photosynthesis by having impact ... ...

    Abstract Mineral (Fe/Zn) stress significantly affects fundamental metabolic and physiological responses in plants that results in reduction of plant growth and development. Deficiency of these micronutrients leads to inhibition of photosynthesis by having impact on various crucial biological processes like protein synthesis, primary and secondary metabolism and carbohydrate partitioning between source and sink tissues. In the present study, common bean variety Shalimar French Bean-1 (SFB-1) plants were used as an experimental material and were grown under in vitro condition on four different MGRL media i.e. normal MGRL medium (Control), MGRL without Fe (0-Fe), MGRL without Zinc (0-Zn) and MGRL with excess Zn (300-Zn) for 21 days under optimum conditions. Shoot and root tissues from all the treatments were harvested and further subjected to estimation of total chlorophyll, total sugar and extraction of total RNA for differential gene expression of sugar transporter 13 (STP13). We observed significant decrease in total chlorophyll content in samples harvested from mineral stress plants. However, the concentration of total sugar and fold expression of STP13 gene was significantly higher in shoots of Fe/Zn stressed and in roots of 300-Zn plants. We observed higher accumulation of sugar under stress condition that correlated with high expression of sugar transporter 13 (STP 13). Further, we observed decrease in the chlorophyll content under stress conditions. Based on these findings, we propose the role of sugar driven signaling in decreasing photosynthesis in case of common bean. The decrease in photosynthesis is confirmed by observing significant decrease in chlorophyll content in stressed plants.
    MeSH term(s) Crops, Agricultural/drug effects ; Crops, Agricultural/physiology ; Gene Expression Regulation, Plant/drug effects ; Genes, Plant ; Iron/toxicity ; Phaseolus/drug effects ; Phaseolus/genetics ; Phaseolus/physiology ; Photosynthesis/drug effects ; Photosynthesis/genetics ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Signal Transduction/drug effects ; Stress, Physiological/drug effects ; Stress, Physiological/genetics ; Sugars/metabolism ; Zinc/toxicity
    Chemical Substances Plant Proteins ; Sugars ; Iron (E1UOL152H7) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2021-03-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-06295-z
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  9. Article ; Online: Comparative Analysis of Physical and Chemical Mutagenesis in Chrysanthemum cv. 'Candid': Assessing Genetic Variation and Breeding Potential.

    Din, Ambreena / Qadri, Zahoor Ahmad / Wani, Muneeb Ahmad / Iqbal, Shameen / Malik, Sajid Ali / Zargar, Sajad Majeed / Banday, Neelofar / Nazki, Imtiyaz Tahir

    ACS omega

    2023  Volume 8, Issue 46, Page(s) 43836–43849

    Abstract: In this study, we developed a mutagenesis protocol specifically designed for chrysanthemum cv. "Candid" in order to introduce genetic variation. By subjecting chrysanthemum shoots to different doses of physical and chemical mutagens, we successfully ... ...

    Abstract In this study, we developed a mutagenesis protocol specifically designed for chrysanthemum cv. "Candid" in order to introduce genetic variation. By subjecting chrysanthemum shoots to different doses of physical and chemical mutagens, we successfully generated a total of 24 mutants, each with unique genetic compositions. We observed that the mortality rate was lowest when the shoots were exposed to 10 Gy gamma irradiation and 1.00% EMS. To assess the diversity and relatedness among the mutants, we employed RAPD and SSR markers. The combination of these markers allowed us to construct a dendrogram that effectively categorized the mutant population into distinct clusters based on the specific mutagen treatments. Interestingly, the mutants induced by 10 Gy gamma irradiation exhibited greater genetic diversity in terms of flower colors. On the other hand, mutants created with 1.00% EMS displayed a higher level of variation and yielded more viable mutants. To determine the optimal markers for studying genetic diversity, we analyzed the polymorphic information content (PIC) of different markers. Among the tested markers, OPA-07 (RAPD) and JH47 (SSR) showed the highest PIC values, indicating their effectiveness in capturing genetic variability within the mutant population. Conversely, the PIC values of OPD-07 and JH20 demonstrated the lowest among the markers tested. Our results revealed a percentage of polymorphism ranging from 81.81% to 100% for RAPD markers and 66.66% to 100% for SSR markers. These findings indicate that physical mutation induced by 10 Gy gamma irradiation can be clearly distinguished from chemical mutation induced by EMS at concentrations of 1% and 0.75% in chrysanthemum cv. "Candid.″ Overall, this study provides valuable insights into the genetic composition of the generated mutants and highlights their potential for enhancing chrysanthemum-breeding programs. The identified markers, particularly, OPA-07 and JH47, can serve as valuable tools for future studies aimed at exploring and exploiting the genetic diversity within the chrysanthemum population.
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05723
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  10. Article ; Online: Network pharmacology and experimental insights into STAT3 inhibition by novel isoxazole derivatives of piperic acid in triple negative breast cancer.

    Yatoo, G N / Bhat, Basharat A / Zubaid-Ul-Khazir / Asif, Mohammad / Bhat, Sajad A / Gulzar, Farhana / Rashied, Fehmida / Wani, Abdul Haleem / Ahmed, Ishfaq / Zargar, Sajad Majeed / Mir, Mushtaq A / Banday, Javid A

    Fitoterapia

    2024  Volume 175, Page(s) 105927

    Abstract: STAT3 is a crucial member within a family of seven essential transcription factors. Elevated STAT3 levels have been identified in various cancer types, notably in breast cancer (BC). Consequently, inhibiting STAT3 is recognized as a promising and ... ...

    Abstract STAT3 is a crucial member within a family of seven essential transcription factors. Elevated STAT3 levels have been identified in various cancer types, notably in breast cancer (BC). Consequently, inhibiting STAT3 is recognized as a promising and effective strategy for therapeutic intervention against breast cancer. We herein synthesize a library of isoxazole (PAIs) from piperic acid [2E, 4E)-5-(2H-1,3-Benzodioxol-5-yl) penta-2,4-dienoic acid] on treatment with propargyl bromide followed by oxime under prescribed reaction conditions. Piperic acid was obtained by hydrolysis of piperine extracted from Piper nigrum. First, we checked the binding potential of isoxazole derivatives with breast cancer target proteins by network pharmacology, molecular docking, molecular dynamic (MD) simulation and cytotoxicity analysis as potential anti-breast cancer (BC) agents. The multi-source databases were used to identify possible targets for isoxazole derivatives. A network of protein-protein interactions (PPIs) was generated by obtaining 877 target genes that overlapped gene symbols associated with isoxazole derivatives and BC. Molecular docking and MD modelling demonstrated a strong affinity between isoxazole derivatives and essential target genes. Further, the cell viability studies of isoxazole derivatives on the human breast carcinoma cell lines showed toxicity in all breast cancer cell lines. In summary, our study indicated that the isoxazole derivative showed the significant anticancer activity. The results highlight the prospective utility of isoxazole derivatives as new drug candidates for anticancer chemotherapy, suggesting route for the continued exploration and development of drugs suitable for clinical applications.
    Language English
    Publishing date 2024-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2024.105927
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    Zs.B 1873: Show issues Location:
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