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  1. Article: Analiz predstavlennosti mikroRNK v mikrovezikulakh mochi i beskletochnoĭ moche pri zabolevaniiakh predstatel'noĭ zhelezy.

    Zaporozhchenko, I A / Bryzgunova, O E / Lekchnov, E A / Osipov, I D / Zaripov, M M / Yurchenko, Yu B / Yarmoschuk, S V / Pashkovskaya, O A / Rykova, E Yu / Zheravin, A A / Laktionov, P P

    Biomeditsinskaia khimiia

    2018  Volume 64, Issue 1, Page(s) 38–45

    Abstract: Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesiclesassociated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urine extracellular vesicles and demonstrated ... ...

    Title translation Representation analysis of miRNA from clarified urine and urine microvesicles in prostate malignancies and non-malignant neoplasms.
    Abstract Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesiclesassociated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urine extracellular vesicles and demonstrated diagnostic potential of their miRNA cargo. In this study, we have performed a comparative analysis of the expression of 84 miRNA in paired samples of urine microvesicles and clarified urine from healthy men, patients with benign hyperplasia and cancer of the prostate using miRCURY LNA miRNA qPCR Panels. Subsets of miRNAs with differences in expression between the fractions of the urine were found in all three groups. Two groups of miRNA were identified based on the patterns of their differential expression. They regulate several key signaling pathways associated with prostate cancer development.
    MeSH term(s) Body Fluids ; Cell-Derived Microparticles ; Extracellular Vesicles ; Humans ; Male ; MicroRNAs ; Prostatic Neoplasms
    Chemical Substances MicroRNAs
    Language Russian
    Publishing date 2018-03-12
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 2130758-1
    ISSN 2310-6905 ; 2310-6972 ; 0042-8809
    ISSN (online) 2310-6905
    ISSN 2310-6972 ; 0042-8809
    DOI 10.18097/PBMC20186401038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 743: Show issues Location:
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  2. Article: [A New Simple Technique for Producing Labeled Monoclonal Antibodies for Antibody Pair Screening in Sandwich-ELISA].

    Zaripov, M M / Afanasieva, G V / Glukhova, X A / Trizna, Y A / Glukhov, A S / Beletsky, I P / Prusakova, O V

    Bioorganicheskaia khimiia

    2014  Volume 41, Issue 4, Page(s) 411–415

    Abstract: A simple and fast method for obtaining biotin-labeled monoclonal antibodies was developed usingcontent of hybridoma culture supernatant sufficient to select antibody pairs in sandwich ELISA. The method consists in chemical biotinylation of antigen-bound ... ...

    Abstract A simple and fast method for obtaining biotin-labeled monoclonal antibodies was developed usingcontent of hybridoma culture supernatant sufficient to select antibody pairs in sandwich ELISA. The method consists in chemical biotinylation of antigen-bound antibodies in a well of ELISA plate. Using as an example target Vaccinia virus A27L protein it was shown that the yield of biotinylated reactant is enough to set comprehensive sandwich ELISA for a moderate size panel of up to 25 monoclonal antibodies with an aim to determine candidate pairs. The technique is a cheap and effective solution since it avoids obtaining preparative amounts of antibodies.
    MeSH term(s) Antibodies, Monoclonal, Murine-Derived/chemistry ; Antibodies, Viral/chemistry ; Biotin/chemistry ; Enzyme-Linked Immunosorbent Assay/methods ; Vaccinia virus ; Viral Proteins/analysis
    Chemical Substances A27L protein, Orthopoxvirus ; Antibodies, Monoclonal, Murine-Derived ; Antibodies, Viral ; Viral Proteins ; Biotin (6SO6U10H04)
    Language Russian
    Publishing date 2014-06-20
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194993-7
    ISSN 0132-3423
    ISSN 0132-3423
    DOI 10.1134/s1068162015030127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2847: Show issues Location:
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  3. Book: Fizika židkosti

    Zaripov, M. M

    (Kazanskij gosudarstvennyj pedagogičeskij Institut ; 202 ; Učenye Zapiski. Kazanskij ordena Trudovogo Krasnogo Znameni gosudarstvennyj pedagogičeskij Institut. Ministerstvo prosveščenija RSFSR ; 202)

    1980  

    Author's details M. M. Zaripov [Hrsg.]
    Series title Kazanskij gosudarstvennyj pedagogičeskij Institut ; 202
    Učenye Zapiski. Kazanskij ordena Trudovogo Krasnogo Znameni gosudarstvennyj pedagogičeskij Institut. Ministerstvo prosveščenija RSFSR ; 202
    Size 135 S
    Publishing place Kazan̉
    Document type Book
    Note Physik von Flüssigkeiten
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book: Radiospektroskopija kondensirovannych sred

    Kozyrev, Boris Michajlovič / Zaripov, M. M

    pamjati člena-korrespondenta AN SSSR Borisa Michajloviča Kozyreva

    1990  

    Title variant Radiospectroscopy of condensed matter
    Institution Akademija Nauk SSSR, Kazanskij Fiziko-Techničeskij Institut im. E. K. Zavojskogo
    Author's details M. M. Zaripov [Hrsg.]. Akademija Nauk SSSR, Kazanskij Fiziko-Techničeskij Institut im. E. K. Zavojskogo
    Language Undetermined
    Size 289 S
    Publisher Nauka
    Publishing place Moskva
    Document type Book
    ISBN 5020006769 ; 9785020006768
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article: Distribution of B-cell epitopes on the pseudorabies virus glycoprotein B. [Erratum: Aug 1999, v. 80 (pt.8), p. 2285.]

    Zaripov, M.M / Morenkov, O.S / Fodor, N / Braun, A / Schmatchenko, V.V / Fodor, I

    Journal of general virology. Mar 1999. v. 80 (pt.3)

    1999  

    Abstract: In order to map antigenically important regions of glycoprotein B (gB) of pseudorabies virus (PrV), a panel of recombinant fragments of gB expressed in E. coli and truncated fragments of gB generated by cleavage of purified native gB with trypsin and ... ...

    Abstract In order to map antigenically important regions of glycoprotein B (gB) of pseudorabies virus (PrV), a panel of recombinant fragments of gB expressed in E. coli and truncated fragments of gB generated by cleavage of purified native gB with trypsin and cyanogen bromide was analysed by using 26 monoclonal antibodies directed against gB. Three continuous epitopes were localized in the vicinity of the N terminus of gB, between amino acids (aa) 59 and 126. One continuous epitope mapped between residues 214 and 279. The residues involved in the assembly of eight discontinuous epitopes were located between aa 540 and 734. The constituents of two discontinuous epitopes were harboured in a segment encompassing aa 540-646. The clustering of continuous epitopes at the extreme N terminus of PrV gB and the locations of residues involved in the assembly of discontinuous epitopes of PrV gB are in good agreement with data on epitope locations in gB homologues from other herpesviruses.
    Keywords Suid herpesvirus 1 ; viral antigens
    Language English
    Dates of publication 1999-03
    Size p. 537-541.
    Document type Article
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 70/131: Show issues

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  6. Article: Immunologicheskaia i funktsional'naia kharakteristika épitopov i oblasteĭ glikoproteina gB virusa bolezni Aueski.

    Zaripov, M M / Morenkov, O S / Shmatchenko, V V / Smirnov, S V / Funtikov, V A / Fodor, I

    Voprosy virusologii

    2001  Volume 46, Issue 2, Page(s) 41–45

    Abstract: The role of different gB epitopes and regions at some stages of virus replication in cell cultures and in the formation of immunity to Aujeszky's disease virus (ADV) was studied using a panel of 13 monoclonal antibodies (MAB) that recognize glycoprotein ... ...

    Title translation Immunological and functional characteristics of epitopes and regions of gB glycoprotein of Aujeszky's disease virus.
    Abstract The role of different gB epitopes and regions at some stages of virus replication in cell cultures and in the formation of immunity to Aujeszky's disease virus (ADV) was studied using a panel of 13 monoclonal antibodies (MAB) that recognize glycoprotein gB (gB) of ADV and antisera against fusion recombinant proteins expressing gB fragments. Productive infection following virion attachment was prevented by antibodies to the N-terminal domain of gB. Three MABs against the N-terminal domain of gB and 5 MABs directed against the immunodominant region located in the gBc-subunit of gB inhibited the cell-to-cell spread of viral infection. After immunization with recombinant proteins expressing the N-terminal fragments of gB 80% mice were protected from lethal ADV challenge. After passive immunization the majority of MABs protected 20-80% mice from lethal ADV challenge. Hence, the N-terminal domain of ADV gB is associated with the virus penetration into the cell and is important for anti-ADV immunity.
    MeSH term(s) Animals ; Antigens, Viral/immunology ; Epitope Mapping ; Epitopes/immunology ; Glycoproteins/immunology ; Herpesvirus 1, Suid/immunology ; Viral Envelope Proteins/immunology
    Chemical Substances Antigens, Viral ; Epitopes ; Glycoproteins ; Viral Envelope Proteins
    Language Russian
    Publishing date 2001-03
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 201241-8
    ISSN 0507-4088
    ISSN 0507-4088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1162: Show issues Location:
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  7. Article: Distribution of B-cell epitopes on the pseudorabies virus glycoprotein B.

    Zaripov, M M / Morenkov, O S / Fodor, N / Braun, A / Schmatchenko, V V / Fodor, I / Brown, A

    The Journal of general virology

    1999  Volume 80 Pt 3, Page(s) 537–541

    Abstract: In order to map antigenically important regions of glycoprotein B (gB) of pseudorabies virus (PrV), a panel of recombinant fragments of gB expressed in E. coli and truncated fragments of gB generated by cleavage of purified native gB with trypsin and ... ...

    Abstract In order to map antigenically important regions of glycoprotein B (gB) of pseudorabies virus (PrV), a panel of recombinant fragments of gB expressed in E. coli and truncated fragments of gB generated by cleavage of purified native gB with trypsin and cyanogen bromide was analysed by using 26 monoclonal antibodies directed against gB. Three continuous epitopes were localized in the vicinity of the N terminus of gB, between amino acids (aa) 59 and 126. One continuous epitope mapped between residues 214 and 279. The residues involved in the assembly of eight discontinuous epitopes were located between aa 540 and 734. The constituents of two discontinuous epitopes were harboured in a segment encompassing aa 540-646. The clustering of continuous epitopes at the extreme N terminus of PrV gB and the locations of residues involved in the assembly of discontinuous epitopes of PrV gB are in good agreement with data on epitope locations in gB homologues from other herpesviruses.
    MeSH term(s) Antibodies, Monoclonal/immunology ; Antibody Specificity ; Antigens, Viral/chemistry ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; Binding Sites, Antibody/immunology ; Blotting, Western ; Electrophoresis, Polyacrylamide Gel ; Epitope Mapping ; Epitopes/chemistry ; Epitopes/genetics ; Epitopes/immunology ; Escherichia coli/genetics ; Herpesviridae/immunology ; Herpesvirus 1, Suid/immunology ; Molecular Weight ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Protein Denaturation ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/metabolism ; Viral Envelope Proteins/chemistry ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology ; Viral Envelope Proteins/metabolism
    Chemical Substances Antibodies, Monoclonal ; Antigens, Viral ; Epitopes ; Peptide Fragments ; Recombinant Fusion Proteins ; Viral Envelope Proteins ; glycoprotein gII, pseudorabies virus
    Language English
    Publishing date 1999-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/0022-1317-80-3-537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 610: Show issues Location:
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  8. Article: Glycoprotein B of Aujeszky's disease virus: topographical epitope mapping and epitope-specific antibody response.

    Zaripov, M M / Morenkov, O S / Siklodi, B / Barna-Vetro, I / Gyöngyösi-Horvath, A / Fodor, I

    Research in virology

    1998  Volume 149, Issue 1, Page(s) 29–41

    Abstract: A panel of 26 monoclonal antibodies (mAbs) against glycoprotein B (gB) of Aujeszky's disease (pseudorabies) virus (ADV), a glycoprotein complex consisting of three glycoproteins, gBa, gBb, and gBc, was produced by two research groups and was used for the ...

    Abstract A panel of 26 monoclonal antibodies (mAbs) against glycoprotein B (gB) of Aujeszky's disease (pseudorabies) virus (ADV), a glycoprotein complex consisting of three glycoproteins, gBa, gBb, and gBc, was produced by two research groups and was used for the topographical epitope mapping of gB. An epitope map was constructed in which the identified epitopes of gB were situated in 14 topologically distinct antigenic domains; ten antigenic domains represented by 22 mAbs were localized on gBc, while four antigenic domains represented by four mAbs resided on gBb of the gB complex. All the epitopes located on gBc appeared to be conformation-dependent, whereas all the epitopes on gBb were conformation-independent. The identified epitopes of gB were conserved among laboratory, vaccine and field ADV strains. Conformation-dependent epitopes were shown to contribute largely to the overall antibody response to gB in naturally infected swine and immunized mice. Moreover, it was found that most of the infected animals responded relatively weakly to the identified conformation-independent epitopes of gB, while a group of immunodominant epitopes that induced a strong antibody response was represented exclusively by conformation-dependent epitopes from different antigenic domains. The results clearly demonstrated that conformation-dependent epitopes of gBc play a crucial role in inducing the humoral immune response to gB of ADV during the natural infection of swine and immunization of mice. The application of mAbs of our panel as research and diagnostic tools is discussed.
    MeSH term(s) Animals ; Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/immunology ; Antibodies, Viral/biosynthesis ; Antibody Specificity ; Antigens, Viral/immunology ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Epitope Mapping ; Herpesvirus 1, Suid/immunology ; Immunodominant Epitopes/immunology ; Immunoenzyme Techniques ; Mice ; Neutralization Tests ; Precipitin Tests ; Pseudorabies/immunology ; Swine ; Swine Diseases/immunology ; Viral Envelope Proteins/immunology
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral ; Antigens, Viral ; Immunodominant Epitopes ; Viral Envelope Proteins ; glycoprotein gII, pseudorabies virus
    Language English
    Publishing date 1998-01
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1012930-3
    ISSN 1879-1417 ; 0923-2516
    ISSN (online) 1879-1417
    ISSN 0923-2516
    DOI 10.1016/s0923-2516(97)86898-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1602: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Book: Paramagnitnyj rezonans obmennych klasterov

    Jablokov, Jurij Vasilʹevič / Mosina, Ljajlja Vasilʹevna / Voronkova, Violeta Konstantinovna / Zaripov, M.M

    1988  

    Author's details Jurij Vasilʹevič Jablokov; Violeta Konstantinovna Voronkova; Ljajlja Vasilʹevna Mosina. Otv. red. M.M. Zaripov
    Language Undetermined
    Size 180 S, graph. Darst
    Publisher Nauka
    Publishing place Moskva
    Document type Book
    Note In kyrill. Schr ; Paramagnetische Resonanz von Austauschwechselwirkungen in Clustern
    ISBN 5020065870 ; 9785020065871
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article: Uvelichenie sinteza stress-belkov kletkami organizma nepatogennym metodom vozdeĭstviia.

    Islamov, B I / Ladilov, Iu V / Akoev, V R / Zaripov, M M / Islamova, Kh S / Chaĭlakhian, L M

    Doklady Akademii nauk

    1994  Volume 336, Issue 3, Page(s) 421–424

    Title translation Increase in synthesis of stress proteins by cells by a nonpathogenic method of action.
    MeSH term(s) Acupuncture Therapy ; Cells, Cultured ; Epilepsy/blood ; Epilepsy/therapy ; Heat-Shock Proteins/biosynthesis ; Humans ; Lymphocytes/metabolism
    Chemical Substances Heat-Shock Proteins
    Language Russian
    Publishing date 1994-05
    Publishing country Russia (Federation)
    Document type Journal Article
    ISSN 0869-5652
    ISSN 0869-5652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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