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  1. Article ; Online: Mesenchymal Stem Cells in the Pathogenesis and Therapy of Autoimmune and Autoinflammatory Diseases.

    Zaripova, Lina N / Midgley, Angela / Christmas, Stephen E / Beresford, Michael W / Pain, Clare / Baildam, Eileen M / Oldershaw, Rachel A

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: Mesenchymal stem cells (MSCs) modulate immune responses and maintain self-tolerance. Their trophic activities and regenerative properties make them potential immunosuppressants for treating autoimmune and autoinflammatory diseases. MSCs are drawn to ... ...

    Abstract Mesenchymal stem cells (MSCs) modulate immune responses and maintain self-tolerance. Their trophic activities and regenerative properties make them potential immunosuppressants for treating autoimmune and autoinflammatory diseases. MSCs are drawn to sites of injury and inflammation where they can both reduce inflammation and contribute to tissue regeneration. An increased understanding of the role of MSCs in the development and progression of autoimmune disorders has revealed that MSCs are passive targets in the inflammatory process, becoming impaired by it and exhibiting loss of immunomodulatory activity. MSCs have been considered as potential novel cell therapies for severe autoimmune and autoinflammatory diseases, which at present have only disease modifying rather than curative treatment options. MSCs are emerging as potential therapies for severe autoimmune and autoinflammatory diseases. Clinical application of MSCs in rare cases of severe disease in which other existing treatment modalities have failed, have demonstrated potential use in treating multiple diseases, including rheumatoid arthritis, systemic lupus erythematosus, myocardial infarction, liver cirrhosis, spinal cord injury, multiple sclerosis, and COVID-19 pneumonia. This review explores the biological mechanisms behind the role of MSCs in autoimmune and autoinflammatory diseases. It also covers their immunomodulatory capabilities, potential therapeutic applications, and the challenges and risks associated with MSC therapy.
    MeSH term(s) Humans ; Mesenchymal Stem Cells/pathology ; Autoimmune Diseases/etiology ; Autoimmune Diseases/therapy ; Inflammation/therapy ; Inflammation/pathology ; Immune Tolerance ; Immunomodulation ; Hereditary Autoinflammatory Diseases ; Mesenchymal Stem Cell Transplantation
    Language English
    Publishing date 2023-11-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches.

    Zaripova, Lina N / Midgley, Angela / Christmas, Stephen E / Beresford, Michael W / Baildam, Eileen M / Oldershaw, Rachel A

    Pediatric rheumatology online journal

    2021  Volume 19, Issue 1, Page(s) 135

    Abstract: Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder and is classified by subtype according to International League of Associations for Rheumatology criteria. Depending on the number of joints affected, presence of ... ...

    Abstract Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder and is classified by subtype according to International League of Associations for Rheumatology criteria. Depending on the number of joints affected, presence of extra-articular manifestations, systemic symptoms, serology and genetic factors, JIA is divided into oligoarticular, polyarticular, systemic, psoriatic, enthesitis-related and undifferentiated arthritis. This review provides an overview of advances in understanding of JIA pathogenesis focusing on aetiology, histopathology, immunological changes associated with disease activity, and best treatment options. Greater understanding of JIA as a collective of complex inflammatory diseases is discussed within the context of therapeutic interventions, including traditional non-biologic and up-to-date biologic disease-modifying anti-rheumatic drugs. Whilst the advent of advanced therapeutics has improved clinical outcomes, a considerable number of patients remain unresponsive to treatment, emphasising the need for further understanding of disease progression and remission to support stratification of patients to treatment pathways.
    MeSH term(s) Antirheumatic Agents/classification ; Antirheumatic Agents/pharmacology ; Arthritis, Juvenile/drug therapy ; Arthritis, Juvenile/etiology ; Arthritis, Juvenile/immunology ; Arthritis, Juvenile/physiopathology ; Child ; Disease Progression ; Humans ; Medication Therapy Management/trends ; Risk Assessment
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2021-08-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2279468-2
    ISSN 1546-0096 ; 1546-0096
    ISSN (online) 1546-0096
    ISSN 1546-0096
    DOI 10.1186/s12969-021-00629-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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