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  1. Article ; Online: Intersection of immune checkpoints and CD8+ T cell noncytolytic suppression of HIV-1 infection: putting on the brakes versus the nuclear option.

    Zaunders, John

    AIDS (London, England)

    2019  Volume 33, Issue 3, Page(s) 581–583

    MeSH term(s) CD8-Positive T-Lymphocytes ; HIV Infections ; HIV Seropositivity ; HIV-1 ; Humans ; Virus Replication
    Language English
    Publishing date 2019-01-31
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000002069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2228: Show issues Location:
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  2. Article ; Online: Editorial: Infectious Agent-Induced Chronic Immune Activation: Causes, Phenotypes, and Consequences.

    Petitdemange, Caroline / Funderburg, Nicholas / Zaunders, John / Corbeau, Pierre

    Frontiers in immunology

    2021  Volume 12, Page(s) 740556

    MeSH term(s) Anti-Infective Agents/adverse effects ; Humans ; Infections/drug therapy ; Infections/immunology ; Phenotype
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2021-12-10
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.740556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Parallel analysis of multiple human memory CD4

    Cook, Laura / Zaunders, John / Seddiki, Nabila / van Bockel, David / Kelleher, Anthony D / Munier, C Mee Ling

    Immunology and cell biology

    2022  Volume 101, Issue 2, Page(s) 171–178

    Abstract: Activation induced marker (AIM) assays are being used increasingly to measure antigen-specific T-cell responses, but this activation can alter cell lineage defining phenotypic markers. We aimed to extend the utility of AIM assays to enable pre-activation ...

    Abstract Activation induced marker (AIM) assays are being used increasingly to measure antigen-specific T-cell responses, but this activation can alter cell lineage defining phenotypic markers. We aimed to extend the utility of AIM assays to enable pre-activation defined cell populations to be tracked and quantified within T-cell memory responses. We sorted three ex vivo CD4
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Coloring Agents/metabolism ; T-Lymphocyte Subsets ; CD4-Positive T-Lymphocytes ; Antigens/metabolism ; Cell Proliferation ; Forkhead Transcription Factors/metabolism
    Chemical Substances Coloring Agents ; Antigens ; Forkhead Transcription Factors
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12606
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  4. Article: Editorial: Cytotoxic CD4+ T Cells in Viral Infections.

    Phetsouphanh, Chansavath / Pillai, Shiv / Zaunders, John J

    Frontiers in immunology

    2017  Volume 8, Page(s) 1729

    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.01729
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  5. Article: Innate and Adaptive Immunity in Long-Term Non-Progression in HIV Disease.

    Zaunders, John / van Bockel, David

    Frontiers in immunology

    2013  Volume 4, Page(s) 95

    Abstract: Long-term non-progressors (LTNP) were identified after 10-15 years of the epidemic, and have been the subject of intense investigation ever since. In a small minority of cases, infection with nef/3'LTR deleted attenuated viral strains allowed control ... ...

    Abstract Long-term non-progressors (LTNP) were identified after 10-15 years of the epidemic, and have been the subject of intense investigation ever since. In a small minority of cases, infection with nef/3'LTR deleted attenuated viral strains allowed control over viral replication. A common feature of LTNP is the readily detected proliferation of CD4 T-cells in vitro, in response to p24. In some cases, the responding CD4 T-cells have cytotoxic effector function and may target conserved p24 epitopes, similar to the CD8 T-cells described below. LTNP may also carry much lower HIV DNA burden in key CD4 subsets, presumably resulting from lower viral replication during primary infection. Some studies, but not others, suggest that LTNP have CD4 T-cells that are relatively resistant to HIV infection in vitro. One possible mechanism may involve up-regulation of the cell cycle regulator p21/waf in CD4 T-cells from LTNP. Delayed progression in Caucasian LTNP is also partly associated with heterozygosity of the Δ32 CCR5 allele, probably through decreased expression of CCR5 co-receptor on CD4 T-cells. However, in approximately half of Caucasian LTNP, two host genotypes, namely HLA-B57 and HLA-B27, are associated with viral control. Immunodominant CD8 T-cells from these individuals target epitopes in p24 that are highly conserved, and escape mutations have significant fitness costs to the virus. Furthermore, recent studies have suggested that these CD8 T-cells from LTNP, but not from HLA-B27 or HLA-B57 progressors, can cross-react with intermediate escape mutations, preventing full escape via compensatory mutations. Humoral immunity appears to play little part in LTNP subjects, since broadly neutralizing antibodies are rare, even amongst slow progressors. Recent genome-wide comparisons between LTNP and progressors have confirmed the HLA-B57, HLA-B27, and delta32 CCR5 allelic associations, plus indicated a role for HLA-C/KIR interactions, but have not revealed any new genotypes so far. Nevertheless, it is hoped that studying the mechanisms of intracellular restriction factors, such as the recently identified SAMHD1, will lead to a better understanding of non-progression.
    Language English
    Publishing date 2013-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2013.00095
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  6. Article ; Online: Comment on "A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood".

    Cook, Laura / Zaunders, John J / Kelleher, Anthony D

    Journal of immunology (Baltimore, Md. : 1950)

    2016  Volume 197, Issue 7, Page(s) 2557–2558

    Language English
    Publishing date 2016-10-01
    Publishing country United States
    Document type Letter
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1601311
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Zeb2 drives the formation of CD11c

    Gao, Xin / Shen, Qian / Roco, Jonathan A / Dalton, Becan / Frith, Katie / Munier, C Mee Ling / Ballard, Fiona D / Wang, Ke / Kelly, Hannah G / Nekrasov, Maxim / He, Jin-Shu / Jaeger, Rebecca / Carreira, Patricia / Ellyard, Julia I / Beattie, Lynette / Enders, Anselm / Cook, Matthew C / Zaunders, John J / Cockburn, Ian A

    Science immunology

    2024  Volume 9, Issue 93, Page(s) eadj4748

    Abstract: ... ...

    Abstract CD11c
    MeSH term(s) Animals ; Humans ; Mice ; Germinal Center ; Immunization ; Persistent Infection ; Vaccination ; Zinc Finger E-box Binding Homeobox 2/genetics
    Chemical Substances Zinc Finger E-box Binding Homeobox 2 ; ZEB2 protein, human ; ZEB2 protein, mouse
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adj4748
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  8. Article ; Online: Haematopoietic Stem Cell Transplantation Results in Extensive Remodelling of the Clonal T Cell Repertoire in Multiple Sclerosis.

    Massey, Jennifer / Jackson, Katherine / Singh, Mandeep / Hughes, Brendan / Withers, Barbara / Ford, Carole / Khoo, Melissa / Hendrawan, Kevin / Zaunders, John / Charmeteau-De Muylder, Bénédicte / Cheynier, Rémi / Luciani, Fabio / Ma, David / Moore, John / Sutton, Ian

    Frontiers in immunology

    2022  Volume 13, Page(s) 798300

    Abstract: Autologous haematopoietic stem cell transplantation (AHSCT) is a vital therapeutic option for patients with highly active multiple sclerosis (MS). Rates of remission suggest AHSCT is the most effective form of immunotherapy in controlling the disease. ... ...

    Abstract Autologous haematopoietic stem cell transplantation (AHSCT) is a vital therapeutic option for patients with highly active multiple sclerosis (MS). Rates of remission suggest AHSCT is the most effective form of immunotherapy in controlling the disease. Despite an evolving understanding of the biology of immune reconstitution following AHSCT, the mechanism by which AHSCT enables sustained disease remission beyond the period of lymphopenia remains to be elucidated. Auto-reactive T cells are considered central to MS pathogenesis. Here, we analyse T cell reconstitution for 36 months following AHSCT in a cohort of highly active MS patients. Through longitudinal analysis of sorted naïve and memory T cell clones, we establish that AHSCT induces profound changes in the dominant T cell landscape of both CD4+ and CD8+ memory T cell clones. Lymphopenia induced homeostatic proliferation is followed by clonal attrition; with only 19% of dominant CD4 (p <0.025) and 13% of dominant CD8 (p <0.005) clones from the pre-transplant repertoire detected at 36 months. Recovery of a thymically-derived CD4 naïve T cell repertoire occurs at 12 months and is ongoing at 36 months, however diversity of the naïve populations is not increased from baseline suggesting the principal mechanism of durable remission from MS after AHSCT relates to depletion of putative auto-reactive clones. In a cohort of MS patients expressing the MS risk allele HLA DRB1*15:01, public clones are probed as potential biomarkers of disease. AHSCT appears to induce sustained periods of disease remission with dynamic changes in the clonal T cell repertoire out to 36 months post-transplant.
    MeSH term(s) CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cells, Cultured ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Immunologic Factors ; Lymphocyte Count ; Multiple Sclerosis/immunology ; Transplantation, Autologous
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2022-02-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.798300
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  9. Article ; Online: Sustained immunotolerance in multiple sclerosis after stem cell transplant.

    Visweswaran, Malini / Hendrawan, Kevin / Massey, Jennifer C / Khoo, Melissa L / Ford, Carole D / Zaunders, John J / Withers, Barbara / Sutton, Ian J / Ma, David D F / Moore, John J

    Annals of clinical and translational neurology

    2022  Volume 9, Issue 2, Page(s) 206–220

    Abstract: Objective: Autologous haematopoietic stem cell transplantation (AHSCT) has the potential to induce sustained periods of disease remission in multiple sclerosis (MS), which is an inflammatory disease of the central nervous system (CNS) characterised by ... ...

    Abstract Objective: Autologous haematopoietic stem cell transplantation (AHSCT) has the potential to induce sustained periods of disease remission in multiple sclerosis (MS), which is an inflammatory disease of the central nervous system (CNS) characterised by demyelination and axonal degeneration. However, the mechanisms associated with durable treatment responses in MS require further elucidation.
    Methods: To characterise the longer term immune reconstitution effects of AHSCT at 24 and 36 months (M) post-transplant, high-dimensional immunophenotyping of peripheral blood mononuclear cells from 22 MS patients was performed using two custom-designed 18-colour flow cytometry panels.
    Results: The higher baseline frequencies of specific pro-inflammatory immune cells (T-helper-17 (Th17) cells, mucosal-associated invariant T-cells and CNS-homing T-conventional (T-conv) cells observed in MS patients were decreased post-AHSCT by 36M. This was accompanied by a post-AHSCT increase in frequencies and absolute counts of immunoregulatory CD56
    Interpretation: AHSCT induces substantial recalibration of pro-inflammatory and immunoregulatory components of the immune system of MS patients for up to 36M post-transplant.
    MeSH term(s) Adult ; Female ; Follow-Up Studies ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukocytes, Mononuclear ; Male ; Middle Aged ; Multiple Sclerosis/blood ; Multiple Sclerosis/immunology ; Multiple Sclerosis/therapy ; Outcome Assessment, Health Care ; Young Adult
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2740696-9
    ISSN 2328-9503 ; 2328-9503
    ISSN (online) 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.51510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Elevation of cell-associated HIV-1 transcripts in CSF CD4+ T cells, despite effective antiretroviral therapy, is linked to brain injury.

    Suzuki, Kazuo / Zaunders, John / Gates, Thomas M / Levert, Angelique / Butterly, Shannen / Liu, Zhixin / Ishida, Takaomi / Palmer, Sarah / Rae, Caroline D / Jugé, Lauriane / Cysique, Lucette A / Brew, Bruce J

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 48, Page(s) e2210584119

    Abstract: Antiretroviral therapy (ART) can attain prolonged undetectable HIV-1 in plasma and cerebrospinal fluid (CSF), but brain injury remains prevalent in people living with HIV-1 infection (PLHIV). We investigated cell-associated (CA)-HIV-1 RNA transcripts in ... ...

    Abstract Antiretroviral therapy (ART) can attain prolonged undetectable HIV-1 in plasma and cerebrospinal fluid (CSF), but brain injury remains prevalent in people living with HIV-1 infection (PLHIV). We investigated cell-associated (CA)-HIV-1 RNA transcripts in cells in CSF and blood, using the highly sensitive Double-R assay, together with proton Magnetic Resonance Spectroscopy (
    MeSH term(s) Humans ; HIV-1/genetics ; CD4-Positive T-Lymphocytes ; Leukocytes, Mononuclear ; HIV Seropositivity ; HIV Infections/drug therapy ; Brain Injuries
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2210584119
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