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  1. Article: A link between ghrelin and major depressive disorder: a mini review.

    Lis, Michał / Miłuch, Tymoteusz / Majdowski, Maciej / Zawodny, Tomasz

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1367523

    Abstract: Ghrelin is primarily responsible for regulating energy balance, as it increases appetite. However, in recent years, its new physiological functions have been discovered-it regulates lipogenesis, plays a role in the development of insulin resistance, and ... ...

    Abstract Ghrelin is primarily responsible for regulating energy balance, as it increases appetite. However, in recent years, its new physiological functions have been discovered-it regulates lipogenesis, plays a role in the development of insulin resistance, and even acts protectively on heart muscle. Moreover, ghrelin was associated with many psychiatric disorders, including major depressive disorder (MDD) or schizophrenia. Ghrelin levels were elevated in patients diagnosed with depression and in patients after suicide attempts. Moreover, ghrelin was connected to depression among postmenopausal women and was shown to be a predictive marker of MDD among the elderly. Ghrelin may influence mood disorders in various ways: by regulating stress response or inflammation or altering neurotransmission in the amygdala, dorsal raphe nucleus, or hippocampus, brain regions previously connected to the pathophysiology of MDD. Genetic variants of ghrelin and its receptor have also been associated with depression. Moreover, ghrelin can interfere with the antidepressant's action and may play a role in treatment resistance. This review highlights ghrelin's role in depression, summarizes the existing knowledge on the subject, and presents ideas for further research.
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1367523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of berberine in polycystic ovary syndrome - a summary of knowledge.

    Jurgiel, Jan / Graniak, Adrianna / Opyd, Piotr / Zawodny, Tomasz / Lis, Michal

    Ginekologia polska

    2023  Volume 95, Issue 4, Page(s) 276–284

    Abstract: Polycystic ovary syndrome (PCOS) is a widely prevalent condition that affects approximately 5-10% of women of reproductive age. Although first described in the 18th century, a detailed account of the disease was not provided until Stein and Leventhal's ... ...

    Abstract Polycystic ovary syndrome (PCOS) is a widely prevalent condition that affects approximately 5-10% of women of reproductive age. Although first described in the 18th century, a detailed account of the disease was not provided until Stein and Leventhal's 1935 report. Due to the varied symptomatology of PCOS, treatment must be tailored and often involves using multiple drugs for optimal pharmacotherapy. Berberine, an alkaloid with a longstanding history of use, has gained popularity as a potential treatment option for PCOS. Previous studies have demonstrated that berberine can improve hormonal imbalances by reducing testosterone and FAI, increasing SHBG, and mitigating the clinical symptoms of androgen excess, including hirsutism and acne. Moreover, berberine enhances the therapeutic effects of other drugs commonly used in PCOS, such as metformin and oral contraceptive pills. It is generally well-tolerated with a favourable safety profile. However, further research is warranted to establish conclusive evidence regarding berberine's mechanistic underpinnings, therapeutic potential, and long-term safety as a PCOS treatment modality.
    MeSH term(s) Humans ; Polycystic Ovary Syndrome/drug therapy ; Berberine/therapeutic use ; Female ; Metformin/therapeutic use ; Testosterone ; Hypoglycemic Agents/therapeutic use
    Chemical Substances Berberine (0I8Y3P32UF) ; Metformin (9100L32L2N) ; Testosterone (3XMK78S47O) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-12-18
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 130894-4
    ISSN 2543-6767 ; 0017-0011
    ISSN (online) 2543-6767
    ISSN 0017-0011
    DOI 10.5603/gpl.95138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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