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  1. Article ; Online: Antitumor Effects of Dietary Compounds.

    Bhutta, Zeeshan Ahmad / Choi, Kyung-Chul

    Nutrients

    2023  Volume 15, Issue 10

    Abstract: Cancer is reported to be a major cause of death worldwide, accounting for 10 million in 2020 based on 19 [ ... ]. ...

    Abstract Cancer is reported to be a major cause of death worldwide, accounting for 10 million in 2020 based on 19 [...].
    MeSH term(s) Humans ; Diet ; Neoplasms/drug therapy ; Global Health
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15102349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of isoflurane and xylazine on inducing cerebral ischemia by the model of middle cerebral artery occlusion in mice

    Jinyoung Won / Zeeshan Ahmad Khan / Yonggeun Hong

    Laboratory Animal Research, Vol 39, Iss 1, Pp 1-

    2023  Volume 7

    Abstract: Abstract Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia administration is an essential step for MCAo, but anesthetic agents can lead to adverse effects ...

    Abstract Abstract Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia administration is an essential step for MCAo, but anesthetic agents can lead to adverse effects causing death and making a considerable impact on inducing cerebral ischemia. The purpose of this study was to comparatively assess the effect of isoflurane and xylazine on transient cerebral ischemia in a mouse model of MCAo. Twenty animals were randomly divided into four groups: sham group (no MCAo), control group (MCAo under isoflurane, no agent till reperfusion), isoflurane group (MCAo under isoflurane continued till reperfusion), xylazine group (MCAo under isoflurane, and administration of xylazine till reperfusion). The survival rate, brain infarct volume, and neurologic deficits were studied to assess the effect of isoflurane and xylazine on the stroke model. Our results showed that the body weight showed statistically significant change before and 24 h after surgery in the control and Isoflurane groups, but no difference in the Xylazine group. Also, the survival rate, brain infarct volume, and neurologic deficits were slightly reduced in the isoflurane group at 24 h after reperfusion injury. However, the xylazine and control groups showed similar BIV and neurologic deficits. Interestingly, a high survival rate was observed in the xylazine group. Our results indicate that the modified method of inhalation anesthetics combined with xylazine can reduce the risk of mortality and develop a reproducible MCAo model with predictable brain ischemia. In addition, extended isoflurane anesthesia after MCAo is associated with the risk of mortality.
    Keywords Anesthesia ; Middle cerebral artery occlusion ; Ischemic stroke ; Isoflurane ; Xylazine ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 610 ; 630
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Effects of isoflurane and xylazine on inducing cerebral ischemia by the model of middle cerebral artery occlusion in mice.

    Won, Jinyoung / Khan, Zeeshan Ahmad / Hong, Yonggeun

    Laboratory animal research

    2023  Volume 39, Issue 1, Page(s) 11

    Abstract: Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia administration is an essential step for MCAo, but anesthetic agents can lead to adverse effects causing ... ...

    Abstract Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia administration is an essential step for MCAo, but anesthetic agents can lead to adverse effects causing death and making a considerable impact on inducing cerebral ischemia. The purpose of this study was to comparatively assess the effect of isoflurane and xylazine on transient cerebral ischemia in a mouse model of MCAo. Twenty animals were randomly divided into four groups: sham group (no MCAo), control group (MCAo under isoflurane, no agent till reperfusion), isoflurane group (MCAo under isoflurane continued till reperfusion), xylazine group (MCAo under isoflurane, and administration of xylazine till reperfusion). The survival rate, brain infarct volume, and neurologic deficits were studied to assess the effect of isoflurane and xylazine on the stroke model. Our results showed that the body weight showed statistically significant change before and 24 h after surgery in the control and Isoflurane groups, but no difference in the Xylazine group. Also, the survival rate, brain infarct volume, and neurologic deficits were slightly reduced in the isoflurane group at 24 h after reperfusion injury. However, the xylazine and control groups showed similar BIV and neurologic deficits. Interestingly, a high survival rate was observed in the xylazine group. Our results indicate that the modified method of inhalation anesthetics combined with xylazine can reduce the risk of mortality and develop a reproducible MCAo model with predictable brain ischemia. In addition, extended isoflurane anesthesia after MCAo is associated with the risk of mortality.
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2623220-0
    ISSN 2233-7660 ; 1738-6055
    ISSN (online) 2233-7660
    ISSN 1738-6055
    DOI 10.1186/s42826-023-00163-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antimicrobial activity of comfort related properties of silk treated with herbal extracts in making of reusable masks

    Shama Sadaf / Neelma Munir / Ayesha Saeed / Komal Hassan / Zeeshan Ahmad

    Bioscience Journal, Vol 39, Pp e39035-e

    2023  Volume 39035

    Abstract: The study was aimed at divulging an eco-friendly antimicrobial finish on 100 % silk woven fabric. The leaves’ extract of Azadirachata indica, Butea monosperma and Litche chinensis were used as the development of eco-friendly antimicrobial finish. The ... ...

    Abstract The study was aimed at divulging an eco-friendly antimicrobial finish on 100 % silk woven fabric. The leaves’ extract of Azadirachata indica, Butea monosperma and Litche chinensis were used as the development of eco-friendly antimicrobial finish. The antimicrobial property and comfort related property were checked before and after applying antimicrobial finish. In comfort related property absorbency & air permeability were checked. The ASTEM E2149 Shake Flask method was used to check antimicrobial finish and AATCC method was used for checking fabric property. One way ANOVA statistical test was applied for analysis of results. The FTIR and SEM results showed the presences of finish on fabrics. In comfort related property, absorbency and air permeability was increased. The results showed that antimicrobial finish made 100% reduction against microorganism up to 25 washes which can be used in making reusable masks fight against COVID- 19.
    Keywords antimicrobial ; azadirachata indica ; butea monosperma ; litchi chinensis ; silk ; Agriculture ; S ; Biology (General) ; QH301-705.5
    Subject code 690
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Universidade Federal de Uberlândia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Hyperspectral image reconstruction from colored natural flame luminosity imaging in a tri-fuel optical engine

    Qiang Cheng / Shervin Karimkashi / Zeeshan Ahmad / Ossi Kaario / Ville Vuorinen / Martti Larmi

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 18

    Abstract: Abstract The detection of chemiluminescence from various radicals and molecules in a hydrocarbon flame can provide valuable information on the rate of local heat release, combustion stability, and combustion completeness. In this study, chemiluminescence ...

    Abstract Abstract The detection of chemiluminescence from various radicals and molecules in a hydrocarbon flame can provide valuable information on the rate of local heat release, combustion stability, and combustion completeness. In this study, chemiluminescence from the combustion process is detected using a high-speed color camera within the broadband spectrum of visible light. Whereon, a novel hyperspectral reconstruction approach based on the physically plausible spectral reconstruction (PPSR) is employed to reconstruct the spectral chemiluminescence signals from 400 to 700 nm with a resolution of 10 nm to provide 31 different spectral channels. The reconstructed key chemiluminescence signals (e.g., CH*, CH2O*, C2*, and CO2*) from the color images are further analyzed to characterize the chemical kinetics and combustion processes under engine conditions. The spectral chemiluminescence evolution with engine crank angle is identified to comprehend the effect of H2 fraction on flame characteristics and combustion kinetics. Additionally, in this study, a detailed kinetic mechanism is adopted to deepen the theoretical understanding and describe the spectral chemiluminescence from H2/CH4 and H2/CH4/n-dodecane flames at relevant conditions for various species including OH*, CH*, C2*, and CO2*. The results indicate that the PPSR is an adequately reliable approach to reconstructing spectral wavelengths based on chemiluminescence signals from the color images, which can potentially provide qualitative information about the evolution of various species during combustion. Here, the reconstructed chemiluminescence images show less than 1% errors compared to the raw images in red, green, and blue channels. Furthermore, the reconstructed chemiluminescence trends of CH*, CH2O*, C2*, and CO2* show a good agreement with the detailed kinetics 0D simulation.
    Keywords Medicine ; R ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A Bibliometric Analysis of Studies on Plant Endemism during the Period of 1991–2022

    Zishan Ahmad Wani / Fareeda Akhter / Qamer Ridwan / Yashwant S. Rawat / Zeeshan Ahmad / Shreekar Pant

    Journal of Zoological and Botanical Gardens, Vol 4, Iss 4, Pp 692-

    2023  Volume 710

    Abstract: A bibliometric analysis of 349 scholarly documents published on the topic plant nativity and endemism from 1991–2022 was carried out using the ‘bibliometrix’ tool, developed through the R programming language. The results revealed a significant increase ... ...

    Abstract A bibliometric analysis of 349 scholarly documents published on the topic plant nativity and endemism from 1991–2022 was carried out using the ‘bibliometrix’ tool, developed through the R programming language. The results revealed a significant increase in the number of publications on plant nativity and endemism research since 1991. Of the total of 349 documents that were analyzed, 38 are single authored documents, and the average number of documents per author is 0.278. Each document has received an average of 33.67 citations, with 3.18 citations per year per document. The relationship between the number of authors and the number of articles that they have published follows a power-law distribution. Based on Bradford’s law, only eight were found to be the core sources. Mexico, followed by the USA, has produced the highest number of documents on plant nativity and endemism. The present study suggests that it is necessary to categorize data on endemism by floristic provinces, not by political subdivisions. Synecological studies are also needed, since endemic plants exist within communities. Models that accurately predict levels of endemism on the basis of easily measurable environmental variables should be useful for the rapid identification of endemic-rich areas. Recognition of the importance of plant endemism and the implementation of conservation measures is crucial for preserving biodiversity hotspots. Both in situ and ex situ conservation efforts are essential for protecting endemic species and preventing their extinction. By integrating these approaches, we can contribute to the long-term conservation and management of endemic plant species.
    Keywords endemism ; biblioshiny ; web of science ; Bradford’s law ; conservation ; Biology (General) ; QH301-705.5 ; Zoology ; QL1-991
    Subject code 333
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Effect of Daily Coffee Consumption on the Risk of Alzheimer's Disease: A Systematic Review and Meta-Analysis.

    Nila, Irin Sultana / Villagra Moran, Vanina Myuriel / Khan, Zeeshan Ahmad / Hong, Yonggeun

    Journal of lifestyle medicine

    2023  Volume 13, Issue 2, Page(s) 83–89

    Abstract: Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder that affects millions of individuals globally. The identification of the lifestyle factors that potentially help prevent or postpone disease onset is of interest to the researchers. ...

    Abstract Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder that affects millions of individuals globally. The identification of the lifestyle factors that potentially help prevent or postpone disease onset is of interest to the researchers. Although the study results are inconsistent, one such factor that has been extensively studied is coffee consumption. Therefore, this meta-analysis primarily aimed to investigate the effects of coffee consumption on the risk of AD. Pubmed, Embase, and Web of Science (Only Writing Web of Science is Fine) databases were searched for relevant studies with the keywords in various combinations, including "coffee", "caffeine", and "Alzheimer's disease". This meta-analysis included 11 studies. The relative risk (RR) with 95% confidence intervals (CI) was calculated to estimate the effect size. The study used the restricted maximum-likelihood method for a generic-inverse-variance analysis with random-effect (when heterogeneity, I
    Language English
    Publishing date 2023-08-25
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3021714-3
    ISSN 2288-1557 ; 2234-8549
    ISSN (online) 2288-1557
    ISSN 2234-8549
    DOI 10.15280/jlm.2023.13.2.83
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neurodegenerative effect of DAPK1 after cerebral hypoxia-ischemia is associated with its post-transcriptional and signal transduction regulations: A systematic review and meta-analysis.

    Khan, Zeeshan Ahmad / Sumsuzzman, Dewan Md / Choi, Jeonghyun / Hong, Yonggeun

    Ageing research reviews

    2022  Volume 76, Page(s) 101593

    Abstract: Cerebral hypoxia-ischemia (CHI) causes brain aging, neurological disorders, cognitive decline, motor function impairment, and mortality. Inhibiting death-associated protein kinase 1 (DAPK1) has shown therapeutic potential against CHI, but several reports ...

    Abstract Cerebral hypoxia-ischemia (CHI) causes brain aging, neurological disorders, cognitive decline, motor function impairment, and mortality. Inhibiting death-associated protein kinase 1 (DAPK1) has shown therapeutic potential against CHI, but several reports contradict its protective function, mechanism of activation, and signal transduction. Here, we systematically reviewed the role and the activation mechanism of DAPK1, and quantitatively assess the efficacy of DAPK1 inhibition (DI) methods in neuroprotection, following a CHI in animal models. Embase and PubMed were searched for relevant studies. Overall, 13 studies met the inclusion criteria, and the SYRCLE Risk of bias tool (RoB) tool was used to assess RoB. StataSE 16 was used for meta-analysis and network meta-analysis (NMA). Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated to estimate the effect size. DI was associated with the reduction of brain infarct volume (BIV) [SMD = -1.70, 95% CI (-2.10, -1.30); p = 0.00], neurological score (N.S.), neuronal degeneration, with no change in the level of in cell death [SMD = -0.83, 95% CI (-2.00, 0.35); p = 0.17], indicating the protective role of DI against CHI. No differences were found in DAPK1 mRNA and protein levels [SMD = 0.50, 95% CI (-0.05, 1.04); p = 0.07] {single-study driven; upregulated after exclusion (p = 0.01, I
    MeSH term(s) Animals ; Cell Death ; Death-Associated Protein Kinases/genetics ; Death-Associated Protein Kinases/metabolism ; Humans ; Hypoxia-Ischemia, Brain/genetics ; Network Meta-Analysis ; Neurodegenerative Diseases/genetics ; RNA Processing, Post-Transcriptional ; Signal Transduction
    Chemical Substances DAPK1 protein, human (EC 2.7.11.1) ; Death-Associated Protein Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2022.101593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Development and Characterization of Natural Chromite Coating on Metal Substrate Using the Plasma Spray Process.

    Abbasi, Zeeshan Ahmad / Mateen, Abdul / Niaz, Akbar / Ur Rehman, Muhammad Atiq / Wadood, Abdul

    ACS omega

    2023  Volume 8, Issue 17, Page(s) 15193–15202

    Abstract: Natural materials are gaining interest as coating feedstock because their "quality to cost" ratio is better and they are more environmentally friendly than most of the synthetic ceramics. They give sufficient protection to metal surfaces against harsh ... ...

    Abstract Natural materials are gaining interest as coating feedstock because their "quality to cost" ratio is better and they are more environmentally friendly than most of the synthetic ceramics. They give sufficient protection to metal surfaces against harsh conditions such as corrosion, wear, and high temperature. In the current study, chromite mineral was beneficiated and reduced to two different sizes to be used as feedstock material for thermal spray coating. Powders were upgraded by gravity and magnetic separation, respectively, and thermally sprayed onto mild steel samples by using atmospheric plasma spray (APS) equipment. Morphology, structure, phases, elemental distribution of chromite powder, and coatings were studied using field emission scanning electron microscopy, X-ray diffraction, X-ray fluorescence spectroscopy, and energy-dispersive X-ray spectroscopy. Tribological properties of APS chromite coatings were investigated by using a ball-on-disk tribometer, and corrosion resistance properties were evaluated by carrying out potentiodynamic polarization testing in 3.5% NaCl solution. It is observed that the coating has better wear and corrosion resistance and is worn by abrasive wear that includes scratching and particles pull out. Coating efficiency, surface morphology, and microhardness of the coating developed by fine powder were better than those of coarse powder coating.
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mixed convection of two layers with radiative electro-magnetohydrodynamics nanofluid flow in vertical enclosure.

    Ellahi, Rahmat / Zeeshan, Ahmad / Shehzad, Nasir / Hussain, Aneel / Sait, Sadiq M

    Nanotechnology

    2023  Volume 35, Issue 9

    Abstract: Mixed convection flow of two layers nanofluid in a vertical enclosure is studied. The channel consists of two regions. Region I is electrically conducting while Region II is electrically non-conducting. Region I is filled with base fluid water with ... ...

    Abstract Mixed convection flow of two layers nanofluid in a vertical enclosure is studied. The channel consists of two regions. Region I is electrically conducting while Region II is electrically non-conducting. Region I is filled with base fluid water with copper oxides nanoparticles and Region II is filled with base fluid kerosene oil with iron oxides. The simultaneous effects of electro-magnetohydrodynamics and Grashof number are also taken into account. The governing flow problem consists of nonlinear coupled differential equations which is tackled using analytical technique. Analytical results have been obtained by the homotopy analysis method (HAM). The results for the leading parameters, such as the Hartmann numbers, Grashof numbers, ratio of viscosities, width ratio, volume fraction of nanoparticles, and the ratio of thermal conductivities for three different electric field scenarios under heat generation/absorption were examined. It is found that the effect of the negative electric load parameter assists the flow while the effect of the positive electric load parameter opposes the flow as compared to the case when the electric load parameter is zero. All outcomes for significant parameters on velocity and temperature are discussed graphically.
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad115b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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